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Article ; Online: Editorial overview: New technologies in 2020: Drug resistance.

Wong, Vincent Kam Wai

2020 Volume 54, Page(s) iii–vi

MeSH term(s)	Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Drug Resistance ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Mucocutaneous Lymph Node Syndrome/drug therapy ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/microbiology
Language	English
Publishing date	2020-12-23
Publishing country	England
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2020.12.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inhibitory effect of plant essential oils on α-glucosidase

You, Zonglin / Li, Yonglian / Zhang, Kun / Zheng, Xi / Wong, Vincent Kam Wai / Liu, Wenfeng

Food Sci Biotechnol. 2022 Nov., v. 31, no. 12 p.1593-1602

2022

Abstract: Diabetes mellitus, associated with α-glucosidase, has been considered as a chronic metabolic disorder, seriously affecting human health. Thus, searching natural α-glucosidase inhibitors and investigating their inhibition mechanism are urgently important. ...

Abstract	Diabetes mellitus, associated with α-glucosidase, has been considered as a chronic metabolic disorder, seriously affecting human health. Thus, searching natural α-glucosidase inhibitors and investigating their inhibition mechanism are urgently important. In this study, sixty-two essential oils (EOs), derived from aromatic plants, were found to exert different inhibition on α-glucosidase. The further study revealed that the most potent EOs against α-glucosidase were chuan-xiong, fructus cnidii, sacha inchi, aloe, ganoderma lucidum spore and ginger with IC₅₀ values of 3.02, 2.88, 7.37, 5.06, 5.32 and 7.40 μg/mL. Moreover, the inhibitory mechanism and kinetics studies found that chuan-xiong and sacha inchi were reversible and mixed-type inhibitors. Fructus cnidii, aloe, ganoderma lucidum spore and ginger were reversible and uncompetitive-type inhibitors. It is suggested that EOs, being of natural origin, would be promising anti-α-glucosidase agents.
Keywords	Aloe ; Ganoderma lucidum ; diabetes mellitus ; ginger ; human health ; spores
Language	English
Dates of publication	2022-11
Size	p. 1593-1602.
Publishing place	Springer Nature Singapore
Document type	Article ; Online
ZDB-ID	2000008-X
ISSN	1226-7708
ISSN	1226-7708
DOI	10.1007/s10068-022-01145-5
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Article ; Online: Inhibitory effect of plant essential oils on α-glucosidase.

You, Zonglin / Li, Yonglian / Zhang, Kun / Zheng, Xi / Wong, Vincent Kam Wai / Liu, Wenfeng

Food science and biotechnology

2022 Volume 31, Issue 12, Page(s) 1593–1602

Abstract	Diabetes mellitus, associated with α-glucosidase, has been considered as a chronic metabolic disorder, seriously affecting human health. Thus, searching natural α-glucosidase inhibitors and investigating their inhibition mechanism are urgently important. In this study, sixty-two essential oils (EOs), derived from aromatic plants, were found to exert different inhibition on α-glucosidase. The further study revealed that the most potent EOs against α-glucosidase were chuan-xiong, fructus cnidii, sacha inchi, aloe, ganoderma lucidum spore and ginger with IC
Language	English
Publishing date	2022-08-09
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2000008-X
ISSN	2092-6456 ; 1226-7708
ISSN (online)	2092-6456
ISSN	1226-7708
DOI	10.1007/s10068-022-01145-5
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Article: External stimulation: A potential therapeutic strategy for tendon-bone healing.

Fu, Shijie / Lan, Yujian / Wang, Guoyou / Bao, Dingsu / Qin, Bo / Zheng, Qiu / Liu, Huan / Wong, Vincent Kam Wai

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1150290

Abstract: Injuries at the tendon-bone interface are very common in the field of sports medicine, and healing at the tendon-bone interface is complex. Injuries to the tendon-bone interface can seriously affect a patient's quality of life, so it is essential to ... ...

