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  1. Article ; Online: Hypertensive Crisis in a Patient With a Functioning Mesenteric Paraganglioma: Dramatic Response to Octreotide Treatment.

    Elshafie, Omayma T / Bou Khalil, Abir C / Alshaibi, Maha A / Itkin, Boris L / Ismail, Babikir M / Woodhouse, Nicholas J

    AACE clinical case reports

    2023  Volume 9, Issue 5, Page(s) 149–152

    Abstract: Background/objective: To report a dramatic and immediate clinical and biochemical response during treatment with octreotide in a patient with a functioning mesenteric paraganglioma (PGL).: Case report: A 44-year-old woman was admitted with a severe ... ...

    Abstract Background/objective: To report a dramatic and immediate clinical and biochemical response during treatment with octreotide in a patient with a functioning mesenteric paraganglioma (PGL).
    Case report: A 44-year-old woman was admitted with a severe hypertensive crisis and a blood pressure reaching 260/150 mm Hg. She was 2 months postpartum and had been previously diagnosed with pre-eclampsia. Secondary hypertension was suspected. This was confirmed by finding a 6 × 5-cm
    Discussion: PGLs and pheochromocytomas are neuroendocrine tumors, and most have receptors for octreotide. This case and another patient previously reported responded dramatically to treatment with a high dose of octreotide. Earlier reports of patients failing to respond are likely to have been the result of using a smaller octreotide dose.
    Conclusion: We conclude that high doses of short- and long-acting octreotide are valuable in severely hypertensive patients. Our experience suggests that octreotide is of value in other patients with PGLs and pheochromocytomas. The response is rapid, sustained, effective, and with minimal reported side effects. To the best of our knowledge, this is the first report of a hypertensive crisis in a functional mesenteric PGL.
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Case Reports
    ISSN 2376-0605
    ISSN (online) 2376-0605
    DOI 10.1016/j.aace.2023.05.003
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  2. Article: Are scintigraphy and ultrasonography necessary before fine-needle aspiration cytology for thyroid nodules?

    Sankhla, Dilip K / Hussein, Samir S / Bererhi, Haddia / El Shafie, Omeima / Woodhouse, Nicholas J / Nirmala, V

    Journal for scientific research. Medical sciences

    2016  Volume 3, Issue 1, Page(s) 29–33

    Abstract: Objective: To evaluate the efficacy of scintigraphy, ultrasound and fine-needle aspiration in thyroid nodules and to establish the best diagnostic pathway in detecting thyroid cancer.: Method: Two hundred and sixteen patients with thyroid nodules ... ...

    Abstract Objective: To evaluate the efficacy of scintigraphy, ultrasound and fine-needle aspiration in thyroid nodules and to establish the best diagnostic pathway in detecting thyroid cancer.
    Method: Two hundred and sixteen patients with thyroid nodules were examined using high-resolution ultrasonography,
    Results: Cytopathology classified 71% of the aspirate as benign, 3% as positive for malignancy, 21% as suspected neoplasia and 5% as unsatisfactory. Fine-needle aspiration cytology had a sensitivity of 87.5% and specificity of 80%. On ultrasound 33% of malignant nodules were hypo-echoic and on scintigraphy 16% of solitary cold nodules were malignant. Neither test could reliably diagnose thyroid cancer.
    Conclusion: Ultrasound-guided fine-needle aspiration cytology should be the first test performed in euthyroid patients with a thyroid nodule. Scintigraphy and ultrasound imaging should be reserved for follow-up studies and patients who have suppressed levels of thyroid stimulating hormone.
    Language English
    Publishing date 2016-08-25
    Publishing country Oman
    Document type Journal Article
    ISSN 1029-4066
    ISSN 1029-4066
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  3. Article: Cushing's Disease: Pituitary Surgery versus Adrenalectomy.

    El-Shafie, Omayma / Abid, Fatma B / Al-Kindy, Nayal / Sankhla, Dilip / Woodhouse, Nicholas J

    Sultan Qaboos University medical journal

    2011  Volume 8, Issue 2, Page(s) 211–214

    Abstract: We describe two patients of the Department of Medicine at Sultan Qaboos University Hospital, Muscat, Oman, with Cushing's disease. Their magnetic resonance imaging scans of the pituitary were negative. One patient was treated by transsphenoidal surgery ... ...

