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  1. Article ; Online: Targeted Delivery of Cisplatin by Gold Nanoparticles: The Influence of Nanocarrier Surface Modification Type on the Efficiency of Drug Binding Examined by CE-ICP-MS/MS.

    Wróblewska, Anna M / Milewska, Aleksandra / Drozd, Marcin / Matczuk, Magdalena

    International journal of molecular sciences

    2022  Volume 23, Issue 4

    Abstract: Spherical gold nanoparticles (GNPs), whose unique properties regarding biomedical applications were broadly investigated, are an object of interest as nanocarriers in drug targeted delivery systems (DTDSs). The possibility of surface functionalization, ... ...

    Abstract Spherical gold nanoparticles (GNPs), whose unique properties regarding biomedical applications were broadly investigated, are an object of interest as nanocarriers in drug targeted delivery systems (DTDSs). The possibility of surface functionalization, especially in enabling longer half-life in the bloodstream and enhancing cellular uptake, provides an opportunity to overcome the limitations of popular anticancer drugs (such as cisplatin) that cause severe side effects due to their nonselective transportation. Herein, we present investigations of gold nanoparticle-cisplatin systems formation (regarding reaction kinetics and equilibrium) in which it was proved that the formation efficiency and stability strongly depend on the nanoparticle surface functionalization. In this study, the capillary electrophoresis hyphenated with inductively coupled plasma tandem mass spectrometry (CE-ICP-MS/MS) was used for the first time to monitor gold-drug nanoconjugates formation. The research included optimizing CE separation conditions and determining reaction kinetics using the CE-ICP-MS/MS developed method. To characterize nanocarriers and portray changes in their physicochemical properties induced by the surface's processes, additional hydrodynamic size and ζ-potential by dynamic light scattering (DLS) measurements were carried out. The examinations of three types of functionalized GNPs (GNP-PEG-COOH, GNP-PEG-OCH
    MeSH term(s) Antineoplastic Agents/chemistry ; Cisplatin/chemistry ; Drug Carriers/chemistry ; Dynamic Light Scattering/methods ; Electrophoresis, Capillary/methods ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Nanoconjugates/chemistry ; Particle Size ; Tandem Mass Spectrometry/methods
    Chemical Substances Antineoplastic Agents ; Drug Carriers ; Nanoconjugates ; Gold (7440-57-5) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23042324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Toward the boosted loading of cisplatin drug into liposome nanocarriers.

    Wróblewska, Anna M / Łukawska, Ewelina / Wakuła, Zuzanna / Zajda, Joanna / Keppler, Bernhard K / Timerbaev, Andrei R / Matczuk, Magdalena

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2024  Volume 198, Page(s) 114245

    Abstract: Current challenges in oncology are largely associated with the need to improve the effectiveness of cancer treatment and to reduce drug's side effects. An effective strategy to cope with these challenges is behind designing and developing drug delivery ... ...

    Abstract Current challenges in oncology are largely associated with the need to improve the effectiveness of cancer treatment and to reduce drug's side effects. An effective strategy to cope with these challenges is behind designing and developing drug delivery systems based on smart nanomaterials and approved anticancer drugs. The present study offers a novel and straightforward approach to efficiently load the cisplatin drug into the newly constructed liposome-based nanosystems as well a reliable technique for monitoring this process based on capillary electrophoresis hyphenated with inductively coupled plasma tandem mass spectrometry. The proposed drug-loading methodology comprises liposome formation via a simple ethanol-injection method and propels increased drug encapsulation using tailor-made freeze-thawing or lyophilization-hydration procedures. To optimize liposome generation and drug encapsulation, the effects of dilution medium and liposome composition (types of phospholipids and their percentage ratio) have been investigated in detail. It was shown that modest alterations of the composition of three-component phospholipid liposomes and parameters of the freeze-thawing procedure have a strong impact on the formation of cisplatin-liposome systems. The obtained cisplatin-liposome formulation features a remarkable degree of drug encapsulation, over 100 mg L
    MeSH term(s) Cisplatin ; Liposomes/chemistry ; Antineoplastic Agents ; Phospholipids/chemistry ; Drug Delivery Systems
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Liposomes ; Antineoplastic Agents ; Phospholipids
    Language English
    Publishing date 2024-03-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2024.114245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Drawbacks in the efficient monitoring of gold nanoparticle-based cisplatin delivery systems formation by HPLC-ICP-MS.

    Wróblewska, Anna M / Gos, Nina / Zajda, Joanna / Ruzik, Lena / Matczuk, Magdalena

    Metallomics : integrated biometal science

    2022  Volume 15, Issue 1

    Abstract: Since chemotherapy suffers many limitations related to side effects of anticancer drugs (e.g. cisplatin - CDDP), nanoparticles are probed as carriers in targeted drug delivery. Gold nanoparticles (AuNPs) are broadly investigated due to their ... ...

