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Article ; Online: Laboratory biosafety in China: past, present, and future.

Wu, Guizhen

Biosafety and health

2019 Volume 1, Issue 2, Page(s) 56–58

Abstract: The launch of the new journal, Biosafety and Health, presents me with a unique opportunity to recount the progress of laboratory biosafety (LB) in China and my contribution to this area over the past 30 years. Since the severe acute respiratory syndrome ... ...

Abstract	The launch of the new journal, Biosafety and Health, presents me with a unique opportunity to recount the progress of laboratory biosafety (LB) in China and my contribution to this area over the past 30 years. Since the severe acute respiratory syndrome epidemic in 2003, China has constructed a primary network of high-level biosafety laboratories at different levels and established an expert team on LB. Furthermore, a series of LB management documents, including laws, regulations, standards, and guidelines, have been developed and published. This gradually maturing LB system has played a pivotal role in emerging infectious disease control and prevention, as well as in research, which in turn contributes to public health. In recent years, international collaboration between China and other countries has also been accelerated. Despite these achievements, we are still facing many challenges and opportunities in the field of LB. Sustainable LB development requires the joint efforts of the entire society and continuous international cooperation to safeguard global public health.
Keywords	covid19
Language	English
Publishing date	2019-10-31
Publishing country	Netherlands
Document type	Editorial
ISSN	2590-0536
ISSN (online)	2590-0536
DOI	10.1016/j.bsheal.2019.10.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Laboratory biosafety in China: past, present, and future

Wu, Guizhen

Biosafety and Health

Abstract: Abstract The launch of the new journal, Biosafety and Health, presents me with a unique opportunity to recount the progress of laboratory biosafety (LB) in China and my contribution to this area over the past 30 years. Since the severe acute respiratory ... ...

Abstract	Abstract The launch of the new journal, Biosafety and Health, presents me with a unique opportunity to recount the progress of laboratory biosafety (LB) in China and my contribution to this area over the past 30 years. Since the severe acute respiratory syndrome epidemic in 2003, China has constructed a primary network of high-level biosafety laboratories at different levels and established an expert team on LB. Furthermore, a series of LB management documents, including laws, regulations, standards, and guidelines, have been developed and published. This gradually maturing LB system has played a pivotal role in emerging infectious disease control and prevention, as well as in research, which in turn contributes to public health. In recent years, international collaboration between China and other countries has also been accelerated. Despite these achievements, we are still facing many challenges and opportunities in the field of LB. Sustainable LB development requires the joint efforts of the entire society and continuous international cooperation to safeguard global public health.
Keywords	covid19
Publisher	Elsevier; PMC
Document type	Article ; Online
DOI	10.1016/j.bsheal.2019.10.003
Database	COVID19

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Article: Impact of the COVID-19 epidemic anxiety on college students' employment confidence and employment situation perception in China.

Zheng, Sining / Wu, Guizhen / Zhao, Jiahao / Chen, Weiqi

Frontiers in psychology

2022 Volume 13, Page(s) 980634

Abstract: The psychological problems and employment problems of college students have always been the focus of attention of all sectors of society. The COVID-19 epidemic has a great impact on the mental health and employment of Chinese college students. Under this ...

Abstract	The psychological problems and employment problems of college students have always been the focus of attention of all sectors of society. The COVID-19 epidemic has a great impact on the mental health and employment of Chinese college students. Under this background, this study discusses how epidemic anxiety affects the employment confidence and perception of employment situation of Chinese college students. Through the online questionnaire survey of 1,132 college students nationwide, and the ordinal logistic regression analysis of the survey data using Stata 16.0 software, the results show that: (1) Epidemic anxiety negatively affects Chinese college students' employment confidence and employment situation perception, and has a significant impact on employment confidence. The three control variables of employment guidance, older age and higher education have a significant positive impact on college students' employment confidence and employment situation perception. College students in the eastern region have stronger employment confidence and more optimistic employment situation perception. But the expected monthly salary is negatively correlated with employment confidence. (2) Male college students and Science and Engineering students' epidemic anxiety have a stronger negative impact on employment confidence and employment situation perception. (3) Employment guidance has a moderating effect on the relationship between epidemic anxiety, employment confidence and employment situation perception. Employment guidance can enhance college students' employment confidence and reduce their sense of employment crisis by alleviating epidemic anxiety. Combined with the research conclusions, it is proposed that the state and schools should pay attention to the psychological counseling of college students, strengthen the employment guidance of colleges and universities, vigorously support the development of small, medium-sized and micro enterprises, and improve the employment and entrepreneurship service system of college students, so as to promote the employment of college students.
Language	English
Publishing date	2022-09-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.980634
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Convincing the confidence to conquer COVID-19: From epidemiological intervention to laboratory investigation.

