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  1. Article ; Online: Fatalism and Suicidal Behaviors Among Chinese College Students: The Mediating Role of Depressive Symptoms and the Moderating Role of Coping Strategies.

    Wu, Caizhi / Bai, Xin / Peng, Xueyu / Huang, Tingting / Zhu, Xu

    Omega

    2023  , Page(s) 302228231221844

    Abstract: The aim of this study was to investigate the relationship between fatalism and suicidal behaviors, the mediating role of depressive symptoms, and the moderating effect of coping strategies on the mediating process. A total of 519 participants completed ... ...

    Abstract The aim of this study was to investigate the relationship between fatalism and suicidal behaviors, the mediating role of depressive symptoms, and the moderating effect of coping strategies on the mediating process. A total of 519 participants completed the Multidimensional Fatalism Scale for General Life Events, the Center for Epidemiologic Studies-Depression scale, the Simplified Coping Style Questionnaire, and the Suicidal Behaviors Questionnaire-Revised. Results suggest that depressive symptoms partially mediated the relationship between fatalism and suicidal behaviors. Active coping moderated the mediating effect of depressive symptoms. The higher the active coping level, the weaker the mediating effect. The findings revealed that the mechanism of fatalism affecting suicidal behaviors, and had theoretical and empirical value for the prevention and intervention of suicide among college students.
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207363-8
    ISSN 1541-3764 ; 0030-2228
    ISSN (online) 1541-3764
    ISSN 0030-2228
    DOI 10.1177/00302228231221844
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    Zs.A 1391: Show issues Location:
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  2. Article: Ligand-controlled cobalt-catalyzed regiodivergent hydroboration of aryl,alkyl-disubstituted internal allenes.

    Wu, Caizhi / Ge, Shaozhong

    Chemical science

    2020  Volume 11, Issue 10, Page(s) 2783–2789

    Abstract: We report a stereoselective regiodivergent hydroboration of aryl,alkyl-disubstituted internal allenes with pinacolborane (HBpin) in the presence of cobalt catalysts generated from bench-stable Co(acac) ...

    Abstract We report a stereoselective regiodivergent hydroboration of aryl,alkyl-disubstituted internal allenes with pinacolborane (HBpin) in the presence of cobalt catalysts generated from bench-stable Co(acac)
    Language English
    Publishing date 2020-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/c9sc06136c
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  3. Article ; Online: Outcome expectations and working alliance may be more important for patients from rural areas during the transition to college life: An exploratory within-patient analysis.

    Sun, Qiwu / Zhang, Chaoli / Zhu, Xu / Wu, Caizhi / Ren, Zhihong / Falkenström, Fredrik

    Psychotherapy research : journal of the Society for Psychotherapy Research

    2023  Volume 34, Issue 5, Page(s) 679–693

    Abstract: ... ...

    Abstract ABSTRACT
    MeSH term(s) Humans ; Female ; Male ; Adult ; Rural Population/statistics & numerical data ; Young Adult ; China ; Universities ; Therapeutic Alliance ; Students ; Outcome Assessment, Health Care ; Urban Population/statistics & numerical data ; Adolescent
    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1080323-3
    ISSN 1468-4381 ; 1050-3307
    ISSN (online) 1468-4381
    ISSN 1050-3307
    DOI 10.1080/10503307.2023.2256461
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    Zs.A 3316: Show issues Location:
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  4. Article ; Online: Childhood maltreatment influences suicidal behavior: Rumination mediates and regulatory emotional self-efficacy moderates.

    Wu, Cai-Zhi / Zong, Zhi-Ying / Huang, Ting-Ting / Yu, Li-Xia / Sun, Qi-Wu

    Death studies

    2022  Volume 47, Issue 7, Page(s) 784–791

    Abstract: To investigate the mediating role of rumination in the association between childhood maltreatment and suicidal behavior, and the moderating role of regulatory emotional self-efficacy, university students ( ...

    Abstract To investigate the mediating role of rumination in the association between childhood maltreatment and suicidal behavior, and the moderating role of regulatory emotional self-efficacy, university students (
    MeSH term(s) Child ; Humans ; Suicidal Ideation ; Self Efficacy ; Child Abuse ; Emotions ; Universities
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632596-8
    ISSN 1091-7683 ; 0748-1187
    ISSN (online) 1091-7683
    ISSN 0748-1187
    DOI 10.1080/07481187.2022.2132319
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  5. Article ; Online: Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma.

