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Article: Retinopathy of prematurity: from oxygen management to molecular manipulation.

Woods, Jonathan / Biswas, Susmito

2023 Volume 10, Issue 1, Page(s) 12

Abstract: Introduction: Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the premature retina with the potential to progress to extraretinal neovascularisation. This review serves as an introduction to retinopathy of prematurity (ROP), ... ...

Abstract	Introduction: Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the premature retina with the potential to progress to extraretinal neovascularisation. This review serves as an introduction to retinopathy of prematurity (ROP), outlining key parts of ROP pathophysiology, diagnosis and treatment. ROP is traditionally diagnosed by indirect ophthalmoscopy and classified using anatomical zones, stages of disease, and the presence or absence of "plus disease" (dilation and tortuosity of the major retinal arterioles and venules). ROP has a bi-phasic pathophysiology: initial hyperoxia causes reduced retinal vascularisation, followed by pathological vaso-proliferation resulting from subsequent hypoxia and driven by vascular endothelial growth factor (VEGF). Advancements in management: This review summarises previous trials to establish optimum oxygen exposure levels in newborns and more recently the development of anti-VEGF agents locally delivered to block pathological neovascularisation, which is technically easier to administer and less destructive than laser treatment. Future directions: There remains an ongoing concern regarding the potential unwanted systemic effects of intravitreally administered anti-VEGF on the overall development of the premature baby. Ongoing dosing studies may lessen these fears by identifying the minimally effective dose required to block extraretinal neovascularisation.
Language	English
Publishing date	2023-09-15
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2785551-X
ISSN	2194-7791
ISSN	2194-7791
DOI	10.1186/s40348-023-00163-5
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Article: Solution-focused approaches in adult mental health research: A conceptual literature review and narrative synthesis.

Jerome, Lauren / McNamee, Philip / Abdel-Halim, Nadia / Elliot, Kathryn / Woods, Jonathan

Frontiers in psychiatry

2023 Volume 14, Page(s) 1068006

Abstract: Solution-focused approaches are one approach to treatment used in a wide variety of settings in modern mental healthcare services. As yet, there has been no overall synthesis of how this approach is understood in the adult mental health literature. This ... ...

Abstract	Solution-focused approaches are one approach to treatment used in a wide variety of settings in modern mental healthcare services. As yet, there has been no overall synthesis of how this approach is understood in the adult mental health literature. This conceptual review aimed to synthesize the ways that solution-focused approaches have been conceptualized and understood, within the adult mental health literature, in the five decades since their conception. A systematic search followed by multiple techniques from the narrative synthesis approach were used to develop a conceptual framework of the extracted data. Fifty-six papers published between 1993 and 2019 were included in the review. These papers spanned a variety of clinical contexts and countries, but despite this the underlying key principles and concepts of solution-focused approaches were remarkably similar over time and setting. Thematic analysis of extracted data outlined five key themes relevant to the conceptualization of this approach. This conceptual framework will help support clinicians using solution-focused techniques or therapies by giving them a coherent understanding of such approaches, by what mechanisms they work, and how key principles of this approach can be utilized in adult mental health settings.
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1068006
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Article ; Online: Bi-frequency operation in a membrane external-cavity surface-emitting laser.

Daykin, Jake / Woods, Jonathan R C / Bek, Roman / Jetter, Michael / Michler, Peter / Mills, Ben / Horak, Peter / Wilkinson, James S / Apostolopoulos, Vasilis

PloS one

2023 Volume 18, Issue 7, Page(s) e0289223

Abstract: We report on the achievement of continuous wave bi-frequency operation in a membrane external-cavity surface-emitting laser (MECSEL), which is optically pumped with up to 4 W of 808 nm pump light. The presence of spatially specific loss of the intra- ... ...

Abstract	We report on the achievement of continuous wave bi-frequency operation in a membrane external-cavity surface-emitting laser (MECSEL), which is optically pumped with up to 4 W of 808 nm pump light. The presence of spatially specific loss of the intra-cavity high reflectivity mirror allows loss to be controlled on certain transverse cavity modes. The regions of spatially specific loss are defined through the removal of Bragg layers from the surface of the cavity high reflectivity mirror in the form of crosshair patterns with undamaged central regions, which are created using a laser ablation system incorporating a digital micromirror device (DMD). By aligning the laser cavity mode with the geometric centre of the loss patterns, the laser simultaneously operated on two Hermite-Gaussian spatial modes: the fundamental HG00 and the higher order HG11 mode. We demonstrate bi-frequency operation over a range of pump powers and sizes of spatial loss features, with a wavelength separation of approximately 5 nm centred at 1005 nm.
MeSH term(s)	Lasers ; Membranes ; Normal Distribution ; Records
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0289223
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Article ; Online: Cutting Edge: Systemic Autoimmunity in Murine STAT3 Gain-of-Function Syndrome Is Characterized by Effector T Cell Expansion in the Absence of Overt Regulatory T Cell Dysfunction.

