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  1. Book ; Thesis: Herstellung und Charakterisierung Myobacterium-tuberculosis-Komplex-spezifischer monoklonaler Antikörper

    Wrede, Holger

    1997  

    Author's details vorgelegt von Holger Wrede
    Language German
    Size II, 66 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1998
    HBZ-ID HT008491355
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    98 D 1228 order for loan Magazin

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  2. Article: Telemedicine in allergology: practical aspects: A position paper of the Association of German Allergists (AeDA).

    Dramburg, Stephanie / Walter, Uso / Becker, Sven / Casper, Ingrid / Röseler, Stefani / Schareina, Astrid / Wrede, Holger / Klimek, Ludger

    Allergo journal international

    2021  Volume 30, Issue 4, Page(s) 119–129

    Abstract: Since spring 2020, the wide-ranging contact restriction measures in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have also led to a reduction in physician-patient contacts in the ambulatory care setting. ... ...

    Abstract Since spring 2020, the wide-ranging contact restriction measures in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have also led to a reduction in physician-patient contacts in the ambulatory care setting. Telemedicine applications will increasingly provide a way to efficiently deliver patient care under infection control measures. In allergology, telemedical as well as digital applications can also significantly facilitate everyday clinical practice. However, the technical and legal hurdles associated with the implementation of digital strategies must be overcome for this to happen. The aim of this article is to provide an intuitive overview of the aspects to be considered in the implementation of telemedicine consultations and to highlight the current state of the framework as well as optimization possibilities and perspectives in allergology. If a structured use is guaranteed, digital and telemedical applications can improve patient care-also in allergology. There is potential to be exploited in many areas, from the remote collection of clinical history, and video consultations, to the discussion of diagnostic findings, disease monitoring, and therapy support. The use of telemedical applications, especially video consultations, has experienced a remarkable acceleration in the context of the coronavirus disease 2019 (COVID-19) pandemic. The present overview of the legal, technical and professional framework is intended to support the anchoring of digital and telemedical technologies in everyday allergology. However, in order to consolidate these in the future, an agreement is needed regarding professional standards of action as well as a remuneration structure that is permanently defined beyond the current pandemic.
    Language English
    Publishing date 2021-02-22
    Publishing country Germany
    Document type Journal Article
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-021-00167-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [No title information]

    Dramburg, Stephanie / Walter, Uso / Becker, Sven / Casper, Ingrid / Röseler, Stefani / Schareina, Astrid / Wrede, Holger / Klimek, Ludger

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2021  Volume 30, Issue 4, Page(s) 24–38

    Title translation Praktischer Leitfaden zum Einsatz telemedizinischer Anwendungen bei der Betreuung von Allergiepatienten: Ein Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA).
    Language German
    Publishing date 2021-06-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-021-4823-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Monitoring mepolizumab treatment in chronic rhinosinusitis with nasal polyps (CRSwNP): Discontinue, change, continue therapy?

    Klimek, Ludger / Förster-Ruhrmann, Ulrike / Olze, Heidi / Beule, Achim G / Chaker, Adam M / Hagemann, Jan / Huppertz, Tilman / Hoffmann, Thomas K / Dazert, Stefan / Deitmer, Thomas / Strieth, Sebastian / Wrede, Holger / Schlenter, Wolfgang W / Welkoborsky, Hans-Jürgen / Wollenberg, Barbara / Becker, Sven / Bärhold, Fredericke / Klimek, Felix / Casper, Ingrid /
    Zuberbier, Jaron / Rudack, Claudia / Cuevas, Mandy / Hintschich, Constantin A / Guntinas-Lichius, Orlando / Stöver, Timo / Bergmann, Christoph / Werminghaus, Pascal / Pfaar, Oliver / Gosepath, Jan / Gröger, Moritz / Beutner, Caroline / Laudien, Martin / Weber, Rainer K / Hildebrand, Tanja / Hoffmann, Anna S / Bachert, Claus

    Allergologie select

    2024  Volume 8, Page(s) 26–39

    Abstract: Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease of the mucous membranes of the nose and sinuses. Eosinophilic inflammation is described as a common endotype. The anti-IL-5 antibody mepolizumab was ... ...