Liu, William J / Wu, Guizhen

Biosafety and health

2020 Volume 2, Issue 4, Page(s) 185–186

Language	English
Publishing date	2020-11-27
Publishing country	Netherlands
Document type	Editorial
ISSN	2590-0536
ISSN (online)	2590-0536
DOI	10.1016/j.bsheal.2020.11.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biosafety chemistry and biosafety materials: A new perspective to solve biosafety problems.

Yu, Yingjie / Ding, Jianxun / Zhou, Yunhao / Xiao, Haihua / Wu, Guizhen

Biosafety and health

2022 Volume 4, Issue 1, Page(s) 15–22

Abstract: Coronavirus disease 2019 (COVID-19) has rapidly swept around the globe since its emergence near 2020. However, people have failed to fully understand its origin or mutation. Defined as an international biosafety incident, COVID-19 has again encouraged ... ...

Abstract	Coronavirus disease 2019 (COVID-19) has rapidly swept around the globe since its emergence near 2020. However, people have failed to fully understand its origin or mutation. Defined as an international biosafety incident, COVID-19 has again encouraged worldwide attention to reconsider the importance of biosafety due to the adverse impact on personal well-being and social stability. Most countries have already taken measures to advocate progress in biosafety-relevant research, aiming to prevent and solve biosafety problems with more advanced techniques and products. Herein, we propose a new concept of biosafety chemistry and reiterate the notion of biosafety materials, which refer to the interdisciplinary integration of biosafety and chemistry or materials. We attempt to illustrate the exquisite association that chemistry and materials science possess with biosafety -science, and we hope to provide a pragmatic perspective on approaches to utilize the knowledge of these two subjects to handle specific biosafety issues, such as detection and disinfection of pathogenic microorganisms, personal protective equipment, vaccine adjuvants and specific drugs,
Language	English
Publishing date	2022-01-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2590-0536
ISSN (online)	2590-0536
DOI	10.1016/j.bsheal.2022.01.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pathological Features of Echovirus-11-Associated Brain Damage in Mice Based on RNA-Seq Analysis

Zhang, Guoyan / Li, Jichen / Sun, Qiang / Zhang, Keyi / Xu, Wenbo / Zhang, Yong / Wu, Guizhen

Viruses. 2021 Dec. 10, v. 13, no. 12

2021

Abstract: Echovirus 11 (E11) is a neurotropic virus that occasionally causes fatal neurological diseases in infected children. However, the molecular mechanism underlying the disease and pathological spectrum of E11 infection remains unclear. Therefore, we ... ...

Abstract	Echovirus 11 (E11) is a neurotropic virus that occasionally causes fatal neurological diseases in infected children. However, the molecular mechanism underlying the disease and pathological spectrum of E11 infection remains unclear. Therefore, we modelled E11 infection in 2-day-old type I interferon receptor knockout (IFNAR−/−) mice, which are susceptible to enteroviruses, with E11, and identified symptoms consistent with the clinical signs observed in human cases. All organs of infected suckling mice were found to show viral replication and pathological changes; the muscle tissue showed the highest viral replication, whereas the brain and muscle tissues showed the most obvious pathological changes. Brain tissues showed oedema and a large number of dead nerve cells; RNA-Seq analysis of the brain and hindlimb muscle tissues revealed differentially expressed genes to be abundantly enriched in immune response-related pathways, with changes in the Guanylate-binding protein (GBP) and MHC class genes, causing aseptic meningitis-related symptoms. Furthermore, human glioma U251 cell was identified as sensitive target cells for E11 infection. Overall, these results provide new insights into the pathogenesis and progress of aseptic meningitis caused by E11.
Keywords	Enterovirus ; brain ; brain damage ; edema ; gene expression regulation ; glioma ; hindlimbs ; humans ; interferons ; meningitis ; muscle tissues ; muscles ; nerve tissue ; pathogenesis ; sequence analysis ; virus replication ; viruses
Language	English
Dates of publication	2021-1210
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13122477
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Pathological Features of Echovirus-11-Associated Brain Damage in Mice Based on RNA-Seq Analysis.

