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  1. Article: Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin.

    Leignadier, Julie / Drago, Marie / Lesouhaitier, Olivier / Barreau, Magalie / Dashi, Albert / Worsley, Oliver / Attia-Vigneau, Joan

    Pharmaceutics

    2023  Volume 15, Issue 8

    Abstract: Acne is a chronic inflammatory skin disease that affects the quality of life of patients. Several treatments exist for acne, but their effectiveness tends to decrease over time due to increasing resistance to treatment and associated side effects. To ... ...

    Abstract Acne is a chronic inflammatory skin disease that affects the quality of life of patients. Several treatments exist for acne, but their effectiveness tends to decrease over time due to increasing resistance to treatment and associated side effects. To circumvent these issues, a new approach has emerged that involves combating the pathogen
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15082083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Persistent changes in liver methylation and microbiome composition following reversal of diet-induced non-alcoholic-fatty liver disease

    Kim, Hyejin / Chow, Pierce Kah Hoe / Fan, Vanessa / Foo, Roger SY / Hartono, Septian / Liang, Ai Leng / Lim, Tony Kiat Hon / Moses, Daniela I. Drautz / Pettersson, Sven / Purbojati, Rikky Wenang / Schuster, Stephan C / Tan, Wilson / Worsley, Oliver / Yang, Edwin

    Cellular and molecular life sciences. 2019 Nov., v. 76, no. 21

    2019  

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is a metabolic liver disease that is thought to be reversible by changing the diet. To examine the impact of dietary changes on progression and cure of NAFLD, we fed mice a high-fat diet (HFD) or high-fructose ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is a metabolic liver disease that is thought to be reversible by changing the diet. To examine the impact of dietary changes on progression and cure of NAFLD, we fed mice a high-fat diet (HFD) or high-fructose diet (HFrD) for 9 weeks, followed by an additional 9 weeks, where mice were given normal chow diet. As predicted, the diet-induced NAFLD elicited changes in glucose tolerance, serum cholesterol, and triglyceride levels in both diet groups. Moreover, the diet-induced NAFLD phenotype was reversed, as measured by the recovery of glucose intolerance and high cholesterol levels when mice were given normal chow diet. However, surprisingly, the elevated serum triglyceride levels persisted. Metagenomic analysis revealed dietary-induced changes of microbiome composition, some of which remained altered even after reversing the diet to normal chow, as illustrated by species of the Odoribacter genus. Genome-wide DNA methylation analysis revealed a “priming effect” through changes in DNA methylation in key liver genes. For example, the lipid-regulating gene Apoa4 remained hypomethylated in both groups even after introduction to normal chow diet. Our results support that dietary change, in part, reverses the NAFLD phenotype. However, some diet-induced effects remain, such as changes in microbiome composition, elevated serum triglyceride levels, and hypomethylation of key liver genes. While the results are correlative in nature, it is tempting to speculate that the dietary-induced changes in microbiome composition may in part contribute to the persistent epigenetic modifications in the liver.
    Keywords blood serum ; cholesterol ; DNA methylation ; epigenetics ; fatty liver ; genes ; glucose ; glucose tolerance ; high fat diet ; high fructose diet ; liver ; metagenomics ; mice ; microbiome ; phenotype ; triacylglycerols
    Language English
    Dates of publication 2019-11
    Size p. 4341-4354.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-019-03114-4
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Persistent changes in liver methylation and microbiome composition following reversal of diet-induced non-alcoholic-fatty liver disease.

    Kim, Hyejin / Worsley, Oliver / Yang, Edwin / Purbojati, Rikky Wenang / Liang, Ai Leng / Tan, Wilson / Moses, Daniela I Drautz / Hartono, Septian / Fan, Vanessa / Lim, Tony Kiat Hon / Schuster, Stephan C / Foo, Roger Sy / Chow, Pierce Kah Hoe / Pettersson, Sven

    Cellular and molecular life sciences : CMLS

    2019  Volume 76, Issue 21, Page(s) 4341–4354

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is a metabolic liver disease that is thought to be reversible by changing the diet. To examine the impact of dietary changes on progression and cure of NAFLD, we fed mice a high-fat diet (HFD) or high-fructose ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is a metabolic liver disease that is thought to be reversible by changing the diet. To examine the impact of dietary changes on progression and cure of NAFLD, we fed mice a high-fat diet (HFD) or high-fructose diet (HFrD) for 9 weeks, followed by an additional 9 weeks, where mice were given normal chow diet. As predicted, the diet-induced NAFLD elicited changes in glucose tolerance, serum cholesterol, and triglyceride levels in both diet groups. Moreover, the diet-induced NAFLD phenotype was reversed, as measured by the recovery of glucose intolerance and high cholesterol levels when mice were given normal chow diet. However, surprisingly, the elevated serum triglyceride levels persisted. Metagenomic analysis revealed dietary-induced changes of microbiome composition, some of which remained altered even after reversing the diet to normal chow, as illustrated by species of the Odoribacter genus. Genome-wide DNA methylation analysis revealed a "priming effect" through changes in DNA methylation in key liver genes. For example, the lipid-regulating gene Apoa4 remained hypomethylated in both groups even after introduction to normal chow diet. Our results support that dietary change, in part, reverses the NAFLD phenotype. However, some diet-induced effects remain, such as changes in microbiome composition, elevated serum triglyceride levels, and hypomethylation of key liver genes. While the results are correlative in nature, it is tempting to speculate that the dietary-induced changes in microbiome composition may in part contribute to the persistent epigenetic modifications in the liver.
    MeSH term(s) Animals ; DNA Methylation/drug effects ; Diet, High-Fat/adverse effects ; Dietary Fats/adverse effects ; Dietary Fats/pharmacology ; Gastrointestinal Microbiome/drug effects ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/microbiology ; Obesity/genetics ; Obesity/metabolism ; Obesity/microbiology
    Chemical Substances Dietary Fats
    Language English
    Publishing date 2019-05-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-019-03114-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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