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  1. Article: Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities.

    Pandey, Himani / Tang, Daryl W T / Wong, Sunny H / Lal, Devi

    Cancers

    2023  Volume 15, Issue 3

    Abstract: Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. While CRC is thought to be an interplay between genetic and environmental factors, several lines of evidence suggest the involvement of gut microbiota in promoting ... ...

    Abstract Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. While CRC is thought to be an interplay between genetic and environmental factors, several lines of evidence suggest the involvement of gut microbiota in promoting inflammation and tumor progression. Gut microbiota refer to the ~40 trillion microorganisms that inhabit the human gut. Advances in next-generation sequencing technologies and metagenomics have provided new insights into the gut microbial ecology and have helped in linking gut microbiota to CRC. Many studies carried out in humans and animal models have emphasized the role of certain gut bacteria, such as
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030866
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  2. Article: Looking for Young-onset Colorectal Cancer - It is Coming to Asia.

    Wong, Sunny H / Sung, Joseph Jy

    Annals of the Academy of Medicine, Singapore

    2020  Volume 49, Issue 11, Page(s) 836–837

    MeSH term(s) Age of Onset ; Asia/epidemiology ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Humans ; Incidence
    Language English
    Publishing date 2020-12-09
    Publishing country Singapore
    Document type Editorial
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
    DOI 10.47102/annals-acadmedsg.2020549
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  3. Article ; Online: Proton-pump inhibitor use before fecal microbiota transplant: A wonder drug, a necessary evil, or a needless prescription?

    Wong, Sunny H / Yu, Jun

    Journal of gastroenterology and hepatology

    2020  Volume 35, Issue 6, Page(s) 913–914

    MeSH term(s) Clostridium Infections/microbiology ; Clostridium Infections/therapy ; Clostridium difficile ; Fecal Microbiota Transplantation/methods ; Humans ; Proton Pump Inhibitors/administration & dosage ; Proton Pump Inhibitors/adverse effects ; Recurrence ; Unnecessary Procedures
    Chemical Substances Proton Pump Inhibitors
    Language English
    Publishing date 2020-06-12
    Publishing country Australia
    Document type Editorial
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.15103
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  4. Article: Gut microbiota in pathophysiology, diagnosis, and therapeutics of inflammatory bowel disease.

    Pandey, Himani / Jain, Dheeraj / Tang, Daryl W T / Wong, Sunny H / Lal, Devi

    Intestinal research

    2023  Volume 22, Issue 1, Page(s) 15–43

    Abstract: Inflammatory bowel disease (IBD) is a multifactorial disease, which is thought to be an interplay between genetic, environment, microbiota, and immune-mediated factors. Dysbiosis in the gut microbial composition, caused by antibiotics and diet, is ... ...

    Abstract Inflammatory bowel disease (IBD) is a multifactorial disease, which is thought to be an interplay between genetic, environment, microbiota, and immune-mediated factors. Dysbiosis in the gut microbial composition, caused by antibiotics and diet, is closely related to the initiation and progression of IBD. Differences in gut microbiota composition between IBD patients and healthy individuals have been found, with reduced biodiversity of commensal microbes and colonization of opportunistic microbes in IBD patients. Gut microbiota can, therefore, potentially be used for diagnosing and prognosticating IBD, and predicting its treatment response. Currently, there are no curative therapies for IBD. Microbiota-based interventions, including probiotics, prebiotics, synbiotics, and fecal microbiota transplantation, have been recognized as promising therapeutic strategies. Clinical studies and studies done in animal models have provided sufficient evidence that microbiota-based interventions may improve inflammation, the remission rate, and microscopic aspects of IBD. Further studies are required to better understand the mechanisms of action of such interventions. This will help in enhancing their effectiveness and developing personalized therapies. The present review summarizes the relationship between gut microbiota and IBD immunopathogenesis. It also discusses the use of gut microbiota as a noninvasive biomarker and potential therapeutic option.
    Language English
    Publishing date 2023-11-08
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3018469-1
    ISSN 2288-1956 ; 1598-9100
    ISSN (online) 2288-1956
    ISSN 1598-9100
    DOI 10.5217/ir.2023.00080
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  5. Article ; Online: Gut microbiota in colorectal cancer: mechanisms of action and clinical applications.

