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Article ; Online: Pulmonary valve replacement and quality-of-life assessment.

Tsang, Flora H F / Wong, Sophia J / Cheung, Yiu-fai

2016 Volume 24, Issue 1, Page(s) 5–11

Abstract: Background: Chronic pulmonary regurgitation is common after repair of tetralogy of Fallot. Despite the deleterious effects of chronic pulmonary regurgitation on right ventricular function, many patients with repaired tetralogy of Fallot remain ... ...

Abstract	Background: Chronic pulmonary regurgitation is common after repair of tetralogy of Fallot. Despite the deleterious effects of chronic pulmonary regurgitation on right ventricular function, many patients with repaired tetralogy of Fallot remain asymptomatic. Health is defined not only by the absence of disease but also by physical, mental, and social wellbeing. We sought to examine the impact of pulmonary valve replacement on quality of life in asymptomatic patients with repaired tetralogy of Fallot and chronic pulmonary regurgitation. Methods: From January 2009 to December 2012, 25 (18 male) asymptomatic patients (mean age 23.4 ± 7.4 years) who underwent pulmonary valve replacement for significant pulmonary regurgitation were recruited. Cardiac magnetic resonance was performed pre- and postoperatively. Quality of life was assessed using the Chinese version of the SF-36v2 evaluation tool. Demographics, clinical data, magnetic resonance findings, and quality-of-life scores were collected and calculated for comparison. Results: After surgery, the indexed right ventricular end-diastolic volume (193 ± 47.3 vs. 105.6 ± 29.6 mL m(-2), p < 0.001) and indexed right ventricular end-systolic volume (108.5 ± 32.9 vs. 61.1 ± 23 mL m(-2), p < 0.001) decreased significantly. The response rates for pre- and postoperative quality-of-life assessments were 100%. Patients demonstrated improvements in all 8 domains of the SF-36v2 assessment. The physical (46.5 ± 6.6 vs. 49.9 ± 6.4, p = 0.012) and mental (43.7 ± 7.8 vs. 51.9 ± 7.6, p < 0.001) component summary scores increased after surgery. Conclusion: Pulmonary valve replacement can improve the quality of life in patients with chronic asymptomatic pulmonary regurgitation.
MeSH term(s)	Adolescent ; Adult ; Asymptomatic Diseases ; Cardiac Surgical Procedures/adverse effects ; Chronic Disease ; Female ; Heart Valve Prosthesis Implantation ; Humans ; Magnetic Resonance Imaging, Cine ; Male ; Mental Health ; Pulmonary Valve/physiopathology ; Pulmonary Valve/surgery ; Pulmonary Valve Insufficiency/diagnosis ; Pulmonary Valve Insufficiency/etiology ; Pulmonary Valve Insufficiency/physiopathology ; Pulmonary Valve Insufficiency/psychology ; Pulmonary Valve Insufficiency/surgery ; Quality of Life ; Recovery of Function ; Stroke Volume ; Surveys and Questionnaires ; Tetralogy of Fallot/diagnosis ; Tetralogy of Fallot/physiopathology ; Tetralogy of Fallot/surgery ; Time Factors ; Treatment Outcome ; Ventricular Function, Right ; Young Adult
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1400468-9
ISSN	1816-5370 ; 0218-4923
ISSN (online)	1816-5370
ISSN	0218-4923
DOI	10.1177/0218492315617631
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Article ; Online: Atrial and ventricular mechanics in patients after Fontan-type procedures: atriopulmonary connection versus extracardiac conduit.

Li, Shu-Juan / Wong, Sophia J / Cheung, Yiu-fai

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2014 Volume 27, Issue 6, Page(s) 666–674

Abstract: Background: Differences in systemic venous flow dynamics and energy losses exist in various Fontan-type procedures, which may affect atrial and ventricular filling. The aim of this study was to test the hypothesis that atrial and ventricular mechanics ... ...

