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Article ; Online: Regulatory mechanisms and therapeutic implications of insulin-like growth factor 2 mRNA-binding proteins, the emerging crucial m

Zhou, Heng / Sun, Qiang / Feng, Mingliang / Gao, Ziming / Jia, Shiheng / Cao, Lanxin / Yu, Xue / Gao, Shan / Wu, Huizhe / Li, Kai

Theranostics

2023 Volume 13, Issue 12, Page(s) 4247–4265

Abstract: Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) serve essential biological functions as post-transcriptional performers, participating in the acquisition or maintenance of tumor hallmarks due to their distinct protein structures. Emerging ... ...

Abstract	Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) serve essential biological functions as post-transcriptional performers, participating in the acquisition or maintenance of tumor hallmarks due to their distinct protein structures. Emerging evidence indicates that IGF2BPs belong to the class III type of RNA N
MeSH term(s)	Humans ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Carrier Proteins ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; RNA/metabolism
Chemical Substances	RNA, Messenger ; Carrier Proteins ; RNA-Binding Proteins ; RNA (63231-63-0)
Language	English
Publishing date	2023-07-24
Publishing country	Australia
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.86528
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The interplay between non-coding RNAs and alternative splicing: from regulatory mechanism to therapeutic implications in cancer.

Liu, Min / Zhang, Subo / Zhou, Heng / Hu, Xiaoyun / Li, Jianing / Fu, Boshi / Wei, Minjie / Huang, Huilin / Wu, Huizhe

Theranostics

2023 Volume 13, Issue 8, Page(s) 2616–2631

Abstract: Alternative splicing (AS) is a common and conserved process in eukaryotic gene regulation. It occurs in approximately 95% of multi-exon genes, greatly enriching the complexity and diversity of mRNAs and proteins. Recent studies have found that in ... ...

Abstract	Alternative splicing (AS) is a common and conserved process in eukaryotic gene regulation. It occurs in approximately 95% of multi-exon genes, greatly enriching the complexity and diversity of mRNAs and proteins. Recent studies have found that in addition to coding RNAs, non-coding RNAs (ncRNAs) are also inextricably linked with AS. Multiple different types of ncRNAs are generated by AS of precursor long non-coding (pre-lncRNAs) or precursor messenger RNAs (pre-mRNAs). Furthermore, ncRNAs, as a novel class of regulators, can participate in AS regulation by interacting with the cis-acting elements or trans-acting factors. Several studies have implicated abnormal expression of ncRNAs and ncRNA-related AS events in the initiation, progression, and therapy resistance in various types of cancers. Therefore, owing to their roles in mediating drug resistance, ncRNAs, AS-related factors and AS-related novel antigens may serve as promising therapeutic targets in cancer treatment. In this review, we summarize the interaction between ncRNAs and AS processes, emphasizing their great influences on cancer, especially on chemoresistance, and highlighting their potential values in clinical treatment.
MeSH term(s)	Humans ; Alternative Splicing/genetics ; RNA, Untranslated/genetics ; RNA, Untranslated/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics
Chemical Substances	RNA, Untranslated ; RNA, Long Noncoding
Language	English
Publishing date	2023-04-23
Publishing country	Australia
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.83920
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Article ; Online: Colon cancer-specific diagnostic and prognostic biomarkers based on genome-wide abnormal DNA methylation.

Wang, Yilin / Zhang, Ming / Hu, Xiaoyun / Qin, Wenyan / Wu, Huizhe / Wei, Minjie

Aging

2020 Volume 12, Issue 22, Page(s) 22626–22655

Abstract: Abnormal DNA methylation is a major early contributor to colon cancer (COAD) development. We conducted a cohort-based systematic investigation of genome-wide DNA methylation using 299 COAD and 38 normal tissue samples from TCGA. Through conditional ... ...

