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Article: Comparing easywrap with six other adjustable wraps for compression therapy in venous and lymphatic disease by variation in pressure, stiffness and elasticity.

Phillips, Natalie / Wright, Tom

2024 Volume 33, Issue Sup1a, Page(s) S10–S14

Abstract: Background: There is no clear guidance or comprehensive comparative evidence to help clinicians select between adjustable wraps for compression therapy. However, adjustable wraps could be compared with three metrics used for compression bandages: ... ...

Abstract	Background: There is no clear guidance or comprehensive comparative evidence to help clinicians select between adjustable wraps for compression therapy. However, adjustable wraps could be compared with three metrics used for compression bandages: variation in pressure, stiffness and elasticity. Aims: To determine whether easywrap (Haddenham Healthcare) had lower standard deviation (SD) in lying pressure, greater static stiffness index (SSI) and/or a greater mean elongation ratio than six other adjustable wraps. Methods: In this preliminary exploratory study, seven adjustable wraps were tested in vivo 20 times each (140 tests in total), on 20 people (with a variable number of readings per participant), to give the SD in lying pressure and mean SSI. The same wraps were tested in vitro five times each to give the mean elongation ratio. Findings: Of all seven adjustable wraps, easywrap had the second lowest SD in lying pressure at 5.9 mmHg, compared with 8.9 mmHg overall; the highest mean SSI at 13.2 mmHg, compared with 9.5 mmHg overall; and the highest mean elongation ratio at 137.0%, compared with 107.1% overall. Conclusions: These metrics suggest that easywrap has clinical advantages over other adjustable wraps. A lower variation in lying pressure suggests more consistent application of pressures within intended therapeutic levels. Higher SSI indicates greater resistance to stretching, which is linked to improved venous function and oedema reduction. Higher elongation ratio demonstrates greater tensile strength, which should maintain therapeutic pressure for longer without readjustment.
MeSH term(s)	Humans ; Lymphatic Diseases ; Compression Bandages ; Elasticity ; Health Facilities ; Massage
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1353951-6
ISSN	0969-0700
ISSN	0969-0700
DOI	10.12968/jowc.2024.33.Sup1a.S10
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Article: Comparing easywrap with six other adjustable wraps for compression therapy in venous and lymphatic disease by variation in pressure, stiffness and elasticity.

Phillips, Natalie / Wright, Tom

Journal of wound care

2023 Volume 33, Issue Sup1, Page(s) S10–S14

Abstract	Background: There is no clear guidance or comprehensive comparative evidence to help clinicians select between adjustable wraps for compression therapy. However, adjustable wraps could be compared with three metrics used for compression bandages: variation in pressure, stiffness and elasticity. Aims: To determine whether easywrap (Haddenham Healthcare) had lower standard deviation (SD) in lying pressure, greater static stiffness index (SSI) and/or a greater mean elongation ratio than six other adjustable wraps. Methods: In this preliminary exploratory study, seven adjustable wraps were tested in vivo 20 times each (140 tests in total), on 20 people (with a variable number of readings per participant), to give the SD in lying pressure and mean SSI. The same wraps were tested in vitro five times each to give the mean elongation ratio. Findings: Of all seven adjustable wraps, easywrap had the second lowest SD in lying pressure at 5.9 mmHg, compared with 8.9 mmHg overall; the highest mean SSI at 13.2 mmHg, compared with 9.5 mmHg overall; and the highest mean elongation ratio at 137.0%, compared with 107.1% overall. Conclusions: These metrics suggest that easywrap has clinical advantages over other adjustable wraps. A lower variation in lying pressure suggests more consistent application of pressures within intended therapeutic levels. Higher SSI indicates greater resistance to stretching, which is linked to improved venous function and oedema reduction. Higher elongation ratio demonstrates greater tensile strength, which should maintain therapeutic pressure for longer without readjustment.
MeSH term(s)	Humans ; Lymphatic Diseases ; Compression Bandages ; Elasticity ; Health Facilities ; Massage
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1353951-6
ISSN	0969-0700
ISSN	0969-0700
DOI	10.12968/jowc.2024.33.Sup1.S10
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Article ; Online: A survey of Canadian dairy nutritionists to assess current trace element formulation practices

Duplessis, Mélissa / Wright, Tom C. / Bejaei, Masoumeh

American Dairy Science Association Journal of Dairy Science. 2023 June, v. 106, no. 6 p.4030-4041

2023

Abstract: The purpose of this study was to identify current practices and perceptions around trace element feeding for dairy cows through a Canadian dairy nutritionist survey. An online survey with 23 questions was used to collect data from Canadian dairy ... ...

