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Article ; Online: Pancreatic follicular dendritic cell sarcoma: a rare case report and systematic literature review of 7 cases.

Li, Xu / Gu, Jin / He, Qingyun / Han, Shuwen / Wu, Huichao

2023 Volume 21, Issue 1, Page(s) 212

Abstract: Introduction: Pancreatic follicular dendritic cell sarcoma (FDCS) is an exceptionally rare and low-to-moderate malignancy, with only seven reported cases to date. Clinical diagnosis of FDCS is challenging due to the lack of distinct biological and ... ...

Abstract	Introduction: Pancreatic follicular dendritic cell sarcoma (FDCS) is an exceptionally rare and low-to-moderate malignancy, with only seven reported cases to date. Clinical diagnosis of FDCS is challenging due to the lack of distinct biological and radiographic features. Case presentation: A 67-year-old woman presented to the hospital with a 4-day history of severe abdominal pain. Imaging studies (CT and MRI) revealed a large cystic mass located at the tail of the pancreas, which was suspected to be myeloid sarcoma (MS) based on EUS and CT-guided pancreatic puncture. Postoperative pathology and immunohistochemistry confirmed the diagnosis of pancreatic FDCS. After the diagnosis was confirmed, the patient received postoperative chemotherapy with the CHOP regimen. At 11 months of follow-up, there was no evidence of recurrence. Seven published cases have been reviewed to comprehensively summarize the clinical characteristics, diagnosis, and treatment options of FDCS. Conclusion: While imaging can be useful in detecting pancreatic FDCS, it should be interpreted with caution as it can be challenging to differentiate from other pancreatic tumors. Pathology and immunohistochemistry are considered the gold standard for diagnosis, with CD21, CD23, and CD35 being specific tumor cell markers. However, preoperative diagnosis of pancreatic FDCS remains difficult, and the pancreatic puncture may further increase the risk of misdiagnosis. The disease is highly prone to recurrence and metastasis, and surgery is the preferred method for both diagnosis and treatment of localized disease.
MeSH term(s)	Female ; Humans ; Aged ; Dendritic Cell Sarcoma, Follicular/diagnosis ; Dendritic Cell Sarcoma, Follicular/surgery ; Pancreas ; Pancreatic Neoplasms/surgery ; Abdominal Pain ; Biomarkers, Tumor
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Systematic Review ; Case Reports ; Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-023-03115-5
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Article ; Online: Chemical components with antibacterial properties found in sanchen powder from traditional Tibetan medicine.

Zhao, Yueying / Xi, Cheng / Liu, Donghan / Ren, Xiaoqiao / Fan, Jiayi / Tangthianchaichana, Jakkree / Lu, Yang / Wu, Huichao

Journal of ethnopharmacology

2024 Volume 326, Page(s) 117981

Abstract: Ethnopharmacological relevance: Sanchen powder is a traditional Tibetan medicine comprising Bambusae Concretio Silicea, Carthami Flos, and Bovis Calculus Artifactus. Bambusae Concretio Silicea is the dried mass of secreted fluid in the stalks of ... ...

