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  1. Article ; Online: Conversion of Upper-Limb Inertial Measurement Unit Data to Joint Angles: A Systematic Review.

    Fang, Zhou / Woodford, Sarah / Senanayake, Damith / Ackland, David

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 14

    Abstract: Inertial measurement units (IMUs) have become the mainstay in human motion evaluation outside of the laboratory; however, quantification of 3-dimensional upper limb motion using IMUs remains challenging. The objective of this systematic review is twofold. ...

    Abstract Inertial measurement units (IMUs) have become the mainstay in human motion evaluation outside of the laboratory; however, quantification of 3-dimensional upper limb motion using IMUs remains challenging. The objective of this systematic review is twofold. Firstly, to evaluate computational methods used to convert IMU data to joint angles in the upper limb, including for the scapulothoracic, humerothoracic, glenohumeral, and elbow joints; and secondly, to quantify the accuracy of these approaches when compared to optoelectronic motion analysis. Fifty-two studies were included. Maximum joint motion measurement accuracy from IMUs was achieved using Euler angle decomposition and Kalman-based filters. This resulted in differences between IMU and optoelectronic motion analysis of 4° across all degrees of freedom of humerothoracic movement. Higher accuracy has been achieved at the elbow joint with functional joint axis calibration tasks and the use of kinematic constraints on gyroscope data, resulting in RMS errors between IMU and optoelectronic motion for flexion-extension as low as 2°. For the glenohumeral joint, 3D joint motion has been described with RMS errors of 6° and higher. In contrast, scapulothoracic joint motion tracking yielded RMS errors in excess of 10° in the protraction-retraction and anterior-posterior tilt direction. The findings of this study demonstrate high-quality 3D humerothoracic and elbow joint motion measurement capability using IMUs and underscore the challenges of skin motion artifacts in scapulothoracic and glenohumeral joint motion analysis. Future studies ought to implement functional joint axis calibrations, and IMU-based scapula locators to address skin motion artifacts at the scapula, and explore the use of artificial neural networks and data-driven approaches to directly convert IMU data to joint angles.
    MeSH term(s) Humans ; Range of Motion, Articular ; Shoulder Joint ; Upper Extremity ; Motion ; Movement ; Biomechanical Phenomena
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23146535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Headache Disorders: Differentiating Primary and Secondary Etiologies.

    Hernandez, Jairo / Molina, Eduardo / Rodriguez, Ashley / Woodford, Samuel / Nguyen, Andrew / Parker, Grace / Lucke-Wold, Brandon

    Journal of integrative neuroscience

    2024  Volume 23, Issue 2, Page(s) 43

    Abstract: In the initial assessment of a headache patient, several dangerous secondary etiologies must be considered. A thorough history and physical examination, along with a comprehensive differential diagnosis may alert a physician to the diagnosis of a ... ...

    Abstract In the initial assessment of a headache patient, several dangerous secondary etiologies must be considered. A thorough history and physical examination, along with a comprehensive differential diagnosis may alert a physician to the diagnosis of a secondary headache particularly when it is accompanied by certain clinical features. Evaluation and workup include a complete neurological examination, consideration of neuroimaging, and serum/spinal fluid analysis if indicated. Careful attention to the patients' history and physical examination will guide the diagnostic work-up and management. In this review, we summarize the diagnostic workup of various primary and secondary headache etiologies. Although most headaches are primary in nature, it is essential to screen for headache "red flags", as they can suggest life threatening secondary etiologies. When secondary causes are suspected, appropriate neuroimaging can further differentiate the underlying cause. The appropriate imaging is dependent on the most likely secondary etiology, which is deduced from history and physical examination. When no red flags are present, primary headaches are more likely. These can be differentiated by frequency, location, duration, triggers, and presence of aura. The different clinical presentations for secondary headaches, as well as the distinguishing features for primary headaches are outlined in this review.
    MeSH term(s) Humans ; Headache Disorders ; Headache/diagnosis ; Headache/etiology ; Neuroimaging/adverse effects ; Diagnosis, Differential
    Language English
    Publishing date 2024-03-01
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2136427-8
    ISSN 0219-6352
    ISSN 0219-6352
    DOI 10.31083/j.jin2302043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Using Data to Rethink the Ban on Cornea Donation From Men Who Have Sex With Men.