    Abstract Since chemotherapy suffers many limitations related to side effects of anticancer drugs (e.g. cisplatin - CDDP), nanoparticles are probed as carriers in targeted drug delivery. Gold nanoparticles (AuNPs) are broadly investigated due to their biocompatibility, nontoxicity, and tunable surface. Despite many AuNPs-cisplatin systems (AuNP-CS) reports found in the literature, only a few include studies of their synthesis and formation efficiency using analytical tools providing simultaneously qualitative and quantitative analytical information. Therefore, this research continues our previous study of AuNP-CS formation investigated by capillary electrophoresis with inductively coupled plasma mass spectrometry (ICP-MS). Namely, it presents the analogical approach but employs the coupling of another separation technique: isocratic reversed-phase high-performance liquid chromatography. The study concerns the difficulties of analytical method optimization path and contains a discussion of the observed problematic issues related to the analysis and preparation of AuNP-CS. Moreover, the presented work confronts the performance and applicability of both tools for the scrutiny of AuNP-CS, especially considering the comparison of their resolution power.
    MeSH term(s) Cisplatin ; Gold/chemistry ; Chromatography, High Pressure Liquid ; Mass Spectrometry/methods ; Metal Nanoparticles/chemistry
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Gold (7440-57-5)
    Language English
    Publishing date 2022-11-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2474317-3
    ISSN 1756-591X ; 1756-5901
    ISSN (online) 1756-591X
    ISSN 1756-5901
    DOI 10.1093/mtomcs/mfad002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Phenolic content, chemical composition and anti-/pro-oxidant activity of Gold Milenium and Papierowka apple peel extracts.

    Kalinowska, Monika / Gryko, Kamila / Wróblewska, Anna M / Jabłońska-Trypuć, Agata / Karpowicz, Danuta

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 14951

    Abstract: In this study the peels of ecologically grown apple (Malus domestica) cultivars: Gold Milenium (a new scab-resistant variety) and Papierowka (Papirovka; an old, sensitive to apple scab variety) were examined for their composition (phenolic compounds, ... ...

    Abstract In this study the peels of ecologically grown apple (Malus domestica) cultivars: Gold Milenium (a new scab-resistant variety) and Papierowka (Papirovka; an old, sensitive to apple scab variety) were examined for their composition (phenolic compounds, triterpenoids, simple organic acids, macro-, microelements, reducing sugars, L-ascorbic acid), pro- and antioxidant properties as well as their application in reduction of the oxidative stress in cultured human skin fibroblast. The higher content of phenolic compounds correlated with the greater pro- and antioxidant activity of the peels of Papierowka compared to Gold Milenium in DPPH·, ABTS
    MeSH term(s) Antioxidants/analysis ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Fibroblasts/metabolism ; Fruit/chemistry ; Humans ; Malus/chemistry ; Plant Extracts/analysis ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Polyphenols/analysis ; Polyphenols/chemistry ; Polyphenols/pharmacology
    Chemical Substances Antioxidants ; Plant Extracts ; Polyphenols
    Language English
    Publishing date 2020-09-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-71351-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Spektryna--bogactwo funkcji ukrytych w strukturze.

    Wolny, Marcin / Wróblewska, Anna M / Machnicka, Beata / Sikorski, Aleksander F

    Postepy biochemii

    2012  Volume 58, Issue 3, Page(s) 245–254

    Abstract: Membrane skeleton is a structure that provides strength and elasticity to the erythrocyte membrane. This features stem from the main component of this structure, a multifunctional protein called spectrin. Spectrin forms a network underlying membrane ... ...

    Title translation Spectrin--variety of functions hidden in the structure.
    Abstract Membrane skeleton is a structure that provides strength and elasticity to the erythrocyte membrane. This features stem from the main component of this structure, a multifunctional protein called spectrin. Spectrin forms a network underlying membrane bilayer containing integral membrane proteins which interact with multiple proteins and lipid partners. Although membrane skeleton and spectrin structure have been described before, the latest discoveries show their new details and properties. In this work we summarize recent findings concerning structure and function of spectrin together with its possible role in pathology. We focus our interest on lately published structural data and we make an attempt to combine these findings with possible physiological functions.
    MeSH term(s) Animals ; Erythrocyte Membrane/metabolism ; Humans ; Models, Molecular ; Spectrin/chemistry ; Spectrin/physiology
    Chemical Substances Spectrin (12634-43-4)
    Language Polish
    Publishing date 2012
    Publishing country Poland
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 414019-9
    ISSN 0032-5422
    ISSN 0032-5422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 633: Show issues Location:
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