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Article ; Online: A review of the relatively complex mechanism of JS-K induced apoptosis in cancer cells.

Tan, Guobin / Wu, Aiming / Li, Zhiqin / Awasthi, Prashant

2022 Volume 8, Issue 4, Page(s) 1602–1608

Abstract: Nitric oxide (NO) works as a signaling molecule, toxicant, and antioxidant in the body's physiological and pathological processes. JS-K is designed to be activated by glutathione-S-transferase (GST) and release NO in a sustained and controlled manner ... ...

Abstract	Nitric oxide (NO) works as a signaling molecule, toxicant, and antioxidant in the body's physiological and pathological processes. JS-K is designed to be activated by glutathione-S-transferase (GST) and release NO in a sustained and controlled manner within the tumor cells. JS-K also promotes apoptosis in cancer cells through mitogen-activated protein kinase (MAPK) pathway, ubiquitin-proteasome pathway, cell factor β-catenin/T (TCF) signaling pathway, and other mechanisms. In future studies, we should further develop new NO precursors, so that new drugs in the treatment of cancer can become more efficient, more accurate, and have less adverse reactions.
Language	English
Publishing date	2022-01-15
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr.2019.07.20
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Article ; Online: The Misdiagnosis of Intravesical Ectopic Prostatic Tissue as a Tumor.

Wu, Yong-Lu / Li, Zhi-Qin / Wu, Ai-Ming

Urologia internationalis

2022 Volume 107, Issue 7, Page(s) 738–741

Abstract: Ectopic prostatic tissue is rare, and it is usually only discovered by chance during imaging examinations or surgery. However, between 1967 and 2021, reports of ectopic prostatic tissue in the medical literature increased. It is rarely reported that ... ...

Abstract	Ectopic prostatic tissue is rare, and it is usually only discovered by chance during imaging examinations or surgery. However, between 1967 and 2021, reports of ectopic prostatic tissue in the medical literature increased. It is rarely reported that ectopic prostatic tissue can be misdiagnosed as a nephrogenic adenoma (NA). This case study aimed to increase the awareness of ectopic prostatic tissue to improve its rates of diagnosis. This paper is focused on a 45-year-old male patient with a history of bladder lesions that were accidentally discovered through a health examination. A computed tomography scan revealed a homogeneous isoechoic mass in the posterior inferior wall of the bladder. At first, a transurethral cystoscopy revealed a smooth sessile mass covering the normal bladder mucosa, which was located in the middle of the interureteric ridge. The biopsy results suggested a possible intravesical NA. The mass was then completely resected under pneumovesicoscopy, and the pathological diagnosis was ectopic prostatic tissue. The clinical symptoms of ectopic prostatic tissue are similar to other bladder neoplasms, but there are too few characteristics available in imaging examinations to allow for an accurate diagnosis. Since ectopic prostatic tissue can present as a tumor in the bladder, urologists may easily misdiagnose the condition. Surgery is the basis of treatment for ectopic prostatic tissue, and it has a good prognosis.
MeSH term(s)	Male ; Humans ; Middle Aged ; Urinary Bladder Neoplasms/diagnostic imaging ; Urinary Bladder Neoplasms/pathology ; Prostate/diagnostic imaging ; Prostate/pathology ; Urinary Bladder/diagnostic imaging ; Urinary Bladder/pathology ; Cystoscopy ; Choristoma/diagnostic imaging ; Choristoma/pathology ; Diagnostic Errors
Language	English
Publishing date	2022-12-23
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000528347
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Article ; Online: Mirabegron Add-On Tamsulosin for Men with Overactive Bladder Symptoms: A Pooled Analysis of Four Randomized Controlled Trials.