Abstract	Background: Differences in systemic venous flow dynamics and energy losses exist in various Fontan-type procedures, which may affect atrial and ventricular filling. The aim of this study was to test the hypothesis that atrial and ventricular mechanics differ between two types of Fontan procedures, atriopulmonary connection (APC) and extracardiac conduit, which have distinctly different systemic venous hemodynamics. Methods: This was a cross-sectional, case-control study of 28 Fontan patients (13 with APC, 15 with extracardiac conduit) aged 19.8 ± 6.5 years and 26 healthy controls. Atrial and systemic ventricular myocardial deformation was determined using speckle-tracking echocardiography, while ventricular volumes and systolic dyssynchrony index were assessed using three-dimensional echocardiography. Results: Compared with controls, patients had significantly lower values of global ventricular longitudinal, circumferential, and radial systolic strain in all three directions, reduced systolic and early diastolic strain rates (SRs) in more than one dimension, lower ejection fractions, and worse ventricular dyssynchrony. For atrial deformation, patients had lower global and positive strain and conduit and reservoir SRs and delayed electromechanical coupling. Among patients, those with APC had significantly lower ventricular longitudinal strain and early diastolic SRs, worse ventricular dyssynchrony, and reduced atrial positive and negative strain and conduit and active contractile SRs. Atrial global strain (r = 0.60, P = .001) and conduit SR (r = 0.49, P = .008) correlated positively with systemic ventricular early diastolic SR. Conclusions: Atrial and ventricular mechanics are impaired in patients after Fontan-type operation, which is worse with APC than extracardiac conduit.
MeSH term(s)	Adolescent ; Atrial Function ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Echocardiography, Doppler ; Echocardiography, Doppler, Pulsed ; Female ; Fontan Procedure/methods ; Heart Atria/diagnostic imaging ; Heart Ventricles/diagnostic imaging ; Humans ; Male ; Postoperative Complications/epidemiology ; Postoperative Period ; Ventricular Dysfunction/epidemiology ; Ventricular Function ; Young Adult
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2014.01.027
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Zs.A 2638: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Left ventricular mechanics in adolescents and young adults with a history of kawasaki disease: analysis by three-dimensional speckle tracking echocardiography.

Yu, Wei / Wong, Sophia J / Cheung, Yiu-fai

Echocardiography (Mount Kisco, N.Y.)

2014 Volume 31, Issue 4, Page(s) 483–491

Abstract: Background: Myocardial fibrosis and perfusion abnormalities can occur in patients with Kawasaki disease (KD). We explored using the new three-dimensional speckle tracking echocardiography (3DSTE) the left ventricular (LV) mechanics in adolescents and ... ...

Abstract	Background: Myocardial fibrosis and perfusion abnormalities can occur in patients with Kawasaki disease (KD). We explored using the new three-dimensional speckle tracking echocardiography (3DSTE) the left ventricular (LV) mechanics in adolescents and young adults with a history of KD. Methods: Twenty-five KD patients (18 males) aged 17.0 ± 5.2 years, 14 with (group I) and 11 without (group II) coronary aneurysms, were studied. The 3D volume datasets were acquired for quantification of LV global 3D strain, global and regional area strain, systolic dyssynchrony index (SDI), twist, twist gradient (twist/LV length), and ejection fraction. Results: The results were compared with those of 14 age-matched controls. Of the 14 group I patients, 6 had left, 2 had right, and 6 had both left and right coronary aneurysms. Compared with controls, group I patients had significantly lower LV systolic global 3D strain (43.7 ± 7.3% vs. 50.4 ± 6.6%, P = 0.02), twist (8.7 ± 1.3° vs. 11.4 ± 2.0°, P < 0.001), and twist gradient (1.5 ± 0.3°/cm vs. 1.9 ± 0.4°/cm, P = 0.01), greater SDI (6.8 ± 1.9% vs. 4.7 ± 1.9%, P < 0.001), and similar ejection fractions. Six patients in group I had perfusion defects, who had global 3DSTE parameters similar to those of the 8 patients without perfusion abnormalities (all P > 0.05). For group II patients, only the global area strain was significantly lower than that of controls (37.6 ± 3.5% vs. 40.7 ± 3.6%, P = 0.038). Conclusion: In adolescents and young adults with a history of KD, impairment of LV mechanics occurs and is worse in patients with than those without coronary complications.
MeSH term(s)	Adolescent ; Age Factors ; Cardiac Catheterization/methods ; Case-Control Studies ; Coronary Aneurysm/complications ; Coronary Aneurysm/diagnostic imaging ; Echocardiography, Three-Dimensional ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Linear Models ; Male ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnostic imaging ; Multivariate Analysis ; Prognosis ; Reference Values ; Risk Assessment ; Severity of Illness Index ; Sex Factors ; Tomography, X-Ray Computed/methods ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function/physiology ; Young Adult
Language	English
Publishing date	2014-04
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.12394
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Zs.A 2170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Atrial mechanics after surgical repair of tetralogy of Fallot.