Woods, Jonathan / Pemberton, Sarah E / Largent, Andrea D / Chiang, Kristy / Liggitt, Denny / Oukka, Mohamed / Rawlings, David J / Jackson, Shaun W

Journal of immunology (Baltimore, Md. : 1950)

2022 Volume 209, Issue 6, Page(s) 1033–1038

Abstract: Germline gain-of-function mutations in the transcriptional ... ...

Abstract	Germline gain-of-function mutations in the transcriptional factor
MeSH term(s)	Animals ; Autoimmunity ; CD8-Positive T-Lymphocytes/metabolism ; Cell Differentiation ; Gain of Function Mutation ; Gene Knock-In Techniques ; Humans ; Inflammation/pathology ; Mice ; Mice, Transgenic ; STAT3 Transcription Factor/genetics ; T-Lymphocytes, Regulatory ; Th17 Cells
Chemical Substances	STAT3 Transcription Factor ; STAT3 protein, human ; Stat3 protein, mouse
Language	English
Publishing date	2022-08-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2100920
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Article ; Online: High power 739 nm VECSELs for future Yb

Woods, Jonathan R C / Kahle, Hermann / Gray, Alan C / Daykin, Jake / Tropper, Anne C / Gawith, Corin / Guina, Mircea / Apostolopoulos, Vasilis

Applied optics

2021 Volume 60, Issue 3, Page(s) 676–680

Abstract: We present an operational characterization of a vertical-external-cavity surface-emitting laser emitting around 739 nm with over 150 mW in a single fundamental spatial mode. Results show that the laser is capable of oscillating on a single cavity axial ... ...

Abstract	We present an operational characterization of a vertical-external-cavity surface-emitting laser emitting around 739 nm with over 150 mW in a single fundamental spatial mode. Results show that the laser is capable of oscillating on a single cavity axial mode at 740 nm for up to 22 mW. Tuning of the optical emission is shown to reach 737.3 nm. Furthermore, at best performance, the laser exhibits a slope efficiency of 8.3% and a threshold power of 1.27 W for an output coupler reflectivity of 98%.
Language	English
Publishing date	2021-03-09
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.409970
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Article ; Online: Carrier frequency modulation of an acousto-optic modulator for laser stabilization.

Aldous, Matthew / Woods, Jonathan / Dragomir, Andrei / Roy, Ritayan / Himsworth, Matt

Optics express

2017 Volume 25, Issue 11, Page(s) 12830–12838

Abstract: The stabilization of lasers to absolute frequency references is a fundamental requirement in several areas of atomic, molecular and optical physics. A range of techniques are available to produce a suitable reference onto which one can 'lock' the laser, ... ...

Abstract	The stabilization of lasers to absolute frequency references is a fundamental requirement in several areas of atomic, molecular and optical physics. A range of techniques are available to produce a suitable reference onto which one can 'lock' the laser, many of which depend on the specific internal structure of the reference or are sensitive to laser intensity noise. We present a novel method using the frequency modulation of an acousto-optic modulator's carrier (drive) signal to generate two spatially separated beams, with a frequency difference of only a few MHz. These beams are used to probe a narrow absorption feature and the difference in their detected signals leads to a dispersion-like feature suitable for wavelength stabilization of a diode laser. This simple and versatile method only requires a narrow absorption line and is therefore suitable for both atomic and cavity based stabilization schemes. To demonstrate the suitability of this method we lock an external cavity diode laser near the
Language	English
Publishing date	2017-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.25.012830
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Article ; Online: Coherent waveguide laser arrays in semiconductor quantum well membranes.

Woods, Jonathan R C / Gorecki, Jon / Bek, Roman / Richardson, Stephen C / Daykin, Jake / Hooper, Grace / Branagan-Harris, Emelia / Tropper, Anne C / Wilkinson, James S / Jetter, Michael / Michler, Peter / Apostolopoulos, Vasilis

Optics express

2022 Volume 30, Issue 18, Page(s) 32174–32188

Abstract: Coherent laser arrays compatible with silicon photonics are demonstrated in a waveguide geometry in epitaxially grown semiconductor membrane quantum well lasers transferred on substrates of silicon carbide and oxidised silicon; we record lasing ... ...