Wu, Yonglu / Li, Guanjun / Zhou, Haimin / Wu, Aiming / Tan, Guobin / Huang, Shuitong / Chen, Guangming / Chen, Xianxi / Li, Zhiqin

Urologia internationalis

2024 Volume 108, Issue 2, Page(s) 118–127

Abstract: Introduction: Overactive bladder symptoms (OABSs) affect patients' quality of life (QOL) worldwide. This pooled analysis compared the efficacy and safety of mirabegron add-on tamsulosin with those of tamsulosin add-on placebo in OABS treatment.: ... ...

Abstract	Introduction: Overactive bladder symptoms (OABSs) affect patients' quality of life (QOL) worldwide. This pooled analysis compared the efficacy and safety of mirabegron add-on tamsulosin with those of tamsulosin add-on placebo in OABS treatment. Methods: PubMed, Embase, MEDLINE, and the Cochrane Controlled Trial Register databases were searched for randomized controlled trials (RCTs) examining the efficacy of mirabegron add-on therapy to tamsulosin in the treatment of OABS. Moreover, references from the selected studies were screened. Review Manager 5.4 was used to analyze data. Results: Four RCTs involving 1,397 patients with OABS were selected. Of the total, 697 patients receiving mirabegron add-on tamsulosin constituted the experimental group, and 700 patients receiving tamsulosin add-on placebo constituted the control group. The efficacy endpoints were as follows: mean number of micturition per day (mean difference [MD] = -0.26, 95% confidence interval [CI] = -0.41 to -0.10, p = 0.0001), urgency episodes per day (MD = -0.67, 95% CI = -1.02 to -0.32, p = 0.0002), urgency urinary incontinence (UUI) episodes per day (MD = -0.42, 95% CI = -0.66 to -0.19, p = 0.0005), mean volume voided/micturition (MD = 10.84, 95% CI = 4.97-16.71, p = 0.0003), total International Prostate Symptom Score (IPSS) (MD = -2.01, 95% CI = -4.02 to -0.01, p = 0.05), and IPSS QOL index (MD = -0.65, 95% CI = -0.94 to -0.35, p < 0.0001). Mirabegron therapy, an add-on therapy to tamsulosin, was effective in treating patients with OABS. Moreover, mirabegron might reduce the total IPSS (MD = -2.01, 95% CI = -4.02 to -0.01, p = 0.05). The safety endpoint, treatment-emergent adverse events (odds ratio = 0.94, 95% CI = 0.78-1.13, p = 0.49), suggested that although mirabegron was well-tolerated, it possibly increased the post-void residual urine volume (MD = 10.28, 95% CI = 1.82-18.75, p = 0.02). Conclusion: Combination therapy using mirabegron and tamsulosin may be effective in treating patients with non-neurogenic OABS in terms of UUI episodes, total IPSS, and IPSS QOL index. However, its effectiveness must be verified by analyzing additional factors for OABS through further RCTs.
MeSH term(s)	Male ; Humans ; Tamsulosin/therapeutic use ; Urinary Bladder, Overactive/drug therapy ; Urinary Bladder, Overactive/diagnosis ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Acetanilides ; Urinary Incontinence ; Double-Blind Method ; Thiazoles
Chemical Substances	Tamsulosin (G3P28OML5I) ; mirabegron (MVR3JL3B2V) ; Acetanilides ; Thiazoles
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000536110
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Article ; Online: Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress.

Ji, Xiao-di / Yang, Ding / Cui, Xi-Yuan / Lou, Li-Xia / Nie, Bo / Zhao, Jiu-Li / Zhao, Ming-Jing / Wu, Ai-Ming

Chinese journal of integrative medicine

2024 Volume 30, Issue 5, Page(s) 398–407

Abstract: Objective: To investigate the pharmacological mechanism of Qili Qiangxin Capsule (QLQX) improvement of heart failure (HF) based on miR133a-endoplasmic reticulum stress (ERS) pathway.: Methods: A left coronary artery ligation-induced HF after ... ...

