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  1. Article: Early-onset colorectal cancer: Current insights and future directions.

    Wu, Claudia Wing-Kwan / Lui, Rashid N

    World journal of gastrointestinal oncology

    2022  Volume 14, Issue 1, Page(s) 230–241

    Abstract: Early-onset colorectal cancer (EOCRC) has seen an alarming rise worldwide over the past two decades. The reason for this global trend is poorly understood. EOCRC appears to have its own unique clinical and molecular features when compared with late-onset ...

    Abstract Early-onset colorectal cancer (EOCRC) has seen an alarming rise worldwide over the past two decades. The reason for this global trend is poorly understood. EOCRC appears to have its own unique clinical and molecular features when compared with late-onset colorectal cancer. Younger patients appear to have more distal or rectal disease, a more advanced stage of disease at presentation, and more unfavorable histological features. Identifying risk factors for EOCRC is the first step in mitigating the rising burden of this disease. Here we summarize several noteworthy biological factors and environmental exposures that are postulated to be responsible culprits. This can hopefully translate in clinical practice to the development of better risk stratification tool for identifying high-risk individuals for early colorectal cancer screening, and identifying areas needed for further research to curb this rising trend.
    Language English
    Publishing date 2022-01-25
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v14.i1.230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Reply to Allaire, M.; Thabut, D. Comment on "Wu et al. Baveno VII Criteria Is an Accurate Risk Stratification Tool to Predict High-Risk Varices Requiring Intervention and Hepatic Events in Patients with Advanced Hepatocellular Carcinoma.

    Wu, Claudia Wing-Kwan / Yip, Terry Cheuk-Fung / Wong, Vincent Wai-Sun / Wong, Grace Lai-Hung / Liu, Ken / Lui, Rashid Nok-Shun

    Cancers

    2024  Volume 16, Issue 4

    Abstract: We thank Allaire et al [ ... ]. ...

    Abstract We thank Allaire et al [...].
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16040725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: HCV elimination in Hong Kong - Non-government organisation (NGO) activities.

    Lai, Jimmy Che-To / Ho, Agnes Hiu-Yan / Wu, Claudia Wing-Kwan / Wong, Grace Lai-Hung

    Global health & medicine

    2021  Volume 3, Issue 5, Page(s) 283–287

    Abstract: World Health Organization (WHO) calls for global hepatitis strategy to eliminate viral hepatitis by 2030. Yet many high-income countries were unable to achieve HCV elimination by 2030. Apart from the tremendous efforts and resources from the governments, ...

    Abstract World Health Organization (WHO) calls for global hepatitis strategy to eliminate viral hepatitis by 2030. Yet many high-income countries were unable to achieve HCV elimination by 2030. Apart from the tremendous efforts and resources from the governments, many non-government organizations (NGOs) have been working very hard to contribute to HCV elimination. In Hong Kong, the Center for Liver Health of The Chinese University of Hong Kong (CUHK) has been working very closely with various NGOs to educate and screen subjects who previously use intravenous drugs. In this review article, we discussed in details the New Life New Liver Program, and the barriers to HCV elimination, with special highlight the role of NGOs in overcoming the barriers.
    Language English
    Publishing date 2021-10-26
    Publishing country Japan
    Document type Journal Article ; Review
    ISSN 2434-9194
    ISSN (online) 2434-9194
    DOI 10.35772/ghm.2021.01049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Baveno VII Criteria Is an Accurate Risk Stratification Tool to Predict High-Risk Varices Requiring Intervention and Hepatic Events in Patients with Advanced Hepatocellular Carcinoma.

    Wu, Claudia Wing-Kwan / Lui, Rashid Nok-Shun / Wong, Vincent Wai-Sun / Yam, Tsz-Fai / Yip, Terry Cheuk-Fung / Liu, Ken / Lai, Jimmy Che-To / Tse, Yee-Kit / Mok, Tony Shu-Kam / Chan, Henry Lik-Yuen / Ng, Kelvin Kwok-Chai / Wong, Grace Lai-Hung / Chan, Stephen Lam

    Cancers

    2023  Volume 15, Issue 9

    Abstract: The Baveno VII criteria are used in patients with liver cirrhosis to predict high-risk varices in patients with liver cirrhosis. Yet its use in patients with advanced hepatocellular carcinoma (HCC) has not been validated. HCC alone is accompanied with a ... ...