Hou, Jia / Yu, Hong-kui / Wong, Sophia J / Cheung, Yiu-fai

Echocardiography (Mount Kisco, N.Y.)

2015 Volume 32, Issue 1, Page(s) 126–134

Abstract: Background: Ventricular diastolic dysfunction in patients with repaired tetralogy of Fallot (TOF) may affect atrial mechanics. This study aimed to explore right atrial (RA) and left atrial (LA) mechanics in repaired TOF patients and their relationship ... ...

Abstract	Background: Ventricular diastolic dysfunction in patients with repaired tetralogy of Fallot (TOF) may affect atrial mechanics. This study aimed to explore right atrial (RA) and left atrial (LA) mechanics in repaired TOF patients and their relationship with ventricular diastolic function. Methods: Fifty-four patients (36 males), aged 17.8 ± 8.3 years, who had undergone TOF repair at 3.9 ± 3.3 years and 40 healthy subjects aged 16.9 ± 6.3 years (P = 0.57) were studied. Right and LA peak positive, peak negative, and total strain, strain rate at ventricular systole (SRs ), early diastole (SRed ), and atrial contraction (SRac ), and electromechanical delay were determined using speckle tracking echocardiography (STE). Ventricular diastolic function was assessed by tissue Doppler imaging and STE. Ventricular volumes and pulmonary regurgitant volume were derived from 3D echocardiography. Results: Compared with controls, patients had significantly lower RA and LA peak positive and total strain, SRs , SRed , and SRac (all P < 0.001). The timing of RA (178 ± 33 msec vs. 152 ± 17 msec, P < 0.001) and LA (170 ± 32 msec vs. 152 ± 24 msec, P = 0.006) electromechanical coupling (EMC) was significantly longer in patients than in controls. The RA total strain, SRs , SRed , SRac , and EMC correlated positively with corresponding LA parameters (all P < 0.001). The RA and LA total strain and SRed were associated positively with diastolic annular velocities and strain rates of respective ventricles (all P < 0.05). The LA SRed correlated negatively with pulmonary regurgitant volume (r = -0.33, P = 0.016) and RV end-diastolic volume (r = -0.33, P = 0.015). Conclusion: Mechanics of both atria are impaired in patients after repair of TOF and are associated with diastolic performance of the respective ventricles.
MeSH term(s)	Adolescent ; Cardiovascular Surgical Procedures ; Echocardiography/methods ; Elasticity Imaging Techniques/methods ; Female ; Heart Atria/diagnostic imaging ; Heart Atria/physiopathology ; Humans ; Male ; Reconstructive Surgical Procedures ; Tetralogy of Fallot/diagnostic imaging ; Tetralogy of Fallot/physiopathology ; Tetralogy of Fallot/surgery ; Treatment Outcome ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/prevention & control
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.12611
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Zs.A 2170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Right and left ventricular mechanics and interaction late after balloon valvoplasty for pulmonary stenosis.

Li, Shu-Juan / Yu, Hong-Kui / Wong, Sophia J / Cheung, Yiu-Fai

European heart journal cardiovascular Imaging

2014 Volume 15, Issue 9, Page(s) 1020–1028

Abstract: Aims: This study sought to explore right (RV) and left ventricular (LV) mechanics and ventricular-ventricular interaction in adolescents and young adults late after percutaneous balloon pulmonary valvoplasty (PBPV) for valvar pulmonary stenosis (PS).: ...