    Fisher, Matthew L / Balinth, Seamus / Hwangbo, Yon / Wu, Caizhi / Ballon, Carlos / Goldberg, Gary L / Mills, Alea A

    Carcinogenesis

    2023  Volume 44, Issue 6, Page(s) 485–496

    Abstract: The chromobox-containing protein CBX4 is an important regulator of epithelial cell proliferation and differentiation, and has been implicated in several cancer types. The cancer stem cell (CSC) population is a key driver of metastasis and recurrence. The ...

    Abstract The chromobox-containing protein CBX4 is an important regulator of epithelial cell proliferation and differentiation, and has been implicated in several cancer types. The cancer stem cell (CSC) population is a key driver of metastasis and recurrence. The undifferentiated, plastic state characteristic of CSCs relies on cues from the microenvironment. Cancer-associated fibroblasts (CAFs) are a major component of the microenvironment that can influence the CSC population through the secretion of extracellular matrix and a variety of growth factors. Here we show CBX4 is a critical regulator of the CSC phenotype in squamous cell carcinomas of the skin and hypopharynx. Moreover, CAFs can promote the expression of CBX4 in the CSC population through the secretion of interleukin-6 (IL-6). IL-6 activates JAK/STAT3 signaling to increase ∆Np63α-a key transcription factor that is essential for epithelial stem cell function and the maintenance of proliferative potential that is capable of regulating CBX4. Targeting the JAK/STAT3 axis or CBX4 directly suppresses the aggressive phenotype of CSCs and represents a novel opportunity for therapeutic intervention.
    MeSH term(s) Humans ; Cancer-Associated Fibroblasts/metabolism ; Interleukin-6/metabolism ; Cell Line, Tumor ; Carcinoma, Squamous Cell/pathology ; Cell Proliferation/genetics ; Chromatin/metabolism ; Neoplastic Stem Cells/pathology ; Fibroblasts/metabolism ; Tumor Microenvironment/genetics ; Ligases/genetics ; Ligases/metabolism ; Polycomb-Group Proteins/genetics ; Polycomb-Group Proteins/metabolism
    Chemical Substances Interleukin-6 ; Chromatin ; CBX4 protein, human (EC 6.3.2.-) ; Ligases (EC 6.-) ; Polycomb-Group Proteins
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603134-1
    ISSN 1460-2180 ; 0143-3334
    ISSN (online) 1460-2180
    ISSN 0143-3334
    DOI 10.1093/carcin/bgad048
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    Zs.A 1558: Show issues Location:
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  6. Article ; Online: Pd/Cu-Catalyzed Enantioselective Sequential Heck/Sonogashira Coupling: Asymmetric Synthesis of Oxindoles Containing Trifluoromethylated Quaternary Stereogenic Centers.

    Bai, Xingfeng / Wu, Caizhi / Ge, Shaozhong / Lu, Yixin

    Angewandte Chemie (International ed. in English)

    2019  Volume 59, Issue 7, Page(s) 2764–2768

    Abstract: An asymmetric palladium and copper co-catalyzed Heck/Sonogashira reaction between o-iodoacrylanilides and terminal alkynes to synthesize chiral oxindoles was developed. In particular, a wide range of ... ...

    Abstract An asymmetric palladium and copper co-catalyzed Heck/Sonogashira reaction between o-iodoacrylanilides and terminal alkynes to synthesize chiral oxindoles was developed. In particular, a wide range of CF
    Language English
    Publishing date 2019-12-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201913148
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  7. Article ; Online: Cobalt-Catalyzed Enantioselective Hydroboration/Cyclization of 1,7-Enynes: Asymmetric Synthesis of Chiral Quinolinones Containing Quaternary Stereogenic Centers.

    Wu, Caizhi / Liao, Jiayu / Ge, Shaozhong

    Angewandte Chemie (International ed. in English)

    2019  Volume 58, Issue 26, Page(s) 8882–8886

    Abstract: An asymmetric cobalt-catalyzed hydroboration/cyclization of 1,7-enynes to synthesize chiral six-membered N-heterocyclic compounds was developed. A variety of aniline-tethered 1,7-enynes react with pinacolborane to afford the corresponding chiral boryl- ... ...

    Abstract An asymmetric cobalt-catalyzed hydroboration/cyclization of 1,7-enynes to synthesize chiral six-membered N-heterocyclic compounds was developed. A variety of aniline-tethered 1,7-enynes react with pinacolborane to afford the corresponding chiral boryl-functionalized quinoline derivatives in high yields with high enantioselectivity. This cobalt-catalyzed asymmetric cyclization of 1,7-enyens provides a general approach to access a series of chiral quinoline derivatives containing quaternary stereocenters.
    Language English
    Publishing date 2019-05-21
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201903377
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  8. Article ; Online: EZH2 regulates a SETDB1/ΔNp63α axis via RUNX3 to drive a cancer stem cell phenotype in squamous cell carcinoma.

