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  1. AU="Wooten, A Lake"
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  1. Article ; Online: Cross-sections for (p,x) reactions on natural chromium for the production of (52,52m,54)Mn radioisotopes.

    Wooten, A Lake / Lewis, Benjamin C / Lapi, Suzanne E

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2015  Volume 96, Page(s) 154–161

    Abstract: The production of positron-emitting isotopes of manganese is potentially important for developing contrast agents for dual-modality positron emission tomography and magnetic resonance (PET/MR) imaging, as well as for in vivo imaging of the ... ...

    Abstract The production of positron-emitting isotopes of manganese is potentially important for developing contrast agents for dual-modality positron emission tomography and magnetic resonance (PET/MR) imaging, as well as for in vivo imaging of the biodistribution and toxicity of manganese. The decay properties of (52)Mn make it an excellent candidate for these applications, and it can easily be produced by bombardment of a chromium target with protons or deuterons from a low-energy biomedical cyclotron. Several parameters that are essential to this mode of production—target thickness, beam energy, beam current, and bombardment time—depend heavily on the availability of reliable, reproducible cross-section data. This work contributes to the routine production of (52g)Mn for biomedical research by contributing experimental cross-sections for natural chromium ((nat)Cr) targets for the (nat)Cr(p,x)(52g)Mn reaction, as well as for the production of the radiocontaminants (52m,54)Mn.
    MeSH term(s) Chromium/radiation effects ; Cyclotrons ; Deuterium ; Humans ; Magnetic Resonance Imaging ; Manganese/isolation & purification ; Positron-Emission Tomography ; Protons ; Radioisotopes/isolation & purification ; Radiopharmaceuticals/isolation & purification ; Spectrometry, Gamma
    Chemical Substances Protons ; Radioisotopes ; Radiopharmaceuticals ; Chromium (0R0008Q3JB) ; Manganese (42Z2K6ZL8P) ; Deuterium (AR09D82C7G)
    Language English
    Publishing date 2015-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2014.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52.

    Wooten, A Lake / Aweda, Tolulope A / Lewis, Benjamin C / Gross, Rebecca B / Lapi, Suzanne E

    PloS one

    2017  Volume 12, Issue 3, Page(s) e0174351

    Abstract: Manganese is essential to life, and humans typically absorb sufficient quantities of this element from a normal healthy diet; however, chronic, elevated ingestion or inhalation of manganese can be neurotoxic, potentially leading to manganism. Although ... ...

    Abstract Manganese is essential to life, and humans typically absorb sufficient quantities of this element from a normal healthy diet; however, chronic, elevated ingestion or inhalation of manganese can be neurotoxic, potentially leading to manganism. Although imaging of large amounts of accumulated Mn(II) is possible by MRI, quantitative measurement of the biodistribution of manganese, particularly at the trace level, can be challenging. In this study, we produced the positron-emitting radionuclide 52Mn (t1/2 = 5.6 d) by proton bombardment (Ep<15 MeV) of chromium metal, followed by solid-phase isolation by cation-exchange chromatography. An aqueous solution of [52Mn]MnCl2 was nebulized into a closed chamber with openings through which mice inhaled the aerosol, and a separate cohort of mice received intravenous (IV) injections of [52Mn]MnCl2. Ex vivo biodistribution was performed at 1 h and 1 d post-injection/inhalation (p.i.). In both trials, we observed uptake in lungs and thyroid at 1 d p.i. Manganese is known to cross the blood-brain barrier, as confirmed in our studies following IV injection (0.86%ID/g, 1 d p.i.) and following inhalation of aerosol, (0.31%ID/g, 1 d p.i.). Uptake in salivary gland and pancreas were observed at 1 d p.i. (0.5 and 0.8%ID/g), but to a much greater degree from IV injection (6.8 and 10%ID/g). In a separate study, mice received IV injection of an imaging dose of [52Mn]MnCl2, followed by in vivo imaging by positron emission tomography (PET) and ex vivo biodistribution. The results from this study supported many of the results from the biodistribution-only studies. In this work, we have confirmed results in the literature and contributed new results for the biodistribution of inhaled radiomanganese for several organs. Our results could serve as supporting information for environmental and occupational regulations, for designing PET studies utilizing 52Mn, and/or for predicting the biodistribution of manganese-based MR contrast agents.
    MeSH term(s) Animals ; Blood-Brain Barrier ; Manganese/pharmacokinetics ; Mice ; Positron-Emission Tomography/methods ; Tissue Distribution
    Chemical Substances Manganese (42Z2K6ZL8P)
    Language English
    Publishing date 2017-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0174351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Calibration setting numbers for dose calibrators for the PET isotopes (52)Mn, (64)Cu, (76)Br, (86)Y, (89)Zr, (124)I.

