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Article ; Online: Knowledge, attitudes and practices towards the diagnosis and management of paediatric sepsis among paediatric physicians and nurses: a cross-sectional study of 21 hospitals in Hubei Province, China.

Yue, Jing / Zhao, Hui / Li, Jie / Wu, Jiannan / Zheng, Ronghao

2024 Volume 14, Issue 2, Page(s) e079411

Abstract: Objectives: To evaluate the knowledge, attitudes and practices towards diagnosing and managing paediatric sepsis among paediatric physicians and nurses.: Design: A cross-sectional, questionnaire-based study.: Setting: 21 hospitals in Hubei ... ...

Abstract	Objectives: To evaluate the knowledge, attitudes and practices towards diagnosing and managing paediatric sepsis among paediatric physicians and nurses. Design: A cross-sectional, questionnaire-based study. Setting: 21 hospitals in Hubei Province between February 2023 and March 2023. Participants: Paediatric physicians and nurses. Interventions: None. Primary and secondary outcome measures: The questionnaire contained 35 items across four dimensions (demographic information, knowledge, attitude and practice). Results: The study included 295 participants (173 women). The average knowledge, attitude and practice scores were 10.93±2.61 points (possible range, 0-20 points), 32.22±2.65 points (possible range, 7-35 points) and 36.54±5.24 points (possible range, 9-45 points), respectively. Knowledge had a direct influence on both attitude (β=0.240, 95% CI 0.136 to 0.365, p=0.009) and practice (β=0.278, 95% CI 0.084 to 0.513, p=0.010), which also indirectly influenced practice through attitude (β=0.162, 95% CI 0.078 to 0.290, p=0.007). Attitude directly influenced practice (β=0.677, 95% CI 0.384 to 0.902, p=0.025). A higher attitude score was associated with good practice (OR=1.392; 95% CI 1.231 to 1.576; p<0.001), while not working in a tertiary hospital reduced the odds of good practice (OR=0.443; 95% CI 0.2390.821; p=0.010). Conclusions: The knowledge regarding paediatric sepsis, especially knowledge about sepsis management, is poor among paediatric physicians and nurses in Hubei Province. The findings of this study may facilitate the development and implementation of training programmes to improve the diagnosis and management of paediatric sepsis.
MeSH term(s)	Humans ; Child ; Female ; Cross-Sectional Studies ; Health Knowledge, Attitudes, Practice ; China ; Physicians ; Tertiary Care Centers ; Surveys and Questionnaires ; Sepsis/diagnosis ; Sepsis/therapy
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-079411
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Article: Sustained delivery of osteogenic growth peptide through injectable photoinitiated composite hydrogel for osteogenesis.

Liu, Beibei / Wu, Jiannan / Sun, Xiaodi / Meng, Qingxun / Zhang, Jian

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1228250

Abstract: One of the most challenging clinical issues continues to be the effective bone regeneration and rebuilding following bone abnormalities. Although osteogenic growth peptide (OGP) has been proven to be effective in promoting osteoblast activity, its ... ...

Abstract	One of the most challenging clinical issues continues to be the effective bone regeneration and rebuilding following bone abnormalities. Although osteogenic growth peptide (OGP) has been proven to be effective in promoting osteoblast activity, its clinical application is constrained by abrupt release and easily degradation. We developed a GelMA/HAMA dual network hydrogel loaded with OGP based on a combination of physical chain entanglement and chemical cross-linking effects to produce an efficient long-term sustained release of OGP. The hydrogel polymers were quickly molded under ultraviolet (UV) light and had the suitable physical characteristics, porosity structure and biocompatibility. Significantly, the GelMA/HAMA-OGP hydrogel could promote cell proliferation, adhesion, increase osteogenic-related gene and protein expression
Language	English
Publishing date	2023-08-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1228250
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Article ; Online: Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Disease: A Meta-Analysis.