Abstract	Ethnopharmacological relevance: Sanchen powder is a traditional Tibetan medicine comprising Bambusae Concretio Silicea, Carthami Flos, and Bovis Calculus Artifactus. Bambusae Concretio Silicea is the dried mass of secreted fluid in the stalks of Gramineae plants such as Bambusa textilis McClure or Schizostachyum chinense Rendle. Carthami Flos is the dried flower of Carthamus tinctorius L. in the Compositae plant. Bovis Calculus Artifactus is made from ox bile powder, cholic acid, hyodeoxycholic acid, taurine, bilirubin, cholesterol, and trace elements. Research has evidenced the antibacterial efficacy of Sanchen powder, albeit its active constituents for this effect are yet to be established. Aim of the study: To investigate effective compounds, potential targets, and molecular mechanism of Sanchen powder for its antibacterial properties by using network pharmacology combined with in vitro validation, with the aims of observing the action of effective compounds in Sanchen powder and exploring new therapeutic strategies for antibacterial. Materials and methods: In this study, UPLC-Q-TOF-MS was utilized to identify the chemical composition in Sanchen powder and its blood-borne chemical ingredients post-oral intake. A network pharmacology analysis was used to establish the chemical compound in the blood following oral administration-target-disease network. The study aimed to identify antibacterial active ingredients, which were then subjected to molecular docking and pharmacodynamic experiments to verify their efficacy. Results: The findings demonstrate that following oral administration, the blood contains seven key components of Sanchen powder, including bilirubin, glycochenodeoxycholic acid, glycocholic acid, taurocholic acid, phenylalanine, safflomin A, and tryptophan. Additionally, the network pharmacology and molecular docking study results indicate the potential antibacterial effects of bilirubin, glycocholic acid, and glycochenodeoxycholic acid. In vitro antibacterial experiments revealed that bilirubin, glycocholic acid, and glycochenodeoxycholic acid could restrict the growth of the Staphylococcus aureus cell membrane at a certain concentration. Moreover, they exhibited antibacterial effects on Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis, and Escherichia coli. Conclusions: Bilirubin, glycocholic acid, and glycochenodeoxycholic acid could be effective therapeutic ingredients for the antibacterial effects of Sanchen powder. These results offer a foundation for further clinical application and research on the antibacterial effect of Sanchen powder, a Traditional Tibetan Medicine.
MeSH term(s)	Humans ; Medicine, Tibetan Traditional ; Powders ; Molecular Docking Simulation ; Glycochenodeoxycholic Acid ; Calculi ; Anti-Bacterial Agents/pharmacology ; Bilirubin ; Drugs, Chinese Herbal/pharmacology
Chemical Substances	Powders ; Glycochenodeoxycholic Acid (640-79-9) ; Anti-Bacterial Agents ; Bilirubin (RFM9X3LJ49) ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-02-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117981
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Article: Easily misdiagnosed complex Klippel-Trenaunay syndrome: A case report.

Li, Ling-Li / Xie, Rui / Li, Fu-Qing / Huang, Cheng / Tuo, Bi-Guang / Wu, Hui-Chao

World journal of clinical cases

2023 Volume 11, Issue 4, Page(s) 922–930

Abstract: Background: Klippel-Trenaunay syndrome (KTS) is a congenital vascular malformation with a complicated etiology. It is sporadic and clinically rare in occurrence. The typical characteristics are capillary malformation (also known as port-wine stain), ... ...

Abstract	Background: Klippel-Trenaunay syndrome (KTS) is a congenital vascular malformation with a complicated etiology. It is sporadic and clinically rare in occurrence. The typical characteristics are capillary malformation (also known as port-wine stain), varicose veins and malformations, and bony and/or soft tissue hypertrophy with or without lymphatic malformation, which are known as the "classic clinical triad". Herein, a rare case of KTS characterized by crossed-bilateral limb hypertrophy accompanied by intermittent hematochezia and hematuria is reported. Case summary: We described a 37-year-old female with KTS. She was admitted to our hospital owing to the gradual enlargement of the left lower extremity along with intermittent hematochezia and hematuria. The patient was diagnosed to have hemorrhoid bleeding by other hospitals and treated with conventional hemostatic drugs, but continued to have intermittent gastrointestinal bleeding and hematuria. Therefore, she visited our hospital to seek further treatment. During hospitalization, relevant imaging and laboratory examinations and colonoscopy were performed. In combination with the patient's history and relevant examinations, we considered that the patient had a complex form of KTS. We recommended a combined diagnosis and treatment from the vascular, interventional, anorectal, and other departments, although she declined any further treatment for financial reasons. Conclusion: The clinical manifestations of KTS are extensive and diverse and chiefly include the typical triad. However, Vascular malformations of KTS can also involve several parts and systems such as digestive and urogenital systems. Therefore, the atypical manifestations and rare complications necessitate the clinician's attention and are not to be ignored.
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i4.922
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Article: Pancreatic pseudoaneurysm mimicking pancreatic tumor: A case report and review of literature.