Abstract	Aims: This study sought to explore right (RV) and left ventricular (LV) mechanics and ventricular-ventricular interaction in adolescents and young adults late after percutaneous balloon pulmonary valvoplasty (PBPV) for valvar pulmonary stenosis (PS). Methods and results: Potential late effects of PS despite PBPV on cardiac mechanics have not been well defined. Thirty-one patients aged 20.2 ± 7.6 years were studied at 18 ± 6 years after PBPV. Ventricular myocardial deformation was determined using speckle tracking echocardiography, while RV and LV volumes and ejection fraction as well as LV systolic dyssynchrony index were assessed by three-dimensional echocardiography. The results were compared with those of 30 controls. Pulmonary regurgitation, mostly trivial to mild, was present in 90% (28/31) of patients. Compared with controls, patients had significantly greater RV end-diastolic (P < 0.001), RV end-systolic (P < 0.001), and LV end-systolic (P = 0.04) volumes as well as lower LV ejection fraction (P < 0.001). For deformation, patients had significantly reduced RV longitudinal systolic strain (P = 0.004), decreased LV circumferential systolic strain (P < 0.001), and strain rate (P = 0.001) as well as greater LV mechanical dyssynchrony (P < 0.001). In patients, RV end-diastolic and end-systolic volumes correlated with LV circumferential strain (r = -0.47, P = 0.008 and r = -0.36, P = 0.049, respectively) and dyssynchrony (r = 0.53, P = 0.002 and r = 0.49, P = 0.005, respectively). Patients who had PBPV at age ≤1 year had ventricular deformation indices similar to those who had interventions beyond 1 year. Conclusion: Impaired RV and LV mechanics and adverse ventricular-ventricular interaction occur in adolescents and young adults late after balloon valvoplasty for isolated valvar PS.
MeSH term(s)	Adolescent ; Adult ; Balloon Valvuloplasty ; Child ; Echocardiography, Doppler, Color ; Echocardiography, Three-Dimensional ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Male ; Pulmonary Valve Stenosis/diagnostic imaging ; Pulmonary Valve Stenosis/physiopathology ; Pulmonary Valve Stenosis/therapy ; Treatment Outcome
Language	English
Publishing date	2014-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeu058
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Zs.A 5614: Show issues

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Article ; Online: Arterial mechanics at rest and during exercise in adolescents and young adults after arterial switch operation for complete transposition of the great arteries.

Chen, Robin H / Wong, Sophia J / Wong, Wilfred H / Cheung, Yiu-Fai

The American journal of cardiology

2014 Volume 113, Issue 4, Page(s) 713–718

Abstract: We sought to determine the arterial mechanics at rest and during exercise in adolescents and young adults with complete transposition of the great arteries after arterial switch operation and their relations with neoaortic complications. Thirty patients ( ...

Abstract	We sought to determine the arterial mechanics at rest and during exercise in adolescents and young adults with complete transposition of the great arteries after arterial switch operation and their relations with neoaortic complications. Thirty patients (22 men) aged 16.2 ± 2.1 years and 22 controls (15 men) were studied. Central and peripheral arterial pulse wave velocities, carotid and radial augmentation indices, and central systolic blood pressure (cSBP) were determined by oscillometry and applanation tonometry, whereas arterial dimensions were measured by 2-dimensional echocardiography. Arterial strain, distensibility, and stiffness were determined at rest and during supine bicycle exercise testing. At rest, patients had significantly higher heart-carotid pulse wave velocity, carotid and radial augmentation indices, and cSBP than controls. At rest and during submaximal exercise, patients had significantly lower aortic strain and distensibility, greater aortic and carotid stiffness, and higher SBP than controls. Dilated aortic sinus found in 23 (76.7%) patients was associated with lower aortic distensibility, greater aortic stiffness, and higher cSBP at rest and lower aortic distensibility and strain at submaximal exercise. Significant aortic regurgitation found in 20% (6 of 30) of patients was associated with significantly higher neoaortic z scores. Multivariate analysis identified aortic stiffness at rest (β = 0.46, p = 0.003) and age at operation (β = 0.44, p = 0.004) as significant determinants of aortic sinus z scores. In conclusion, altered mechanics of the central arteries are present at rest and during exercise in adolescents and young adults after arterial switch operation. These findings may have important implications on progression of neoaortic root dilation, exercise recommendations, and medical therapy.
MeSH term(s)	Adolescent ; Aorta/diagnostic imaging ; Aorta/physiology ; Blood Pressure/physiology ; Echocardiography ; Exercise/physiology ; Female ; Humans ; Male ; Manometry ; Oscillometry ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/physiology ; Pulse Wave Analysis ; Rest ; Transposition of Great Vessels/diagnostic imaging ; Transposition of Great Vessels/physiopathology ; Transposition of Great Vessels/surgery ; Vascular Resistance/physiology ; Vasoconstriction/physiology ; Vasodilation/physiology ; Young Adult
Language	English
Publishing date	2014-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2013.10.050
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Article ; Online: Right Atrial Mechanics Long-Term after Biventricular Repair of Pulmonary Atresia or Stenosis with Intact Ventricular Septum.