Abstract	Injuries at the tendon-bone interface are very common in the field of sports medicine, and healing at the tendon-bone interface is complex. Injuries to the tendon-bone interface can seriously affect a patient's quality of life, so it is essential to restore stability and promote healing of the tendon-bone interface. In addition to surgical treatment, the healing of tendons and bones can also be properly combined with extracorporeal stimulation therapy during the recovery process. In this review, we discuss the effects of extracorporeal shock waves (ESWs), low-intensity pulsed ultrasound (LIPUS), and mechanical stress on tendon-bone healing, focusing on the possible mechanisms of action of mechanical stress on tendon-bone healing in terms of transcription factors and biomolecules. The aim is to provide possible therapeutic approaches for subsequent clinical treatment.
Language	English
Publishing date	2023-03-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1150290
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Article: Potential enhancement of post-stroke angiogenic response by targeting the oligomeric aggregation of p53 protein.

Tam, Hoi Hei / Zhu, Dongxing / Ho, Samuel Sze King / Vong, Heng Wai / Wong, Vincent Kam Wai / Mok, Simon Wing-Fai / Wong, Io Nam

Frontiers in cellular neuroscience

2023 Volume 17, Page(s) 1193362

Abstract: Tumor suppressor gene p53 and its aggregate have been found to be involved in many angiogenesis-related pathways. We explored the possible p53 aggregation formation mechanisms commonly occur after ischemic stroke, such as hypoxia and the presence of ... ...

Abstract	Tumor suppressor gene p53 and its aggregate have been found to be involved in many angiogenesis-related pathways. We explored the possible p53 aggregation formation mechanisms commonly occur after ischemic stroke, such as hypoxia and the presence of reactive oxygen species (ROS). The angiogenic pathways involving p53 mainly occur in nucleus or cytoplasm, with one exception that occurs in mitochondria. Considering the high mitochondrial density in brain and endothelial cells, we proposed that the cyclophilin D (CypD)-dependent vascular endothelial cell (VECs) necrosis pathway occurring in the mitochondria is one of the major factors that affects angiogenesis. Hence, targeting p53 aggregation, a key intermediate in the pathway, could be an alternative therapeutic target for post-stroke management.
Language	English
Publishing date	2023-07-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2023.1193362
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Article ; Online: Exploring SARS-CoV-2 Delta variant spike protein receptor-binding domain (RBD) as a target for tanshinones and antimalarials.

Coghi, Paolo / Yun, Xiao Yun / Ng, Jerome P L / Law, Betty Yuan Kwan / Memo, Maurizio / Gianoncelli, Alessandra / Wong, Vincent Kam Wai / Ribaudo, Giovanni

Natural product research

2022 Volume 36, Issue 23, Page(s) 6150–6155

Abstract: The interaction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD) of spike protein with angiotensin-converting enzyme 2 (ACE2) mediates cell invasion. While this interaction mechanism is conserved, the RBD is ... ...

Abstract	The interaction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD) of spike protein with angiotensin-converting enzyme 2 (ACE2) mediates cell invasion. While this interaction mechanism is conserved, the RBD is affected by amino acid mutations in variants such as Delta and Omicron, resulting in enhanced transmissibility and altered ligand binding. Tanshinones are currently investigated as multi-target antiviral agents, but the studies were limited to the original SARS-CoV-2. This study aims at investigating the interaction of tanshinones with the Delta RBD. Chloroquine, methylene blue and pyronaridine, antimalarials previously identified as SARS-CoV-2 RBD binders, were studied for reference. Docking indicated the best scores for tanshinones, while bio-layer interferometry and molecular dynamics highlighted methylene blue as the best Delta RBD binder, although with decreased affinity with respect to the original strain.
MeSH term(s)	Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Antimalarials/pharmacology ; Methylene Blue ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; COVID-19/drug therapy ; Binding Sites
Chemical Substances	spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Antimalarials ; tanshinone (03UUH3J385) ; Methylene Blue (T42P99266K) ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
Language	English
Publishing date	2022-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2057492
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Penthorum chinense Pursh inhibits ferroptosis in cellular and Caenorhabditis elegans models of Alzheimer's disease.

Yong, Yuan-Yuan / Yan, Lu / Wang, Bin-Ding / Fan, Dong-Sheng / Guo, Min-Song / Yu, Lu / Wu, Jian-Ming / Qin, Da-Lian / Law, Betty Yuen-Kwan / Wong, Vincent Kam-Wai / Yu, Chong-Lin / Zhou, Xiao-Gang / Wu, An-Guo

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 127, Page(s) 155463

Abstract: Background: Ferroptosis, a unique type of cell death triggered by iron-dependent lipid peroxidation, plays a critical role in the pathogenesis of Alzheimer's disease (AD), a debilitating condition marked by memory loss and cognitive impairment due to ... ...