Zhang, Guoyan / Li, Jichen / Sun, Qiang / Zhang, Keyi / Xu, Wenbo / Zhang, Yong / Wu, Guizhen

Viruses

2021 Volume 13, Issue 12

Abstract	Echovirus 11 (E11) is a neurotropic virus that occasionally causes fatal neurological diseases in infected children. However, the molecular mechanism underlying the disease and pathological spectrum of E11 infection remains unclear. Therefore, we modelled E11 infection in 2-day-old type I interferon receptor knockout (IFNAR-/-) mice, which are susceptible to enteroviruses, with E11, and identified symptoms consistent with the clinical signs observed in human cases. All organs of infected suckling mice were found to show viral replication and pathological changes; the muscle tissue showed the highest viral replication, whereas the brain and muscle tissues showed the most obvious pathological changes. Brain tissues showed oedema and a large number of dead nerve cells; RNA-Seq analysis of the brain and hindlimb muscle tissues revealed differentially expressed genes to be abundantly enriched in immune response-related pathways, with changes in the Guanylate-binding protein (GBP) and MHC class genes, causing aseptic meningitis-related symptoms. Furthermore, human glioma U251 cell was identified as sensitive target cells for E11 infection. Overall, these results provide new insights into the pathogenesis and progress of aseptic meningitis caused by E11.
MeSH term(s)	Animals ; Animals, Newborn ; Brain/metabolism ; Brain/pathology ; Brain/virology ; Cell Line, Tumor ; Disease Models, Animal ; Echovirus Infections/genetics ; Echovirus Infections/pathology ; Echovirus Infections/virology ; Enterovirus B, Human/physiology ; Humans ; Meningitis, Aseptic/genetics ; Meningitis, Aseptic/pathology ; Meningitis, Aseptic/virology ; Mice ; Mice, Knockout ; Muscle, Skeletal/pathology ; Muscle, Skeletal/virology ; RNA-Seq ; Receptor, Interferon alpha-beta/genetics ; Transcriptome ; Viral Load ; Virus Replication
Chemical Substances	Ifnar1 protein, mouse ; Receptor, Interferon alpha-beta (156986-95-7)
Language	English
Publishing date	2021-12-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13122477
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Disinfection of

Guo, Yuntao / Liu, Peipei / Zhang, Liyang / Peng, Siqi / Wang, Xinxin / Luo, Haiyun / Wu, Guizhen

Applied physics letters

2021 Volume 119, Issue 9, Page(s) 90601

Abstract: A variety of pathogens can cause people to suffer from serious diseases, and the transmission of COVID-19 through the cold chain has once again attracted people's attention to cold chain disinfection. Unfortunately, there is no mature cold chain ... ...

Abstract	A variety of pathogens can cause people to suffer from serious diseases, and the transmission of COVID-19 through the cold chain has once again attracted people's attention to cold chain disinfection. Unfortunately, there is no mature cold chain disinfection technique yet. In this study, a low-temperature plasma disinfection technique for a cold chain is proposed. The disinfection effect of plasma generated by surface dielectric barrier discharge on
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1469436-0
ISSN	1077-3118 ; 0003-6951
ISSN (online)	1077-3118
ISSN	0003-6951
DOI	10.1063/5.0064020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rabies virus transmission via solid organs or tissue allotransplantation.

Lu, Xue-Xin / Zhu, Wu-Yang / Wu, Gui-Zhen

Infectious diseases of poverty

2018 Volume 7, Issue 1, Page(s) 82

Abstract: Background: Rabies, for which the mortality rate is almost 100%, is a zoonotic viral disease that can be transmitted via solid organs or tissue allotransplantation. Dozens of deaths from rabies via solid organs or tissues allotransplantation (ROTA) have ...