Yang, Yuan / Liu, Xue-Mei / Li, Hong-Ping / Xie, Rui / Tuo, Bi-Guang / Wu, Hui-Chao

World journal of gastrointestinal oncology

2023 Volume 15, Issue 11, Page(s) 2041–2048

Abstract: Background: Pancreatic pseudoaneurysm is a rare vascular complication of chronic pancreatitis (CP) or necrotizing pancreatitis with an incidence of 4% to 17%, but it is potentially life-threatening. It is well known that most pancreatic pseudoaneurysms ... ...

Abstract	Background: Pancreatic pseudoaneurysm is a rare vascular complication of chronic pancreatitis (CP) or necrotizing pancreatitis with an incidence of 4% to 17%, but it is potentially life-threatening. It is well known that most pancreatic pseudoaneurysms are clinically associated with pancreatic pseudocysts and are usually in the peripancreatic body-tail. A minority of intrapancreatic pseudoaneurysms occur in the absence of pseudocyst formation. Noninvasive computed tomography (CT) and magnetic resonance imaging (MRI) are most commonly used examinations for screening pancreatic pseudoaneurysms. Notably, the rare intrapancreatic pseudoaneurysm in the pancreatic head can mimic a hypervascular solid mass and be misdiagnosed as a pancreatic tumor. Case summary: We report the case of a 67-year-old man who had been admitted to our hospital due to recurrent abdominal pain for 1 mo that was aggravated for 5 d. CT and MRI revealed a mass in the pancreatic head with significant expansion of the main pancreatic duct and mild atrophy of the pancreatic body-tail. He was admitted to the department of hepatobiliary and pancreatic surgery due to the possibility of a pancreatic tumor. The patient was then referred for endoscopic ultrasonography (EUS) with possible EUS-FNA. However, EUS showed a cystic lesion in the pancreatic head with wall thickness and enhancing nodules, which was doubtful because it was inconsistent with the imaging findings. Subsequently, color doppler flow imaging demonstrated turbulent arterial blood flow in the cystic lesion and connection with the surrounding vessel. Therefore, we highly suspected the possibility of CP complicated with intrapancreatic pseudoaneurysm, combined with the patient's long-term drinking history and the sonographic features of CP. Indeed, angiography revealed an oval area of contrast medium extravasation (size: 1.0 cm × 1.5 cm) at the far-end branch of the superior pancreaticoduodenal artery, and angiographic embolization was given immediately at the same time. Conclusion: EUS is an important differential diagnostic tool when pancreatic pseudoaneurysm mimics the imaging appearance of a hypervascular pancreatic tumor.
Language	English
Publishing date	2023-11-21
Publishing country	China
Document type	Case Reports
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v15.i11.2041
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Article ; Online: Ectopic pancreas appearing as a giant gastric cyst mimicking gastric lymphangioma: a case report and a brief review.

Liu, Xuemei / Wu, Xinglong / Tuo, Biguang / Wu, Huichao

BMC gastroenterology

2021 Volume 21, Issue 1, Page(s) 151

Abstract: Background: Ectopic pancreas (EP) is defined as pancreatic tissue that lacks anatomical or vascular communication with the normal body of the pancreas. Despite improvements in diagnostic endoscopy and imaging studies, differentiating ectopic pancreatic ... ...