    Abstract The Baveno VII criteria are used in patients with liver cirrhosis to predict high-risk varices in patients with liver cirrhosis. Yet its use in patients with advanced hepatocellular carcinoma (HCC) has not been validated. HCC alone is accompanied with a higher variceal bleeding risk due to its association with liver cirrhosis and portal vein thrombosis. The use of systemic therapy in advanced HCC has been thought to further augment this risk. Upper endoscopy is commonly used to evaluate for the presence of varices before initiation of treatment with systemic therapy. Yet it is associated with procedural risks, waiting time and limited availability in some localities which may delay the commencement of systemic therapy. Our study successfully validated the Baveno VI criteria with a 3.5% varices needing treatment (VNT) missed rate, also with acceptable <5% VNT missed rates when considering alternative liver stiffness (LSM) and platelet cut-offs. The Baveno VII clinically significant portal hypertension rule-out criteria (LSM < 15 kPa and platelet >150 × 10
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15092480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Baveno VII criteria identify varices needing treatment in patients with hepatocellular carcinoma of different Barcelona Clinic Liver Cancer stages.

    Wu, Claudia Wing-Kwan / Wong, Grace Lai-Hung / Wong, Vincent Wai-Sun / Yam, Tsz-Fai / Yip, Terry Cheuk-Fung / Wong, Angus Chun-Hei / Chan, Brian Wai-Nok / Fong, Matthew Man-Lok / Lai, Jimmy Che-To / Tse, Yee-Kit / Lee, Kit-Fai / Mok, Tony Shu-Kam / Chan, Henry Lik-Yuen / Lui, Rashid Nok-Shun / Chan, Stephen Lam / Ng, Kelvin Kwok-Chai

    Journal of gastroenterology and hepatology

    2023  Volume 38, Issue 8, Page(s) 1381–1388

    Abstract: Background: Baveno VII criteria for predicting varices needing treatment (VNT) have not been tested in hepatocellular carcinoma (HCC) population. We evaluated Baveno VII consensus for VNT in HCC patients of different stages according to Barcelona Clinic ...

    Abstract Background: Baveno VII criteria for predicting varices needing treatment (VNT) have not been tested in hepatocellular carcinoma (HCC) population. We evaluated Baveno VII consensus for VNT in HCC patients of different stages according to Barcelona Clinic Liver Cancer (BCLC) stages undergoing curative hepatectomy.
    Methods: This was a prospective cohort study of patients with HCC. Patients underwent transient elastography examination before HCC treatment and received at least one upper endoscopic examination afterwards. Patients were prospectively followed for clinical events including VNT.
    Results: Six hundred and seventy-three patients (83.1% male, median age 62 years) with HCC of BCLC stage 0 (10%), A (57%), B (17%) and C (15%) were recruited and followed for 47 months. The median (range) LSM was 10.5 (6.9-20.4) kPa; 74% had LSM ≤ 20 kPa and 58% had platelet count ≥150 × 10/L, respectively. VNT occurred in 51 (7.6%) patients. In patients who fulfilled Baveno VII criteria, that is, LSM ≤ 20 kPa and platelet count above 150 × 10/L, only 11 (1.6%) patients had VNT. In all BCLC stages of HCC, the proportion of patients with VNT was below 5%, which support the validity and applicability of Baveno VII criteria in all BCLC stages of HCC.
    Conclusions: The Baveno VII criteria are valid and applicable in HCC patients undergoing curative hepatectomy for selecting patients to undergo screening endoscopy for VNT. The validity was consistent across different BCLC stages of HCC.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Liver Cirrhosis/diagnosis ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/therapy ; Esophageal and Gastric Varices/diagnosis ; Esophageal and Gastric Varices/etiology ; Esophageal and Gastric Varices/therapy ; Prospective Studies ; Liver Neoplasms/complications ; Liver Neoplasms/diagnosis ; Liver Neoplasms/surgery ; Varicose Veins ; Elasticity Imaging Techniques ; Retrospective Studies
    Language English
    Publishing date 2023-05-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.16218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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