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  1. Article ; Online: Homocysteine Facilitates the Formation of Carotid Atherosclerotic Plaque Through Inflammatory and Noninflammatory Mechanisms.

    Zhang, Qiang / Wu, Chunxi / Tan, Xiaoqing / Li, Can / Liu, Ying / Hu, Shixia

    Metabolic syndrome and related disorders

    2024  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2023.0293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5950: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Chronic Inflammation Plays a Role of a Bridge Between Cardiovascular Disease and Hyperglycemia.

    Zhang, Qiang / Wu, Chunxi / Liu, Ying / Tan, Xiaoqing / Li, Can / Li, Lanlan / Hu, Shixia

    Metabolic syndrome and related disorders

    2023  Volume 21, Issue 8, Page(s) 468–474

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Male ; Humans ; Female ; C-Reactive Protein/metabolism ; Carotid Intima-Media Thickness ; Cardiovascular Diseases/epidemiology ; Prediabetic State/complications ; Prediabetic State/epidemiology ; Glycated Hemoglobin ; Atherosclerosis ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/epidemiology ; Inflammation ; Risk Factors ; Hyperglycemia/complications ; Hyperglycemia/epidemiology
    Chemical Substances C-Reactive Protein (9007-41-4) ; Glycated Hemoglobin
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2023.0086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5950: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Double filtration plasmapheresis for hypertriglyceridemic acute pancreatitis caused by fat overload syndrome.

    Wu, Chunxi / Xu, Ting / Yi, Zhongmei / Song, Nali / Zhou, Yumeng / Liang, Fang / Zhang, Bin

    Journal of clinical pharmacy and therapeutics

    2022  Volume 47, Issue 11, Page(s) 1885–1887

    Abstract: What is known and objective: Severe hypertriglyceridemia (HTG) can cause acute pancreatitis (AP).: Case summary: We report a patient with acute lymphoblastic leukaemia who received long-term intravenous parenteral nutrition solution without ... ...

    Abstract What is known and objective: Severe hypertriglyceridemia (HTG) can cause acute pancreatitis (AP).
    Case summary: We report a patient with acute lymphoblastic leukaemia who received long-term intravenous parenteral nutrition solution without monitoring of the serum triglyceride (TG) level, which resulted in fat overload syndrome and HTG-AP.
    What is new and conclusion: Double filtration plasmapheresis was performed to eliminate the TGs and treat the AP.
    MeSH term(s) Humans ; Pancreatitis/therapy ; Acute Disease ; Hypertriglyceridemia/complications ; Hypertriglyceridemia/therapy ; Plasmapheresis/methods ; Triglycerides
    Chemical Substances Triglycerides
    Language English
    Publishing date 2022-10-07
    Publishing country England
    Document type Case Reports
    ZDB-ID 639006-7
    ISSN 1365-2710 ; 0269-4727
    ISSN (online) 1365-2710
    ISSN 0269-4727
    DOI 10.1111/jcpt.13786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1313: Show issues Location:
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  4. Article ; Online: PNPLA3 rs738409 is not associated with the risk of hepatocellular carcinoma and persistent infection of hepatitis B virus (HBV) in HBV-related subjects: A case-control study and meta-analysis on Asians.

    Wang, Peng / Wu, Chunxi / Li, Ying / Gong, Yajie / Shen, Na

    Gene

    2020  Volume 742, Page(s) 144585

    Abstract: The association between rs738409 (C>G, I148M) with patatin-like phospholipase domain-containing 3 (PNPLA3) gene and the risk of hepatocellular carcinoma (HCC) was controversial in different ethnic populations. Our study aimed to explore the effect of ... ...

