Article: Proprotein Convertase Subtilisin Kexin 9 (PCSK9) and nonHDL particles rise during normal pregnancy and differ by BMI.
Journal of clinical lipidology
2022 Volume 16, Issue 4, Page(s) 483–490
Abstract: Background: Serum lipids, including total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c), increase during pregnancy. Serum Proprotein Convertase Subtilisin Kexin 9 (PCSK9) is a vital regulator in lipoprotein ... ...
| Abstract | Background: Serum lipids, including total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c), increase during pregnancy. Serum Proprotein Convertase Subtilisin Kexin 9 (PCSK9) is a vital regulator in lipoprotein metabolism. Circulating PCSK9 downregulates the LDL receptor on the surface of liver cells inhibiting clearance of LDL-c. Objective: To determine the influence of weeks of pregnancy and obesity on circulating levels of essential lipid lipoproteins and PCSK9 in women with normal, uncomplicated pregnancies and deliveries. Methods: We performed a comprehensive lipid and lipoprotein profile during each trimester of pregnancy in 70 mostly Caucasian women with uncomplicated normal pregnancies and deliveries. Based on their first trimester BMI, we placed them into one of three categories: (<25 kg/m Results: Total and active PCSK9, LDL-c, and nonHDL particle concentrations were higher than reported for non-pregnant normal values, increased after the first trimester of pregnancy, and were highest from mid-gestation to the last trimester of pregnancy in the overweight and the obese. Conclusion: PCSK9 levels rise as normal pregnancy progresses. Levels are higher in persons who are obese, even after adjustment for insulin resistance. Defining normal PCSK9 levels during pregnancy must adjust for gestational age and BMI. |
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| MeSH term(s) | Body Mass Index ; Cholesterol ; Cholesterol, LDL ; Female ; Humans ; Insulin Resistance ; Lipoproteins ; Obesity ; Pregnancy ; Proprotein Convertase 9 ; Proprotein Convertases ; Subtilisins ; Triglycerides |
| Chemical Substances | Cholesterol, LDL ; Lipoproteins ; Triglycerides ; Cholesterol (97C5T2UQ7J) ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Proprotein Convertases (EC 3.4.21.-) ; Subtilisins (EC 3.4.21.-) |
| Language | English |
| Publishing date | 2022-06-06 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2365061-8 |
| ISSN | 1876-4789 ; 1933-2874 |
| ISSN (online) | 1876-4789 |
| ISSN | 1933-2874 |
| DOI | 10.1016/j.jacl.2022.05.070 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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