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  1. Book ; Online: Neuroimaging Approaches to the Study of Cognitive Aging

    Cohen, Ronald / Wright, Clinton B. / Woods, Adam J. / Alexander, Gene E. / Visscher, Kristina

    2020  

    Keywords Science: general issues ; Neurosciences ; cognitive aging ; neuroimaging modalities ; age-related brain changes
    Size 1 electronic resource (192 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230170
    ISBN 9782889639014 ; 2889639010
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Rethinking Blood Pressure Treatment and Dementia Risk in Older Adults: Is Adherence the Holy Grail?

    Wright, Clinton B / Egle, Marco

    Journal of the American College of Cardiology

    2024  Volume 83, Issue 13, Page(s) 1204–1206

    MeSH term(s) Humans ; Aged ; Blood Pressure ; Hypertension/drug therapy ; Hypertension/epidemiology ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Dementia/epidemiology ; Cognitive Dysfunction
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2024.02.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Should Hypertension Be Treated in Late Life to Preserve Cognitive Function? Pro Side of the Argument.

    Wright, Clinton B

    Hypertension (Dallas, Tex. : 1979)

    2018  Volume 71, Issue 5, Page(s) 781–786

    MeSH term(s) Aged ; Aged, 80 and over ; Antihypertensive Agents/therapeutic use ; Cognition/drug effects ; Cognition Disorders/prevention & control ; Drug Therapy, Combination ; Female ; Geriatric Assessment/methods ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Male ; Prognosis ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2018-04-11
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.117.09335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Response to Should hypertension be treated in late-life to preserve cognitive function?: Con.

    Wright, Clinton B

    Hypertension (Dallas, Tex. : 1979)

    2018  Volume 71, Issue 5, Page(s) 792

    MeSH term(s) Blood Pressure ; Cognition ; Humans ; Hypertension
    Language English
    Publishing date 2018-06-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
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  5. Article ; Online: Show Me Your White Matter, I Will Tell You Who You Are ….

    Kuchcinski, Gregory / Wright, Clinton B

    Stroke

    2021  Volume 52, Issue 2, Page(s) 631–633

    MeSH term(s) Humans ; White Matter/diagnostic imaging
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.033225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Organizational Update: The NINDS Reperfusion Research Pipeline.

    Wright, Clinton B / Bosetti, Francesca / Koenig, James I / Janis, L Scott

    Stroke

    2023  Volume 54, Issue 8, Page(s) e393–e394

    MeSH term(s) United States ; Humans ; National Institute of Neurological Disorders and Stroke (U.S.) ; Stroke ; Tissue Plasminogen Activator ; Reperfusion
    Chemical Substances Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type News
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.123.043610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Global changes in diffusion tensor imaging during acute ischemic stroke and post-stroke cognitive performance.

    Kern, Kyle C / Wright, Clinton B / Leigh, Richard

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2022  Volume 42, Issue 10, Page(s) 1854–1866

    Abstract: Post-stroke cognitive impairment is related to the effects of the acute stroke and pre-stroke brain health. We tested whether diffusion tensor imaging (DTI) can detect acute, global effects of stroke and predict post-stroke cognitive performance. ... ...

    Abstract Post-stroke cognitive impairment is related to the effects of the acute stroke and pre-stroke brain health. We tested whether diffusion tensor imaging (DTI) can detect acute, global effects of stroke and predict post-stroke cognitive performance. Patients with stroke or TIA enrolled in a prospective cohort study were included if they had 1) at least one DTI acquisition at acute presentation, 24 hours, 5 days, or 30 days, and 2) follow-up testing with the telephone Montreal Cognitive Assessment (T-MoCA) at 30 and/or 90 days. A whole brain, white-matter skeleton excluding the infarct was used to derive mean global DTI measures for mean diffusivity (MD), fractional anisotropy (FA), free water (FW), FW-corrected MD (MD
    MeSH term(s) Cognition ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/etiology ; Diffusion Tensor Imaging/methods ; Humans ; Ischemic Attack, Transient/complications ; Ischemic Stroke ; Prospective Studies ; Stroke/complications ; Stroke/diagnostic imaging ; Water ; White Matter
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X221101644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Diffusion tensor free water MRI predicts progression of FLAIR white matter hyperintensities after ischemic stroke.

    Kern, Kyle C / Zagzoug, Marwah S / Gottesman, Rebecca F / Wright, Clinton B / Leigh, Richard

    Frontiers in neurology

    2023  Volume 14, Page(s) 1172031

    Abstract: Background: The progression of FLAIR white matter hyperintensities (WMHs) on MRI heralds vascular-mediated cognitive decline. Even before FLAIR WMH progression, adjacent normal appearing white matter (NAWM) already demonstrates microstructural ... ...