    Abstract The association between rs738409 (C>G, I148M) with patatin-like phospholipase domain-containing 3 (PNPLA3) gene and the risk of hepatocellular carcinoma (HCC) was controversial in different ethnic populations. Our study aimed to explore the effect of PNPLA3 rs738409 on the risk of HCC and persistent infection of Hepatitis B virus (HBV) in a Chinese HBV-related population, and further evaluate its role in HCC risk among Asians. First, we performed a case-control study by recruiting 786 HBV-related HCC cases, 695 HBV persistent carriers and 719 HBV natural clearance subjects. PNPLA3 rs738409 was genotyped by MassARRAY platform. Second, we conducted a systematic review and meta-analysis on Asians to further validate our results. Our case-control study demonstrated that PNPLA3 rs738409 was not associated with HCC risk or persistent HBV infection (All P > 0.05). The subsequent meta-analysis included 13 Asian studies with 9,802 subjects. Results showed that PNPLA3 rs738409 might increase HCC risk among healthy subjects (pooled odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.11-1.95), but it had no influence on the development of HCC among HBV-related subjects (pooled OR = 1.07, 95%CI = 0.89-1.30). Our case-control study highlights that PNPLA3 rs738409 is probably not associated with the risk of HCC or persistent HBV infection in a Chinese HBV-related population. Besides, our systematic review and meta-analysis on Asians further suggest that PNPLA3 rs738409 may confer an increased risk of HCC among healthy people, but contribute little to the development of HCC among HBV-related subjects. Future studies are required to confirm these results.
    MeSH term(s) Adult ; Aged ; Asian Continental Ancestry Group/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/virology ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Hepatitis B virus/isolation & purification ; Hepatitis B, Chronic/genetics ; Hepatitis B, Chronic/pathology ; Hepatitis B, Chronic/virology ; Humans ; Lipase/genetics ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/virology ; Male ; Membrane Proteins/genetics ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Assessment ; Risk Factors
    Chemical Substances Membrane Proteins ; Lipase (EC 3.1.1.3) ; adiponutrin, human (EC 3.1.1.3)
    Language English
    Publishing date 2020-03-13
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2020.144585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article: PNPLA3 rs738409 is not associated with the risk of hepatocellular carcinoma and persistent infection of hepatitis B virus (HBV) in HBV-related subjects: A case-control study and meta-analysis on Asians

    Wang, Peng / Wu, Chunxi / Li, Ying / Gong, Yajie / Shen, Na

    Gene. 2020 June 05, v. 742

    2020  

    Abstract: The association between rs738409 (C>G, I148M) with patatin-like phospholipase domain-containing 3 (PNPLA3) gene and the risk of hepatocellular carcinoma (HCC) was controversial in different ethnic populations. Our study aimed to explore the effect of ... ...

    Abstract The association between rs738409 (C>G, I148M) with patatin-like phospholipase domain-containing 3 (PNPLA3) gene and the risk of hepatocellular carcinoma (HCC) was controversial in different ethnic populations. Our study aimed to explore the effect of PNPLA3 rs738409 on the risk of HCC and persistent infection of Hepatitis B virus (HBV) in a Chinese HBV-related population, and further evaluate its role in HCC risk among Asians. First, we performed a case-control study by recruiting 786 HBV-related HCC cases, 695 HBV persistent carriers and 719 HBV natural clearance subjects. PNPLA3 rs738409 was genotyped by MassARRAY platform. Second, we conducted a systematic review and meta-analysis on Asians to further validate our results. Our case-control study demonstrated that PNPLA3 rs738409 was not associated with HCC risk or persistent HBV infection (All P > 0.05). The subsequent meta-analysis included 13 Asian studies with 9,802 subjects. Results showed that PNPLA3 rs738409 might increase HCC risk among healthy subjects (pooled odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.11–1.95), but it had no influence on the development of HCC among HBV-related subjects (pooled OR = 1.07, 95%CI = 0.89–1.30). Our case-control study highlights that PNPLA3 rs738409 is probably not associated with the risk of HCC or persistent HBV infection in a Chinese HBV-related population. Besides, our systematic review and meta-analysis on Asians further suggest that PNPLA3 rs738409 may confer an increased risk of HCC among healthy people, but contribute little to the development of HCC among HBV-related subjects. Future studies are required to confirm these results.
    Keywords Hepatitis B virus ; case-control studies ; chronic diseases ; confidence interval ; genes ; genotyping ; hepatoma ; meta-analysis ; odds ratio ; phospholipases ; risk ; systematic review
    Language English
    Dates of publication 2020-0605
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2020.144585
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 79/715: Show issues

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  6. Article ; Online: Nucleic acid-targeted pathogen reduction technique in red blood cells by UV-generated oxygen radicals for optimising recipient safety.

    Zhang, Qiang / Wu, Chunxi / Fan, Yahan / Xu, Ting / Meng, Qiang / Wang, Shichun / Liu, Qi / Yao, Chunyan / Jiang, Tianlun

    Transfusion medicine (Oxford, England)

    2019  Volume 30, Issue 1, Page(s) 51–60

    Abstract: Objectives: A novel pathogen reduction technique based on vacuum ultraviolet (VUV) irradiation was developed to reduce pathogen numbers in red blood cell (RBC) components.: Background: Contaminated blood components pose a great risk of infection in ... ...