Abstract	The purpose of this study was to identify current practices and perceptions around trace element feeding for dairy cows through a Canadian dairy nutritionist survey. An online survey with 23 questions was used to collect data from Canadian dairy nutritionists with the help of professional associations and social media. The survey was active from November 2021 to April 2022. The first 7 questions collected descriptive information on respondents, and the subsequent 16 questions focused on trace element feeding. A total of 92 participants from all over Canada filled out the survey, and about 26% of Canadian herds and cows were represented by these respondents. The participants had diverse views on the importance of diet formulations for trace elements to optimize cow health and productivity, with perceptions varying from very important to not important. In comparison, macronutrients and selenium were consistently rated as very important by between 58% and 74% of respondents. Software reference values were used by 54%, 72%, and 73% of participants to estimate trace element concentrations of forages, cereals, and protein sources, respectively, highlighting the importance of regularly updating the feed library of the software. More than 60% of nutritionists participating in this study had intentionally formulated diets above trace element software recommendations, considered mineral interactions occurring in the rumen, and used a trace element source known for its better bioavailability (e.g., organic, chelate) when they formulated diets. Herds with more than 80 cows were more likely to be given trace element supplements known for their greater bioavailability. The most used supplement with enhanced bioavailability was selenium. In addition, different trace element feeding strategies pertaining to different stages of lactation and breeds were reported. This finding can be explained by the absence of clear recommendations on trace element feeding by breed. The participants who adjusted trace element feeding according to the stages of lactation considered the transition period as the most challenging period, and they identified the need for a source of trace element known for its greater bioavailability for this period. Further research should aim to identify environmental risk of trace element overfeeding using the One Health approach. Moreover, strategies to avoid trace element overfeeding should be evaluated.
Keywords	One Health initiative ; bioavailability ; computer software ; cows ; dairy science ; diet ; lactation ; risk ; selenium ; surveys ; Canada ; dairy cattle ; questionnaire ; trace mineral ; advisor ; recommendation
Language	English
Dates of publication	2023-06
Size	p. 4030-4041.
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2022-22943
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Article ; Online: A survey of Canadian dairy nutritionists to assess current trace element formulation practices.

Duplessis, Mélissa / Wright, Tom C / Bejaei, Masoumeh

Journal of dairy science

2023 Volume 106, Issue 6, Page(s) 4030–4041

Abstract	The purpose of this study was to identify current practices and perceptions around trace element feeding for dairy cows through a Canadian dairy nutritionist survey. An online survey with 23 questions was used to collect data from Canadian dairy nutritionists with the help of professional associations and social media. The survey was active from November 2021 to April 2022. The first 7 questions collected descriptive information on respondents, and the subsequent 16 questions focused on trace element feeding. A total of 92 participants from all over Canada filled out the survey, and about 26% of Canadian herds and cows were represented by these respondents. The participants had diverse views on the importance of diet formulations for trace elements to optimize cow health and productivity, with perceptions varying from very important to not important. In comparison, macronutrients and selenium were consistently rated as very important by between 58% and 74% of respondents. Software reference values were used by 54%, 72%, and 73% of participants to estimate trace element concentrations of forages, cereals, and protein sources, respectively, highlighting the importance of regularly updating the feed library of the software. More than 60% of nutritionists participating in this study had intentionally formulated diets above trace element software recommendations, considered mineral interactions occurring in the rumen, and used a trace element source known for its better bioavailability (e.g., organic, chelate) when they formulated diets. Herds with more than 80 cows were more likely to be given trace element supplements known for their greater bioavailability. The most used supplement with enhanced bioavailability was selenium. In addition, different trace element feeding strategies pertaining to different stages of lactation and breeds were reported. This finding can be explained by the absence of clear recommendations on trace element feeding by breed. The participants who adjusted trace element feeding according to the stages of lactation considered the transition period as the most challenging period, and they identified the need for a source of trace element known for its greater bioavailability for this period. Further research should aim to identify environmental risk of trace element overfeeding using the One Health approach. Moreover, strategies to avoid trace element overfeeding should be evaluated.
MeSH term(s)	Female ; Cattle ; Animals ; Humans ; Trace Elements/metabolism ; Selenium/metabolism ; Nutritionists ; Milk/metabolism ; Canada ; Plant Breeding ; Diet/veterinary ; Lactation ; Surveys and Questionnaires ; Animal Feed/analysis
Chemical Substances	Trace Elements ; Selenium (H6241UJ22B)
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2022-22943
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Article ; Online: X-linked cone dystrophy with an uncommon tapetal-like sheen caused by a novel RPGR variant.