Abstract	Background: Rabies, for which the mortality rate is almost 100%, is a zoonotic viral disease that can be transmitted via solid organs or tissue allotransplantation. Dozens of deaths from rabies via solid organs or tissues allotransplantation (ROTA) have been documented during the last decades. In 2015 and 2016, two cases of rabies virus transmission via solid organs or tissue allotransplantation were reported in China, which further underscore the risk and importance of this special type of rabies for organ transplant recipients. Main text: From 1978 to 2017, at least 13 cases of ROTA, causing dozens of deaths, have been reported worldwide, whether in the high-risk or low-risk countries of rabies. The reported incubation period of ROTA ranges from 11 days to more than 17 months, while the historical incubation period of rabies is generally considered to range from ~ 1 week to several years. The pathogenesis of ROTA is not clear, but the use of post-exposure prophylaxis (PEP) can play a protective role in the transplant recipients. We also summarize reports about ROTA in China, combined with the actual situation regarding work on rabies surveillance and elimination, and suggest countermeasures for the prevention and control of ROTA in the future. Conclusions: Understanding the significance of ROTA, screening the suspected organs, assessing the risk and protecting the related population will be effective way to prevent and control further occurrence of ROTA.
MeSH term(s)	China/epidemiology ; Female ; Humans ; Male ; Organ Transplantation/adverse effects ; Organ Transplantation/mortality ; Post-Exposure Prophylaxis/organization & administration ; Rabies/epidemiology ; Rabies/mortality ; Rabies/prevention & control ; Rabies/virology ; Rabies Vaccines/administration & dosage ; Rabies virus/immunology ; Rabies virus/pathogenicity ; Survival Analysis ; Tissue Transplantation/adverse effects ; Tissue Transplantation/mortality ; Transplantation, Homologous ; Vaccination
Chemical Substances	Rabies Vaccines
Language	English
Publishing date	2018-08-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2689396-4
ISSN	2049-9957 ; 2049-9957
ISSN (online)	2049-9957
ISSN	2049-9957
DOI	10.1186/s40249-018-0467-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An adjusted ELISpot-based immunoassay for evaluation of SARS-CoV-2-specific T-cell responses.

Lin, Hao / Zhang, Jie / Dong, Shaobo / Liu, Yaning / Liu, Peipei / Gao, George F / Liu, William J / Wu, Guizhen

Biosafety and health

2022 Volume 4, Issue 3, Page(s) 179–185

Abstract: Like antibody evaluation, using an effective antigen-specific T-cell immunity assessment method in coronavirus disease 2019 (COVID-19) patients, survivors and vaccinees is crucial for understanding the immune persistence, prognosis assessment, and ... ...

Abstract	Like antibody evaluation, using an effective antigen-specific T-cell immunity assessment method in coronavirus disease 2019 (COVID-19) patients, survivors and vaccinees is crucial for understanding the immune persistence, prognosis assessment, and vaccine development for COVID-19. This study evaluated an empirically adjusted enzyme-linked immunospot assay for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T-cell immunity in 175 peripheral blood samples from COVID-19 convalescents and healthy individuals. Results of viral nucleic acid were used as the gold standard of infection confirmation. The SARS-CoV-2M peptide pool had higher sensitivity of 85% and specificity of 71% for the single peptide pool. For combined peptide pools, the parallel evaluation (at least one of the peptide pools is positive) of total peptide pools (S1&S2&M&N) had higher sensitivity (up to 93%), and the serial evaluation (all peptide pools are positive) of total peptide pools had higher specificity (up to 100%). The result of the serial evaluation was better than that of the parallel evaluation as a whole. The detection efficiency of M and N peptide pool serial evaluation appeared the highest, with a sensitivity of 80% and specificity of 93%. This T-cell immunity detection assay introduced in this report can achieve high operability and applicability. Therefore, it can be an effective SARS-CoV-2-specific cellular immune function evaluation method.
Language	English
Publishing date	2022-04-28
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-0536
ISSN (online)	2590-0536
DOI	10.1016/j.bsheal.2022.04.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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