Sun, Wenjie / Yan, Junqiang / Wu, Jiannan / Ma, Hongxia

Medical science monitor : international medical journal of experimental and clinical research

2022 Volume 28, Page(s) e935074

Abstract: BACKGROUND Non-visual effects of the retina have been increasingly confirmed in developing Parkinson disease (PD). Light therapy (LT) has been proven to be an effective non-pharmacotherapy for improving the prognosis of PD, but the pathway of action is ... ...

Abstract	BACKGROUND Non-visual effects of the retina have been increasingly confirmed in developing Parkinson disease (PD). Light therapy (LT) has been proven to be an effective non-pharmacotherapy for improving the prognosis of PD, but the pathway of action is unclear, and there is a lack of a unified and standardized LT regimen. We aimed to evaluate the efficacy and safety of various LT measures in improving motor and non-motor symptoms in patients with idiopathic PD via a meta-analysis. MATERIAL AND METHODS CENTRAL, EMBASE, CINAHL, PEDro, and PubMed were searched for randomized controlled trials (RCTs) investigating the efficacy of LT for PD. Cochrane's Risk of bias tool and the GRADE approach were used to assess evidence quality. A meta-analysis and subgroup analyses evaluated the differences in efficacy produced by the different LT protocols. Trial sequential analysis (TSA) verified the analyses outcome and quantified the statistical relevance of the data.[color=#0e101a] [/color] RESULTS Patients receiving LT had significantly better scores for motor function (MD=-4.68, 95% Cl -8.25 to -1.12, P=0.01) compared with the control group exposed to dim-red light. In addition, in terms of non-motor symptoms, depression (SMD=-0.27, 95% Cl -0.52 to -0.02, P=0.04) and sleep disturbance-related scores (MD=3.45, 95% Cl 0.12 to 6.78, P=0.04) similarly showed significant optimization after receiving LT. CONCLUSIONS The results of this meta-analysis show strong evidence that LT has significant efficacy on motor and non-motor function in PD patients.
MeSH term(s)	Humans ; Parkinson Disease/diagnosis ; Parkinson Disease/therapy ; Phototherapy/methods ; Phototherapy/standards ; Prognosis ; Symptom Assessment/methods ; Treatment Outcome
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.935074
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Zs.A 4924: Show issues

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Article: Nursing research on a new silver-based antibacterial agent for pneumonia.

Wu, Jiannan / Cao, Dan / Xu, Laifang

Applied nanoscience

2022 Volume 12, Issue 12, Page(s) 3813–3821

Abstract: As a highly contagious bacterium, pneumonia can cause a series of respiratory diseases, and its treatment has become a concern of people. This study mainly discusses the nursing research of a new silver-based antibacterial agent in the treatment of ... ...

Abstract	As a highly contagious bacterium, pneumonia can cause a series of respiratory diseases, and its treatment has become a concern of people. This study mainly discusses the nursing research of a new silver-based antibacterial agent in the treatment of pneumonia. The following procedures were performed: (1) a sterilized expectoration suction device was inserted into the nasopharynx (7-8 cm), and the nasopharyngeal secretions were suck by controlling the pressure of the suction device; and (2) the catheter was washed with 2 mL of sterilized physiological saline, and the sample was immediately sent to the laboratory for bacterial culture of the lower airway and respiratory secretions to determine viral antigens. The drug resistance coefficient of the lysozyme, benzoate, and pneumonia bacteria is 4.5-26.8%. In addition, the fourth generation sefalos posephin and pneumonia bacteria presented drug sensitivity, and the drug resistance coefficient is 13.1-33.3%. The sensitivity to the new silver-based antimicrobial agent and lopenem is 100%. The sensitivity of other germs is between 2 and 5%. The results of the study indicate that the antibacterial properties of the new silver-based antibacterial agent increase with the degree of amino acid substitution of the same sample concentration. The new silver-based antibacterial agent has excellent antibacterial properties against
Language	English
Publishing date	2022-09-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2607723-1
ISSN	2190-5517 ; 2190-5509
ISSN (online)	2190-5517
ISSN	2190-5509
DOI	10.1007/s13204-022-02519-1
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Article: Autophagy-Dependent Ferroptosis-Related Signature is Closely Associated with the Prognosis and Tumor Immune Escape of Patients with Glioma.