Zhai, Yi / Wright, Tom / Ballios, Brian G

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2023 Volume 59, Issue 3, Page(s) e289–e293

MeSH term(s)	Humans ; Male ; Eye Proteins/genetics ; Tomography, Optical Coherence/methods ; Electroretinography ; Genetic Diseases, X-Linked/genetics ; Genetic Diseases, X-Linked/diagnosis ; Mutation ; DNA Mutational Analysis ; Pedigree ; Visual Acuity ; Retinal Cone Photoreceptor Cells/pathology
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2023.11.016
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Article ; Online: Small-Molecule Organocatalysis Facilitates In Situ Nucleotide Activation and RNA Copying.

Aitken, Harry R M / Wright, Tom H / Radakovic, Aleksandar / Szostak, Jack W

Journal of the American Chemical Society

2023 Volume 145, Issue 29, Page(s) 16142–16149

Abstract: A key challenge in origin-of-life research is the identification of plausible conditions that facilitate multiple steps along the pathway from chemistry to biology. The incompatibility of nucleotide activation chemistry and nonenzymatic template-directed ...

Abstract	A key challenge in origin-of-life research is the identification of plausible conditions that facilitate multiple steps along the pathway from chemistry to biology. The incompatibility of nucleotide activation chemistry and nonenzymatic template-directed RNA copying has hindered attempts to define such a pathway. Here, we show that adding heteroaromatic small molecules to the reaction network facilitates in situ nucleotide phosphate activation under conditions compatible with RNA copying, allowing both reactions to take place in the same mixture. This is achieved using Passerini-type phosphate activation in concert with nucleophilic organocatalysts that intercept high-energy reactive intermediates; this sequence ultimately affords 5',5'-imidazolium-bridged dinucleotides─the active species in template-directed RNA polymerization. Our results suggest that mixtures of prebiotically relevant heteroaromatic small molecules could have played a key role in the transition from chemistry to biology.
MeSH term(s)	RNA/chemistry ; Nucleotides/chemistry ; Polymerization
Chemical Substances	RNA (63231-63-0) ; Nucleotides
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c04635
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Article ; Online: MERCI: a machine learning approach to identifying hydroxychloroquine retinopathy using mfERG.

Habib, Faisal / Huang, Huaxiong / Gupta, Arvind / Wright, Tom

Documenta ophthalmologica. Advances in ophthalmology

2022 Volume 145, Issue 1, Page(s) 53–63

Abstract: Purpose: Hydroxychloroquine (HCQ) is an anti-inflammatory drug in widespread use for the treatment of systemic auto-immune diseases. Vision loss caused by retinal toxicity is a significant risk associated with long term HCQ therapy. Identifying patients ...

Abstract	Purpose: Hydroxychloroquine (HCQ) is an anti-inflammatory drug in widespread use for the treatment of systemic auto-immune diseases. Vision loss caused by retinal toxicity is a significant risk associated with long term HCQ therapy. Identifying patients at risk of developing retinal toxicity can help prevent vision loss and improve the quality of life for patients. This paper presents updated reference thresholds and examines the diagnostic accuracy of a machine learning approach for identifying retinal toxicity using the multifocal Electroretinogram (mfERG). Methods: A retrospective study of patients referred for mfERG testing to detect HCQ retinopathy. A consecutive series of all patients referred to Kensington Vision and Research Centre between August 2017 and July 2020 were considered eligible. Eyes suspect for other ocular pathology including widespread retinal disease and advanced macular pathology unrelated to HCQ or with poor quality mfERG recordings were excluded. All patients received mfERG testing and Ocular Coherence Tomography (OCT) imaging. Presence of HCQ retinopathy was based on ring ratio analysis using clinical reference thresholds established at KVRC coupled with structural features observed on OCT, the clinical reference standard. A Support Vector Machine (SVM) using selected features of the mfERG was trained. Accuracy, sensitivity and specificity are reported. Results: 1463 eyes of 748 patients were included in the study. SVM model performance was assessed on 293 eyes from 265 patients. 55 eyes from 54 patients were identified as demonstrating HCQ retinopathy based on the clinical reference standard, 50 eyes from 49 patients were identified by the SVM. Our SVM achieves an accuracy of 85.3% with a sensitivity of 90.9% and specificity of 84.0%. Conclusions: Machine learning approaches can be applied to mfERG analysis to identify patients at risk of retinopathy caused by HCQ therapy.
MeSH term(s)	Antirheumatic Agents/adverse effects ; Electroretinography/methods ; Humans ; Hydroxychloroquine/adverse effects ; Machine Learning ; Quality of Life ; Retinal Diseases/chemically induced ; Retinal Diseases/diagnosis ; Retinal Diseases/pathology ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Vision Disorders/chemically induced
Chemical Substances	Antirheumatic Agents ; Hydroxychloroquine (4QWG6N8QKH)
Language	English
Publishing date	2022-06-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	212594-8
ISSN	1573-2622 ; 0012-4486
ISSN (online)	1573-2622
ISSN	0012-4486
DOI	10.1007/s10633-022-09879-7
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Article ; Online: The effect of COVID-19 on referral patterns for clinical electrophysiological testing.