Abstract	Objective: To investigate the pharmacological mechanism of Qili Qiangxin Capsule (QLQX) improvement of heart failure (HF) based on miR133a-endoplasmic reticulum stress (ERS) pathway. Methods: A left coronary artery ligation-induced HF after myocardial infarction model was used in this study. Rats were randomly assigned to the sham group, the model group, the QLQX group [0.32 g/(kg·d)], and the captopril group [2.25 mg/(kg·d)], 15 rats per group, followed by 4 weeks of medication. Cardiac function such as left ventricular ejection fraction (EF), fractional shortening (FS), left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), the maximal rate of increase of left ventricular pressure (+dp/dt max), and the maximal rate of decrease of left ventricular pressure (-dp/dt max) were monitored by echocardiography and hemodynamics. Hematoxylin and eosin (HE) and Masson stainings were used to visualize pathological changes in myocardial tissue. The mRNA expression of miR133a, glucose-regulated protein78 (GRP78), inositol-requiring enzyme 1 (IRE1), activating transcription factor 6 (ATF6), X-box binding protein1 (XBP1), C/EBP homologous protein (CHOP) and Caspase 12 were detected by RT-PCR. The protein expression of GRP78, p-IRE1/IRE1 ratio, cleaved-ATF6, XBP1-s (the spliced form of XBP1), CHOP and Caspase 12 were detected by Western blot. TdT-mediated dUTP nick-end labeling (TUNEL) staining was used to detect the rate of apoptosis. Results: QLQX significantly improved cardiac function as evidenced by increased EF, FS, LVSP, +dp/dt max, -dp/dt max, and decreased LVEDP (P<0.05, P<0.01). HE staining showed that QLQX ameliorated cardiac pathologic damage to some extent. Masson staining indicated that QLQX significantly reduced collagen volume fraction in myocardial tissue (P<0.01). Results from RT-PCR and Western blot showed that QLQX significantly increased the expression of miR133a and inhibited the mRNA expressions of GRP78, IRE1, ATF6 and XBP1, as well as decreased the protein expressions of GRP78, cleaved-ATF6 and XBP1-s and decreased p-IRE1/IRE1 ratio (P<0.05, P<0.01). Further studies showed that QLQX significantly reduced the expression of CHOP and Caspase12, resulting in a significant reduction in apoptosis rate (P<0.05, P<0.01). Conclusion: The pharmacological mechanism of QLQX in improving HF is partly attributed to its regulatory effect on the miR133a-IRE1/XBP1 pathway.
MeSH term(s)	Animals ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Endoplasmic Reticulum Stress/drug effects ; Drugs, Chinese Herbal/pharmacology ; Heart Failure/drug therapy ; Heart Failure/genetics ; Male ; Rats, Sprague-Dawley ; Capsules ; Activating Transcription Factor 6/metabolism ; Activating Transcription Factor 6/genetics ; Endoplasmic Reticulum Chaperone BiP ; Apoptosis/drug effects ; Caspase 12/metabolism ; Caspase 12/genetics ; Myocardium/pathology ; Myocardium/metabolism ; Heat-Shock Proteins/metabolism ; Heat-Shock Proteins/genetics ; Rats ; X-Box Binding Protein 1/metabolism ; X-Box Binding Protein 1/genetics ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Myocardial Infarction/drug therapy ; Myocardial Infarction/pathology ; Myocardial Infarction/genetics ; Myocardial Infarction/physiopathology
Chemical Substances	MicroRNAs ; Drugs, Chinese Herbal ; qiliqiangxin ; MIRN133 microRNA, rat ; Capsules ; Activating Transcription Factor 6 ; Endoplasmic Reticulum Chaperone BiP ; Caspase 12 (EC 3.4.22.-) ; Heat-Shock Proteins ; X-Box Binding Protein 1 ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; GRP78 protein, rat
Language	English
Publishing date	2024-02-22
Publishing country	China
Document type	Journal Article
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-024-3654-3
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Zs.A 5823: Show issues