Sun, Wenjie / Yan, Junqiang / Ma, Hongxia / Wu, Jiannan / Zhang, Yongjiang

International journal of general medicine

2022 Volume 15, Page(s) 253–270

Abstract: Background: Ferroptosis is an autophagy-dependent form of cell death, sometimes called "ferritinophagy". Its related pathway has been proven to regulate the programmed death of glioma stem cells. Mining autophagy-dependent ferroptosis-related gene (AD- ... ...

Abstract	Background: Ferroptosis is an autophagy-dependent form of cell death, sometimes called "ferritinophagy". Its related pathway has been proven to regulate the programmed death of glioma stem cells. Mining autophagy-dependent ferroptosis-related gene (AD-FRG) signature could facilitate the discovery of mechanisms and therapeutic targets showing drug resistance to chemotherapeutic drugs. Methods: We exhaustively searched HADB, MSigDB and FerrDb datasets and obtained 25 genes confirmed to exist in autophagy and ferroptosis death pathways. Glioma gene expression and clinicopathological data were collected from TCGA and CGGA datasets. Results: Lasso regression and Cox regression analysis were carried out to construct a nine AD-FRGs signature ( Conclusion: Based on autophagy-dependent ferroptosis-related genes, we established gene signature and nomogram that maybe effectively predict the overall survival rate of glioma and correlate with the immunosuppressive tumor microenvironment (TME).
Language	English
Publishing date	2022-01-06
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S343046
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Article: Effects of LEF-11 acetylation modification on the regulation of baculovirus infection.

Wu, Jiannan / Shen, Shuli / Gao, Xu / Miao, Meng / Quan, Yanping / Yu, Wei

Acta virologica

2023 Volume 67, Issue 1, Page(s) 42–50

Abstract: Late expression factor 11 (LEF-11) is an essential protein in the regulation of Bombyx mori nucleopolyhedrovirus (BmNPV) DNA replication and late gene expression. Our recent quantitative analysis of protein acetylome revealed for the first time that LEF- ... ...

Abstract	Late expression factor 11 (LEF-11) is an essential protein in the regulation of Bombyx mori nucleopolyhedrovirus (BmNPV) DNA replication and late gene expression. Our recent quantitative analysis of protein acetylome revealed for the first time that LEF-11 can be acetylated at one lysine residue (K83) during viral infection, but the underlying mechanism is unclear. The acetylation level for K83 was down-regulated after 36 h post-infection by approximately 30%. To clarify the regulatory function of this modification, overlap PCR was used for site-specific mutagenesis for acetylated (K83Q) or deacetylated (K83R) mimic mutants of LEF-11. The results of viral titration and quantitative polymerase chain reaction showed that after K83 acetylation, budding virion production and the viral genome replication level were significantly upregulated. Meanwhile, the results of yeast two-hybrid (Y2H) system confirmed that K83 deacetylation modification inhibited the interaction between LEF-11 and immediate early gene 1 (IE-1). In conclusion, the acetylation of LEF-11 at K83 might enhance the interaction with IE-1 in the host cell nucleus to promote viral DNA replication, and might be one of the antiviral strategies of the silkworm host. The host inhibits virus proliferation by deacetylating LEF-11. Keywords: BmNPV; LEF-11; acetylation; virus replication; protein interaction.
MeSH term(s)	Animals ; DNA Replication ; Virus Replication/physiology ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Factor XI/genetics ; Factor XI/metabolism ; Acetylation ; DNA, Viral ; Nucleopolyhedroviruses/genetics ; Nucleopolyhedroviruses/metabolism ; Bombyx
Chemical Substances	Viral Proteins ; Factor XI (9013-55-2) ; DNA, Viral
Language	English
Publishing date	2023-03-23
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	210452-0
ISSN	1336-2305 ; 0001-723X
ISSN (online)	1336-2305
ISSN	0001-723X
DOI	10.4149/av_2023_104
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease.