    Sugar, Alan / Van Meter, Woodford S

    JAMA ophthalmology

    2020  Volume 138, Issue 11, Page(s) 1150

    MeSH term(s) Canada ; Cornea ; Homosexuality, Male ; Humans ; Male ; Sexual and Gender Minorities ; United States
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2020.3629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: International Online Survey on the Management of Patent Ductus Arteriosus.

    Woodford, Sarah / Parmar, Trisha / Leong, Emily / Zhong, Jiayue / Oei, Ju Lee / Suzuki, Keiji / Kumar, Kishore / Yeo, Kee Thai / Ma, Li / De Luca, Daniele / Hummler, Helmut / Schmölzer, Georg / Vento, Maximo / Schindler, Timothy

    Neonatology

    2024  , Page(s) 1–7

    Abstract: Introduction: There is uncertainty and lack of consensus regarding optimal management of patent ductus arteriosus (PDA). We aimed to determine current clinical practice in PDA management across a range of different regions internationally.: Materials ... ...

    Abstract Introduction: There is uncertainty and lack of consensus regarding optimal management of patent ductus arteriosus (PDA). We aimed to determine current clinical practice in PDA management across a range of different regions internationally.
    Materials and methods: We surveyed PDA management practices in neonatal intensive care units using a pre-piloted web-based survey, which was distributed to perinatal societies in 31 countries. The survey was available online from March 2018 to March 2019.
    Results: There were 812 responses. The majority of clinicians (54%) did not have institutional protocols for PDA treatment, and 42% reported variable management within their own unit. Among infants <28 weeks (or <1,000 g), most clinicians (60%) treat symptomatically. Respondents in Australasia were more likely to treat PDA pre-symptomatically (44% vs. 18% all countries [OR 4.1; 95% CI 2.6-6.5; p < 0.001]), and respondents from North America were more likely to treat symptomatic PDA (67% vs. 60% all countries [OR 2.0; 95% CI 1.5-2.6; p < 0.001]). In infants ≥28 weeks (or ≥1,000 g), most clinicians (54%) treat symptomatically. Respondents in North America were more likely to treat PDAs in this group of infants conservatively (47% vs. 38% all countries [OR 2.3; 95% CI 1.7-3.2; p < 0.001]), and respondents from Asia were more likely to treat the PDA pre-symptomatically (21% vs. 7% all countries [OR 5.5; 95% CI 3.2-9.8; p < 0.001]).
    Discussion/conclusion: There were marked international differences in clinical practice, highlighting ongoing uncertainty and a lack of consensus regarding PDA management. An international conglomeration to coordinate research that prioritises and addresses these areas of contention is indicated.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000535121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Focused Delivery of Chemotherapy to Augment Surgical Management of Brain Tumors.

    Mehkri, Yusuf / Woodford, Samuel / Pierre, Kevin / Dagra, Abeer / Hernandez, Jairo / Reza Hosseini Siyanaki, Mohammad / Azab, Mohammed / Lucke-Wold, Brandon

    Current oncology (Toronto, Ont.)

    2022  Volume 29, Issue 11, Page(s) 8846–8861

    Abstract: Chemotherapy as an adjuvant therapy that has largely failed to significantly improve outcomes for aggressive brain tumors; some reasons include a weak blood brain barrier penetration and tumor heterogeneity. Recently, there has been interest in designing ...

    Abstract Chemotherapy as an adjuvant therapy that has largely failed to significantly improve outcomes for aggressive brain tumors; some reasons include a weak blood brain barrier penetration and tumor heterogeneity. Recently, there has been interest in designing effective ways to deliver chemotherapy to the tumor. In this review, we discuss the mechanisms of focused chemotherapies that are currently under investigation. Nanoparticle delivery demonstrates both a superior permeability and retention. However, thus far, it has not demonstrated a therapeutic efficacy for brain tumors. Convection-enhanced delivery is an invasive, yet versatile method, which appears to have the greatest potential. Other vehicles, such as angiopep-2 decorated gold nanoparticles, polyamidoamine dendrimers, and lipid nanostructures have demonstrated efficacy through sustained release of focused chemotherapy and have either improved cell death or survival in humans or animal models. Finally, focused ultrasound is a safe and effective way to disrupt the blood brain barrier and augment other delivery methods. Clinical trials are currently underway to study the safety and efficacy of these methods in combination with standard of care.
    MeSH term(s) Animals ; Humans ; Gold/metabolism ; Gold/therapeutic use ; Metal Nanoparticles ; Brain Neoplasms/drug therapy ; Brain Neoplasms/surgery ; Blood-Brain Barrier/metabolism
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29110696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exploring brainstem auditory evoked potentials and mental development index as early indicators of autism spectrum disorders in high-risk infants.

