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  1. Book: Jatin Shah's head and neck surgery and oncology

    Shah, Jatin P. / Patel, Snehal G. / Singh, Bhuvanesh / Wong, Richard J.

    2020  

    Title variant Head and neck surgery and oncology
    Author's details Jatin P. Shah, Snehal G. Patel, Bhuvanesh Singh, Richard J. Wong
    Keywords Head/Surgery ; Neck/Surgery ; Head/Tumors ; Neck/Tumors
    Subject code 617.51059
    Language English
    Size xi, 882 Seiten, Illustrationen, Diagramme
    Edition Fifth edition
    Publisher Elsevier
    Publishing place Edinburgh
    Publishing country Great Britain
    Document type Book
    Note Zugang zur Internetausgabe über Code
    HBZ-ID HT020132286
    ISBN 978-0-323-41518-7 ; 9780323417891 ; 0-323-41518-0 ; 0323417892
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 C 33 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: New Activities of the Nuclear Pore Complexes.

    Wong, Richard W

    Cells

    2021  Volume 10, Issue 8

    Abstract: Nuclear pore complexes (NPCs) at the surface of nuclear membranes play a critical role in regulating the transport of both small molecules and macromolecules between the cell nucleus and cytoplasm via their multilayered spiderweb-like central channel. ... ...

    Abstract Nuclear pore complexes (NPCs) at the surface of nuclear membranes play a critical role in regulating the transport of both small molecules and macromolecules between the cell nucleus and cytoplasm via their multilayered spiderweb-like central channel. During mitosis, nuclear envelope breakdown leads to the rapid disintegration of NPCs, allowing some NPC proteins to play crucial roles in the kinetochore structure, spindle bipolarity, and centrosome homeostasis. The aberrant functioning of nucleoporins (Nups) and NPCs has been associated with autoimmune diseases, viral infections, neurological diseases, cardiomyopathies, and cancers, especially leukemia. This Special Issue highlights several new contributions to the understanding of NPC proteostasis.
    MeSH term(s) Cell Nucleus/metabolism ; Humans ; Kinetochores/metabolism ; Nanomedicine/methods ; Nuclear Pore/metabolism
    Language English
    Publishing date 2021-08-18
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10082123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Step-by-Step Thyroidectomy-Incision, Nerve Identification, Parathyroid Preservation, and Gland Removal.

    Scott, Britney / Wong, Richard J

    Otolaryngologic clinics of North America

    2023  Volume 57, Issue 1, Page(s) 25–37

    Abstract: Thyroidectomy is a surgical procedure to remove part or all of the thyroid gland. Although the general tenets of surgery have remained the same, improvements in techniques, diagnostics, understanding of anatomy, and technology have allowed thyroid ... ...

    Abstract Thyroidectomy is a surgical procedure to remove part or all of the thyroid gland. Although the general tenets of surgery have remained the same, improvements in techniques, diagnostics, understanding of anatomy, and technology have allowed thyroid surgery to become a standard, effective, and safe surgery. For surgeons undertaking this procedure, it is imperative to have an in-depth knowledge of critical anatomy and a comprehensive understanding of surgical techniques to perform safe and effective surgery. This article aims to provide an overview of surgical techniques that may be applied in both benign and malignant disease settings.
    MeSH term(s) Humans ; Thyroidectomy/adverse effects ; Thyroidectomy/methods ; Thyroid Gland/surgery ; Parathyroid Glands/surgery ; Surgeons ; Recurrent Laryngeal Nerve/surgery
    Language English
    Publishing date 2023-09-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 417489-6
    ISSN 1557-8259 ; 0030-6665
    ISSN (online) 1557-8259
    ISSN 0030-6665
    DOI 10.1016/j.otc.2023.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Crafty mimicry grants nuclear pore entry to HIV.

    Lim, Keesiang / Hazawa, Masaharu / Wong, Richard W

    Cell host & microbe

    2024  Volume 32, Issue 4, Page(s) 441–442

    Abstract: The size of the nuclear pore should, in principle, prevent HIV-1 entry. However, HIV-1 capsid is able to gain nuclear pore entry. In a recent issue of Nature, Fu et al. and Dickson et al. demonstrate that the HIV-1 capsid mimics the nuclear transport ... ...

