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Book ; Online ; E-Book: Understanding the HIV/AIDS epidemic in the United States

Wright, Eric R. / Carnes, Neal

the role of syndemics in the production of health disparities

(Social disparities in health and health care)

2016

Author's details	Eric R. Wright, Neal Carnes editors
Series title	Social disparities in health and health care
Keywords	Social sciences ; Infectious diseases ; Medical research ; Sociology ; Quality of life
Subject code	301
Language	English
Size	1 Online-Ressource (x, 303 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019471301
ISBN	978-3-319-34004-3 ; 9783319340029 ; 3-319-34004-2 ; 3319340026
DOI	10.1007/978-3-319-34004-3
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: A handbook for the study of mental health

Scheid, Teresa L. / Wright, Eric R.

social contexts, theories, and systems

2017

Author's details	[edited by] Teresa L. Scheid, Eric R. Wright
Keywords	Community Mental Health Services / methods ; Sociological Factors ; Health Policy ; Mental Health ; Community Psychiatry
Language	English
Size	xxv, 798 Seiten, Illustrationen, Diagramme
Edition	Third edition
Publisher	Cambridge University Press
Publishing place	Cambridge
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT019499196
ISBN	978-1-107-13487-4 ; 978-1-316-50096-5 ; 9781108184618 ; 1-107-13487-0 ; 1-316-50096-9 ; 1108184618
Database	Catalogue ZB MED Medicine, Health

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Article: Automated Test for Monthly Quality Assurance of Optical Surface Imaging Dynamic Localization Accuracy.

Young, Kaleigh / Wright, Eric A

Cureus

2024 Volume 16, Issue 3, Page(s) e56242

Abstract: The American Association of Physicists in Medicine (AAPM) recently published the report of Task Group (TG) 302, which provides recommendations on acceptance, commissioning, and ongoing routine quality assurance (QA) for surface-guided radiation therapy ( ... ...

Abstract	The American Association of Physicists in Medicine (AAPM) recently published the report of Task Group (TG) 302, which provides recommendations on acceptance, commissioning, and ongoing routine quality assurance (QA) for surface-guided radiation therapy (SGRT) systems. One of the recommended monthly QA tests is a dynamic localization accuracy test. This work aimed to develop an automated procedure for monthly SGRT dynamic localization QA. An anthropomorphic head phantom was rigidly attached to the 6-dof couch of a TrueBeam linac. TrueBeam Developer Mode was used to take an MV image of the phantom at the starting position, then automatically drive the couch through a series of translations and rotations, taking an MV image after each translation. The Identify SGRT system monitored the motion of the phantom surface from the starting position. Translations assessed on MV images were compared to translations reported in trajectory log files and Identify log files. Rotations were compared between trajectory log files and Identify log files. Three experiments were conducted. None of the translations or rotations from any experiment exceeded the tolerance values for stereotactic ablative body radiation therapy (SABR) recommended by AAPM TG-142. Maximum deviations from the expected translation values from MV imaging, trajectory log files, and Identify log files were -0.94mm, -0.11mm, and -0.78mm, respectively. Maximum deviations from the expected rotation values from trajectory log files and Identify log files were 0.01 and -0.2 degrees, respectively. The proposed method is a simple automated way to complete monthly dynamic localization QA of SGRT systems.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56242
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Article: Therapeutic targeting of p90 ribosomal S6 kinase.

Wright, Eric B / Lannigan, Deborah A

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1297292

Abstract: The Serine/Threonine protein kinase family, p90 ribosomal S6 kinases (RSK) are downstream effectors of extracellular signal regulated kinase 1/2 (ERK1/2) and are activated in response to tyrosine kinase receptor or G-protein coupled receptor signaling. ... ...