Zhang, Yongjiang / Yin, Shiyi / Song, Run / Lai, Xiaoyi / Shen, Mengmeng / Wu, Jiannan / Yan, Junqiang

Neural regeneration research

2023 Volume 19, Issue 8, Page(s) 1828–1834

Abstract: JOURNAL/nrgr/04.03/01300535-202408000-00037/figure1/v/2023-12-16T180322Z/r/image-tiff Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson's disease, but the regulatory mechanism remains elusive. Prohibitin-2 (PHB2) ...

Abstract	JOURNAL/nrgr/04.03/01300535-202408000-00037/figure1/v/2023-12-16T180322Z/r/image-tiff Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson's disease, but the regulatory mechanism remains elusive. Prohibitin-2 (PHB2) is a newly discovered autophagy receptor in the mitochondrial inner membrane, and its role in Parkinson's disease remains unclear. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is a factor that regulates cell fate during endoplasmic reticulum stress. Parkin is regulated by PERK and is a target of the unfolded protein response. It is unclear whether PERK regulates PHB2-mediated mitophagy through Parkin. In this study, we established a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease. We used adeno-associated virus to knockdown PHB2 expression. Our results showed that loss of dopaminergic neurons and motor deficits were aggravated in the MPTP-induced mouse model of Parkinson's disease. Overexpression of PHB2 inhibited these abnormalities. We also established a 1-methyl-4-phenylpyridine (MPP+)-induced SH-SY5Y cell model of Parkinson's disease. We found that overexpression of Parkin increased co-localization of PHB2 and microtubule-associated protein 1 light chain 3, and promoted mitophagy. In addition, MPP+ regulated Parkin involvement in PHB2-mediated mitophagy through phosphorylation of PERK. These findings suggest that PHB2 participates in the development of Parkinson's disease by interacting with endoplasmic reticulum stress and Parkin.
Language	English
Publishing date	2023-11-08
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.389356
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Article ; Online: Nur77 increases mitophagy and decreases aggregation of α-synuclein by modulating the p-c-Abl/p-PHB2 Y121 in α-synuclein PFF SH-SY5Y cells and mice.

Yin, Shiyi / Shen, Mengmeng / Zhang, Yongjiang / Wu, Jiannan / Song, Run / Lai, Xiaoyi / Tian, Zhenzhen / Wang, Tingting / Jin, Weina / Yan, Junqiang

European journal of medicinal chemistry

2024 Volume 268, Page(s) 116251

Abstract: Parkinson's disease (PD) is characterized by the progressive death of dopamine (DA) neurons and the pathological accumulation of α-synuclein (α-syn) fibrils. In our previous study, simulated PHB2 phosphorylation was utilized to clarify the regulatory ... ...

Abstract	Parkinson's disease (PD) is characterized by the progressive death of dopamine (DA) neurons and the pathological accumulation of α-synuclein (α-syn) fibrils. In our previous study, simulated PHB2 phosphorylation was utilized to clarify the regulatory role of c-Abl in PHB2-mediated mitophagy in PD models. In this investigation, we employed an independently patented PHB2Y121 phosphorylated antibody in the PD model to further verify that the c-Abl inhibitor STI571 can impede PHB2Y121 phosphorylation, decrease the formation of α-Syn polymers, and improve autophagic levels. The specific involvement of Nur77 in PD pathology has remained elusive. We also investigate the contribution of Nur77, a nuclear transcription factor, to α-syn and mitophagy in PD. Our findings demonstrate that under α-syn, Nur77 translocates from the cytoplasm to the mitochondria, improving PHB-mediated mitophagy by regulating c-Abl phosphorylation. Moreover, Nur77 overexpression alleviates the expression level of pS129-α-syn and the loss of DA neurons in α-syn PFF mice, potentially associated with the p-c-Abl/p-PHB2 Y121 axis. This study provides initial in vivo and in vitro evidence that Nur77 protects PD DA neurons by modulating the p-c-Abl/p-PHB2 Y121 axis, and STI571 holds promise as a treatment for PD.
MeSH term(s)	Mice ; Humans ; Animals ; alpha-Synuclein/metabolism ; Mitophagy ; Imatinib Mesylate ; Neuroblastoma/pathology ; Parkinson Disease/metabolism ; Dopaminergic Neurons/metabolism
Chemical Substances	alpha-Synuclein ; Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2024-02-23
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2024.116251
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Zs.B 784: Show issues