    Abstract We describe two patients of the Department of Medicine at Sultan Qaboos University Hospital, Muscat, Oman, with Cushing's disease. Their magnetic resonance imaging scans of the pituitary were negative. One patient was treated by transsphenoidal surgery and the other by bilateral endoscopic adrenalectomy. Both procedures were successful and the patients cured. The advantages and disadvantages of these two approaches are discussed.
    Language English
    Publishing date 2011-06-30
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-051X
    ISSN (online) 2075-0528
    ISSN 2075-051X
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  4. Article: Nodular Lymphocyte Predominant Hodgkin's Lymphoma Presenting as Severe Hypercalcaemia: A Case Report.

    Burney, Ikram A / Nirmala, V / Al-Moundhri, Mansour S / Woodhouse, Nicholas J

    Sultan Qaboos University medical journal

    2011  Volume 7, Issue 3, Page(s) 247–251

    Abstract: Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a recently described type of Hodgkin's lymphoma (HL) and accounts for 5-6% of all the cases of HL. Here we report the case of an elderly man who presented to Sultan Qaboos University Hospital, ... ...

    Abstract Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a recently described type of Hodgkin's lymphoma (HL) and accounts for 5-6% of all the cases of HL. Here we report the case of an elderly man who presented to Sultan Qaboos University Hospital, Oman, with severe hypercalcemia, and was diagnosed to have stage IV NLPHL. Although the incidence of hypercalcemia is estimated to be between 1-5% in classical HL, to our knowledge this is the first report of NLPHL presenting with severe hypercalcemia. The patient responded to the anti-CD20 monoclonal antibody, Rituximab, and has been in clinical remission for more than 3 years.
    Language English
    Publishing date 2011-06-30
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-051X
    ISSN (online) 2075-0528
    ISSN 2075-051X
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  5. Article ; Online: Ablation of the thyroid remnant and I-131 dose in differentiated thyroid cancer: a meta-analysis revisited.

    Doi, Suhail A R / Woodhouse, Nicholas J / Thalib, Lukman / Onitilo, Adedayo

    Clinical medicine & research

    2007  Volume 5, Issue 2, Page(s) 87–90

    MeSH term(s) Carcinoma, Papillary/mortality ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary/surgery ; Cell Differentiation ; Humans ; Iodine Radioisotopes/administration & dosage ; Meta-Analysis as Topic ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/radiotherapy ; Radiation Dosage ; Risk Factors ; Thyroid Neoplasms/mortality ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2007-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2303793-3
    ISSN 1554-6179 ; 1539-4182
    ISSN (online) 1554-6179
    ISSN 1539-4182
    DOI 10.3121/cmr.2007.763
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  6. Article ; Online: Ablation of the thyroid remnant and

    Doi, Suhail A R / Woodhouse, Nicholas J Y

    Clinical endocrinology

    2000  Volume 52, Issue 6, Page(s) 765–773

    Abstract: Aims: To compare the efficacy of remnant ablation following a single low dose (specific activity of : Methods: Nineteen studies have reported the results of low dose : Results: The average failure of a single low dose was 46 ± 28% (SD). Meta- ... ...

    Abstract Aims: To compare the efficacy of remnant ablation following a single low dose (specific activity of
    Methods: Nineteen studies have reported the results of low dose
    Results: The average failure of a single low dose was 46 ± 28% (SD). Meta-analysis revealed a statistically significant advantage for a single high over a single low dose and a pooled reduction in relative risk of failure of the high dose of about 27% (P < 0.01). From this we estimate that for every seven patients treated one more would be ablated given a high rather than a low dose (assuming a low dose failure risk of 50%). Also, a significantly greater proportion of patients are ablated after a single high or low dose, if they underwent near-total as opposed to sub-total thyroidectomy (summary relative risk (RR) 1.4; P < 0.05).
    Conclusion: High dose
    Language English
    Publishing date 2000-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1046/j.1365-2265.2000.01014.x
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  7. Article: Gallium-67 lymph node localization in toxic Kikuchi-Fujimoto's disease.

    Elshafie, Omeima T / Woodhouse, Nicholas J / Hussein, Samir S / Nirmala, V

    Saudi medical journal

    2003  Volume 24, Issue 4, Page(s) 417–418

    MeSH term(s) Adolescent ; Gallium Radioisotopes ; Histiocytic Necrotizing Lymphadenitis/diagnostic imaging ; Humans ; Lymph Nodes/diagnostic imaging ; Male ; Radionuclide Imaging
    Chemical Substances Gallium Radioisotopes
    Language English
    Publishing date 2003-04
    Publishing country Saudi Arabia
    Document type Case Reports ; Journal Article
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
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    Zs.B 2330: Show issues Location:
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  8. Article: Spironolactone responsive familial hypertension. A potentially high prevalence of mineralocorticoid disease in Oman.

