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  1. Article ; Online: Synthesis of Functionalized Hexahydrocarbazoles by Beckmann Elimination and Nucleophile-Intercepted Beckmann Fragmentation.

    Saha, Dhiman / Protich, Zachary / Wu, Jimmy

    Organic letters

    2023  Volume 26, Issue 1, Page(s) 18–21

    Abstract: The Beckmann elimination and nucleophile-intercepted Beckmann fragmentation (NuBFr) of oximes starting from regioisomeric indolinyl bicyclic ketones lead to products that are subjected to further synthetic manipulations and ultimately result in the ... ...

    Abstract The Beckmann elimination and nucleophile-intercepted Beckmann fragmentation (NuBFr) of oximes starting from regioisomeric indolinyl bicyclic ketones lead to products that are subjected to further synthetic manipulations and ultimately result in the stereospecific formation of densely functionalized hexahydrocarbazoles. The Pd-catalyzed Suzuki-Miyaura cross-coupling reaction of a key alkenyl bromide intermediate with various boronic acids gives arylated products.
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Regiodivergent (3 + 2) annulation reactions of oxyallyl cations.

    Protich, Zachary / Lowder, Leah L / Hughes, Russell P / Wu, Jimmy

    Chemical science

    2023  Volume 14, Issue 19, Page(s) 5196–5203

    Abstract: We report a new method for the regiodivergent dearomative (3 + 2) reaction between 3-substituted indoles and oxyallyl cations. Access to both regioisomeric products is possible and is contingent on the presence or absence of a bromine atom on the ... ...

    Abstract We report a new method for the regiodivergent dearomative (3 + 2) reaction between 3-substituted indoles and oxyallyl cations. Access to both regioisomeric products is possible and is contingent on the presence or absence of a bromine atom on the substituted oxyallyl cation. In this way, we are able to prepare molecules that contain highly-hindered, stereodefined, vicinal, quaternary centers. Detailed computational studies employing energy decomposition analysis (EDA) at the DFT level establishes that regiochemical control arises from either reactant distortion energy or orbital mixing and dispersive forces, depending on the oxyallyl cation. Examination of the Natural Orbitals for Chemical Valence (NOCV) confirms that indole acts as the nucleophilic partner in the annulation reaction.
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d2sc06999g
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  3. Article ; Online: Establishment of an open biomedical database for commercial spaceflight.

    Urquieta, Emmanuel / Wu, Jimmy / Hury, James / Donoviel, Dorit

    Nature medicine

    2022  Volume 28, Issue 4, Page(s) 611–612

    MeSH term(s) Aerospace Medicine ; Data Management ; Databases, Factual ; Space Flight
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Letter ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-01761-y
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  4. Article: Challenges to leather glove quality.

    Wu, Jimmy

    Occupational health & safety (Waco, Tex.)

    2013  Volume 82, Issue 4, Page(s) 24, 26

    MeSH term(s) Animals ; Decision Making ; Gloves, Protective/economics ; Gloves, Protective/standards ; Humans ; Occupational Health ; Tanning
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752994-6
    ISSN 0362-4064
    ISSN 0362-4064
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    In stock of ZB MED Cologne/Königswinter

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  5. Book ; Online: Metric-Fair Classifier Derandomization

    Wu, Jimmy / Chen, Yatong / Liu, Yang

    2022  

    Abstract: We study the problem of classifier derandomization in machine learning: given a stochastic binary classifier $f: X \to [0,1]$, sample a deterministic classifier $\hat{f}: X \to \{0,1\}$ that approximates the output of $f$ in aggregate over any data ... ...