Abstract	Background: Ectopic pancreas (EP) is defined as pancreatic tissue that lacks anatomical or vascular communication with the normal body of the pancreas. Despite improvements in diagnostic endoscopy and imaging studies, differentiating ectopic pancreatic tissue from gastric submucosal diseases remains a challenge. Case presentation: Here, we present a case of a 44-year-old woman with severe epigastric pain. Initially, gastric lymphangioma was highly suspected due to a well-demarcated protruding mass with a large size that occurred in the submucosal layer of the gastric antrum and appeared as a cystic lesion. The final correct diagnosis of gastric EP was made during surgery. Conclusion: Gastric EP with serous oligocystic adenoma appearing as a giant gastric cyst is extremely rare. The difficulty of making an accurate diagnosis and differential diagnosis is highlighted, which may provide additional clinical experience for the diagnosis of EP with serous oligocystic adenoma in the stomach.
MeSH term(s)	Adult ; Choristoma ; Cysts ; Female ; Humans ; Lymphangioma ; Pancreas/diagnostic imaging ; Stomach Diseases/diagnosis
Language	English
Publishing date	2021-04-06
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ISSN	1471-230X
ISSN (online)	1471-230X
DOI	10.1186/s12876-021-01686-9
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Article ; Online: Nylon ring with titanium clip assists endoscopic cyanoacrylate injection for the treatment of GOV1-type gastric varices.

Mou, Haijun / Liu, Qi / Fan, Yi / Shi, Guoqing / Wu, Huichao / Tuo, Biguang / Xie, Rui

Endoscopy

2023 Volume 55, Issue S 01, Page(s) E578–E580

MeSH term(s)	Humans ; Cyanoacrylates ; Nylons ; Titanium ; Esophageal and Gastric Varices/complications ; Esophageal and Gastric Varices/therapy ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Surgical Instruments ; Treatment Outcome ; Recurrence ; Enbucrilate
Chemical Substances	Cyanoacrylates ; Nylons ; Titanium (D1JT611TNE) ; Enbucrilate (F8CEP82QNP)
Language	English
Publishing date	2023-04-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2011-5595
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Correction: Endoscopic ultrasonography successfully diagnosed pancreas divisum and santorinicele.

He, Qingyun / Xie, Rui / Li, Xu / Han, Shuwen / Shi, Guoqing / Tuo, Biguang / Wu, Huichao

Endoscopy

2023 Volume 55, Issue S 01, Page(s) C2

Language	English
Publishing date	2023-03-15
Publishing country	Germany
Document type	Journal Article ; Published Erratum
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2053-3119
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Endoscopic ultrasonography successfully diagnosed pancreas divisum and santorinicele.

He, Qingyun / Xie, Rui / Li, Xu / Han, Shuwen / Shi, Guoqing / Tuo, Biguang / Wu, Huichao

Endoscopy

2023 Volume 55, Issue S 01, Page(s) E527–E528

MeSH term(s)	Humans ; Pancreas Divisum ; Endosonography ; Pancreas/diagnostic imaging ; Pancreatic Ducts/diagnostic imaging ; Cholangiopancreatography, Endoscopic Retrograde
Language	English
Publishing date	2023-03-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2037-5436
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Impact of prior antiplatelet therapy on outcomes of acute ischemic stroke undergoing endovascular treatment: A systematic review and meta-analysis.

Wu, Huichao / Qian, Jiale / Shen, Wei / Zhu, Jiayi / Wu, Yuanling / Gu, Jingying / Zhang, Qing

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2023 Volume 119, Page(s) 22–29

Abstract: It is unclear how prior antiplatelet (APT) therapy affects outcomes of acute ischemic stroke (AIS) undergoing endovascular treatment. This review pooled data from the literature to compare outcomes of AIS between prior APT users vs non-users. PubMed, ... ...