    Abstract The size of the nuclear pore should, in principle, prevent HIV-1 entry. However, HIV-1 capsid is able to gain nuclear pore entry. In a recent issue of Nature, Fu et al. and Dickson et al. demonstrate that the HIV-1 capsid mimics the nuclear transport protein karyopherins to access host nuclei.
    MeSH term(s) Humans ; Nuclear Pore ; Capsid/metabolism ; Capsid Proteins/metabolism ; HIV Infections/metabolism ; Active Transport, Cell Nucleus ; Cell Nucleus/metabolism ; Nuclear Pore Complex Proteins/metabolism
    Chemical Substances Capsid Proteins ; Nuclear Pore Complex Proteins
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2024.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6578: Show issues Location:
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  5. Article ; Online: Head and neck surgical oncology.

    Shah, Jatin P / Wong, Richard J

    Journal of surgical oncology

    2022  Volume 126, Issue 5, Page(s) 860–864

    Abstract: During the past five decades, major technological advances, including availability of imaging techniques such as computed tomography, magnetic resonance imaging, and positron emission tomography scans, have improved accurate assessment of tumors. Major ... ...

    Abstract During the past five decades, major technological advances, including availability of imaging techniques such as computed tomography, magnetic resonance imaging, and positron emission tomography scans, have improved accurate assessment of tumors. Major advances in reconstructive surgery with development of microvascular free-flap reconstruction have made one-stage resection and reconstruction a reality, leading to a better quality of life. Multimodality treatments combining chemotherapy with radiation have led to development of organ preservation strategies and improved locoregional control of head and neck cancer.
    MeSH term(s) Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/surgery ; Humans ; Positron-Emission Tomography/methods ; Quality of Life ; Surgical Oncology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.27029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Role of Schwann Cells in Cancer.

    Deborde, Sylvie / Wong, Richard J

    Advanced biology

    2022  Volume 6, Issue 9, Page(s) e2200089

    Abstract: Schwann cells (SCs) are the most abundant cell type in the nerves in the peripheral nervous system and compose a family of subtypes that are endowed with a variety of different functions. SCs facilitate the transmission of neural impulses, provide ... ...

    Abstract Schwann cells (SCs) are the most abundant cell type in the nerves in the peripheral nervous system and compose a family of subtypes that are endowed with a variety of different functions. SCs facilitate the transmission of neural impulses, provide nutrients and protection for neurons, guide axons in nerve repair, and regulate immune functions. In the context of cancer, recent studies have revealed an active role of SCs in promoting cancer cell invasion, modulating immune responses, and transmitting pain sensation.
    MeSH term(s) Axons/physiology ; Neoplasms/metabolism ; Nerve Regeneration/physiology ; Peripheral Nervous System ; Schwann Cells/metabolism
    Language English
    Publishing date 2022-06-04
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ISSN 2701-0198
    ISSN (online) 2701-0198
    DOI 10.1002/adbi.202200089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Gastric-type glandular lesions of the female genital tract excluding the cervix: emerging pathological entities.

    Wong, Richard W-C / Talia, Karen L / McCluggage, W Glenn

    Histopathology

    2024  

    Abstract: In the last two decades or so, a spectrum of benign, premalignant and malignant cervical glandular lesions exhibiting gastric differentiation has been described, with gastric-type adenocarcinoma representing the most common human papillomavirus (HPV)- ... ...

    Abstract In the last two decades or so, a spectrum of benign, premalignant and malignant cervical glandular lesions exhibiting gastric differentiation has been described, with gastric-type adenocarcinoma representing the most common human papillomavirus (HPV)-independent cervical adenocarcinoma. More recently, limited literature has reported a variety of gastric-type glandular lesions at other sites within the female genital tract and, as in the cervix (the most common site for these lesions), a spectrum of benign, premalignant and malignant lesions has been proposed. We provide an update and review of the emerging spectrum of gastric-type glandular lesions at female genital tract sites other than the cervix. In the endometrium, putative gastric-type glandular lesions include mucinous metaplasia of gastric-type, atypical mucinous proliferation of gastric-type and gastric-type adenocarcinoma. Similarly in the vagina, gastric-type adenosis, atypical adenosis and adenocarcinoma have been described. There have also been occasional reports of gastric-type lesions involving the ovary and fallopian tube. We provide guidance on how to recognise gastric-type lesions morphologically and immunophenotypically and stress that sometimes these lesions occur at more than one site within the female genital tract (synchronous/multifocal gastric-type lesions of the female genital tract), sometimes in association with Peutz-Jeghers syndrome.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.15174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1328: Show issues Location:
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  8. Article ; Online: Predictive and prognostic biomarkers in female genital tract tumours: an update highlighting their clinical relevance and practical issues.