    Abstract We study the problem of classifier derandomization in machine learning: given a stochastic binary classifier $f: X \to [0,1]$, sample a deterministic classifier $\hat{f}: X \to \{0,1\}$ that approximates the output of $f$ in aggregate over any data distribution. Recent work revealed how to efficiently derandomize a stochastic classifier with strong output approximation guarantees, but at the cost of individual fairness -- that is, if $f$ treated similar inputs similarly, $\hat{f}$ did not. In this paper, we initiate a systematic study of classifier derandomization with metric fairness guarantees. We show that the prior derandomization approach is almost maximally metric-unfair, and that a simple ``random threshold'' derandomization achieves optimal fairness preservation but with weaker output approximation. We then devise a derandomization procedure that provides an appealing tradeoff between these two: if $f$ is $\alpha$-metric fair according to a metric $d$ with a locality-sensitive hash (LSH) family, then our derandomized $\hat{f}$ is, with high probability, $O(\alpha)$-metric fair and a close approximation of $f$. We also prove generic results applicable to all (fair and unfair) classifier derandomization procedures, including a bias-variance decomposition and reductions between various notions of metric fairness.

    Comment: Proceedings of ICML 2022
    Keywords Computer Science - Machine Learning ; Computer Science - Computers and Society ; Computer Science - Data Structures and Algorithms
    Subject code 006
    Publishing date 2022-06-15
    Publishing country us
    Document type Book ; Online
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  6. Article: Catalytic vinylogous cross-coupling reactions of rhenium vinylcarbenoids.

    Chen, Ji / Wu, Jimmy

    Chemical science

    2018  Volume 9, Issue 9, Page(s) 2489–2492

    Abstract: We report the first example of the rhenium-catalyzed allylation reaction of indolyl compounds by means of cross-coupling with propargyl ethers as non-obvious allylating reagents. Data from isotope-labeling and kinetic isotopic studies are consistent with ...

    Abstract We report the first example of the rhenium-catalyzed allylation reaction of indolyl compounds by means of cross-coupling with propargyl ethers as non-obvious allylating reagents. Data from isotope-labeling and kinetic isotopic studies are consistent with a mechanism that proceeds by vinylidene formation as the rate determining step, followed by 1,5-hydride shift to generate a key rhenium vinylcarbenoid complex. Bond formation occurs at the vinylogous site and the reaction is conveniently carried out in air.
    Language English
    Publishing date 2018-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/c7sc05477g
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  7. Article: Review of recent advances in nucleophilic C–F bond-forming reactions at sp3 centers

    Wu, Jimmy

    Tetrahedron letters. 2014 July 30, v. 55, no. 31

    2014  

    Abstract: Because of the broad utility of organofluorine compounds, efficient nucleophilic fluorination reactions are of high synthetic value. This is because fluoride is generally less costly, more readily available as its positron-emitting isotope (18F−), and ... ...

    Abstract Because of the broad utility of organofluorine compounds, efficient nucleophilic fluorination reactions are of high synthetic value. This is because fluoride is generally less costly, more readily available as its positron-emitting isotope (18F−), and has a higher specific activity than its ‘F+’ counterparts. New reactions for the construction of CF bonds, that make use of contemporary chemical methods, have only lately begun to emerge. This review provides a brief summary of some of the recent disclosures in transition metal-catalyzed fluorination reactions at sp3-hybridized carbon centers with nucleophilic fluoride sources.
    Keywords carbon ; chemical bonding ; chemical reactions ; chemical structure ; fluorides ; isotopes ; Lewis bases ; organofluorine compounds
    Language English
    Dates of publication 2014-0730
    Size p. 4289-4294.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2014.06.006
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    Zs.A 2837: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: A Long Short-Term Memory Network Stock Price Prediction with Leading Indicators.

    Wu, Jimmy Ming-Tai / Sun, Lingyun / Srivastava, Gautam / Lin, Jerry Chun-Wei

    Big data

    2021  Volume 9, Issue 5, Page(s) 343–357

    Abstract: The accuracy of the prediction of stock price fluctuations is crucial for investors, and it helps investors manage funds better when formulating trading strategies. Using forecasting tools to get a predicted value that is closer to the actual value from ... ...