Abstract	Background: Ferroptosis, a unique type of cell death triggered by iron-dependent lipid peroxidation, plays a critical role in the pathogenesis of Alzheimer's disease (AD), a debilitating condition marked by memory loss and cognitive impairment due to the accumulation of beta-amyloid (Aβ) and hyperphosphorylated Tau protein. Increasing evidence suggests that inhibitors of ferroptosis could be groundbreaking in the treatment of AD. Method: In this study, we established in vitro ferroptosis using erastin-, RSL-3-, hemin-, and iFSP1-induced PC-12 cells. Using MTT along with Hoechst/PI staining, we assessed cell viability and death. To determine various aspects of ferroptosis, we employed fluorescence probes, including DCFDA, JC-1, C11 BODIPY, Mito-Tracker, and PGSK, to measure ROS production, mitochondrial membrane potential, lipid peroxidation, mitochondrial morphology, and intracellular iron levels. Additionally, Western blotting, biolayer interferometry technology, and shRNA were utilized to investigate the underlying molecular mechanisms. Furthermore, p-CAX APP Swe/Ind- and pRK5-EGFP-Tau P301L overexpressing PC-12 cells, along with Caenorhabditis elegans (C. elegans) strains CL4176, CL2331, and BR5270, were employed to examine ferroptosis in AD models. Results: Here, we conducted a screening of our natural medicine libraries and identified the ethanol extract of Penthorum chinense Pursh (PEE), particularly its ethyl acetate fraction (PEF), displayed inhibitory effects on ferroptosis in cells. Specifically, PEF inhibited the generation of ROS, lipid peroxidation, and intracellular iron levels. Furthermore, PEF demonstrated protective effects against H Conclusion: Our findings highlight the suppressive effects of PEF on ferroptosis in AD cellular and C. elegans models. This study helps us better understand how ferroptosis affects AD and emphasizes the potential of PCP as a candidate for AD intervention.
MeSH term(s)	Animals ; Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Caenorhabditis elegans ; Reactive Oxygen Species/metabolism ; Hydrogen Peroxide/pharmacology ; Ferroptosis ; Iron/metabolism
Chemical Substances	Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Iron (E1UOL152H7)
Language	English
Publishing date	2024-02-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155463
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Article ; Online: Computational and experimental insights on the interaction of artemisinin, dihydroartemisinin and chloroquine with SARS-CoV-2 spike protein receptor-binding domain (RBD)

Ribaudo, Giovanni / Coghi, Paolo / Yang, Li Jun / Ng, Jerome P. L. / Mastinu, Andrea / Memo, Maurizio / Wong, Vincent Kam Wai / Gianoncelli, Alessandra

Natural Product Research. 2022 Oct. 13, v. 36, no. 20 p.5358-5363

2022

Abstract: The mechanism of host cell invasion of severe acute respiratory syndrome coronavirus-2 SARS-CoV-2 is connected with the interaction of spike protein (S) with angiotensin-converting enzyme 2 (ACE2) through receptor-binding domain (RBD). Small molecules ... ...

Abstract	The mechanism of host cell invasion of severe acute respiratory syndrome coronavirus-2 SARS-CoV-2 is connected with the interaction of spike protein (S) with angiotensin-converting enzyme 2 (ACE2) through receptor-binding domain (RBD). Small molecules targeting this assembly are being investigated as drug candidates to contrast SARS-CoV-2. In this context, chloroquine, an antimalarial agent proposed as a repurposed drug to treat coronavirus disease-19 (COVID-19), was hypothesized to bind RBD among its other mechanisms. Similarly, artemisinin and its derivatives are being studied as potential antiviral agents. In this work, we investigated the interaction of artemisinin, its metabolite dihydroartemisinin and chloroquine with RBD by means of computational tools and in vitro. Docking studies showed that the compounds interfere with the same region of the protein and molecular dynamics (MD) simulations demonstrated the stability of the predicted complexes. Bio-layer interferometry showed that chloroquine dose-dependently binds RBD (KD = 35.9 µM) more efficiently than artemisinins.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; artemisinin ; chloroquine ; host cell invasion ; interferometry ; metabolites ; molecular dynamics ; peptidyl-dipeptidase A ; research ; SARS-CoV-2 ; spike protein ; bio-layer interferometry
Language	English
Dates of publication	2022-1013
Size	p. 5358-5363.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.1925894
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Exploring SARS-CoV-2 Delta variant spike protein receptor-binding domain (RBD) as a target for tanshinones and antimalarials