    Abstract Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease of the mucous membranes of the nose and sinuses. Eosinophilic inflammation is described as a common endotype. The anti-IL-5 antibody mepolizumab was approved in November 2021 as an add-on therapy to intranasal glucocorticosteroids for the treatment of adults with severe chronic rhinosinusitis with nasal polyps when systemic glucocorticosteroids or surgery do not provide adequate disease control. While national and international recommendations exist for the use of mepolizumab in CRSwNP, it has not yet been adequately specified how this therapy should be monitored, what follow-up documentation is necessary, and when it should be discontinued if necessary.
    Materials and methods: A literature search was performed to analyze previous data on the treatment of CRSwNP with mepolizumab and to determine the available evidence by searching Medline, Pubmed, the national and international trial and guideline registries, and the Cochrane Library. Human studies published in the period up to and including 10/2022 were considered.
    Results: Based on the international literature and previous experience by an expert panel, recommendations for follow-up, adherence to therapy intervals, and possible therapy breaks as well as discontinuation of therapy when using mepolizumab for the indication CRSwNP in the German healthcare system are given on the basis of a documentation sheet.
    Conclusion: Understanding the immunological basis of CRSwNP opens up new non-surgical therapeutic approaches with biologics for patients with severe, uncontrolled courses. Here, we provide recommendations for follow-up, adherence to therapy intervals, possible therapy pauses, or discontinuation of therapy when mepolizumab is used as add-on therapy with intranasal glucocorticosteroids to treat adult patients with severe CRSwNP that cannot be adequately controlled with systemic glucocorticosteroids and/or surgical intervention.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02460E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [No title information]

    Klimek, Ludger / Förster-Ruhrmann, Ulrike / Beule, Achim G / Chaker, Adam M / Hagemann, Jan / Klimek, Felix / Casper, Ingrid / Huppertz, Tilman / Hoffmann, Thomas K / Dazert, Stefan / Deitmer, Thomas / Olze, Heidi / Strieth, Sebastian / Wrede, Holger / W Schlenter, Wolfgang / Welkoborsky, Hans-Jürgen / Wollenberg, Barbara / Bergmann, Christoph / Cuevas, Mandy /
    Beutner, Caroline / Gröger, Moritz / Becker, Sven

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2022  Volume 31, Issue 6, Page(s) 24–39

    Title translation Dokumentation von Biologika-Therapien bei chronischer Rhinosinusitis mit Polyposis nasi (CRSwNP): Dupilumab, Omalizumab und Mepolizumab: Empfehlungen des Ärzteverbandes Deutscher Allergologen (AeDA) und der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC).
    Language German
    Publishing date 2022-09-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-022-5080-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Thesis: Herstellung und Charakterisierung Mycobacterium tuberculosis-Komplex spezifischer monoklonaler Antikörper

    Wrede, Holger

    1997  

    Author's details vorgelegt von Holger Wrede
    Language German
    Size II, 66 S, Ill., graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Würzburg, 1998
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  7. Article: White paper on peanut allergy - part 1: Epidemiology, burden of disease, health economic aspects.

    Lange, Lars / Klimek, Ludger / Beyer, Kirsten / Blümchen, Katharina / Novak, Natalija / Hamelmann, Eckard / Bauer, Andrea / Merk, Hans / Rabe, Uta / Jung, Kirsten / Schlenter, Wolfgang / Ring, Johannes / Chaker, Adam / Wehrmann, Wolfgang / Becker, Sven / Mülleneisen, Norbert / Nemat, Katja / Czech, Wolfgang / Wrede, Holger /
    Brehler, Randolf / Fuchs, Thomas / Jakob, Thilo / Ankermann, Tobias / Schmidt, Sebastian M / Gerstlauer, Michael / Zuberbier, Torsten / Spindler, Thomas / Vogelberg, Christian

    Allergo journal international

    2021  Volume 30, Issue 8, Page(s) 261–269

    Abstract: Peanuts are Leguminosae, commonly known as the legume or pea family, and peanut allergy is among the most common food allergies and the most common cause of fatal food reactions and anaphylaxis. The prevalence of peanut allergy increased 3.5-fold over ... ...

    Abstract Peanuts are Leguminosae, commonly known as the legume or pea family, and peanut allergy is among the most common food allergies and the most common cause of fatal food reactions and anaphylaxis. The prevalence of peanut allergy increased 3.5-fold over the past two decades reaching 1.4-2% in Europe and the United States. The reasons for this increase in prevalence are likely multifaceted. Sensitization via the skin appears to be associated with the development of peanut allergy and atopic eczema in infancy is associated with a high risk of developing peanut allergy. Until recently, the only possible management strategy for peanut allergy was strict allergen avoidance and emergency treatment including adrenaline auto-injector in cases of accidental exposure and reaction. This paper discusses the various factors that impact the risks of peanut allergy and the burden of self-management on peanut-allergic children and their caregivers.
    Language English
    Publishing date 2021-09-28
    Publishing country Germany
    Document type Journal Article
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-021-00189-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [No title information]

    Klimek, Ludger / Worm, Margitta / Lange, Lars / Beyer, Kirsten / Rietschel, Ernst / Vogelberg, Christian / Schnadt, Sabine / Stöcker, Britta / Brockow, Knut / Hagemann, Jan / Bieber, Thomas / Wehrmann, Wolfgang / Becker, Sven / Freudelsperger, Laura / Mülleneisen, Norbert K / Nemat, Katja / Czech, Wolfgang / Wrede, Holger / Brehler, Randolf /
    Fuchs, Thomas / Dramburg, Stephanie / Matricardi, Paolo / Hamelmann, Eckard / Werfel, Thomas / Wagenmann, Martin / Taube, Christian / Zuberbier, Torsten / Ring, Johannes