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Article ; Online: Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP

Lai, Xiaoyi / Zhang, Yongjiang / Wu, Jiannan / Shen, Mengmeng / Yin, Shiyi / Yan, Junqiang

Neurotoxicity research

2023 Volume 41, Issue 3, Page(s) 242–255

Abstract: Oxidative stress plays a crucial role in the occurrence and development of Parkinson's disease (PD). Rutin, a natural botanical ingredient, has been shown to have antioxidant properties. Therefore, the aim of this study was to investigate the ... ...

Abstract	Oxidative stress plays a crucial role in the occurrence and development of Parkinson's disease (PD). Rutin, a natural botanical ingredient, has been shown to have antioxidant properties. Therefore, the aim of this study was to investigate the neuroprotective effects of rutin on PD and the underlying mechanisms. MPP
MeSH term(s)	Humans ; Reactive Oxygen Species/metabolism ; Antioxidants/pharmacology ; Mitophagy ; 1-Methyl-4-phenylpyridinium/toxicity ; Rutin/pharmacology ; NF-E2-Related Factor 2/metabolism ; Neuroblastoma ; Oxidative Stress ; Cell Line, Tumor ; Parkinson Disease/drug therapy ; Microtubule-Associated Proteins/metabolism ; Apoptosis
Chemical Substances	Reactive Oxygen Species ; Antioxidants ; 1-Methyl-4-phenylpyridinium (R865A5OY8J) ; Rutin (5G06TVY3R7) ; NF-E2-Related Factor 2 ; Microtubule-Associated Proteins
Language	English
Publishing date	2023-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036826-4
ISSN	1476-3524 ; 1029-8428
ISSN (online)	1476-3524
ISSN	1029-8428
DOI	10.1007/s12640-023-00636-5
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Zs.A 5749: Show issues

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Article: Performance-Based or Politic-Related Decomposition of Environmental Targets: A Multilevel Analysis in China

Zhang, Pan / Wu, Jiannan

Sustainability. 2018 Sept. 25, v. 10, no. 10

2018

Abstract: China relies on the total pollutant emission control and environmental target responsibility system to curb environmental pollution and improve energy conversation. How the central government breaks down environmental targets among provincial governments ...

Abstract	China relies on the total pollutant emission control and environmental target responsibility system to curb environmental pollution and improve energy conversation. How the central government breaks down environmental targets among provincial governments lies at the core, but little research has been done to explore the determinants of environmental target-setting empirically. This work models the decomposition process of environmental targets by focusing on the roles of historical performance and provinces’ political status. With the method of hierarchical linear model, data on five kinds of environmental obligatory targets (energy consumption per unit GDP and other four kinds of pollutants) during China’s “12th Five-year Plan” period is used to test the hypotheses. The results show that provincial historical structural performance is negatively significantly correlated with their environmental target levels, while the effects of historical scale performance and intensity performance are not significant. Besides, provinces with higher political rankings tend to be allocated higher targets, which is in accordance with the model effect hypothesis rather than the bargaining effect hypothesis.
Keywords	energy ; linear models ; politics ; pollutants ; pollution ; China
Language	English
Dates of publication	2018-0925
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518383-7
ISSN	2071-1050
ISSN	2071-1050
DOI	10.3390/su10103410
Database	NAL-Catalogue (AGRICOLA)

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