LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 13

Search options

  1. Article ; Online: Sharing space at the research table: exploring public and patient involvement in a methodology priority setting partnership.

    Burke, Nikita N / Stewart, Derek / Tierney, Theresa / Worrall, Andrew / Smith, Maureen / Elliott, Jim / Beecher, Claire / Devane, Declan / Biesty, Linda

    Research involvement and engagement

    2023  Volume 9, Issue 1, Page(s) 29

    Abstract: Background: Public and patient involvement aims to improve research quality, relevance, and appropriateness. Despite an increasing evidence base on the influence of public involvement in health research, the role of involvement in methodology research ( ... ...

    Abstract Background: Public and patient involvement aims to improve research quality, relevance, and appropriateness. Despite an increasing evidence base on the influence of public involvement in health research, the role of involvement in methodology research (i.e. research that aims to enhance the quality and rigour of research) is less clear. Using a qualitative case study, we explored public involvement in a research priority-setting partnership in rapid review methodology (Priority III) to give practical insights to inform public involvement in priority-setting for future methodological research.
    Methods: Participant observation, documentary analysis, interviews and focus groups were used to explore the processes of Priority III and identify the views and experiences of the participants of a steering group (n = 26) regarding public involvement in Priority III. We used a case study research design and conducted two focus groups with five public partners; one focus group with four researchers; and seven one-to-one interviews with researchers and public partners. Nine episodes of participant observation of meetings were conducted. All data were analysed using template analysis.
    Results: The findings of this case study present three themes and six subthemes: Theme 1 We all bring unique qualities to the table. Subtheme 1.1-Coming from different perspectives towards shared-decision making; Subtheme 1.2-Public partners bring pragmatism and grounding in reality; Theme 2 We need support and space at the table. Subtheme 2.1-Define and develop support needed for meaningful involvement; Subtheme 2.2-Creating safe space to listen, challenge and learn; Theme 3 We all benefit from working together. Subtheme 3.1-Reciprocity in mutual learning and capacity building; Subtheme 3.2-Relationships as partners in research, with a feeling of togetherness. Communication and trust, as inclusive ways of working, underpinned the partnership approach to involvement.
    Conclusions: This case study contributes to knowledge on public involvement in research by explaining the supportive strategies, spaces, attitudes and behaviours that enabled a productive working partnership to develop between a team of researchers and public partners in this research context.
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2834246-X
    ISSN 2056-7529 ; 2056-7529
    ISSN (online) 2056-7529
    ISSN 2056-7529
    DOI 10.1186/s40900-023-00438-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Study protocol for a randomised controlled trial to investigate the effectiveness of thoracic epidural and paravertebral blockade in reducing chronic post-thoracotomy pain: 2 (TOPIC 2).

    Shelley, Ben / Goebel, Andreas / Grant, Stephen / Jackson, Louise / Jarrett, Hugh / Jepson, Marcus / Kerr, Amy / Marczin, Nandor / Mehta, Rajnikant / Melody, Teresa / Middleton, Lee / Naidu, Babu / Szentgyorgyi, Lajos / Tearne, Sarah / Watkins, Ben / Wilson, Matthew / Worrall, Andrew / Yeung, Joyce / Smith, Fang Gao

    Trials

    2023  Volume 24, Issue 1, Page(s) 748

    Abstract: Background: Thoracotomy is considered one of the most painful surgical procedures and can cause debilitating chronic post-surgical pain lasting months or years postoperatively. Aggressive management of acute pain resulting from thoracotomy may reduce ... ...