To, Ashley Hoi-Man / Lai, Clare Tik-Man / Wong, Sophia J / Cheung, Yiu-Fai

Echocardiography (Mount Kisco, N.Y.)

2016 Volume 33, Issue 4, Page(s) 586–595

Abstract: Background: This study tested the hypothesis that right atrial (RA) mechanics are altered in patients after repair of pulmonary atresia with intact ventricular septum (PAIVS) and pulmonary stenosis (PS) and to explore their relationships with right ... ...

Abstract	Background: This study tested the hypothesis that right atrial (RA) mechanics are altered in patients after repair of pulmonary atresia with intact ventricular septum (PAIVS) and pulmonary stenosis (PS) and to explore their relationships with right ventricular (RV) diastolic function and P-wave indices. Methods: Thirty-six adult patients, 16 with PAIVS and 20 with PS patients, and 20 age-matched healthy subjects were studied. Right atrial mechanics were assessed using speckle tracking echocardiography (STE) with quantification of positive, negative, and total strain, and strain rates at ventricular systole (aSRs ), early diastole (aSRed ), and atrial contraction (aSRac ). Right ventricular diastolic function was assessed by Doppler interrogation and STE. Maximum P-wave duration and P-wave dispersion were measured. Results: Compared with controls, PAIVS and PS patients had significantly lower RA positive and total strain, aSRs and aSRed (all P < 0.05). Parameters of RV diastolic function including transtricuspid early (E) and late (A) diastolic inflow velocities, E/A ratio, early diastolic tricuspid annular velocity (e), early to late diastolic annular velocity ratio, E/e ratio, and RV early diastolic strain rate were found to correlate significantly with RA positive and total strain and aSRed (all P < 0.05). Maximum P-wave duration and P-wave dispersion increased progressively across control, PS, and PAIVS groups (P for trend <0.001). Both P-wave indices correlated negatively with RA positive strain, total strain, and aSRed (all P < 0.05). Conclusion: Impairment of RA mechanics occurs in patients long term after repair of PAIVS and PS and is associated with RV diastolic dysfunction, longer P-wave duration, and greater P-wave dispersion.
MeSH term(s)	Adolescent ; Adult ; Atrial Function, Right ; Echocardiography/methods ; Female ; Heart Atria/diagnostic imaging ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnostic imaging ; Heart Defects, Congenital/surgery ; Humans ; Longitudinal Studies ; Male ; Pulmonary Atresia/complications ; Pulmonary Atresia/diagnostic imaging ; Pulmonary Atresia/surgery ; Treatment Outcome ; Ventricular Dysfunction, Right/diagnostic imaging ; Ventricular Dysfunction, Right/etiology ; Ventricular Dysfunction, Right/surgery ; Young Adult
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Clinical Trial ; Controlled Clinical Trial ; Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.13121
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Article ; Online: Novel area strain based on three-dimensional wall motion analysis for assessment of global left ventricular performance after repair of tetralogy of Fallot.

Li, Shu-na / Wong, Sophia J / Cheung, Yiu-fai

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2011 Volume 24, Issue 8, Page(s) 819–825

Abstract: Objective: This study aimed to determine the usefulness of novel parameters of left ventricular (LV) endocardial area strain (AS) in assessing global LV performance in patients with repaired tetralogy of Fallot (TOF).: Methods: Thirty patients, aged ... ...