    Abstract The accuracy of the prediction of stock price fluctuations is crucial for investors, and it helps investors manage funds better when formulating trading strategies. Using forecasting tools to get a predicted value that is closer to the actual value from a given financial data set has always been a major goal of financial researchers and a problem. In recent years, people have paid particular attention to stocks, and gradually used various tools to predict stock prices. There is more than one factor that affects financial trends, and people need to consider it from all aspects, so research on stock price fluctuations has also become extremely difficult. This paper mainly studies the impact of leading indicators on the stock market. The framework used in this article is proposed based on long short-term memory (LSTM). In this study, leading indicators that affect stock market volatility are added, and the proposed framework is thus named as a stock tending prediction framework based on LSTM with leading indicators (LSTMLI). This study uses stock markets in the United States and Taiwan, respectively, with historical data, futures, and options as data sets to predict stock prices in these two markets. We measure the predictive performance of LSTMLI relative to other neural network models, and the impact of leading indicators on stock prices is studied. Besides, when using LSTMLI to predict the rise and fall of stock prices in the article, the conventional regression method is not used, but the classification method is used, which can give a qualitative output based on the data set. The experimental results show that the LSTMLI model using the classification method can effectively reduce the prediction error. Also, the data set with leading indicators is better than the prediction results of the single historical data using the LSTMLI model.
    MeSH term(s) Forecasting ; Humans ; Memory, Short-Term ; Neural Networks, Computer
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article
    ISSN 2167-647X
    ISSN (online) 2167-647X
    DOI 10.1089/big.2020.0391
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  9. Article ; Online: Staying Cool in Space: A Review of Therapeutic Hypothermia and Potential Application for Space Medicine.

    Rosahl, Sophie C / Covarrubias, Claudia / Wu, Jimmy H / Urquieta, Emmanuel

    Therapeutic hypothermia and temperature management

    2021  Volume 12, Issue 2, Page(s) 115–128

    Abstract: Despite rigorous health screenings, medical incidents during spaceflight missions cannot be avoided. With long-duration exploration flights on the rise, the likelihood of critical medical conditions with no suitable treatment on board will increase. ... ...

    Abstract Despite rigorous health screenings, medical incidents during spaceflight missions cannot be avoided. With long-duration exploration flights on the rise, the likelihood of critical medical conditions with no suitable treatment on board will increase. Therapeutic hypothermia (TH) could serve as a bridge treatment in space prolonging survival and reducing neurological damage in ischemic conditions such as stroke and cardiac arrest. We conducted a review of published studies to determine the potential and challenges of TH in space based on its physiological effects, the cooling methods available, and clinical evidence on Earth. Currently, investigators have found that application of low normothermia leads to better outcomes than mild hypothermia. Data on the impact of hypothermia on a favorable neurological outcome are inconclusive due to lack of standardized protocols across hospitals and the heterogeneity of medical conditions. Adverse effects with systemic cooling are widely reported, and could be reduced through selective brain cooling and pharmacological cooling, promising techniques that currently lack clinical evidence. We hypothesize that TH has the potential for application as supportive treatment for multiple medical conditions in space and recommend further investigation of the concept in feasibility studies.
    MeSH term(s) Aerospace Medicine ; Heart Arrest/therapy ; Humans ; Hypothermia/therapy ; Hypothermia, Induced/methods ; Stroke/therapy
    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2609342-X
    ISSN 2153-7933 ; 2153-7658
    ISSN (online) 2153-7933
    ISSN 2153-7658
    DOI 10.1089/ther.2020.0041
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  10. Article: Top-

    Wu, Jimmy Ming-Tai / Wei, Min / Wu, Mu-En / Tayeb, Shahab

    The Journal of supercomputing

    2021  Volume 78, Issue 3, Page(s) 3976–3997

    Abstract: Top- ...

    Abstract Top-
    Language English
    Publishing date 2021-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1479917-0
    ISSN 1573-0484 ; 0920-8542
    ISSN (online) 1573-0484
    ISSN 0920-8542
    DOI 10.1007/s11227-021-04005-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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