    Wang, Xiaoyan / Carroll, Xianming / Zhang, Ping / du Prel, Jean-Baptist / Wang, Hong / Xu, Haiqing / Leeper-Woodford, Sandra

    Autism research : official journal of the International Society for Autism Research

    2022  Volume 15, Issue 11, Page(s) 2012–2025

    Abstract: This study of infants from Hubei Province, China examined brainstem auditory evoked potentials (BAEP) and mental development index (MDI) as possible early indicators associated with autism spectrum disorders (ASD). The 34 ASD cases and 102 controls who ... ...

    Abstract This study of infants from Hubei Province, China examined brainstem auditory evoked potentials (BAEP) and mental development index (MDI) as possible early indicators associated with autism spectrum disorders (ASD). The 34 ASD cases and 102 controls who had recovered from perinatal conditions were matched for age, sex, gestational age, birth weight and maternal age. BAEP absolute latencies (AL) I, III, V and interpeak latencies (IPL) I-III, III-V, I-V were compared in ASD cases and controls at ages 1, 3 and 6 months. MDI scores were compared in these infants from 1 month to 2 years old. Multiple logistic regression analysis was performed to test associations among ASD, BAEP and MDI. Results showed BAEP AL I, V and IPL III-V prolonged in the ASD group (p < 0.001), and MDI scores in ASD cases sharply declining from 12 to 24 months (p < 0.001). Regression analysis revealed odds ratios (OR) indicating that ASD was likely associated with abnormal values of BAEP AL I at 1 and 3 months (OR
    MeSH term(s) Infant ; Humans ; Evoked Potentials, Auditory, Brain Stem/physiology ; Autism Spectrum Disorder/diagnosis ; Mass Screening ; Odds Ratio ; China ; Evoked Potentials, Auditory
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.2821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Prediction of Delayed Neurodevelopment in Infants Using Brainstem Auditory Evoked Potentials and the Bayley II Scales.

    Wang, Xiaoyan / Carroll, Xianming / Wang, Hong / Zhang, Ping / Selvaraj, Jonathan Nimal / Leeper-Woodford, Sandra

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 485

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-08-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Thesis: Ultrafast magnetization dynamics

    Woodford, Simon

    (Schriften des Forschungszentrums Jülich : Reihe Schlüsseltechnologien ; Bd. 6)

    2008  

    Author's details Simon Woodford
    Series title Schriften des Forschungszentrums Jülich : Reihe Schlüsseltechnologien ; Bd. 6
    Language English
    Size 130 S., Ill., graph. Darst., 24 cm
    Publisher Forschungszentrum, Zentralbibliothek
    Publishing place Jülich
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Hochsch., Diss.--Aachen, 2008
    ISBN 9783893365364 ; 3893365362
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book ; Online ; Thesis: Ultrafast magnetization dynamics

    Woodford, Simon

    2008  

    Author's details vorgelegt von Simon Woodford
    Language English ; German
    Size Online-Ressource (PDF-Datei: 126 S., 2.967 KB)
    Publisher Techn. Hochsch.-Bibl
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Techn. Hochsch., Diss.--Aachen, 2008
    Note Zsfassung in engl. und dt. Sprache ; Auch gedr. vorh. als: Schriften des Forschungszentrums Jülich $ Reihe Schlüsseltechnologien ; Bd. 6
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book ; Online ; Thesis: Ultrafast magnetization dynamics

    Woodford, Simon

    2008  

    Author's details vorgelegt von Simon Woodford
    Language English ; German
    Size Online-Ressource (PDF-Datei: 126 S., 2.967 KB)
    Publisher Techn. Hochsch.-Bibl
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Techn. Hochsch., Diss.--Aachen, 2008
    Note Zsfassung in engl. und dt. Sprache ; Auch gedr. vorh. als: Schriften des Forschungszentrums Jülich $ Reihe Schlüsseltechnologien ; Bd. 6
    Database Former special subject collection: coastal and deep sea fishing

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