    Woodhouse, Nicholas J / Elshafie, Omiema T / Mehar, Ali / Johnston, W J / Al-Kaabi, Juma M

    Saudi medical journal

    2003  Volume 24, Issue 2, Page(s) 229–231

    MeSH term(s) Adult ; Aged ; Female ; Humans ; Hypertension/blood ; Hypertension/drug therapy ; Hypertension/genetics ; Male ; Middle Aged ; Mineralocorticoid Excess Syndrome, Apparent/epidemiology ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Oman/epidemiology ; Prevalence ; Renin/blood ; Spironolactone/therapeutic use
    Chemical Substances Mineralocorticoid Receptor Antagonists ; Spironolactone (27O7W4T232) ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2003-02
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
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  9. Article: Occult celiac disease in adult Omanis with unexplained iron deficiency anemia.

    Fraser, J S / Woodhouse, Nicholas J / El-Shafie, O T / Al-Kindy, S S / Ciclitira, P J

    Saudi medical journal

    2003  Volume 24, Issue 7, Page(s) 791

    MeSH term(s) Adolescent ; Adult ; Anemia, Iron-Deficiency/etiology ; Celiac Disease/complications ; Female ; Humans ; Male ; Middle Aged ; Oman
    Language English
    Publishing date 2003-07
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
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  10. Article: Radioactive iodine in the treatment of Graves' disease.

    Al-Kaabi, Juma M / Hussein, Samir S / Bukheit, Charles S / Woodhouse, Nicholas J / Elshafie, Omiema T / Bererhi, Haddia

    Saudi medical journal

    2002  Volume 23, Issue 9, Page(s) 1049–1053

    Abstract: Objectives: This study was performed to evaluate the efficacy of radioactive iodine 131I therapy of Graves' hyperthyroidism at Sultan Qaboos University Hospital, Oman and to determine the optimal dose of 131I needed to achieve the euthyroid or ... ...

    Abstract Objectives: This study was performed to evaluate the efficacy of radioactive iodine 131I therapy of Graves' hyperthyroidism at Sultan Qaboos University Hospital, Oman and to determine the optimal dose of 131I needed to achieve the euthyroid or hypothyroid status.
    Methods: The medical records of 366 patients with Graves hyperthyroidism who received a single dose of 131I at Sultan Qaboos University Hospital, Oman between 1991 and 1999 were reviewed. The diagnosis was based on clinical, biochemical grounds and 99mTc thyroid scintigraphy. The patients were followed up for a minimum period of 12 months. For the analysis, the patients were divided into 6 groups according to the 131I dose administered: Dose one (350-399), dose 2 (400-449), dose 3 (450-499), dose 4 (500-549), dose 5 (550-599) and dose 6 (> or = 600) MBq.
    Results: Fifty-eight percent of all the patients were hypothyroid after 3 months. Three hundred and twenty two patients (88%) were treated by a single dose of 131I in 12 months (85.5% hypothyroid and 2.5% euthyroid). Forty-one patients (11.2%) required a 2nd 131I dose and only 3 patients required 3 doses of 131I. The best cure rate (93%) was observed in group dose 5 (574.0 +/- 16.4 MBq) which however, was not significantly different from other dosage levels. The female to male ratio was 2:1 and the cure rates were not gender or age related.
    Conclusion: Treatment of Graves' hyperthyroidism from a single 131I dose is our aim, rather than avoidance of hypothyroidism. Our results indicate that cure rates are higher with larger doses of 131I except in group dose 6 (special category of patients). In the future, fixed doses would be adopted in our radioactive iodine treatment practice guidelines. As the majority of our patients were hypothyroid at 3 months regular monthly follow-up is essential. Whenever appropriate, physicians are encouraged to consider early referral of Graves' hyperthyroidism patients for radioactive iodine treatment as it is cheap, effective, easy to administer and free from serious side effects.
    MeSH term(s) Adult ; Female ; Graves Disease/therapy ; Humans ; Iodine Radioisotopes/therapeutic use ; Male ; Middle Aged ; Retrospective Studies ; Saudi Arabia ; Treatment Outcome
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2002-09
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
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