Abstract	Abnormal DNA methylation is a major early contributor to colon cancer (COAD) development. We conducted a cohort-based systematic investigation of genome-wide DNA methylation using 299 COAD and 38 normal tissue samples from TCGA. Through conditional screening and machine learning with a training cohort, we identified one hypomethylated and nine hypermethylated differentially methylated CpG sites as potential diagnostic biomarkers, and used them to construct a COAD-specific diagnostic model. Unlike previous models, our model precisely distinguished COAD from nine other cancer types (e.g., breast cancer and liver cancer; error rate ≤ 0.05) and from normal tissues in the training cohort (AUC = 1). The diagnostic model was verified using a validation cohort from The Cancer Genome Atlas (AUC = 1) and five independent cohorts from the Gene Expression Omnibus (AUC ≥ 0.951). Using Cox regression analyses, we established a prognostic model based on six CpG sites in the training cohort, and verified the model in the validation cohort. The prognostic model sensitively predicted patients' survival (
MeSH term(s)	Aged ; Biomarkers, Tumor/genetics ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/genetics ; CpG Islands/genetics ; DNA Methylation ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Sensitivity and Specificity
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2020-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.103874
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Article: The Relationship Between the Network of Non-coding RNAs-Molecular Targets and N6-Methyladenosine Modification in Colorectal Cancer.

Lu, Senxu / Ding, Xiangyu / Wang, Yuanhe / Hu, Xiaoyun / Sun, Tong / Wei, Minjie / Wang, Xiaobin / Wu, Huizhe

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 772542

Abstract: Recent accumulating researches implicate that non-coding RNAs (ncRNAs) including microRNA (miRNA), circular RNA (circRNA), and long non-coding RNA (lncRNAs) play crucial roles in colorectal cancer (CRC) initiation and development. Notably, N6- ... ...

Abstract	Recent accumulating researches implicate that non-coding RNAs (ncRNAs) including microRNA (miRNA), circular RNA (circRNA), and long non-coding RNA (lncRNAs) play crucial roles in colorectal cancer (CRC) initiation and development. Notably, N6-methyladenosine (m
Language	English
Publishing date	2021-12-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.772542
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Article: Identification of Target PTEN-Based miR-425 and miR-576 as Potential Diagnostic and Immunotherapeutic Biomarkers of Colorectal Cancer With Liver Metastasis.

Hu, Xiaoyun / Chen, Qiuchen / Guo, Hao / Li, Kuo / Fu, Boshi / Chen, Yu / Zhao, Haishan / Wei, Minjie / Li, Yalun / Wu, Huizhe

Frontiers in oncology

2021 Volume 11, Page(s) 657984

Abstract: A major complication of colorectal cancer (CRC), one of the most common and fatal types of cancers, is secondary liver metastasis. For patients with this fate, there are very few biomarkers available in clinical application, and the disease remains ... ...

Abstract	A major complication of colorectal cancer (CRC), one of the most common and fatal types of cancers, is secondary liver metastasis. For patients with this fate, there are very few biomarkers available in clinical application, and the disease remains incurable. Recently, increasing studies demonstrated that tumorigenesis and development are closely related to immune escape, indicating that the roles of immune-related indicators might have been neglected in the past in colorectal cancer liver metastases (CRLM). Here, we unveil that elevated miR-425 and miR-576 promote CRLM through inhibiting PTEN-mediated cellular immune function. Specifically, miR-425 and miR-576 were identified for their significant upregulation in CRLM compared with the primary CRC tissues based on GSE81581 (
Language	English
Publishing date	2021-08-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.657984
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Article: Pharmacodynamics and Pharmacokinetics of a New Type of Compound Lansoprazole Capsule in Gastric Ulcer Rats and Beagle Dogs: Importance of Adjusting Oxidative Stress and Inflammation.

Wei, Binbin / Wang, Yan / Wu, Huizhe / Liu, Mingyan / Yao, Weifan / Wei, Minjie

Pharmaceutics

2019 Volume 11, Issue 2

Abstract: ...

Abstract	:
Language	English
Publishing date	2019-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics11020049
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Article ; Online: Circular RNA MTCL1 promotes advanced laryngeal squamous cell carcinoma progression by inhibiting C1QBP ubiquitin degradation and mediating beta-catenin activation.

Wang, Zheng / Sun, Anqi / Yan, Aihui / Yao, Jian / Huang, Haibo / Gao, Ziming / Han, Tao / Gu, Jia / Li, Ni / Wu, Huizhe / Li, Kai

Molecular cancer

2022 Volume 21, Issue 1, Page(s) 92

Abstract: Background: Circular RNAs (circRNAs) are involved in regulatory processes of ubiquitination and deubiquitination in various tumors at post-transcriptional epigenetic modification level. However, the underlying mechanism and its biological functions of ... ...