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Article ; Online: Erchen decoction to reduce oxidative stress in dyslipidemia phlegm-dampness retention syndrome mice: In vivo mechanism revealed by metabolomics (liquid chromatography-mass spectrometry)

Chen, Jing / Ye, Chao / Yang, Zheng / Zhang, Cixiong / Li, Pengyang / Xu, Bing / Wu, Aiming / Zhang, Xiaodong / Xue, Xiaolin

Phytomedicine. 20232023 July 06, Apr. 06, v. 115 p.154808-

2023

Abstract: Erchen decoction, a traditional Chinese medicine formula, can reduce the level of oxidative stress for the treatment of dyslipidemia phlegm-dampness retention syndrome (DPDRS); however, studies have not elucidated the mechanism underlying its metabolic ... ...

Abstract	Erchen decoction, a traditional Chinese medicine formula, can reduce the level of oxidative stress for the treatment of dyslipidemia phlegm-dampness retention syndrome (DPDRS); however, studies have not elucidated the mechanism underlying its metabolic action. Here, liquid chromatography-mass spectrometry (LC-MS)-based metabolomic techniques were utilized to characterize the in vivo effects of Erchen decoction in achieving reduction of oxidative stress levels and understand the potential metabolic mechanisms of action. We constructed a DPDRS animal model using a multifactorial composite modeling approach, and Erchen decoction was administered by gavage. We employed LC-MS-based metabolomic techniques in combination with serum-associated factors, gene transcription, methylation detection, and hematoxylin and eosin staining. In this study, the constructed animal model of DPDRS had satisfactory quality. Erchen decoction treatment reduced the levels of low-density lipoprotein cholesterol, t total cholesterol and riglyceride; it improved the endothelial structure, increased levels of serum β-nicotinamide adenine dinucleotide phosphate and glutathione concentrations, increased aortic phosphoserine aminotransferase and phosphoserine phosphatase gene expression levels, and decreased aortic phosphoglycerate dehydrogenase methylation level. A total of 64 differential metabolites were obtained using LC-MS assay, and 34 differential metabolic pathways were obtained after enrichment. Erchen decoction treatment of DPDRS mice reversed lipid indexes, improved vascular endothelial structure, increased serum and aortic anti-oxidative stress factor concentration and expression levels, and decreased methylation levels, thereby reducing oxidative stress and protecting vascular endothelium. Tricarboxylic acid cycle and metabolic pathways of serum glutamine, serine, tryptophan, pyrimidine, and pyruvate were the most relevant metabolic pathways involved in reducing oxidative stress levels by Erchen decoction during DPDRS treatment; especially, mitochondrial redox homeostasis maintenance in endothelial cells may be crucial. In this work, the therapeutic potential of Erchen decoction for reducing the oxidative stress level in DPDRS was demonstrated; however, its in-depth mechanism is worth further exploration.
Keywords	Oriental traditional medicine ; adenine ; animal models ; blood serum ; endothelium ; eosin ; gene expression ; glutamine ; glutathione ; homeostasis ; hyperlipidemia ; liquid chromatography ; low density lipoprotein cholesterol ; mass spectrometry ; metabolites ; metabolomics ; methylation ; mitochondria ; oxidative stress ; phosphates ; phosphoglycerate dehydrogenase ; phosphoserine phosphatase ; pyruvic acid ; serine ; therapeutics ; transcription (genetics) ; tricarboxylic acid cycle ; tryptophan ; Erchen decoction ; Dyslipidemia ; Phlegm-dampness retention syndrome ; Con group ; ECD ; H-ECD group ; L-ECD group ; M-ECD group ; Mod group ; Nor group
Language	English
Dates of publication	2023-0406
Publishing place	Elsevier GmbH
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154808
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Platinum-Based Nanocomposite Pt@BSA as an Efficient Electrochemical Biosensing Interface for Rapid and Ultrasensitive Determination of Folate Receptor-Positive Tumor Cells.

