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Article ; Online: Is winning the only thing? - Examining the "win ratio" concept in synchronous colorectal liver metastasis.

Wright, G Paul

2023 Volume 225, Issue 3, Page(s) 460

MeSH term(s)	Humans ; Liver Neoplasms/surgery ; Colorectal Neoplasms/surgery ; Hepatectomy ; Retrospective Studies
Language	English
Publishing date	2023-01-28
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2023.01.019
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Article ; Online: Organisational Change: Using Health Informatics Education as a Change Agent.

Wright, Graham

Studies in health technology and informatics

2022 Volume 300, Page(s) 64–76

Abstract: This paper highlights some of the challenges, achievements and collaborations using health informatics education and research as a change agent in which I have been involved over the last 40 years. The Open Software Library (OSL) was a specialist ... ...

Abstract	This paper highlights some of the challenges, achievements and collaborations using health informatics education and research as a change agent in which I have been involved over the last 40 years. The Open Software Library (OSL) was a specialist publisher of Computer-Based Training materials (CBT) mainly authored by nurses and medics. The "Rainbow" series of distance learning materials, "Using Information in Managing the Nursing Resource" sold over 55,000 copies. It was utilized as the basis for seven Universities' Certificate and Diploma programmes and in-house training by the NHS to encourage organisational change. Workshops at Manchester University's HSMU focusing on evaluation studies highlighted that most NHS IT projects failed because of human and organisational issues rather than IT. This led to the development of a master's degree in Health Informatics shared between four European Universities. IMIA conferences, Working Groups and the development of the IMIA approved Education Recommendations and the IMIA Knowledge Base are effectively used worldwide.
MeSH term(s)	Humans ; Medical Informatics/education ; Curriculum ; Education, Distance ; Universities ; Organizational Innovation
Language	English
Publishing date	2022-10-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI220942
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Article: First Report of

Hu, Jiahuai / Wright, Glenn

Plant disease

2024

Abstract: Phoenix dactylifera L. is an economically and aesthetically important tree in the southwestern US. Approximately 4900 ha of dates are commercially grown for its edible fruit in the US, including about 1600 ha in the Yuma area and the Hyder Valley of ... ...

Abstract	Phoenix dactylifera L. is an economically and aesthetically important tree in the southwestern US. Approximately 4900 ha of dates are commercially grown for its edible fruit in the US, including about 1600 ha in the Yuma area and the Hyder Valley of Arizona (USDA, 2023). In October 2022, a severe rot was observed on three date palms in the Phoenix Metropolitan area. Early symptoms were brown spots that turned to a black scorch appearance extending along the leaf base and rachis, leading to the lower fronds' wilting, drying, and folding. As the disease progressed upwards, the terminal bud became necrotic and eventually collapsed. Isolation from the necrotic leaf lesions on a potato dextrose agar (PDA) consistently yielded a fast-growing fungus that was initially white with abundant fluffy aerial mycelium, which gradually turned dark olivaceous after growing at 22-25oC under 12 h light for a week. Pycnidial conidiomata formed on pine needles in a water agar were black and globose. Conidiogenous cells were hyaline and cylindrical. The conidia exhibited a thick-walled, ovoid to ellipsoid morphology, initially appearing hyaline and aseptate and transitioned to 1-septate with a dark brown, striated appearance, measuring 19.6 to 23.0 μm x 10.3 to 12.2 µm (n = 20). For molecular identification, genomic DNA was extracted from the mycelia of two isolates. Partial DNA sequences of the internal transcribed spacer (ITS) region of rDNA and β-tubulin (TUB) gene were amplified and sequenced using primers ITS5/ITS4 (White et al. 1990) and Bt2a/Bt2b (Glass and Donaldson 1995). The resulting sequences of ITS (PP346666) and TUB (PP372690) were deposited in the GenBank. A BLASTn search of ITS and TUB sequences revealed a 99 to 100% similarity with the sequences (JX456475, KF766198, and OK338070) of Neodeightonia phoenicum strains causing palm rot in Greece (Ligoxigakis et al. 2013), leaf spot on pygmy date palm in China (Zhang and Song 2022), and an ex-type CBS 122528 culture. Based on these morphological and molecular data, the fungus was identified as N. phoenicum. A pathogenicity test was conducted twice in a greenhouse (daily temperatures:18 ~ 30 oC, relative humidity: 45% ~ 95%) on 4 healthy 1-year-old date palm plants. The petioles of 3 older leaves per plant were wounded by pricking the epidermis of the leaf with a needle (ca 20 pricks per petiole) and inoculated with agar discs from a 4-day-old PDA culture of the fungus. The control consisted of 4 mock-inoculated plants by placing plain PDA on the wounds of leaf petioles. Five weeks after inoculation, all the inoculated leaves showed symptoms of black scorch, petiole rot, and leaf necrosis, which were the same as those symptoms observed on the original diseased trees, while the controls did not show any symptoms. The fungus was re-isolated and confirmed as N. phoenicum by morphology. N. phoenicum has been reported to cause leaf spot, shoots blights, stalk and root rots as well as black scorch on different palm species all over the world. However, to our knowledge, this is the first report of N. phoenicum causing black scorch and rot disease in Arizona. The possible spread of N. phoenicum could have a significant economic impact and requires immediate attention through suitable disease management initiatives.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-02-24-0491-PDN
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Book ; Online: Improved Time Warp Edit Distance -- A Parallel Dynamic Program in Linear Memory