Abstract	Background: Circular RNAs (circRNAs) are involved in regulatory processes of ubiquitination and deubiquitination in various tumors at post-transcriptional epigenetic modification level. However, the underlying mechanism and its biological functions of circRNAs in the advanced laryngeal squamous cell carcinoma (LSCC) remain obscure. Methods: RNA sequencing and quantitative real-time PCR (qRT-PCR) assays were applied to screen for circRNAs differentially expressed in LSCC tissues and cell lines. The candidate RNA-binding proteins and target signalling pathway were detected by RNA pull-down and mass spectrometry, in situ hybridization (ISH), immunohistochemistry (IHC), qRT-PCR assays, and bioinformatics analysis. The functional roles of these molecules were investigated using in vitro and in vivo experiments including EdU, transwell, wound healing, western blot assays, and the xenograft mice models. The molecular mechanisms were identified using RNA pull-down assays, RNA immunoprecipitation (RIP), Co-IP, ISH, Ubiquitination assay, bioinformatics analysis, and the rescue experiments. Results: Here, we unveil that microtubule cross-linking factor 1 circRNA (circMTCL1, circ0000825) exerts its critical oncogenic functions by promoting complement C1q-binding protein (C1QBP)-dependent ubiquitin degradation and subsequently activating Wnt/β-catenin signalling in laryngeal carcinoma initiation and development. Specifically, circMTCL1 was remarkably up-regulated in the paired tissues of patients with LSCC (n = 67), which predicted a worse clinical outcome. Functionally, circMTCL1 exerted oncogenic biological charactersistics by promoting cell proliferative capability and invasive and migrative abilities. Ectopic circMTCL1 augumented cell proliferation, migration, and invasion of LSCC cells, and this effect could be reversed by C1QBP knocking down in vitro and in vivo. Mechanistically, circMTCL1 directly recruited C1QBP protein by harboring the specific recognized sequence (+ 159 - + 210), thereby accelerating the translation of C1QBP expression by inhibiting its ubiquitin-proteasome-mediated degradation. Importantly, the direct interaction of C1QBP with β-catenin protein was enhanced via suppressing the β-catenin phosphorylation and accelerating its accumulation in cytoplasm and nucleus. Conclusion: Our findings manifested a novel circMTCL1-C1QBP-β-catenin signaling axis involving in LSCC tumorigenesis and progression, which shed new light on circRNAs-ubiquitous acidic glycoprotein mediated ubiquitin degradation and provided strategies and targets in the therapeutic intervention of LSCC.
MeSH term(s)	Animals ; Carrier Proteins/metabolism ; Cell Line, Tumor ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/genetics ; Humans ; Mice ; Microtubule-Associated Proteins/genetics ; Mitochondrial Proteins/genetics ; RNA, Circular/genetics ; Squamous Cell Carcinoma of Head and Neck/genetics ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Wnt Signaling Pathway ; beta Catenin/genetics ; beta Catenin/metabolism
Chemical Substances	C1QBP protein, human ; C1qbp protein, mouse ; Carrier Proteins ; MTCL1 protein, human ; Microtubule-Associated Proteins ; Mitochondrial Proteins ; RNA, Circular ; Ubiquitin ; beta Catenin
Language	English
Publishing date	2022-04-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091373-4
ISSN	1476-4598 ; 1476-4598
ISSN (online)	1476-4598
ISSN	1476-4598
DOI	10.1186/s12943-022-01570-4
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Article ; Online: LINC01021 maintains tumorigenicity by enhancing N6-methyladenosine reader IMP2 dependent stabilization of MSX1 and JARID2: implication in colorectal cancer.

Wu, Huizhe / Ding, Xiangyu / Hu, Xiaoyun / Zhao, Qing / Chen, Qiuchen / Sun, Tong / Li, Yalun / Guo, Hao / Li, Meng / Gao, Ziming / Yao, Weifan / Zhao, Lin / Li, Kai / Wei, Minjie

Oncogene

2022 Volume 41, Issue 13, Page(s) 1959–1973

Abstract: Insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP2, also known as IMP2), a novel class III N6-methyladenosine ( ... ...