Hu, Chenyi / Wei, Guanghua / Zhu, Fengjuan / Wu, Aiming / Luo, Liuxuan / Shen, Shuiyun / Zhang, Junliang

ACS applied bio materials

2022 Volume 5, Issue 6, Page(s) 3038–3048

Abstract: Developing a cytosensing strategy based on electrochemical approaches has attracted wide interest due to the low cost, rapid response, and simple instrumentation. In this work, an electrochemical cytosensor employing the Pt@BSA nanocomposite as the ... ...

Abstract	Developing a cytosensing strategy based on electrochemical approaches has attracted wide interest due to the low cost, rapid response, and simple instrumentation. In this work, an electrochemical cytosensor employing the Pt@BSA nanocomposite as the biosensing substrate along with the covalent cross-linking of targeting molecules folic acid (FA) was constructed for highly sensitive determination of folate receptor (FR)-positive tumor cells. The prepared Pt@BSA nanocomposite revealed excellent biocompatibility for cell adhesion and proliferation, which was confirmed by cell viability evaluation using thiazolyl blue tetrazolium bromide (MTT) colorimetric methods. Due to the satisfactory electrical conductivity originating from Pt@BSA and the high binding affinity of FA to FR on the cell surface, an ultrasensitive and specific cytosensing device was designed for rapid and quantitative determination of HeLa cells (a model system) by differential pulse voltammetry (DPV) tests. This proposed cytosensor resulted in a wide HeLa cell determination range of 2.8 × 10
MeSH term(s)	Biosensing Techniques ; Folic Acid/chemistry ; HeLa Cells ; Humans ; Nanocomposites ; Platinum ; Reproducibility of Results
Chemical Substances	Platinum (49DFR088MY) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.2c00332
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Article ; Online: Erchen decoction to reduce oxidative stress in dyslipidemia phlegm-dampness retention syndrome mice: In vivo mechanism revealed by metabolomics (liquid chromatography-mass spectrometry).

Chen, Jing / Ye, Chao / Yang, Zheng / Zhang, Cixiong / Li, Pengyang / Xu, Bing / Wu, Aiming / Zhang, Xiaodong / Xue, Xiaolin

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 115, Page(s) 154808

Abstract: Objective: Erchen decoction, a traditional Chinese medicine formula, can reduce the level of oxidative stress for the treatment of dyslipidemia phlegm-dampness retention syndrome (DPDRS); however, studies have not elucidated the mechanism underlying its ...

Abstract	Objective: Erchen decoction, a traditional Chinese medicine formula, can reduce the level of oxidative stress for the treatment of dyslipidemia phlegm-dampness retention syndrome (DPDRS); however, studies have not elucidated the mechanism underlying its metabolic action. Here, liquid chromatography-mass spectrometry (LC-MS)-based metabolomic techniques were utilized to characterize the in vivo effects of Erchen decoction in achieving reduction of oxidative stress levels and understand the potential metabolic mechanisms of action. Methods: We constructed a DPDRS animal model using a multifactorial composite modeling approach, and Erchen decoction was administered by gavage. We employed LC-MS-based metabolomic techniques in combination with serum-associated factors, gene transcription, methylation detection, and hematoxylin and eosin staining. Results: In this study, the constructed animal model of DPDRS had satisfactory quality. Erchen decoction treatment reduced the levels of low-density lipoprotein cholesterol, t total cholesterol and riglyceride; it improved the endothelial structure, increased levels of serum β-nicotinamide adenine dinucleotide phosphate and glutathione concentrations, increased aortic phosphoserine aminotransferase and phosphoserine phosphatase gene expression levels, and decreased aortic phosphoglycerate dehydrogenase methylation level. A total of 64 differential metabolites were obtained using LC-MS assay, and 34 differential metabolic pathways were obtained after enrichment. Conclusions: Erchen decoction treatment of DPDRS mice reversed lipid indexes, improved vascular endothelial structure, increased serum and aortic anti-oxidative stress factor concentration and expression levels, and decreased methylation levels, thereby reducing oxidative stress and protecting vascular endothelium. Tricarboxylic acid cycle and metabolic pathways of serum glutamine, serine, tryptophan, pyrimidine, and pyruvate were the most relevant metabolic pathways involved in reducing oxidative stress levels by Erchen decoction during DPDRS treatment; especially, mitochondrial redox homeostasis maintenance in endothelial cells may be crucial. In this work, the therapeutic potential of Erchen decoction for reducing the oxidative stress level in DPDRS was demonstrated; however, its in-depth mechanism is worth further exploration.
MeSH term(s)	Mice ; Animals ; Endothelial Cells ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Metabolomics/methods ; Chromatography, Liquid ; Mass Spectrometry/methods ; Cholesterol, LDL ; Dyslipidemias/drug therapy ; Oxidative Stress
Chemical Substances	Drugs, Chinese Herbal ; Cholesterol, LDL
Language	English
Publishing date	2023-04-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154808
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Article: Application of combined QSAR-ICE models in calculation of hazardous concentrations for linear alkylbenzene sulfonate