Wright, Garrett

2020

Abstract: Edit Distance is a classic family of dynamic programming problems, among which Time Warp Edit Distance refines the problem with the notion of a metric and temporal elasticity. A novel Improved Time Warp Edit Distance algorithm that is both massively ... ...

Abstract	Edit Distance is a classic family of dynamic programming problems, among which Time Warp Edit Distance refines the problem with the notion of a metric and temporal elasticity. A novel Improved Time Warp Edit Distance algorithm that is both massively parallelizable and requiring only linear storage is presented. This method uses the procession of a three diagonal band to cover the original dynamic program space. Every element of the diagonal update can be computed in parallel. The core method is a feature of the TWED Longest Common Subsequence data dependence and is applicable to dynamic programs that share similar band subproblem structure. The algorithm has been implemented as a CUDA C library with Python bindings. Speedups for challenging problems are phenomenal. Comment: 16 pages
Keywords	Computer Science - Computational Geometry ; Computer Science - Distributed ; Parallel ; and Cluster Computing ; Computer Science - Machine Learning ; Computer Science - Mathematical Software ; Mathematics - Metric Geometry
Subject code	005 ; 000
Publishing date	2020-07-31
Publishing country	us
Document type	Book ; Online
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Article: Association between systemic sclerosis, palmar fasciitis with polyarthritis, Raynaud's phenomenon and erythromelalgia with underlying malignancy.

Nowak, Katarzyna / Wright, Gary

Reumatologia

2022 Volume 60, Issue 4, Page(s) 275–280

Abstract: The symptoms of a rheumatic disease may also be a sign of a proliferative process. These include conditions that present with skin and vascular changes such as systemic sclerosis and Raynaud's phenomenon with peripheral ischaemia and ulceration. ... ...

Abstract	The symptoms of a rheumatic disease may also be a sign of a proliferative process. These include conditions that present with skin and vascular changes such as systemic sclerosis and Raynaud's phenomenon with peripheral ischaemia and ulceration. Furthermore, the less common conditions - erythromelalgia or palmar fasciitis with polyarthritis may also accompany cancer. In this article, we discuss the association of diffuse systemic sclerosis with anorectal tumor, palmar fasciitis and polyarthritis with ovarian cancer, erythromelalgia with underlying ovarian malignancy and Raynaud's phenomenon and digital ischemia associated with renal carcinoma. Based on the literature review on this topic we highlighted the importance of recognizing paraneoplastic syndromes at an early stage. This is a crucial point in the adequate management of a patient. Many of the paraneoplastic symptoms of rheumatic and other described conditions may regress with the management of the underlying malignancy.
Language	English
Publishing date	2022-09-08
Publishing country	Poland
Document type	Case Reports
ZDB-ID	604151-6
ISSN	0034-6233
ISSN	0034-6233
DOI	10.5114/reum.2022.119044
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Article ; Online: Clinical vignette: paraneoplastic diffuse systemic sclerosis.