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2020  Volume 29, Issue 7, Page(s) 16–26

    Title translation Management von Anaphylaxie-gefährdeten Patienten während der Covid-19-Pandemie: Ein Positionspapier des Ärzteverbandes Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C und des Deutschen Allergie- und Asthmabundes (DAAB)D.
    Keywords covid19
    Language German
    Publishing date 2020-11-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-020-2618-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA: Position statement of the German Allergy Societies: Medical Association of German Allergologists (AeDA), German Society for Allergology and Clinical Immunology (DGAKI) and Society for Pediatric Allergology and Environmental Medicine (GPA).

    Klimek, Ludger / Novak, Natalija / Hamelmann, Eckard / Werfel, Thomas / Wagenmann, Martin / Taube, Christian / Bauer, Andrea / Merk, Hans / Rabe, Uta / Jung, Kirsten / Schlenter, Wolfgang / Ring, Johannes / Chaker, Adam / Wehrmann, Wolfgang / Becker, Sven / Mülleneisen, Norbert / Nemat, Katja / Czech, Wolfgang / Wrede, Holger /
    Brehler, Randolf / Fuchs, Thomas / Jakob, Thilo / Ankermann, Tobias / Schmidt, Sebastian M / Gerstlauer, Michael / Vogelberg, Christian / Zuberbier, Thomas / Hartmann, Karin / Worm, Margitta

    Allergo journal international

    2021  Volume 30, Issue 2, Page(s) 51–55

    Abstract: Two employees of the National Health Service (NHS) in England developed severe allergic reactions following administration of BNT162b2 vaccine against COVID-19 (coronavirus disease 2019). The British SmPC for the BNT162b2 vaccine already includes ... ...

    Abstract Two employees of the National Health Service (NHS) in England developed severe allergic reactions following administration of BNT162b2 vaccine against COVID-19 (coronavirus disease 2019). The British SmPC for the BNT162b2 vaccine already includes reference to a contraindication for use in individuals who have had an allergic reaction to the vaccine or any of its components. As a precautionary measure, the Medicines and Healthcare products Regulatory Agency (MHRA) has issued interim guidance to the NHS not to vaccinate in principle in "patients with severe allergies". Allergic reactions to vaccines are very rare, but vaccine components are known to cause allergic reactions. BNT162b2 is a vaccine based on an mRNA embedded in lipid nanoparticles and blended with other substances to enable its transport into the cells. In the pivotal phase III clinical trial, the BNT162b2 vaccine was generally well tolerated, but this large clinical trial, used to support vaccine approval by the MHRA and US Food and Drug Administration, excluded individuals with a "history of a severe adverse reaction related to the vaccine and/or a severe allergic reaction (e.g., anaphylaxis) to a component of the study medication". Vaccines are recognized as one of the most effective public health interventions. This repeated administration of a foreign protein (antigen) necessitates a careful allergological history before each application and diagnostic clarification and a risk-benefit assessment before each injection. Severe allergic reactions to vaccines are rare but can be life-threatening, and it is prudent to raise awareness of this hazard among vaccination teams and to take adequate precautions while more experience is gained with this new vaccine.
    Language English
    Publishing date 2021-02-24
    Publishing country Germany
    Document type Journal Article
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-020-00160-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [No title information]

    Klimek, Ludger / Novak, Natalija / Hamelmann, Eckard / Werfel, Thomas / Wagenmann, Martin / Taube, Christian / Bauer, Andrea / Merk, Hans F / Rabe, Uta / Jung, Kirsten / Schlenter, Wolfgang W / Ring, Johannes / Chaker, Adam M / Wehrmann, Wolfgang / Becker, Sven / Mülleneisen, Norbert K / Nemat, Katja / Czech, Wolfgang / Wrede, Holger /
    Brehler, Randolf / Fuchs, Thomas / Jakob, Thilo / Ankermann, Tobias / Schmidt, Sebastian M / Gerstlauer, Michael / Vogelberg, Christian / Zuberbier, Torsten / Hartmann, Karin / Worm, Margitta

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2021  Volume 30, Issue 2, Page(s) 24–29

    Title translation Schwere allergische Reaktionen nach COVID-19-Impfung mit dem Impfstoff von Pfizer/BioNTech in Großbritannien und USA: Stellungnahme der deutschen allergologischen Gesellschaften AeDA (Ärzteverband Deutscher Allergologen), DGAKI (Deutsche Gesellschaft für Allergologie und klinische Immunologie) und GPA (Gesellschaft für Pädiatrische Allergologie und Umweltmedizin).
    Language German
    Publishing date 2021-03-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-021-4762-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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