Liang, Weigang / Wang, Xiaolei / Wu, Aiming / Zhang, Xiao / Niu, Lin / Wang, Junyu / Wang, Xia / Zhao, Xiaoli

Chemosphere. 2022 Mar. 20,

2022

Abstract: Linear alkylbenzene sulfonate (LAS) is a widely used anionic surfactant that exists as a mixture of various homologous structures in water environment. In the calculation of hazardous concentrations of LAS, cross-taxonomies toxicity estimation was often ... ...

Abstract	Linear alkylbenzene sulfonate (LAS) is a widely used anionic surfactant that exists as a mixture of various homologous structures in water environment. In the calculation of hazardous concentrations of LAS, cross-taxonomies toxicity estimation was often used instead of species-level-specific estimation for the normalization of toxicity data, which led to substantial uncertainties. In this study, combined quantitative structure–activity relationship (QSAR) and interspecific relationship estimation (ICE) models were developed to normalize the alkyl chain length of toxicity data and calculate the 5th percentile hazard concentrations (HC₅s) of LAS. Using seven acute QSAR models based on measured data and 29 acute QSAR-ICE models derived from them, the acute HC₅s of LAS were calculated as 2.09–3.67 mg/L. Furthermore, species- and family-level-specific QSAR and QSAR-ICE models were used to calculate chronic HC₅s (0.19–0.38 mg/L). Additionally, the sensitivity of biological toxicity to the hydrophobicity of LAS, represented by the slope of the QSAR models, had a significant correlation with the taxa of the species. Further risk assessment based on chronic HC₅s showed potential ecological risks in the Dianchi Lake basin and Haihe River basin in China, which should cause concern.
Keywords	anionic surfactants ; hydrophobicity ; quantitative structure-activity relationships ; risk assessment ; sulfonates ; toxicity ; watersheds ; China
Language	English
Dates of publication	2022-0320
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.134400
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Overexpression of

Yu, Hong / Liu, Mingjun / Zhu, Zhangsheng / Wu, Aiming / Mounet, Fabien / Pesquet, Edouard / Grima-Pettenati, Jacqueline / Cassan-Wang, Hua

International journal of molecular sciences

2022 Volume 23, Issue 9

Abstract: Wood (secondary xylem) formation is regulated by auxin, which plays a pivotal role as an integrator of developmental and environmental cues. However, our current knowledge of auxin-signaling during wood formation is incomplete. Our previous genome-wide ... ...