    Abstract Objectives: A novel pathogen reduction technique based on vacuum ultraviolet (VUV) irradiation was developed to reduce pathogen numbers in red blood cell (RBC) components.
    Background: Contaminated blood components pose a great risk of infection in blood recipients. The continuous development of blood screening techniques and pathogen inactivating systems has significantly reduced this risk, but many limitations remain.
    Methods: Escherichia coli and Bacillus cereus, and bacteriophage (BP) and Lentivirus (LV) were spiked into suspended red blood cells (sRBCs) or plasma. VUV light with maximum emission at 185 nm and an average dosage of 164 μW/cm
    Results: Treatment for 5 minutes was effective; 3 and 10 log reductions of E coli counts were observed in sRBCs and plasma, and 2 and 3 log reductions of B cereus counts were observed in sRBCs and plasma, respectively. The BP titre was reduced by two and five log points in sRBCs and plasma, respectively; the LV titre was reduced by at least three log points in both sRBCs and plasma. VUV-based irradiation of RBCs does not cause significant structural and functional harmful effects. This novel strategy provides moderate photonic energy to generate oxygen radicals from H
    Conclusion: The VUV-based pathogen reduction technique is a simple and fast procedure with high pathogen reduction efficacy, low toxicity and limited adverse effects on cellular blood products.
    MeSH term(s) Bacillus cereus/growth & development ; Disinfection ; Erythrocytes/microbiology ; Erythrocytes/virology ; Escherichia coli/growth & development ; Humans ; Lentivirus/growth & development ; Nucleic Acids/metabolism ; Reactive Oxygen Species/chemistry ; Ultraviolet Rays
    Chemical Substances Nucleic Acids ; Reactive Oxygen Species
    Language English
    Publishing date 2019-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article: [Feasibility of multi models targeting home pain alleviation service used on 220 cases with advanced cancer].

    Huang, Xiu-hong / DU, Jian-long / Wu, Chun-xi / Liu, Yi-shan / Bao, Mei-fang

    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

    2013  Volume 34, Issue 12, Page(s) 1242–1244

    Abstract: Objective: To investigate the feasibility and effectiveness of multiple modes on home pain alleviation service used for advanced cancer patients to in prove clinical therapy services.: Methods: The study was involved with 220 patients with advanced ... ...

    Abstract Objective: To investigate the feasibility and effectiveness of multiple modes on home pain alleviation service used for advanced cancer patients to in prove clinical therapy services.
    Methods: The study was involved with 220 patients with advanced cancers to provide them with multimodal analgesia services at home, from February 2010 to February 2013. Patients in this study had been taking both opioid treatments. They were randomly divided into two groups with the number as 112 and 108 and were given different doses of morphine or other drugs. During the period of observation, data was collected under the M. D. Anderson symptom Inventory (MDASI) score and classification of score on pain.
    Results: Differences of pain scores in the two groups and the MDASI score were significant and presented as skewed distribution. Scores on pain score were between groups were significantly different (Z = -9.735, P < 0.001). The average rankings of A group and B group were 76.68 and 162.79 respectively. Under the application of 0.4 mg alprazolam, the degree of pain alleviation seemed to be better. The differences on comprehensive scores between different drug groups were statistically significant (Z = -13.334, P < 0.001). The average rankings of groups A and B were respectively 59.87 and 179.08. Under the use of 0.4 mg of alprazolam, the results could be considered to show better improvements in symptomatic patients. Application of 0.4 mg alprazolam on patients with advanced-cancer-induced-pain showed a better symptomatic improvement than using morphine.
    Conclusion: Patients with advanced cancers receiving multimodal analgesia short-term sedation therapies at home, showed both ideal feasibility and good effectiveness. When morphine was combined used with midazolam at home, a better outcome could be seen in pain-releasing on patients with cancer, than single morphine analgesia was used.
    MeSH term(s) Adult ; Analgesia/methods ; Female ; Home Care Services ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Neoplasms/complications ; Neoplasms/pathology ; Neoplasms/therapy ; Pain/drug therapy ; Pain/etiology
    Language Chinese
    Publishing date 2013-12
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645026-x
    ISSN 0254-6450
    ISSN 0254-6450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3276: Show issues Location:
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