    Abstract Background: The progression of FLAIR white matter hyperintensities (WMHs) on MRI heralds vascular-mediated cognitive decline. Even before FLAIR WMH progression, adjacent normal appearing white matter (NAWM) already demonstrates microstructural deterioration on diffusion tensor imaging (DTI). We hypothesized that elevated DTI free water (FW) would precede FLAIR WMH progression, implicating interstitial fluid accumulation as a key pathological step in the progression of cerebral small vessel disease.
    Methods: Participants at least 3 months after an ischemic stroke or TIA with WMH on MRI underwent serial brain MRIs every 3 months over the subsequent year. For each participant, the WMHs were automatically segmented, serial MRIs were aligned, and a region of WMH penumbra tissue at risk was defined by dilating lesions at any time point and subtracting baseline lesions. Penumbra voxels were classified as either stable or progressing to WMH if they were segmented as new lesions and demonstrated increasing FLAIR intensity over time. Aligned DTI images included FW and FW-corrected fractional anisotropy (FA
    Results: In the included participants (
    Discussion: Baseline increased interstitial fluid, estimated as FW on DTI, predicted the progression of NAWM to WMH over the following year. These results implicate the presence of FW in the pathogenesis of cerebral small vessel disease progression.
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1172031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Intensive systolic blood pressure treatment remodels brain perivascular spaces: A secondary analysis of the Systolic Pressure Intervention Trial (SPRINT).

    Kern, Kyle C / Nasrallah, Ilya M / Bryan, Robert Nick / Reboussin, David M / Wright, Clinton B

    NeuroImage. Clinical

    2023  Volume 40, Page(s) 103513

    Abstract: Background: Brain perivascular spaces (PVS) are part of the glymphatic system and facilitate clearance of metabolic byproducts. Since enlarged PVS are associated with vascular health, we tested whether intensive systolic blood pressure (SBP) treatment ... ...

    Abstract Background: Brain perivascular spaces (PVS) are part of the glymphatic system and facilitate clearance of metabolic byproducts. Since enlarged PVS are associated with vascular health, we tested whether intensive systolic blood pressure (SBP) treatment affects PVS structure.
    Methods: This is a secondary analysis of the Systolic PRessure INtervention Trial (SPRINT) MRI Substudy: a randomized trial of intensive SBP treatment to goal < 120 mm Hg vs < 140 mm Hg. Participants had increased cardiovascular risk, pre-treatment SBP 130-180, and no clinical stroke, dementia, or diabetes. Brain MRIs acquired at baseline and follow-up were used to automatically segment PVS in the supratentorial white matter and basal ganglia using a Frangi filtering method. PVS volumes were quantified as a fraction of the total tissue volume. The effects of SBP treatment group and major antihypertensive classes on PVS volume fraction were separately tested using linear mixed-effects models while covarying for MRI site, age, sex, Black race, baseline SBP, history of cardiovascular disease (CVD), chronic kidney disease, and white matter hyperintensities (WMH).
    Results: For 610 participants with sufficient quality MRI at baseline (mean age 67 ± 8, 40 % female, 32 % Black), greater PVS volume fraction was associated with older age, male sex, non-Black race, concurrent CVD, WMH, and brain atrophy. For 381 participants with MRI at baseline and at follow-up (median ± IQR = 3.9 ± 0.4 years), intensive treatment was associated with decreased PVS volume fraction relative to standard treatment (interaction coefficient: -0.029 [-0.055 to -0.0029] p = 0.029). Reduced PVS volume fraction was also associated with exposure to calcium channel blockers (CCB).
    Conclusions: PVS enlargement was partially reversed in the intensive SBP treatment group. The association with CCB use suggests that improved vascular compliance may be partly responsible. Improved vascular health may facilitate glymphatic clearance. Clincaltrials.gov: NCT01206062.
    MeSH term(s) Female ; Humans ; Male ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Blood Pressure/physiology ; Cardiovascular Diseases ; Glymphatic System/diagnostic imaging ; Hypertension/complications ; Middle Aged ; Aged ; Randomized Controlled Trials as Topic
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-09-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2023.103513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Herpes simplex virus 2 serology is associated with thinner whole-brain cortex in community-dwelling older adults.

    Roberts, Jackson A / Elkind, Mitchell S V / Liu, Minghua / Wright, Clinton B / Rundek, Tatjana / Gutierrez, Jose

    Journal of the neurological sciences

    2023  Volume 454, Page(s) 120856

    Abstract: Prior work in the Northern Manhattan Study (NOMAS) identified impaired cognition in cross-sectional analyses and more rapid memory decline in individuals with evidence of prior common infectious disease exposures. In this study, we sought to determine ... ...

    Abstract Prior work in the Northern Manhattan Study (NOMAS) identified impaired cognition in cross-sectional analyses and more rapid memory decline in individuals with evidence of prior common infectious disease exposures. In this study, we sought to determine the cross-sectional relationship between prior exposure to cytomegalovirus, herpes simplex viruses 1 and 2, Chlamydia pneumoniae, and Helicobacter pylori and three magnetic resonance imaging (MRI) signatures (whole-brain cortical thickness, a previously validated AD signature, and hippocampal volume) in 455 NOMAS participants. We performed confounder-adjusted linear regression analyses between neuroimaging scores and both continuous serologies and categorical seropositivity of each pathogen, as well as a combined infectious burden index (IBI). We identified that increased serologic titers of herpes simplex virus 2 were associated with reduced whole-brain cortical thickness, and a combined score of HSV-2 and C. pneumoniae displayed an additive effect on reduced cortical thickness. Our findings suggest herpes simplex virus 2 seropositivity may contribute to accelerated brain aging, possibly resulting in an increased vulnerability to cognitive impairment and neurodegenerative disease in aging populations.
    MeSH term(s) Humans ; Aged ; Herpesvirus 2, Human ; Neurodegenerative Diseases/complications ; Independent Living ; Noma/complications ; Brain ; Herpes Simplex/complications ; Herpes Simplex/diagnostic imaging ; Alzheimer Disease/complications
    Language English
    Publishing date 2023-10-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2023.120856
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