Abstract	Wood (secondary xylem) formation is regulated by auxin, which plays a pivotal role as an integrator of developmental and environmental cues. However, our current knowledge of auxin-signaling during wood formation is incomplete. Our previous genome-wide analysis of
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis/metabolism ; Eucalyptus/genetics ; Eucalyptus/metabolism ; Gene Expression Regulation, Plant ; Indoleacetic Acids/metabolism ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism ; Wood/metabolism ; Xylem/metabolism
Chemical Substances	Indoleacetic Acids
Language	English
Publishing date	2022-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23095068
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Article: Effect of WenXin KeLi on Improvement of Arrhythmia after Myocardial Infarction by Intervening PI3K-AKT-mTOR Autophagy Pathway.

Lv, Meng / Yang, Ding / Ji, Xiaodi / Lou, Lixia / Nie, Bo / Zhao, Jiuli / Wu, Aiming / Zhao, Mingjing

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 2022970

Abstract: Background: Myocardial infarction (MI) is an acute and serious cardiovascular disease. Arrhythmia after MI can lead to sudden cardiac death, which seriously affects the survival outcome of patients. WenXin KeLi is a Chinese patent medicine for the ... ...

Abstract	Background: Myocardial infarction (MI) is an acute and serious cardiovascular disease. Arrhythmia after MI can lead to sudden cardiac death, which seriously affects the survival outcome of patients. WenXin KeLi is a Chinese patent medicine for the treatment of arrhythmia in a clinic, which can significantly improve symptoms of palpitation and play an important role in reducing the risk of arrhythmia after MI. In this study, we aimed to explore the pharmacological mechanism of WenXin KeLi in protecting the heart. Methods: The MI model was established by ligating the left coronary artery and the ventricular fibrillation threshold (VFT) was measured by electrical stimulation. The expression of connexin43 (CX43) and autophagy-related protein were measured by Western Blot, and correlation analysis was conducted to study the relationship between cardiac autophagy, CX43, and arrhythmia in rats after MI. The effects of WenXin KeLi on arrhythmia, cardiac structure, and function in MI rats were respectively observed by electrical stimulation, cardiac gross section, Masson staining, and cardiac ultrasound. The effects of WenXin KeLi on the expression of phosphoinositide 3 kinase-protein kinase B-mammalian targets of rapamycin (PI3K-AKT-mTOR) autophagy pathway and CX43 were observed by Western Blot. Results: After 4 weeks of MI, the VFT in the model group was significantly reduced, the expression levels of yeast ATG6 homolog (Beclin1), microtubule-associated protein 1A/1B-light chain 3 (LC3II/LC3I), and p-CX43 (S368) significantly increased, the expression of sequestosome-1(P62) and CX43 significantly decreased. LC3II/LC3I and Beclin1 expression were significantly negatively correlated with the VFT, and the expression of P62 and CX43 were significantly positively correlated with the VFT. LC3II/LC3I and Beclin1 expression were negatively correlated with CX43 expression, while P62 expression was positively correlated with CX43 expression. WenXin KeLi could significantly increase the VFT, reduce the deposition of collagen fibers, and increase the index levels of the left ventricular end-diastolic anterior wall (LVEDAW), interventricular septum end-diastolic (IVSED), left ventricular end-systolic anterior wall (LVESAW), interventricular septum end-systolic (IVSES), left ventricular end-diastolic posterior wall (LVEDPW), left ventricular end-systolic posterior wall (LVESPW), left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS), and reduce the index levels of the left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD), left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV). WenXin KeLi could increase the expression of CX43, P62, AKT, p-PI3K, p-AKT (308), p-AKT (473), and p-mTOR and decrease the expression of LC3II/LC3I and Beclin1. Conclusion: WenXin KeLi can activate the PI3K-AKT-mTOR signaling pathway, improve cardiac autophagy and Cx43 expression in rats after MI, reduce the risk of arrhythmia after MI, and play a cardioprotective role.
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/2022970
Database	MEDical Literature Analysis and Retrieval System OnLINE

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