    Abstract Background: Thoracotomy is considered one of the most painful surgical procedures and can cause debilitating chronic post-surgical pain lasting months or years postoperatively. Aggressive management of acute pain resulting from thoracotomy may reduce the likelihood of developing chronic pain. This trial compares the two most commonly used modes of acute analgesia provision at the time of thoracotomy (thoracic epidural blockade (TEB) and paravertebral blockade (PVB)) in terms of their clinical and cost-effectiveness in preventing chronic post-thoracotomy pain.
    Methods: TOPIC 2 is a multi-centre, open-label, parallel group, superiority, randomised controlled trial, with an internal pilot investigating the use of TEB and PVB in 1026 adult (≥ 18 years old) patients undergoing thoracotomy in up to 20 thoracic centres throughout the UK. Patients (N = 1026) will be randomised in a 1:1 ratio to receive either TEB or PVB. During the first year, the trial will include an integrated QuinteT (Qualitative Research Integrated into Trials) Recruitment Intervention (QRI) with the aim of optimising recruitment and informed consent. The primary outcome is the incidence of chronic post-surgical pain at 6 months post-randomisation defined as 'worst chest pain over the last week' equating to a visual analogue score greater than or equal to 40 mm indicating at least a moderate level of pain. Secondary outcomes include acute pain, complications of regional analgesia and surgery, health-related quality of life, mortality and a health economic analysis.
    Discussion: Both TEB and PVB have been demonstrated to be effective in the prevention of acute pain following thoracotomy and nationally practice is divided. Identification of which mode of analgesia is both clinically and cost-effective in preventing chronic post-thoracotomy pain could ameliorate the debilitating effects of chronic pain, improving health-related quality of life, facilitating return to work and caring responsibilities and resulting in a cost saving to the NHS.
    Trial registration: NCT03677856 [ClinicalTrials.gov] registered September 19, 2018. https://clinicaltrials.gov/ct2/show/NCT03677856 . First patient recruited 8 January 2019.
    MeSH term(s) Adult ; Humans ; Adolescent ; Thoracotomy/adverse effects ; Chronic Pain/diagnosis ; Chronic Pain/etiology ; Chronic Pain/prevention & control ; Analgesia, Epidural/adverse effects ; Analgesia, Epidural/methods ; Acute Pain/diagnosis ; Acute Pain/etiology ; Acute Pain/prevention & control ; Quality of Life ; Nerve Block/adverse effects ; Nerve Block/methods ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07463-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Remote Teaching of Programming in Mathematica: Lessons Learned

    Cahill, Samuel T. / Mann, Patrick E. Bergstrom / Worrall, Andrew F. / Stewart, Malcolm I.

    Journal of Chemical Education

    Abstract: The COVID-19 pandemic has resulted in a need for social distancing measures in public spaces and will have an important impact on university level teaching going forward Remote methods to complete laboratory related activities are a potential means of ... ...

    Abstract The COVID-19 pandemic has resulted in a need for social distancing measures in public spaces and will have an important impact on university level teaching going forward Remote methods to complete laboratory related activities are a potential means of students achieving practical credit while still isolating or social distancing We outline the implementation of two novel remote exercises, based on coding in Mathematica, and the methods used to provide ongoing help to students These exercises are used as a case study to identify potential problems with remote exercises based on student feedback Suggestions for how these problems might be overcome in further iterations of these remote exercises are explored
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #804304
    Database COVID19

    Kategorien

  4. Article ; Online: Developing a skills-based practical chemistry programme

    Campbell Craig D. / Midson Megan O. / Bergstrom Mann Patrick E. / Cahill Samuel T. / Green Nicholas J. B. / Harris Matthew T. / Hibble Simon J. / O’Sullivan Saskia K. E. / To Trang / Rowlands Lucy J. / Smallwood Zoe M. / Vallance Claire / Worrall Andrew F. / Stewart Malcolm I.

    Chemistry Teacher International, Vol 4, Iss 3, Pp 243-

    an integrated, spiral curriculum approach

    2022  Volume 257

    Abstract: Teaching practical laboratory skills is a key component of preparing undergraduate students for future careers in chemistry and elsewhere. In this paper, we present our new strategy to teach practical skills to undergraduate chemistry students. We report ...

    Abstract Teaching practical laboratory skills is a key component of preparing undergraduate students for future careers in chemistry and elsewhere. In this paper, we present our new strategy to teach practical skills to undergraduate chemistry students. We report a Skills Inventory, a list of the suggested practical skills a graduate chemist should possess; this list was compiled by chemists across the UK. In our new practical course we begin by decoupling the practical skill from the theoretical background, compelling students to first master the basic processes needed to carry out a specific technique. In what we have termed a ‘spiral curriculum’ approach, skills are revisited on multiple occasions, with increasing complexity and greater emphasis on underlying theory. The new course makes links across traditional subdisciplines of chemistry to avoid compartmentalisation of ideas.
    Keywords integrated ; skills inventory ; spiral curriculum ; undergraduate students ; Chemistry ; QD1-999
    Subject code 370
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  5. Article: Benefits of Simulations as Remote Exercises During the COVID-19 Pandemic: An Enzyme Kinetics Case Study

    Worrall, Andrew F. / Mann, Patrick E. Bergstrom / Young, Damion / Wormald, Mark R. / Cahill, Samuel T. / Stewart, Malcolm I.