Grinton, Michael E / Yan, Peng / Wright, Tom

Documenta ophthalmologica. Advances in ophthalmology

2022 Volume 146, Issue 1, Page(s) 3–6

Abstract: Purpose: To provide an overview of the effect that the COVID-19 pandemic has had on visual electrophysiology referral patterns and the subsequent effect this may have on patients.: Methods: All electrodiagnostic tests performed at Kensington Vision ... ...

Abstract	Purpose: To provide an overview of the effect that the COVID-19 pandemic has had on visual electrophysiology referral patterns and the subsequent effect this may have on patients. Methods: All electrodiagnostic tests performed at Kensington Vision and Research Centre, Toronto Canada, in a 3-month period prior to the COVID-19 pandemic (1 September 2019 to 30 November 2019) were compared to a 3-month period after the start of the COVID-19 pandemic (1 September 2021 to 30 November 2021). Results: A total of 502 patients had electrodiagnostic testing carried out in the designated time periods: 292 in the time period prior to the COVID-19 pandemic and 210 patients after. There was a significant change in the reason for referral in patients pre-COVID compared to post-COVID (p = 0.004). There was a 43% reduction in referrals for drug monitoring, 25% reduction for hereditary pathology and a 27% increase in acquired pathology after the start of the COVID-19 pandemic compared to before. Conclusions: There was a substantial decrease in the total number of patients referred after the start of the COVID-19 pandemic compared to pre-COVID with inherited retinal pathology and drug monitoring patients being 2 populations most affected by the disruption to healthcare services.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Pandemics ; Electroretinography ; Referral and Consultation ; Retina
Language	English
Publishing date	2022-12-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	212594-8
ISSN	1573-2622 ; 0012-4486
ISSN (online)	1573-2622
ISSN	0012-4486
DOI	10.1007/s10633-022-09908-5
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Article: The Urgent Need for Transparent and Accountable Procurement of Medicine and Medical Supplies in Times of COVID-19 Pandemic.

Kohler, Jillian Clare / Wright, Tom

Journal of pharmaceutical policy and practice

2020 Volume 13, Page(s) 58

Abstract: The COVID-19 pandemic has unleashed unprecedented and complex public policy issues. One that has emerged as a challenge for many countries globally is how to ensure the efficient and effective procurement of quality medical supplies. Existing corruption ... ...

Abstract	The COVID-19 pandemic has unleashed unprecedented and complex public policy issues. One that has emerged as a challenge for many countries globally is how to ensure the efficient and effective procurement of quality medical supplies. Existing corruption pressures on procurement-everything from undue influence to the outright bribery of public officials-has been amplified by the pandemic, and thus demands commensurate policy responses. We argue that transparency and accountability in procurement are essential to preventing the corruption risks that threaten the health and well-being of populations.
Keywords	covid19
Language	English
Publishing date	2020-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2734772-2
ISSN	2052-3211
ISSN	2052-3211
DOI	10.1186/s40545-020-00256-w
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Article: Preferences of Dairy Cattle for Supplemental Light-Emitting Diode Lighting in the Resting Area.

Wilson, Angela M / Wright, Tom C / Cant, John P / Osborne, Vern R

Animals : an open access journal from MDPI

2022 Volume 12, Issue 15

Abstract: Light from the environment is important for vision and regulating various biological processes. Providing supplemental lighting in the stall area could allow for individually targeted or group-level control of light. This study aimed to determine whether ...

Abstract	Light from the environment is important for vision and regulating various biological processes. Providing supplemental lighting in the stall area could allow for individually targeted or group-level control of light. This study aimed to determine whether dairy cattle had preferences for short-term exposure to white (full-spectrum) light-emitting diode (LED) light or no LED light, yellow-green or white LED light, and blue or white LED light in the stall area. In total, 14 lactating cows were housed in a free-stall pen with unrestricted access to 28 stalls. LED light was controlled separately for each side of the stall platform. Two combinations of light were tested per week, and each week consisted of three adaptation days and four treatment days. Lying behaviour and video data were recorded continuously using leg-mounted pedometers and cameras, respectively. Preference was assessed by the amount of time spent lying and the number of bouts under each light treatment. No differences occurred between treatments within each week for daily lying time and number of bouts. Similarly, no differences occurred between treatments within each time period. Further controlled studies of long-term exposure to different LED wavelengths and intensities are required to determine potential benefits on metabolic processes.
Language	English
Publishing date	2022-07-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12151894
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