    Wong, Sunny H / Yu, Jun

    Nature reviews. Gastroenterology & hepatology

    2019  Volume 16, Issue 11, Page(s) 690–704

    Abstract: Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located at close proximity to the colorectal epithelium, the gut microbiota comprises a large population of microorganisms that interact with host cells to regulate many ... ...

    Abstract Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located at close proximity to the colorectal epithelium, the gut microbiota comprises a large population of microorganisms that interact with host cells to regulate many physiological processes, such as energy harvest, metabolism and immune response. Sequencing studies have revealed microbial compositional and ecological changes in patients with CRC, whereas functional studies in animal models have pinpointed the roles of several bacteria in colorectal carcinogenesis, including Fusobacterium nucleatum and certain strains of Escherichia coli and Bacteroides fragilis. These findings give new opportunities to take advantage of our knowledge on the gut microbiota for clinical applications, such as gut microbiota analysis as screening, prognostic or predictive biomarkers, or modulating microorganisms to prevent cancer, augment therapies and reduce adverse effects of treatment. This Review aims to provide an overview and discussion of the gut microbiota in colorectal neoplasia, including relevant mechanisms in microbiota-related carcinogenesis, the potential of utilizing the microbiota as CRC biomarkers, and the prospect for modulating the microbiota for CRC prevention or treatment. These scientific findings will pave the way to clinically translate the use of gut microbiota for CRC in the near future.
    MeSH term(s) Colorectal Neoplasms/etiology ; Colorectal Neoplasms/microbiology ; Colorectal Neoplasms/physiopathology ; Colorectal Neoplasms/therapy ; Disease Progression ; Gastrointestinal Microbiome ; Humans
    Language English
    Publishing date 2019-09-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-019-0209-8
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  6. Article ; Online: When repeated Helicobacter pylori therapies fail, what should we do?

    Wong, Sunny H / Sung, Joseph Jy

    Journal of gastroenterology and hepatology

    2019  Volume 34, Issue 4, Page(s) 627–628

    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Gastritis/complications ; Gastritis/drug therapy ; Gastritis/microbiology ; Helicobacter Infections ; Helicobacter pylori/drug effects ; Humans ; Risk ; Stomach Neoplasms/etiology ; Stomach Neoplasms/prevention & control ; Treatment Failure
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-07-19
    Publishing country Australia
    Document type Editorial
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.14668
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  7. Article ; Online: Letter regarding "Waiting for the changes after the adoption of steatotic liver disease".

    Yew, Kuo Chao / Wong, Sunny H / Wong, Vincent Wai-Sun / Oon, Hazel H

    Clinical and molecular hepatology

    2023  Volume 30, Issue 1, Page(s) 118–120

    MeSH term(s) Humans ; Fatty Liver ; Liver
    Language English
    Publishing date 2023-11-14
    Publishing country Korea (South)
    Document type Journal Article ; Comment
    ZDB-ID 2672560-5
    ISSN 2287-285X ; 2287-2728
    ISSN (online) 2287-285X
    ISSN 2287-2728
    DOI 10.3350/cmh.2023.0472
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  8. Article ; Online: What is unknown in using microbiota as a therapeutic?

    Sung, Joseph J Y / Wong, Sunny H

    Journal of gastroenterology and hepatology

    2021  Volume 37, Issue 1, Page(s) 39–44

    Abstract: Fecal microbiota transplantation (FMT) has been used extensively in the treatment of various gastrointestinal and extraintestinal conditions, despite that there are still a lot of missing gaps in our knowledge in the gut microbiota and its behavior. This ...