Abstract	Objective: This study aimed to determine the usefulness of novel parameters of left ventricular (LV) endocardial area strain (AS) in assessing global LV performance in patients with repaired tetralogy of Fallot (TOF). Methods: Thirty patients, aged 21.7 ± 5.8 years, with repaired TOF and 25 healthy subjects aged 19.9 ± 5.5 years were studied. Three-dimensional LV wall motion tracking was performed to determine global and regional peak AS, an AS-systolic dyssynchrony index (SDI), and LV volumes and ejection fraction. The AS-SDI was derived from the dispersion of time-to-minimum segmental endocardial areas, expressed as a percentage of RR interval, using a 16-segment model. The LV global performance plot was generated by plotting peak global AS against AS-SDI. Results: The coefficients of variations for intra- and interobserver measurement of LV global AS were 6.3% and 10.6%, respectively. Compared with controls, patients had significantly lower global AS (30.5% ± 4.5% vs. 40.9% ± 2.8%, P < .001) and greater AS-SDI (10.0% ± 2.9% vs. 4.1% ± 1.4%, P < .001). Global AS (r = 0.94, P < .001) and AS-SDI (r = -0.76, P < .001) correlated strongly with LV ejection fraction. The global performance plot identified 87% of patients (26/30) with both reduced LV global AS and LV systolic mechanical dyssynchrony. Conclusion: AS measurement of LV endocardium based on three-dimensional wall motion tracking is reproducible and enables convenient assessment of global LV performance using a composite representation of parameters, including global AS and an AS-derived index of mechanical dyssynchrony.
MeSH term(s)	Adolescent ; Adult ; Algorithms ; Cardiac Surgical Procedures ; Case-Control Studies ; Echocardiography, Three-Dimensional ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Male ; Myocardial Contraction ; Risk Assessment ; Stroke Volume ; Systole ; Tetralogy of Fallot/diagnostic imaging ; Tetralogy of Fallot/physiopathology ; Tetralogy of Fallot/surgery ; Treatment Outcome
Language	English
Publishing date	2011-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2011.03.020
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Zs.A 2638: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Modulating effects of matrix metalloproteinase-3 and -9 polymorphisms on aortic stiffness and aortic root dilation in patients after tetralogy of Fallot repair.

Cheung, Yiu-fai / Hong, Wen-jing / Chan, Koon-wing / Wong, Sophia J

International journal of cardiology

2011 Volume 151, Issue 2, Page(s) 214–217

Abstract: Matrix metalloproteinases (MMPs) are capable of degrading extracellular matrix proteins, which are important determinants of arterial stiffness. This study aimed to test the hypothesis that MMP-3 and MMP-9 polymorphisms may modulate aortic stiffness and ... ...