Abstract	It is unclear how prior antiplatelet (APT) therapy affects outcomes of acute ischemic stroke (AIS) undergoing endovascular treatment. This review pooled data from the literature to compare outcomes of AIS between prior APT users vs non-users. PubMed, Embase, CENTRAL, and Scopus for studies were searched for studies comparing outcomes of AIS between APT users vs non-users up to 30th May 2023. Ten studies were included comparing 2648 APT users with 5076 non-users. Meta-analysis failed to demonstrate any statistically significant difference in symptomatic intracranial hemorrhage (sICH) but there was a tendency of higher mortality rates in prior APT users vs non-users. Although patients with prior APT therapy had significantly higher rates of successful recanalization as compared to patients with no prior APT treatment, meta-analysis showed significantly lower odds of functional independence amongst APT users vs non-users (OR: 0.77 95% CI: 0.68, 0.87 I
MeSH term(s)	Humans ; Brain Ischemia/drug therapy ; Brain Ischemia/surgery ; Endovascular Procedures ; Intracranial Hemorrhages/etiology ; Ischemic Stroke/drug therapy ; Ischemic Stroke/surgery ; Platelet Aggregation Inhibitors/adverse effects ; Stroke/drug therapy ; Thrombectomy ; Treatment Outcome
Chemical Substances	Platelet Aggregation Inhibitors
Language	English
Publishing date	2023-11-16
Publishing country	Scotland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2023.11.001
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Zs.A 3999: Show issues

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Article: Sanchen powder extract combined with vancomycin against methicillin-resistant Staphylococcus aureus

Fan, Jiajia / Sun, Honghao / Liu, Yuanyuan / Li, Xin / Wu, Huichao / Ren, Xiaoqiao

Beijing University of Chinese Medicine Journal of traditional Chinese medical sciences. 2022 Mar. 19,

2022

Abstract: To explore the effects of the extract of Sanchen powder (ESCP) combined with vancomycin on methicillin-resistant Staphylococcus aureus (MRSA) planktonic cells, biofilms, and virulence factors. The herbs in Sanchen powder (SCP) were extracted separately ... ...

Abstract	To explore the effects of the extract of Sanchen powder (ESCP) combined with vancomycin on methicillin-resistant Staphylococcus aureus (MRSA) planktonic cells, biofilms, and virulence factors. The herbs in Sanchen powder (SCP) were extracted separately with 50% ethanol. Then, the content of hydroxysafflower yellow A (HSYA) and cholic acid in the extract of artificial cattle bezoar (artificial Calculus bovis) and safflower (Carthamus tinctorius L.) was measured by ultraviolet visible-vis spectrophotometry and high-performance liquid chromatography. The effects of ESCP combined with vancomycin on MRSA by observing its biofilm viability were assessed using a 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium5-carboxanilide reduction assay and scanning electron microscopy. Additionally, enzyme activity was measured by plasma coagulase test and DNase test. The cholic acid content of the artificial C. bovis extract was 7.34 (0.81) mg/g, and the HSYA content of the C. tinctorius extract was 9.18 (0.09) mg/g. The minimal inhibitory concentrations of ESCP and vancomycin were 25.6 mg/mL and 2 μg/mL. The minimum bactericidal concentration of ESCP was 51.2 mg/mL. ESCP combined with vancomycin could inhibit the expression of coagulase and bacteria in mature biofilms. Neither ESCP nor vancomycin had a significant effect on DNase. This study is the first to show that ESCP combined with vancomycin inhibits coagulase and MRSA embedded in mature biofilms and that it represents a promising treatment for MRSA infection.
Keywords	Carthamus tinctorius ; biofilm ; cattle ; cholic acid ; deoxyribonucleases ; enzyme activity ; ethanol ; high performance liquid chromatography ; methicillin-resistant Staphylococcus aureus ; minimum inhibitory concentration ; plankton ; spectroscopy ; vancomycin ; viability ; virulence
Language	English
Dates of publication	2022-0319
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2834228-8
ISSN	2095-7548 ; 2589-0395
ISSN	2095-7548 ; 2589-0395
DOI	10.1016/j.jtcms.2022.03.002
Database	NAL-Catalogue (AGRICOLA)

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