Abstract	Coherent laser arrays compatible with silicon photonics are demonstrated in a waveguide geometry in epitaxially grown semiconductor membrane quantum well lasers transferred on substrates of silicon carbide and oxidised silicon; we record lasing thresholds as low as 60 mW of pump power. We study the emission of single lasers and arrays of lasers in the sub-mm range. We are able to create waveguide laser arrays with modal widths of approximately 5 - 10 µm separated by 10 - 20 µm, using real and reciprocal space imaging we study their emission characteristics and find that they maintain their mutual coherence while operating on either single or multiple longitudinal modes per lasing cavity.
Language	English
Publishing date	2022-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.457577
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Article ; Online: Hem-1 regulates protective humoral immunity and limits autoantibody production in a B cell-specific manner.

Avalos, Alan / Tietsort, Jacob T / Suwankitwat, Nutthakarn / Woods, Jonathan D / Jackson, Shaun W / Christodoulou, Alexandra / Morrill, Christopher / Liggitt, H Denny / Zhu, Chengsong / Li, Quan-Zhen / Bui, Kevin K / Park, Heon / Iritani, Brian M

JCI insight

2022 Volume 7, Issue 9

Abstract: Hematopoietic protein-1 (Hem-1) is a member of the actin-regulatory WASp family verprolin homolog (WAVE) complex. Loss-of-function variants in the NCKAP1L gene encoding Hem-1 were recently discovered to result in primary immunodeficiency disease (PID) in ...

Abstract	Hematopoietic protein-1 (Hem-1) is a member of the actin-regulatory WASp family verprolin homolog (WAVE) complex. Loss-of-function variants in the NCKAP1L gene encoding Hem-1 were recently discovered to result in primary immunodeficiency disease (PID) in children, characterized by poor specific Ab responses, increased autoantibodies, and high mortality. However, the mechanisms of how Hem-1 deficiency results in PID are unclear. In this study, we utilized constitutive and B cell-specific Nckap1l-KO mice to dissect the importance of Hem-1 in B cell development and functions. B cell-specific disruption of Hem-1 resulted in reduced numbers of recirculating follicular (FO), marginal zone (MZ), and B1 B cells. B cell migration in response to CXCL12 and -13 were reduced. T-independent Ab responses were nearly abolished, resulting in failed protective immunity to Streptococcus pneumoniae challenge. In contrast, T-dependent IgM and IgG2c, memory B cell, and plasma cell responses were more robust relative to WT control mice. B cell-specific Hem-1-deficient mice had increased autoantibodies against multiple autoantigens, and this correlated with hyperresponsive BCR signaling and increased representation of CD11c+T-bet+ age-associated B cell (ABC cells) - alterations associated with autoimmune diseases. These results suggest that dysfunctional B cells may be part of a mechanism explaining why loss-of-function Hem-1 variants result in recurring infections and autoimmunity.
MeSH term(s)	Actins ; Adaptor Proteins, Signal Transducing/immunology ; Animals ; Autoantibodies ; Autoimmune Diseases ; B-Lymphocytes/immunology ; Immunity, Humoral ; Mice ; Mice, Knockout
Chemical Substances	Actins ; Adaptor Proteins, Signal Transducing ; Autoantibodies ; Hem1 protein, mouse
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.153597
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Article ; Online: Cutting Edge: A Threshold of B Cell Costimulatory Signals Is Required for Spontaneous Germinal Center Formation in Autoimmunity.

Chiang, Kristy / Largent, Andrea D / Arkatkar, Tanvi / Thouvenel, Christopher D / Du, Samuel W / Shumlak, Natali / Woods, Jonathan / Li, Quan-Zhen / Liu, Yifan / Hou, Baidong / Rawlings, David J / Jackson, Shaun W

Journal of immunology (Baltimore, Md. : 1950)

2021 Volume 207, Issue 9, Page(s) 2217–2222

Abstract: Cognate interactions between autoreactive B and T cells promote systemic lupus erythematosus pathogenesis by inter alia facilitating spontaneous germinal center (GC) formation. Whereas both myeloid and B cell APCs express B7 ligands (CD80 and CD86), the ... ...