Nowak, Katarzyna / Wright, Gary

Rheumatology (Oxford, England)

2022 Volume 61, Issue 10, Page(s) e323

MeSH term(s)	Autoantibodies ; Humans ; Paraneoplastic Syndromes/etiology ; Scleroderma, Diffuse ; Scleroderma, Systemic/complications
Chemical Substances	Autoantibodies
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keac106
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Article: The value of mass-produced COVID-19 scenarios: A quality evaluation of development processes and scenario content.

Crawford, Megan M / Wright, George

Technological forecasting and social change

2022 Volume 183, Page(s) 121937

Abstract: Hundreds of scenarios were developed across the world in 2020, aimed at generating forward-looking conversations, better understanding for COVID-19 transmission rates, trialling economic outcomes, and stress-testing existing systems in light of the ... ...

Abstract	Hundreds of scenarios were developed across the world in 2020, aimed at generating forward-looking conversations, better understanding for COVID-19 transmission rates, trialling economic outcomes, and stress-testing existing systems in light of the developing pandemic. In response, Cairns & Wright (2020) questioned the value of these mass-produced scenarios created retroactively to existing crises. We address their concerns by evaluating 213 COVID-19 scenarios developed in the first wave of the pandemic. We use two yardsticks as guiding maps against which we plot each scenario's profile and test for values of high-quality process and content. Our analyses reveal various points of high
Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Journal Article
ISSN	0040-1625
ISSN	0040-1625
DOI	10.1016/j.techfore.2022.121937
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Article ; Online: Contemporary approaches to the axilla in breast cancer.

Thompson, Jessica L / Wright, G Paul

American journal of surgery

2022 Volume 225, Issue 3, Page(s) 583–587

Abstract: Over the past decade, axillary management in breast cancer has fundamentally shifted. The former notion that any degree of axillary nodal involvement warrants axillary lymph node dissection (ALND) has been challenged. Following publication of the ACOSOG ... ...

Abstract	Over the past decade, axillary management in breast cancer has fundamentally shifted. The former notion that any degree of axillary nodal involvement warrants axillary lymph node dissection (ALND) has been challenged. Following publication of the ACOSOG Z0011 trial, national trends demonstrated significant reductions in ALND performance. Axillary radiotherapy in lieu of ALND is a consideration for select patients with a positive sentinel lymph node, while ongoing studies are investigating the role of adjuvant regional radiotherapy in women with positive nodes prior to neoadjuvant chemotherapy. Efforts toward de-escalation of axillary surgery continue to evolve, as do the indications for sentinel node biopsy omission in select subsets of patients. This review highlights the recent advances and neoteric approaches to local therapy of the axilla in breast cancer.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Axilla/pathology ; Lymph Node Excision ; Sentinel Lymph Node Biopsy ; Sentinel Lymph Node/pathology ; Lymph Nodes/pathology
Language	English
Publishing date	2022-12-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2022.11.036
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Article ; Online: Unsupervised classification of multi-contrast magnetic resonance histology of peripheral arterial disease lesions using a convolutional variational autoencoder with a Gaussian mixture model in latent space: A technical feasibility study.

Csore, Judit / Roy, Trisha L / Wright, Graham / Karmonik, Christof

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

2024 Volume 115, Page(s) 102372

Abstract: Purpose: To investigate the feasibility of a deep learning algorithm combining variational autoencoder (VAE) and two-dimensional (2D) convolutional neural networks (CNN) for automatically quantifying hard tissue presence and morphology in multi-contrast ...