    Wong, Richard Wing-Cheuk / Cheung, Annie N Y

    Pathology

    2023  Volume 56, Issue 2, Page(s) 214–227

    Abstract: The evaluation of biomarkers by molecular techniques and immunohistochemistry has become increasingly relevant to the treatment of female genital tract tumours as a consequence of the greater availability of therapeutic options and updated disease ... ...

    Abstract The evaluation of biomarkers by molecular techniques and immunohistochemistry has become increasingly relevant to the treatment of female genital tract tumours as a consequence of the greater availability of therapeutic options and updated disease classifications. For ovarian cancer, mutation testing for BRCA1/2 is the standard predictive biomarker for poly(ADP-ribose) polymerase inhibitor therapy, while homologous recombination deficiency testing may allow the identification of eligible patients among cases without demonstrable BRCA1/2 mutations. Clinical recommendations are available which specify how these predictive biomarkers should be applied. Mismatch repair (MMR) protein and folate receptor alpha immunohistochemistry may also be used to guide treatment in ovarian cancer. In endometrial cancer, MMR immunohistochemistry is the preferred test for predicting benefit from immune checkpoint inhibitor (ICI) therapy, but molecular testing for microsatellite instability may have a supplementary role. HER2 testing by immunohistochemistry and in situ hybridisation is applicable to endometrial serous carcinomas to assess trastuzumab eligibility. Immunohistochemistry for oestrogen receptor and progesterone receptor expression may be used for prognostication in endometrial cancer, but its predictive value for hormonal therapy is not yet proven. POLE mutation testing and p53 immunohistochemistry (as a surrogate for TP53 mutation status) serve as prognostic markers for favourable and adverse outcomes, respectively, in endometrial cancer, especially when combined with MMR testing for molecular subtype designation. For cervical cancer, programmed death ligand 1 immunohistochemistry may be used to predict benefit from ICI therapy although its predictive value is under debate. In vulvar cancer, p16 and p53 immunohistochemistry has established prognostic value, stratifying patients into three groups based on the human papillomavirus and TP53 mutation status of the tumour. Awareness of the variety and pitfalls of expression patterns for p16 and p53 in vulvar carcinomas is crucial for accurate designation. It is hoped that collaborative efforts in standardising and optimising biomarker testing for gynaecological tumours will contribute to evidence-based therapeutic decisions.
    MeSH term(s) Humans ; Female ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Prognosis ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; Clinical Relevance ; BRCA2 Protein/genetics ; Endometrial Neoplasms/pathology ; Ovarian Neoplasms/pathology ; Mutation ; Genitalia, Female/metabolism ; Genitalia, Female/pathology ; Carcinoma/pathology ; Biomarkers ; Biomarkers, Tumor/genetics ; DNA Mismatch Repair
    Chemical Substances Tumor Suppressor Protein p53 ; BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein ; Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2023.10.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Integrating teaching practice with developmental norms: the case of phonological teaching in L2.

    Wong, Richard Kwok-Shing / MacWhinney, Brian

    International journal of early years education

    2023  Volume 17, Issue 1, Page(s) 17–31

    Abstract: This paper highlights the crucial role of phonological instruction in early second language English learning. Although older learners can acquire grammar and vocabulary efficiently, younger learners appear to have a greater facility with the learning of ... ...

    Abstract This paper highlights the crucial role of phonological instruction in early second language English learning. Although older learners can acquire grammar and vocabulary efficiently, younger learners appear to have a greater facility with the learning of sounds. Thus, it makes good sense to focus on articulatory skills for these early learners. By comparing the developmental norms in phonology between an L1 (Cantonese in this study) and an L2, detailed predictions can be provided to guide the process of early phonological instruction. It is important that the teaching of articulation should not be reduced to non-engaging lessons that can be characterised as 'drill and kill'. Instead, a framework for improving the articulation of children learning English as a second language is proposed. What is unique about this proposal is that it represents the first attempt in Hong Kong to specify and integrate research findings concerning developmental speech norms with existing teaching practice.
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020377-9
    ISSN 1469-8463 ; 0966-9760
    ISSN (online) 1469-8463
    ISSN 0966-9760
    DOI 10.1080/09669760802699860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Seminar issue on human papillomavirus-related head and neck cancer.

    Shah, Jatin P / Wong, Richard J

    Journal of surgical oncology

    2021  Volume 124, Issue 6, Page(s) 919

    MeSH term(s) Head and Neck Neoplasms/etiology ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/prevention & control ; Humans ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/complications ; Papillomavirus Vaccines/administration & dosage
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.26693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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