    Journal of Chemical Education

    Abstract: Teaching practical chemistry skills remotely is not a ask that would have been high on the agenda only a few months ago However, in light of the COVID-19 pandemic, students around the world are having to work from home, and the chemistry education ... ...

    Abstract Teaching practical chemistry skills remotely is not a ask that would have been high on the agenda only a few months ago However, in light of the COVID-19 pandemic, students around the world are having to work from home, and the chemistry education community has been forced to adapt to the new circumstances In response, we discuss the use of simulations in place of practical laboratory work, with emphasis on the development of students' experimental design skills The simulation of Michaelis Menten enzyme kinetics is given as an example exercise, which other instructors could implement with immediate effect
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #806521
    Database COVID19

    Kategorien

  6. Article ; Online: Benefits of Simulations as Remote Exercises During the COVID-19 Pandemic

    Worrall, Andrew F. / Bergstrom Mann, Patrick E. / Young, Damion / Wormald, Mark R. / Cahill, Samuel T. / Stewart, Malcolm I.

    Journal of Chemical Education

    An Enzyme Kinetics Case Study

    2020  Volume 97, Issue 9, Page(s) 2733–2737

    Keywords General Chemistry ; Education ; covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 218164-2
    ISSN 1938-1328 ; 0021-9584
    ISSN (online) 1938-1328
    ISSN 0021-9584
    DOI 10.1021/acs.jchemed.0c00607
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  7. Article ; Online: Future challenges for nuclear energy in Europe

    Hesketh Kevin / Worrall Andrew / Weaver David

    Europhysics News, Vol 35, Iss 6, Pp 210-

    2008  Volume 211

    Keywords Physics ; QC1-999 ; Science ; Q ; DOAJ:Physics (General) ; DOAJ:Physics and Astronomy
    Language English
    Publishing date 2008-10-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  8. Article ; Online: Priority III: top 10 rapid review methodology research priorities identified using a James Lind Alliance Priority Setting Partnership.

    Beecher, Claire / Toomey, Elaine / Maeso, Beccy / Whiting, Caroline / Stewart, Derek C / Worrall, Andrew / Elliott, Jim / Smith, Maureen / Tierney, Theresa / Blackwood, Bronagh / Maguire, Teresa / Kampman, Melissa / Ling, Benny / Gill, Catherine / Healy, Patricia / Houghton, Catherine / Booth, Andrew / Garritty, Chantelle / Thomas, James /
    Tricco, Andrea C / Burke, Nikita N / Keenan, Ciara / Devane, Declan

    Journal of clinical epidemiology

    2022  Volume 151, Page(s) 151–160

    Abstract: Objectives: A rapid review is a form of evidence synthesis considered a resource-efficient alternative to the conventional systematic review. Despite a dramatic rise in the number of rapid reviews commissioned and conducted in response to the ... ...

    Abstract Objectives: A rapid review is a form of evidence synthesis considered a resource-efficient alternative to the conventional systematic review. Despite a dramatic rise in the number of rapid reviews commissioned and conducted in response to the coronavirus disease 2019 pandemic, published evidence on the optimal methods of planning, doing, and sharing the results of these reviews is lacking. The Priority III study aimed to identify the top 10 unanswered questions on rapid review methodology to be addressed by future research.
    Study design and setting: A modified James Lind Alliance Priority Setting Partnership approach was adopted. This approach used two online surveys and a virtual prioritization workshop with patients and the public, reviewers, researchers, clinicians, policymakers, and funders to identify and prioritize unanswered questions.
    Results: Patients and the public, researchers, reviewers, clinicians, policymakers, and funders identified and prioritized the top 10 unanswered research questions about rapid review methodology. Priorities were identified throughout the entire review process, from stakeholder involvement and formulating the question, to the methods of a systematic review that are appropriate to use, through to the dissemination of results.
    Conclusion: The results of the Priority III study will inform the future research agenda on rapid review methodology. We hope this will enhance the quality of evidence produced by rapid reviews, which will ultimately inform decision-making in the context of healthcare.
    Language English
    Publishing date 2022-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2022.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials.