Coghi, Paolo / Yun, Xiao Yun / Ng, Jerome P. L. / Law, Betty Yuan Kwan / Memo, Maurizio / Gianoncelli, Alessandra / Wong, Vincent Kam Wai / Ribaudo, Giovanni

Natural Product Research. 2022 Dec. 1, v. 36, no. 23 p.6150-6155

2022

Abstract	The interaction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD) of spike protein with angiotensin-converting enzyme 2 (ACE2) mediates cell invasion. While this interaction mechanism is conserved, the RBD is affected by amino acid mutations in variants such as Delta and Omicron, resulting in enhanced transmissibility and altered ligand binding. Tanshinones are currently investigated as multi-target antiviral agents, but the studies were limited to the original SARS-CoV-2. This study aims at investigating the interaction of tanshinones with the Delta RBD. Chloroquine, methylene blue and pyronaridine, antimalarials previously identified as SARS-CoV-2 RBD binders, were studied for reference. Docking indicated the best scores for tanshinones, while bio-layer interferometry and molecular dynamics highlighted methylene blue as the best Delta RBD binder, although with decreased affinity with respect to the original strain.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; amino acids ; chloroquine ; interferometry ; ligands ; methylene blue ; molecular dynamics ; peptidyl-dipeptidase A ; pyronaridine ; research ; Bio-layer interferometry ; Delta variant ; RBD ; SARS-CoV-2 ; spike protein ; tanshinones
Language	English
Dates of publication	2022-1201
Size	p. 6150-6155.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2057492
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Article ; Online: Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic cell death in apoptosis-resistant cancer cells, and reverses the MDR phenotype in cisplatin-resistant tumors in vivo.

Qu, Yuan-Qing / Song, Lin-Lin / Xu, Su-Wei / Yu, Margaret Sum Yee / Kadioglu, Onat / Michelangeli, Francesco / Law, Betty Yuen Kwan / Efferth, Thomas / Lam, Christopher Wai-Kei / Wong, Vincent Kam Wai

Pharmacological research

2023 Volume 191, Page(s) 106769

Abstract: Drug resistance in cancer has been classified as innate resistance or acquired resistance, which were characterized by apoptotic defects and ABC transporters overexpression respectively. Therefore, to preclude or reverse these resistance mechanisms could ...

Abstract	Drug resistance in cancer has been classified as innate resistance or acquired resistance, which were characterized by apoptotic defects and ABC transporters overexpression respectively. Therefore, to preclude or reverse these resistance mechanisms could be a promising strategy to improve chemotherapeutic outcomes. In this study, a natural product from Osage Orange, pomiferin, was identified as a novel autophagy activator that circumvents innate resistance by triggering autophagic cell death via SERCA inhibition and activation of the CaMKKβ-AMPK-mTOR signaling cascade. In addition, pomiferin also directly inhibited the P-gp (MDR1/ABCB1) efflux and reversed acquired resistance by potentiating the accumulation and efficacy of the chemotherapeutic agent, cisplatin. In vivo study demonstrated that pomiferin triggered calcium-mediated tumor suppression and exhibited an anti-metastatic effect in the LLC-1 lung cancer-bearing mouse model. Moreover, as an adjuvant, pomiferin potentiated the anti-tumor effect of the chemotherapeutic agent, cisplatin, in RM-1 drug-resistant prostate cancer-bearing mouse model by specially attenuating ABCB1-mediated drug efflux, but not ABCC5, thereby promoting the accumulation of cisplatin in tumors. Collectively, pomiferin may serve as a novel effective agent for circumventing drug resistance in clinical applications.
MeSH term(s)	Male ; Mice ; Animals ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Autophagic Cell Death ; Drug Resistance, Neoplasm ; Lung Neoplasms/drug therapy ; Apoptosis ; TOR Serine-Threonine Kinases/metabolism ; Cell Line, Tumor
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Antineoplastic Agents ; pomiferin (74YIS40APM) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-04-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2023.106769
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