Abstract	Insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP2, also known as IMP2), a novel class III N6-methyladenosine (m
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/metabolism ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; MSX1 Transcription Factor/genetics ; MSX1 Transcription Factor/metabolism ; Polycomb Repressive Complex 2/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
Chemical Substances	IGF2BP2 protein, human ; JARID2 protein, human ; MSX1 Transcription Factor ; MSX1 protein, human ; RNA, Long Noncoding ; RNA-Binding Proteins ; N-methyladenosine (CLE6G00625) ; Polycomb Repressive Complex 2 (EC 2.1.1.43) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2022-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-022-02189-x
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Article ; Online: [Corrigendum] MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1.

Jiang, Qian / He, Miao / Ma, Meng-Tao / Wu, Hui-Zhe / Yu, Zhao-Jin / Guan, Shu / Jiang, Long-Yang / Wang, Yan / Zheng, Da-Di / Jin, Feng / Wei, Min-Jie

Oncology reports

2022 Volume 47, Issue 6

Abstract: Subsequently to the publication of the above article, an interested reader drew to the authors' attention that the data panel for the MDA‑MB‑231/migration/NC experiment in Fig. 2B on p. 1428 was strikingly similar to the data shown for the MDA‑MB‑231/ ... ...

Abstract	Subsequently to the publication of the above article, an interested reader drew to the authors' attention that the data panel for the MDA‑MB‑231/migration/NC experiment in Fig. 2B on p. 1428 was strikingly similar to the data shown for the MDA‑MB‑231/invasion/Blank experiment in Fig. 2C, such that these data appeared to have been derived from the same original source. The authors have referred back to their original data, and realize that the data panel was selected incorrectly for Fig. 2B. The corrected version of Fig. 2, showing the correct data for the MDA‑MB‑231/migration/NC experiment in Fig. 2B, is shown on the next page. The authors regret the error that was made during the preparation of this figure, and can confirm that the error in the assembly of this figure did not adversely affect the conclusions reported in the study. The authors are grateful to the Editor of
Language	English
Publishing date	2022-04-13
Publishing country	Greece
Document type	Published Erratum
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2022.8317
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Article ; Online: Analysis of DNA methylation-driven genes for predicting the prognosis of patients with colorectal cancer.

Fu, Boshi / Du, Cheng / Wu, Zhikun / Li, Mingwei / Zhao, Yi / Liu, Xinli / Wu, Huizhe / Wei, Minjie

Aging

2020 Volume 12, Issue 22, Page(s) 22814–22839

Abstract: Aberrant promoter methylation and ensuing abnormal gene expression are important epigenetic mechanisms that contribute to colorectal oncogenesis. Yet, the prognostic significance of such methylation-driven genes in colorectal cancer (CRC) remains obscure. ...

Abstract	Aberrant promoter methylation and ensuing abnormal gene expression are important epigenetic mechanisms that contribute to colorectal oncogenesis. Yet, the prognostic significance of such methylation-driven genes in colorectal cancer (CRC) remains obscure. Herein, a total of 181 genes were identified as the methylation-driven molecular features of CRC by integrated analysis of the expression profiles and the matched DNA methylation data from The Cancer Genome Atlas (TCGA) database. Among them, a five-gene signature (POU4F1, NOVA1, MAGEA1, SLCO4C1, and IZUMO2) was developed as a risk assessment model for predicting the clinical outcomes in CRC. The Kaplan-Meier analysis and Harrell's C index demonstrated that the risk assessment model significantly distinguished the patients in high or low-risk groups (
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/therapy ; DNA Methylation ; Databases, Genetic ; Epigenesis, Genetic ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Male ; Melanoma-Specific Antigens/genetics ; Middle Aged ; Organic Anion Transporters/genetics ; Predictive Value of Tests ; Prognosis ; RNA-Binding Proteins/genetics ; Risk Assessment ; Risk Factors ; Transcription Factor Brn-3A/genetics ; Transcriptome
Chemical Substances	Biomarkers, Tumor ; MAGEA1 protein, human ; Melanoma-Specific Antigens ; NOVA1 protein, human ; Organic Anion Transporters ; POU4F1 protein, human ; RNA-Binding Proteins ; SLCO4C1 protein, human ; Transcription Factor Brn-3A
Language	English
Publishing date	2020-11-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.103949
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