Abstract	Matrix metalloproteinases (MMPs) are capable of degrading extracellular matrix proteins, which are important determinants of arterial stiffness. This study aimed to test the hypothesis that MMP-3 and MMP-9 polymorphisms may modulate aortic stiffness and magnitude of aortic root dilation in patients after surgical repair of tetralogy of Fallot (TOF). We analyzed the MMP-3 promoter and MMP-9 -1562 C>T polymorphism in 79 TOF patients aged 19.9 ± 9.5 years and determined their associations with aortic stiffness and sinotubular dimension. Genotypic and allelic frequencies of MMP-3 for the 6A6A genotype and MMP-9 for the T allele did not differ between patients and published control data (all p>0.05). For the MMP-3 locus, patients with a 6A6A genotype and those with a 6A6A/5A6A genotype had similar aortic stiffness (p=0.60), heart-femoral pulse wave velocity (p=0.63), and z score of sinotubular junction (p=0.81). For the MMP-9 locus, the -1562T allele carriers had significantly lower aortic stiffness (p=0.005), slower heart-femoral pulse wave velocity (p=0.03), and smaller z score of sinotubular junction (p=0.047). Multivariate linear regression identified MMP-9 polymorphism (β=-0.31, p=0.005) as a significant correlate of aortic stiffness after adjustments for age at study, age at operation, sex, body mass index, systolic and diastolic blood pressures, and MMP-3 polymorphism. In conclusion, MMP-9 but not MMP-3 polymorphism exerts a modulating influence on aortic stiffness and aortic root dilation in patients after TOF repair.
MeSH term(s)	Alleles ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/physiopathology ; Aortic Aneurysm, Thoracic/enzymology ; Aortic Aneurysm, Thoracic/etiology ; Aortic Aneurysm, Thoracic/genetics ; Cardiac Surgical Procedures/adverse effects ; DNA/genetics ; Echocardiography ; Female ; Gene Frequency ; Genotype ; Humans ; Male ; Matrix Metalloproteinase 3/blood ; Matrix Metalloproteinase 3/genetics ; Matrix Metalloproteinase 9/genetics ; Polymorphism, Genetic ; Tetralogy of Fallot/genetics ; Tetralogy of Fallot/physiopathology ; Tetralogy of Fallot/surgery ; Vascular Resistance/genetics ; Vascular Stiffness/genetics ; Young Adult
Chemical Substances	DNA (9007-49-2) ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	English
Publishing date	2011-09-01
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2010.05.046
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Article ; Online: Role of Three-Dimensional Speckle Tracking Echocardiography in the Quantification of Myocardial Iron Overload in Patients with Beta-Thalassemia Major.

Li, Shu-Juan / Hwang, Yu-Yan / Ha, Shau-Yin / Chan, Godfrey C F / Mok, Amanda S P / Wong, Sophia J / Cheung, Yiu-Fai

Echocardiography (Mount Kisco, N.Y.)

2016 Volume 33, Issue 9, Page(s) 1361–1367

Abstract: Background: The new three-dimensional speckle tracking echocardiography (3DSTE) may enable comprehensive quantification of global left ventricular (LV) myocardial mechanics.: Methods: Twenty-four patients aged 29.3 ± 5.2 years and 22 controls were ... ...

Abstract	Background: The new three-dimensional speckle tracking echocardiography (3DSTE) may enable comprehensive quantification of global left ventricular (LV) myocardial mechanics. Methods: Twenty-four patients aged 29.3 ± 5.2 years and 22 controls were studied. 3DSTE was performed to assess LV 3D global strain, twist and torsion, ejection fraction, and systolic dyssynchrony index (SDI). The LV SDI was calculated as % of SD of times-to-peak strain of 16 segments/RR interval. The global performance index (GPI) was calculated as (global 3D strain·torsion)/SDI. Area under the receiver operating characteristic curve (AUC) was calculated to determine the capability of 3DSTE parameters to discriminate between patients with (cardiac magnetic resonance T2* <20 ms) and those without myocardial iron overload. Results: Compared with controls, patients had significantly lower LV global 3D strain (P < 0.001), twist (P = 0.01), torsion (P = 0.04), and ejection fraction (P < 0.001) and greater SDI (P < 0.001). The GPI was lower in patients than controls (P < 0.001). T2* value correlated positively with global 3D strain (r = 0.74, P < 0.001) and GPI (r = 0.63, P = 0.001), and negatively with SDI (r = -0.44, P = 0.03). The AUCs of GPI, global 3D strain, ejection fraction, torsion, and 1/SDI were 0.94, 0.90, 0.87, 0.82, and 0.70, respectively. The GPI cutoff of 2.7°/cm had a sensitivity of 94.9% and a specificity of 88.9% of differentiating patients with from those without myocardial iron overload. Conclusions: The LV composite index of strain, torsion, and dyssynchrony derived from 3DSTE enables sensitive detection of myocardial iron overload in patients with thalassemia.
MeSH term(s)	Adult ; Echocardiography, Three-Dimensional/methods ; Elasticity Imaging Techniques/methods ; Female ; Humans ; Image Interpretation, Computer-Assisted/methods ; Iron Overload/diagnostic imaging ; Iron Overload/etiology ; Male ; Reproducibility of Results ; Sensitivity and Specificity ; Stroke Volume ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology ; beta-Thalassemia/complications ; beta-Thalassemia/diagnostic imaging
Language	English
Publishing date	2016-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.13266
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