Abstract	Purpose: To investigate the feasibility of a deep learning algorithm combining variational autoencoder (VAE) and two-dimensional (2D) convolutional neural networks (CNN) for automatically quantifying hard tissue presence and morphology in multi-contrast magnetic resonance (MR) images of peripheral arterial disease (PAD) occlusive lesions. Methods: Multi-contrast MR images (T2-weighted and ultrashort echo time) were acquired from lesions harvested from six amputated legs with high isotropic spatial resolution (0.078 mm and 0.156 mm, respectively) at 9.4 T. A total of 4014 pseudo-color combined images were generated, with 75% used to train a VAE employing custom 2D CNN layers. A Gaussian mixture model (GMM) was employed to classify the latent space data into four tissue classes: I) concentric calcified (c), II) eccentric calcified (e), III) occluded with hard tissue (h) and IV) occluded with soft tissue (s). Test image probabilities, encoded by the trained VAE were used to evaluate model performance. Results: GMM component classification probabilities ranged from 0.92 to 0.97 for class (c), 1.00 for class (e), 0.82-0.95 for class (h) and 0.56-0.93 for the remaining class (s). Due to the complexity of soft-tissue lesions reflected in the heterogeneity of the pseudo-color images, more GMM components (n=17) were attributed to class (s), compared to the other three (c, e and h) (n=6). Conclusion: Combination of 2D CNN VAE and GMM achieves high classification probabilities for hard tissue-containing lesions. Automatic recognition of these classes may aid therapeutic decision-making and identifying uncrossable lesions prior to endovascular intervention.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	639451-6
ISSN	1879-0771 ; 0895-6111
ISSN (online)	1879-0771
ISSN	0895-6111
DOI	10.1016/j.compmedimag.2024.102372
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Article ; Online: Budget Impact Analysis of Minimally Invasive versus Open Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Disease

Bassani R / Galvain T / Battaglia S / Maheswaran H / Wright G / Kambli A / Piemontese A

ClinicoEconomics and Outcomes Research, Vol Volume 16, Pp 13-

A European Hospital Perspective

2024 Volume 24

Abstract: Roberto Bassani,1 Thibaut Galvain,2 Suzanne Battaglia,3 Hendramoorthy Maheswaran,4 George Wright,5 Ankita Kambli,5 Alessandra Piemontese3 1II Spinal Surgery Unit, IRCCS Galeazzi-Sant’Ambrogio Hospital, Milano, Italy; 2Johnson and Johnson MedTech, Issy- ... ...

Abstract	Roberto Bassani,1 Thibaut Galvain,2 Suzanne Battaglia,3 Hendramoorthy Maheswaran,4 George Wright,5 Ankita Kambli,5 Alessandra Piemontese3 1II Spinal Surgery Unit, IRCCS Galeazzi-Sant’Ambrogio Hospital, Milano, Italy; 2Johnson and Johnson MedTech, Issy-les-Moulineaux, France; 3Johnson and Johnson MedTech, Pomezia, Italy; 4Johnson and Johnson MedTech, London, UK; 5EVERSANA, Burlington, Ontario, CanadaCorrespondence: George Wright, EVERSANA, 113-3228 South Service Road, Burlington, Ontario, L7N 3H8, Canada, Tel +1 513-827-3035, Email george.wright@eversana.comPurpose: When traditional therapies fail to provide relief from debilitating lower back pain, surgeries such as transforaminal lumbar interbody fusion (TLIF) may be required. This budget impact analysis (BIA) compared minimally-invasive (MI)-TLIF versus open (O)-TLIF for single-level fusion from an Italian hospital perspective.Methods: The BIA compared costs of 100 MI-TLIF and 100 O-TLIF procedures from an Italian hospital perspective over a one-year time horizon. The base case included costs for length of hospital stay (LOS), blood loss, and sterilizing surgical trays. The scenario analysis also included operating room (OR) time and complication costs. Base case inputs were from the Miller et al meta-analysis; scenario analysis inputs were from the Hammad et al meta-analysis. The device costs for MI-TLIF and O-TLIF procedures were from Italian tender prices for Viper Prime™ System and Expedium™ Spine System, respectively.Results: Base case deterministic analysis results showed cost savings of € 207,370 for MI-TLIF compared with O-TLIF. MI-TLIF costs were lower for LOS (€ 215,277), transfusion for blood loss (€ 16,881), and surgical tray sterilization (€ 28,232), whereas device costs were lower for O-TLIF (€ 53,020). The probabilistic result was similar, with MI-TLIF resulting in savings of € 211,026 (95% credible interval [CR]: € 208,725 – € 213,327). All 1000 base case probabilistic sensitivity analysis runs were cost saving. Deterministic scenario analysis ...
Keywords	spine surgery ; incremental cost ; budget impact analysis ; italy ; medical device innovation ; health economic model ; Medicine (General) ; R5-920 ; Therapeutics. Pharmacology ; RM1-950
Subject code	360
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
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