Abstract	Cognate interactions between autoreactive B and T cells promote systemic lupus erythematosus pathogenesis by inter alia facilitating spontaneous germinal center (GC) formation. Whereas both myeloid and B cell APCs express B7 ligands (CD80 and CD86), the prevailing model holds that dendritic cell costimulation is sufficient for CD28-dependent T cell activation. In this study, we report that B cell-intrinsic CD80/CD86 deletion unexpectedly abrogates GCs in murine lupus. Interestingly, absent GCs differentially impacted serum autoantibodies. In keeping with distinct extrafollicular and GC activation pathways driving lupus autoantibodies, lack of GCs correlated with loss of RNA-associated autoantibodies but preserved anti-dsDNA and connective tissue autoantibody titers. Strikingly, even heterozygous B cell CD80/CD86 deletion was sufficient to prevent autoimmune GCs and RNA-associated autoantibodies. Together, these findings identify a key mechanism whereby B cells promote lupus pathogenesis by providing a threshold of costimulatory signals required for autoreactive T cell activation.
MeSH term(s)	Animals ; Autoantibodies/metabolism ; Autoimmunity ; B-Lymphocytes/immunology ; B7-1 Antigen/genetics ; B7-1 Antigen/metabolism ; B7-2 Antigen/genetics ; B7-2 Antigen/metabolism ; Cells, Cultured ; Disease Models, Animal ; Germinal Center/immunology ; Humans ; Lupus Erythematosus, Systemic/immunology ; Lupus Nephritis/immunology ; Lymphocyte Activation ; Mice ; Mice, Knockout ; Receptor Cross-Talk ; T-Lymphocytes, Helper-Inducer/immunology
Chemical Substances	Autoantibodies ; B7-1 Antigen ; B7-2 Antigen
Language	English
Publishing date	2021-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2100548
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Article ; Online: TACI haploinsufficiency protects against BAFF-driven humoral autoimmunity in mice.

Jacobs, Holly M / Arkatkar, Tanvi / Du, Samuel W / Scharping, Nicole E / Woods, Jonathan / Li, Quan-Zhen / Hudkins, Kelly L / Alpers, Charles E / Rawlings, David J / Jackson, Shaun W

European journal of immunology

2021 Volume 51, Issue 9, Page(s) 2225–2236

Abstract: Polymorphisms in TACI, a BAFF family cytokine receptor, are linked to diverse human immune disorders including common variable immunodeficiency (CVID) and systemic lupus erythematosus (SLE). Functional studies of individual variants show modest impacts ... ...

Abstract	Polymorphisms in TACI, a BAFF family cytokine receptor, are linked to diverse human immune disorders including common variable immunodeficiency (CVID) and systemic lupus erythematosus (SLE). Functional studies of individual variants show modest impacts on surface TACI expression and/or downstream signal transduction, indicating that relatively subtle variation in TACI activity can impact human B-cell biology. However, significant complexity underlies TACI biology, including both positive and negative regulation of physiologic and pathogenic B-cell responses. To model these contradictory events, we compared the functional impact of TACI deletion on separate models of murine SLE driven by T cell-independent and -dependent breaks in B-cell tolerance. First, we studied whether reduced surface TACI expression was sufficient to protect against progressive BAFF-mediated systemic autoimmunity. Strikingly, despite a relatively modest impact on surface TACI levels, TACI haploinsufficiency markedly reduced pathogenic RNA-associated autoantibody titers and conferred long-term protection from BAFF-driven lupus nephritis. In contrast, B cell-intrinsic TACI deletion exerted a limited impact of autoantibody generation in murine lupus characterized by spontaneous germinal center formation and T cell-dependent humoral autoimmunity. Together, these combined data provide new insights into TACI biology and highlight how TACI signals must be tightly regulated during protective and pathogenic B-cell responses.
MeSH term(s)	Animals ; Antibodies, Monoclonal, Humanized/pharmacology ; Autoimmunity/genetics ; Autoimmunity/immunology ; B-Cell Activating Factor/antagonists & inhibitors ; B-Cell Activating Factor/genetics ; B-Cell Activating Factor/immunology ; B-Cell Activation Factor Receptor/genetics ; B-Lymphocytes/immunology ; Chimera ; Female ; Haploinsufficiency/genetics ; Immunosuppressive Agents/pharmacology ; Lupus Nephritis/genetics ; Lupus Nephritis/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction/genetics ; Signal Transduction/immunology ; Transmembrane Activator and CAML Interactor Protein/genetics ; Transmembrane Activator and CAML Interactor Protein/immunology
Chemical Substances	Antibodies, Monoclonal, Humanized ; B-Cell Activating Factor ; B-Cell Activation Factor Receptor ; Immunosuppressive Agents ; Tnfrsf13b protein, mouse ; Tnfrsf13c protein, mouse ; Tnfsf13b protein, mouse ; Transmembrane Activator and CAML Interactor Protein ; belimumab (73B0K5S26A)
Language	English
Publishing date	2021-06-27
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202149244
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