    Ciani, Oriana / Manyara, Anthony M / Davies, Philippa / Stewart, Derek / Weir, Christopher J / Young, Amber E / Blazeby, Jane / Butcher, Nancy J / Bujkiewicz, Sylwia / Chan, An-Wen / Dawoud, Dalia / Offringa, Martin / Ouwens, Mario / Hróbjartssson, Asbjørn / Amstutz, Alain / Bertolaccini, Luca / Bruno, Vito Domenico / Devane, Declan / Faria, Christina D C M /
    Gilbert, Peter B / Harris, Ray / Lassere, Marissa / Marinelli, Lucio / Markham, Sarah / Powers, John H / Rezaei, Yousef / Richert, Laura / Schwendicke, Falk / Tereshchenko, Larisa G / Thoma, Achilles / Turan, Alparslan / Worrall, Andrew / Christensen, Robin / Collins, Gary S / Ross, Joseph S / Taylor, Rod S

    EClinicalMedicine

    2023  Volume 65, Page(s) 102283

    Abstract: Background: Interventional trials that evaluate treatment effects using surrogate endpoints have become increasingly common. This paper describes four linked empirical studies and the development of a framework for defining, interpreting and reporting ... ...

    Abstract Background: Interventional trials that evaluate treatment effects using surrogate endpoints have become increasingly common. This paper describes four linked empirical studies and the development of a framework for defining, interpreting and reporting surrogate endpoints in trials.
    Methods: As part of developing the CONSORT (Consolidated Standards of Reporting Trials) and SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) extensions for randomised trials reporting surrogate endpoints, we undertook a scoping review, e-Delphi study, consensus meeting, and a web survey to examine current definitions and stakeholder (including clinicians, trial investigators, patients and public partners, journal editors, and health technology experts) interpretations of surrogate endpoints as primary outcome measures in trials.
    Findings: Current surrogate endpoint definitional frameworks are inconsistent and unclear. Surrogate endpoints are used in trials as a substitute of the treatment effects of an intervention on the target outcome(s) of ultimate interest, events measuring how patients feel, function, or survive. Traditionally the consideration of surrogate endpoints in trials has focused on biomarkers (e.g., HDL cholesterol, blood pressure, tumour response), especially in the medical product regulatory setting. Nevertheless, the concept of surrogacy in trials is potentially broader. Intermediate outcomes that include a measure of function or symptoms (e.g., angina frequency, exercise tolerance) can also be used as substitute for target outcomes (e.g., all-cause mortality)-thereby acting as surrogate endpoints. However, we found a lack of consensus among stakeholders on accepting and interpreting intermediate outcomes in trials as surrogate endpoints or target outcomes. In our assessment, patients and health technology assessment experts appeared more likely to consider intermediate outcomes to be surrogate endpoints than clinicians and regulators.
    Interpretation: There is an urgent need for better understanding and reporting on the use of surrogate endpoints, especially in the setting of interventional trials. We provide a framework for the definition of surrogate endpoints (biomarkers and intermediate outcomes) and target outcomes in trials to improve future reporting and aid stakeholders' interpretation and use of trial surrogate endpoint evidence.
    Funding: SPIRIT-SURROGATE/CONSORT-SURROGATE project is Medical Research Council Better Research Better Health (MR/V038400/1) funded.
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2023.102283
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: What are the most important unanswered research questions on rapid review methodology? A James Lind Alliance research methodology Priority Setting Partnership: the Priority III study protocol.

    Beecher, Claire / Toomey, Elaine / Maeso, Beccy / Whiting, Caroline / Stewart, Derek C / Worrall, Andrew / Elliott, Jim / Smith, Maureen / Tierney, Theresa / Blackwood, Bronagh / Maguire, Teresa / Kampman, Melissa / Ling, Benny / Gravel, Christopher / Gill, Catherine / Healy, Patricia / Houghton, Catherine / Booth, Andrew / Garritty, Chantelle /
    Thomas, James / Tricco, Andrea C / Burke, Nikita N / Keenan, Ciara / Westmore, Matthew / Devane, Declan

    HRB open research

    2021  Volume 4, Page(s) 80

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-18
    Publishing country Ireland
    Document type Journal Article
    ISSN 2515-4826
    ISSN (online) 2515-4826
    DOI 10.12688/hrbopenres.13321.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top