    Balinth, Seamus / Fisher, Matthew L / Hwangbo, Yon / Wu, Caizhi / Ballon, Carlos / Sun, Xueqin / Mills, Alea A

    Oncogene

    2022  Volume 41, Issue 35, Page(s) 4130–4144

    Abstract: Enhancer of zeste homolog 2 (EZH2) and SET domain bifurcated 1 (SETDB1, also known as ESET) are oncogenic methyltransferases implicated in a number of human cancers. These enzymes typically function as epigenetic repressors of target genes by methylating ...

    Abstract Enhancer of zeste homolog 2 (EZH2) and SET domain bifurcated 1 (SETDB1, also known as ESET) are oncogenic methyltransferases implicated in a number of human cancers. These enzymes typically function as epigenetic repressors of target genes by methylating histone H3 K27 and H3-K9 residues, respectively. Here, we show that EZH2 and SETDB1 are essential to proliferation in 3 SCC cell lines, HSC-5, FaDu, and Cal33. Additionally, we find both of these proteins highly expressed in an aggressive stem-like SCC sub-population. Depletion of either EZH2 or SETDB1 disrupts these stem-like cells and their associated phenotypes of spheroid formation, invasion, and tumor growth. We show that SETDB1 regulates this SCC stem cell phenotype through cooperation with ΔNp63α, an oncogenic isoform of the p53-related transcription factor p63. Furthermore, EZH2 is upstream of both SETDB1 and ΔNp63α, activating these targets via repression of the tumor suppressor RUNX3. We show that targeting this pathway with inhibitors of EZH2 results in activation of RUNX3 and repression of both SETDB1 and ΔNp63α, antagonizing the SCC cancer stem cell phenotype. This work highlights a novel pathway that drives an aggressive cancer stem cell phenotype and demonstrates a means of pharmacological intervention.
    MeSH term(s) Carcinoma, Squamous Cell ; Cell Line, Tumor ; Core Binding Factor Alpha 3 Subunit ; Enhancer of Zeste Homolog 2 Protein ; Histone-Lysine N-Methyltransferase ; Humans ; Neoplastic Stem Cells ; Phenotype ; Promoter Regions, Genetic ; Transcription Factors
    Chemical Substances Core Binding Factor Alpha 3 Subunit ; Runx3 protein, human ; Transcription Factors ; EZH2 protein, human (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; SETDB1 protein, human (EC 2.1.1.43)
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-022-02417-4
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  9. Article: Cobalt-Catalyzed Asymmetric Hydroboration/Cyclization of 1,6-Enynes with Pinacolborane

    Yu, Songjie / Ge Shaozhong / Wu Caizhi

    Journal of the American Chemical Society. 2017 May 17, v. 139, no. 19

    2017  

    Abstract: We report a cobalt-catalyzed asymmetric hydroboration/cyclization of 1,6-enynes with catalysts generated from Co(acac)₂ and chiral bisphosphine ligands and activated in situ by reaction with pinacolborane (HBpin). A variety of oxygen-, nitrogen-, and ... ...

    Abstract We report a cobalt-catalyzed asymmetric hydroboration/cyclization of 1,6-enynes with catalysts generated from Co(acac)₂ and chiral bisphosphine ligands and activated in situ by reaction with pinacolborane (HBpin). A variety of oxygen-, nitrogen-, and carbon-tethered 1,6-enynes underwent this asymmetric transformation, yielding both alkyl- and vinyl-substituted boronate esters containing chiral tetrahydrofuran, cyclopentane, and pyrrolidine moieties with high to excellent enantioselectivities (86%–99% ee).
    Keywords catalysts ; cobalt ; enantiomers ; esters ; ligands ; tetrahydrofuran
    Language English
    Dates of publication 2017-0517
    Size p. 6526-6529.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021%2Fjacs.7b01708
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Alliance-outcome relation and progress feedback: Secondary data analyses of a randomized clinical trial study in China.

    Sun, Qiwu / Wu, Caizhi / Wang, Chiachih D C / Yu, Lixia / She, Zhuang / Falkenström, Fredrik

    Psychotherapy research : journal of the Society for Psychotherapy Research

    2020  Volume 31, Issue 2, Page(s) 145–156

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) China ; Data Analysis ; Feedback ; Humans ; Professional-Patient Relations ; Psychotherapy ; Treatment Outcome
    Language English
    Publishing date 2020-06-03
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1080323-3
    ISSN 1468-4381 ; 1050-3307
    ISSN (online) 1468-4381
    ISSN 1050-3307
    DOI 10.1080/10503307.2020.1772517
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