Abstract	The Serine/Threonine protein kinase family, p90 ribosomal S6 kinases (RSK) are downstream effectors of extracellular signal regulated kinase 1/2 (ERK1/2) and are activated in response to tyrosine kinase receptor or G-protein coupled receptor signaling. RSK contains two distinct kinase domains, an N-terminal kinase (NTKD) and a C-terminal kinase (CTKD). The sole function of the CTKD is to aid in the activation of the NTKD, which is responsible for substrate phosphorylation. RSK regulates various homeostatic processes including those involved in transcription, translation and ribosome biogenesis, proliferation and survival, cytoskeleton, nutrient sensing, excitation and inflammation. RSK also acts as a major negative regulator of ERK1/2 signaling. RSK is associated with numerous cancers and has been primarily studied in the context of transformation and metastasis. The development of specific RSK inhibitors as cancer therapeutics has lagged behind that of other members of the mitogen-activated protein kinase signaling pathway. Importantly, a pan-RSK inhibitor, PMD-026, is currently in phase I/1b clinical trials for metastatic breast cancer. However, there are four members of the RSK family, which have overlapping and distinct functions that can vary in a tissue specific manner. Thus, a problem for transitioning a RSK inhibitor to the clinic may be the necessity to develop isoform specific inhibitors, which will be challenging as the NTKDs are very similar to each other. CTKD inhibitors have limited use as therapeutics as they are not able to inhibit the activity of the NTKD but could be used in the development of proteolysis-targeting chimeras.
Language	English
Publishing date	2023-12-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1297292
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Article ; Online: Pharmacogenomics implementation and multidisciplinary genomics collaboration: Real-world experience from Geisinger.

Uber, Ryley / Wright, Eric

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

2022 Volume 79, Issue 13, Page(s) 1038–1041

MeSH term(s)	Genomics ; Humans ; Pharmacogenetics ; Precision Medicine
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1224627-x
ISSN	1535-2900 ; 1079-2082
ISSN (online)	1535-2900
ISSN	1079-2082
DOI	10.1093/ajhp/zxac065
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Article ; Online: ERK1/2-RSK regulation of oestrogen homeostasis.

Wright, Eric B / Lannigan, Deborah A

The FEBS journal

2022 Volume 290, Issue 8, Page(s) 1943–1953

Abstract: The molecular mechanisms regulating oestrogen homeostasis have been primarily studied in the mammary gland, which is the focus of this review. In the non-pregnant adult, the mammary gland undergoes repeated cycles of proliferation and apoptosis in ... ...

Abstract	The molecular mechanisms regulating oestrogen homeostasis have been primarily studied in the mammary gland, which is the focus of this review. In the non-pregnant adult, the mammary gland undergoes repeated cycles of proliferation and apoptosis in response to the fluctuating levels of oestrogen that occur during the reproductive stage. Oestrogen actions are mediated through the steroid hormone receptors, oestrogen receptor α and β and through a G-protein coupled receptor. In the mammary gland, ERα is of particular importance and thus will be highlighted. Mechanisms regulating oestrogen-induced responses through ERα are necessary to maintain homeostasis given that the signalling pathways that are activated in response to ERα-mediated transcription can also induce transformation. ERK1/2 and its downstream effector, p90 ribosomal S6 kinase (RSK), control homeostasis in the mammary gland by limiting oestrogen-mediated ERα responsiveness. ERK1/2 drives degradation coupled ERα-mediated transcription, whereas RSK2 acts as a negative regulator of ERK1/2 activity to limit oestrogen responsiveness. Moreover, RSK2 acts as a positive regulator of translation. Thus, RSK2 provides both positive and negative signals to maintain oestrogen responsiveness. In addition to transmitting signals through tyrosine kinase receptors, ERK1/2-RSK engages with hedgehog signalling to maintain oestrogen levels and with the HIPPO pathway to regulate ERα-mediated transcription. Additionally, ERK1/2-RSK controls the progenitor populations within the mammary gland to maintain the ERα-positive population. RSK2 is involved in increased breast cancer risk in individuals taking oral contraceptives and in parity-induced protection against breast cancer. RSK2 and ERα may also co-operate in diseases in tissues outside of the mammary gland.
MeSH term(s)	Female ; Humans ; Pregnancy ; Breast Neoplasms/metabolism ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Estrogens ; Hedgehog Proteins/metabolism ; MAP Kinase Signaling System ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism
Chemical Substances	Estrogen Receptor alpha ; Estrogens ; Hedgehog Proteins ; Receptors, Estrogen ; ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC 2.7.11.1)
Language	English
Publishing date	2022-02-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16407
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Article ; Online: Impact of cost on prescribing diabetes medications for older adults with type 2 diabetes in the outpatient setting.

