Article ; Online: Associations between maternal overweight/obesity during pregnancy and body composition in young adult offspring.
2024 Volume 12, Page(s) 1346900
Abstract: Background: Maternal obesity is associated with an increased risk of large-for-gestational-age births and childhood obesity. However, evidence on its potential associations with long-term offspring body composition remains limited. This prospective ... ...
| Abstract | Background: Maternal obesity is associated with an increased risk of large-for-gestational-age births and childhood obesity. However, evidence on its potential associations with long-term offspring body composition remains limited. This prospective cohort study examined associations between maternal body mass index (BMI) during pregnancy and body composition in the young adult offspring. Methods: Participants were the offspring from a birth cohort in Chiang Mai (Thailand). Maternal BMI was assessed at the first antenatal clinic visit (≤24 weeks of gestation) in 1989-1990. In 2010-2011, we followed up the offspring at approximately 20 years of age, assessing their body composition using whole-body dual-energy X-ray absorptiometry (DXA) scans. Associations between maternal BMI and offspring body composition were explored using unadjusted and adjusted analyses. Results: We assessed 391 young adults (55% were females). Higher maternal BMI was associated with increased offspring fat mass and lean mass. In adjusted analyses, offspring of mothers with overweight/obesity exhibited total body fat percentages 1.5 (95% CI 0.1, 2.9; Conclusion: Higher maternal BMI during pregnancy was associated with increased adiposity in young adult offspring. Our findings suggest that the cross-generational transmission of maternal obesity-related traits is associated with increased offspring adiposity in the long term. |
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| MeSH term(s) | Young Adult ; Female ; Humans ; Child ; Pregnancy ; Male ; Overweight ; Pediatric Obesity ; Obesity, Maternal ; Prospective Studies ; Adult Children ; Body Composition |
| Language | English |
| Publishing date | 2024-03-13 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2711781-9 |
| ISSN | 2296-2565 ; 2296-2565 |
| ISSN (online) | 2296-2565 |
| ISSN | 2296-2565 |
| DOI | 10.3389/fpubh.2024.1346900 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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