    Abstract Fecal microbiota transplantation (FMT) has been used extensively in the treatment of various gastrointestinal and extraintestinal conditions, despite that there are still a lot of missing gaps in our knowledge in the gut microbiota and its behavior. This article describes the unknowns in microbiota biology (undetected microbes, uncertain colonization, unclear mechanisms of action, uncertain indications, unsure long-term efficacy, or side effects). We discuss how these unknowns may affect the therapeutic uses of FMT, and the potentials and caveats of other related microbiota-based therapies. When used as an experimental therapy or last resort in difficult conditions, caution should be taken against inadvertent complications. Clear documentations of post-treatment events should be made mandatory, classified, and graded as in clinical trials. Further robust scientific experiments and properly designed clinical studies are needed.
    MeSH term(s) Fecal Microbiota Transplantation ; Gastrointestinal Microbiome ; Humans
    Language English
    Publishing date 2021-11-02
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.15716
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  9. Article ; Online: Beyond a vestigial organ: effects of the appendix on gut microbiome and colorectal cancer.

    Yap, Daniel Ren Yi / Lui, Rashid N / Samol, Jens / Ngeow, Joanne / Sung, Joseph Jy / Wong, Sunny H

    Journal of gastroenterology and hepatology

    2024  Volume 39, Issue 5, Page(s) 826–835

    Abstract: The role of appendectomy in the pathogenesis of colorectal cancer (CRC) is a recent topic of contention. Given that appendectomy remains one of the most commonly performed operations and a first-line management strategy of acute appendicitis, it is ... ...

    Abstract The role of appendectomy in the pathogenesis of colorectal cancer (CRC) is a recent topic of contention. Given that appendectomy remains one of the most commonly performed operations and a first-line management strategy of acute appendicitis, it is inherently crucial to elucidate the association between prior appendectomy and subsequent development of CRC, as there may be long-term health repercussions. In this review, we summarize the data behind the relationship of CRC in post-appendectomy patients, discuss the role of the microbiome in relation to appendectomy and CRC pathogenesis, and provide an appraisal of our current understanding of the function of the appendix. We seek to piece together the current landscape surrounding the microbiome and immunological changes in the colon post-appendectomy and suggest a direction for future research involving molecular, transcriptomic, and immunologic analysis to complement our current understanding of the alterations in gut microbiome.
    MeSH term(s) Humans ; Colorectal Neoplasms/microbiology ; Colorectal Neoplasms/etiology ; Gastrointestinal Microbiome ; Appendix/microbiology ; Appendectomy/adverse effects ; Appendicitis/microbiology ; Appendicitis/surgery ; Colon/microbiology ; Postoperative Complications/microbiology ; Postoperative Complications/etiology
    Language English
    Publishing date 2024-02-01
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.16497
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  10. Article ; Online: Covid-19 and the digestive system.

    Wong, Sunny H / Lui, Rashid Ns / Sung, Joseph Jy

    Journal of gastroenterology and hepatology

    2020  Volume 35, Issue 5, Page(s) 744–748

    Abstract: The novel coronavirus disease is currently causing a major pandemic. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the Betacoronavirus genus that also includes the SARS-CoV and Middle East respiratory ... ...

    Abstract The novel coronavirus disease is currently causing a major pandemic. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the Betacoronavirus genus that also includes the SARS-CoV and Middle East respiratory syndrome coronavirus. While patients typically present with fever and a respiratory illness, some patients also report gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain. Studies have identified the SARS-CoV-2 RNA in stool specimens of infected patients, and its viral receptor angiotensin converting enzyme 2 was found to be highly expressed in gastrointestinal epithelial cells. These suggest that SARS-CoV-2 can actively infect and replicate in the gastrointestinal tract. This has important implications to the disease management, transmission, and infection control. In this article, we review the important gastrointestinal aspects of the disease.
    MeSH term(s) Aerosols/adverse effects ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/isolation & purification ; Betacoronavirus/metabolism ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/metabolism ; Coronavirus Infections/transmission ; Digestive System/cytology ; Digestive System/metabolism ; Digestive System/virology ; Digestive System Diseases/metabolism ; Digestive System Diseases/virology ; Disease Transmission, Infectious/prevention & control ; Humans ; Infection Control/methods ; Pandemics ; Peptidyl-Dipeptidase A/biosynthesis ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/transmission ; RNA, Viral/isolation & purification ; SARS-CoV-2
    Chemical Substances Aerosols ; RNA, Viral ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-04-19
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.15047
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