Lussier, Mia E / Desai, Ravi J / Wright, Eric A / Gionfriddo, Michael R

Research in social & administrative pharmacy : RSAP

2024

Abstract: Background: Newer diabetes medications have cardiorenal benefits beyond blood sugar lowering that make them a preferred treatment option in many patients. Despite this, studies have shown that prescribing of these medications remains suboptimal with ... ...

Abstract	Background: Newer diabetes medications have cardiorenal benefits beyond blood sugar lowering that make them a preferred treatment option in many patients. Despite this, studies have shown that prescribing of these medications remains suboptimal with medication costs being hypothesized as a reason for underutilization. Objective: To understand clinicians' decision-making processes for prescribing diabetes medications in older adults, focusing on higher cost medications. Methods: Observations of patient encounters and semi-structured interviews were conducted with clinicians from primary care, endocrinology, and geriatrics to elucidate themes into diabetes medication prescribing. A qualitative descriptive approach was used to analyze the data from interviews using an inductive coding scheme with themes derived from the data. Results: Twenty-one interviews were conducted. Five themes were identified: 1) out-of-pocket costs drive prescribing decisions 2) out-of-pocket costs can be variable due to changing insurance plans or changing coverage 3) clinicians have difficulty with determining patient-specific out-of-pocket costs 4) clinicians manage the tradeoffs existing between cost, efficacy, and safety and 5) clinicians can use cost-modifying strategies such as patient assistance. Conclusion: Addressing the challenges that medication costs pose to prescribing evidence-based medications for type 2 diabetes is necessary to optimize diabetes care for older adults.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2192059-X
ISSN	1934-8150 ; 1551-7411
ISSN (online)	1934-8150
ISSN	1551-7411
DOI	10.1016/j.sapharm.2024.04.013
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Article ; Online: ERK1/2‐RSK regulation of oestrogen homeostasis

Wright, Eric B. / Lannigan, Deborah A.

The FEBS Journal. 2023 Apr., v. 290, no. 8, p. 1943-1953

2023 , Page(s) 1943–1953

Abstract: The molecular mechanisms regulating oestrogen homeostasis have been primarily studied in the mammary gland, which is the focus of this review. In the non‐pregnant adult, the mammary gland undergoes repeated cycles of proliferation and apoptosis in ... ...

Abstract	The molecular mechanisms regulating oestrogen homeostasis have been primarily studied in the mammary gland, which is the focus of this review. In the non‐pregnant adult, the mammary gland undergoes repeated cycles of proliferation and apoptosis in response to the fluctuating levels of oestrogen that occur during the reproductive stage. Oestrogen actions are mediated through the steroid hormone receptors, oestrogen receptor α and β and through a G‐protein coupled receptor. In the mammary gland, ERα is of particular importance and thus will be highlighted. Mechanisms regulating oestrogen‐induced responses through ERα are necessary to maintain homeostasis given that the signalling pathways that are activated in response to ERα‐mediated transcription can also induce transformation. ERK1/2 and its downstream effector, p90 ribosomal S6 kinase (RSK), control homeostasis in the mammary gland by limiting oestrogen‐mediated ERα responsiveness. ERK1/2 drives degradation coupled ERα‐mediated transcription, whereas RSK2 acts as a negative regulator of ERK1/2 activity to limit oestrogen responsiveness. Moreover, RSK2 acts as a positive regulator of translation. Thus, RSK2 provides both positive and negative signals to maintain oestrogen responsiveness. In addition to transmitting signals through tyrosine kinase receptors, ERK1/2‐RSK engages with hedgehog signalling to maintain oestrogen levels and with the HIPPO pathway to regulate ERα‐mediated transcription. Additionally, ERK1/2‐RSK controls the progenitor populations within the mammary gland to maintain the ERα‐positive population. RSK2 is involved in increased breast cancer risk in individuals taking oral contraceptives and in parity‐induced protection against breast cancer. RSK2 and ERα may also co‐operate in diseases in tissues outside of the mammary gland.
Keywords	Erinaceidae ; G-protein coupled receptors ; adults ; apoptosis ; breast neoplasms ; estrogen receptors ; estrogens ; homeostasis ; mammary glands ; non-specific serine/threonine protein kinase ; risk ; steroid hormones ; tyrosine
Language	English
Dates of publication	2023-04
Size	p. 1943-1953
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	REVIEW
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16407
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Factors Affecting Prescribing of Type 2 Diabetes Medications in Older Adults within an Integrated Healthcare System.