    Wooten, A Lake / Lewis, Benjamin C / Szatkowski, Daniel J / Sultan, Deborah H / Abdin, Kinda I / Voller, Thomas F / Liu, Yongjian / Lapi, Suzanne E

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2016  Volume 113, Page(s) 89–95

    Abstract: For PET radionuclides, the radioactivity of a sample can be conveniently measured by a dose calibrator. These devices depend on a "calibration setting number", but many recommended settings from manuals were interpolated based on standard sources of ... ...

    Abstract For PET radionuclides, the radioactivity of a sample can be conveniently measured by a dose calibrator. These devices depend on a "calibration setting number", but many recommended settings from manuals were interpolated based on standard sources of other radionuclide(s). We conducted HPGe gamma-ray spectroscopy, resulting in a reference for determining settings in two types of vessels containing one of several PET radionuclides. Our results reiterate the notion that in-house, experimental calibrations are recommended for different radionuclides and vessels.
    MeSH term(s) Bromine Radioisotopes/analysis ; Calibration ; Copper Radioisotopes/analysis ; Humans ; Iodine Radioisotopes/analysis ; Manganese/analysis ; Positron-Emission Tomography/standards ; Positron-Emission Tomography/statistics & numerical data ; Radioisotopes/analysis ; Radiometry/standards ; Radiometry/statistics & numerical data ; Yttrium Radioisotopes/analysis ; Zirconium/analysis
    Chemical Substances Bromine Radioisotopes ; Bromine-76 ; Copper Radioisotopes ; Copper-64 ; Iodine Radioisotopes ; Iodine-124 ; Manganese-52 ; Radioisotopes ; Yttrium Radioisotopes ; Yttrium-86 ; Manganese (42Z2K6ZL8P) ; Zirconium (C6V6S92N3C) ; Zirconium-89 (NTM296JU95)
    Language English
    Publishing date 2016-04-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2016.04.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Evaluation of

    Feng, Yutian / Phipps, Michael D / Phelps, Tim E / Okoye, Nkemakonam C / Baumeister, Jakob E / Wycoff, Donald E / Dorman, Eric F / Wooten, A Lake / Vlasenko, Vladislav / Berendzen, Ashley F / Wilbur, D Scott / Hoffman, Timothy J / Cutler, Cathy S / Ketring, Alan R / Jurisson, Silvia S

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2018  Volume 143, Page(s) 113–122

    Abstract: ... Positron- ... ...

    Abstract Positron-emitting
    MeSH term(s) Arsenic/isolation & purification ; Germanium/chemistry ; Germanium/isolation & purification ; Germanium/radiation effects ; Humans ; Isotopes/chemistry ; Isotopes/isolation & purification ; Isotopes/radiation effects ; Phantoms, Imaging ; Positron-Emission Tomography ; Radioisotopes/isolation & purification ; Radioligand Assay ; Radionuclide Generators ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/isolation & purification ; Selenium Radioisotopes/isolation & purification
    Chemical Substances Arsenic-72 ; Germanium-70 ; Isotopes ; Radioisotopes ; Radiopharmaceuticals ; Selenium Radioisotopes ; Selenium-72 ; Selenium-75 ; Germanium (00072J7XWS) ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2018-10-30
    Publishing country England
    Document type Evaluation Study ; Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2018.10.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.279: Show issues Location:
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