Lussier, Mia E / Gionfriddo, Michael R / Graham, Jove H / Wright, Eric A

Journal of general internal medicine

2023 Volume 39, Issue 2, Page(s) 195–200

Abstract: Background: Despite type 2 diabetes guidelines recommending against the use of sulfonylureas in older adults and for the use of sodium-glucose cotransporter-2 inhibitors (SGLT2) and glucagon-like peptide-1 agonists (GLP1s) in patients with ... ...

Abstract	Background: Despite type 2 diabetes guidelines recommending against the use of sulfonylureas in older adults and for the use of sodium-glucose cotransporter-2 inhibitors (SGLT2) and glucagon-like peptide-1 agonists (GLP1s) in patients with atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), and heart failure (HF), real-world guideline-concordant prescribing remains low. While some factors such as cost have been suggested, an in-depth analysis of the factors associated with guideline-concordant prescribing is warranted. Objective: To quantify the extent of guideline-concordant prescribing in an integrated health care delivery system and examine provider and patient level factors that influence guideline-concordant prescribing. Design: We performed a cross-sectional study. Participants: Participants were included if they had a diagnosis of type 2 diabetes, were prescribed a second-line diabetes medication between January 1, 2018 and December 31, 2020 and were at least 65 years old at the time of this second-line prescription. Main measures: Our outcome of interest was guideline-concordant prescribing. The definition of guideline-concordant prescribing was based on American Diabetes Association and American Geriatric Society recommendations as well as expert consensus. Factors affecting guideline concordant prescribing included patient demographics and provider characteristics among others. Key results: We included 1,693 patients of which only 50% were prescribed guideline-concordant medications. In a subgroup of 843 patients with cardiorenal conditions, only 30% of prescriptions were guideline concordant. Prescribing of guideline-concordant prescriptions was more likely among pharmacists than physicians (RR 1.34, 95% CI 1.19-1.51, p<0.001) and in endocrinology practices compared to primary care practices (RR 1.41 95% CI 1.16-1.72, p=0.007). Additionally, guideline concordant prescribing increased over time (42% in 2018 vs 53% in 2019 vs 53% in 2020, p<0.001). Conclusions: Guideline-concordant prescribing remains low in older adults, especially among those with cardiorenal conditions. Future studies should examine barriers to prescribing guideline-concordant medications and interventions to improve guideline-concordant prescribing.
MeSH term(s)	Humans ; Aged ; Diabetes Mellitus, Type 2/drug therapy ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Cross-Sectional Studies ; Sulfonylurea Compounds/therapeutic use ; Delivery of Health Care, Integrated ; Hypoglycemic Agents/therapeutic use
Chemical Substances	Sodium-Glucose Transporter 2 Inhibitors ; Sulfonylurea Compounds ; Hypoglycemic Agents
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-023-08435-6
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Article ; Online: Guideline-concordant prescribing or medication adherence: A Medicare Part D predicament.

Lussier, Mia E / Pradhan, Apoorva M / Wright, Eric A

Journal of the American Geriatrics Society

2022 Volume 70, Issue 7, Page(s) 2176–2179

MeSH term(s)	Aged ; Humans ; Medicare Part D ; Medication Adherence ; United States
Language	English
Publishing date	2022-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.17775
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