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  1. Article ; Online: Targeting regulated cell death with plant natural compounds for cancer therapy: A revisited review of apoptosis, autophagy‐dependent cell death, and necroptosis

    Yang, Yuanyuan / Chen, Yanmei / Wu, Jun Hao / Ren, Yueting / Liu, Bo / Zhang, Yan / Yu, Haiyang

    Phytotherapy Research. 2023 Apr., v. 37, no. 4 p.1488-1525

    2023  

    Abstract: Regulated cell death (RCD) refers to programmed cell death regulated by various protein molecules, such as apoptosis, autophagy‐dependent cell death, and necroptosis. Accumulating evidence has recently revealed that RCD subroutines have several links to ... ...

    Abstract Regulated cell death (RCD) refers to programmed cell death regulated by various protein molecules, such as apoptosis, autophagy‐dependent cell death, and necroptosis. Accumulating evidence has recently revealed that RCD subroutines have several links to many types of human cancer; therefore, targeting RCD with pharmacological small‐molecule compounds would be a promising therapeutic strategy. Moreover, plant natural compounds, small‐molecule compounds synthesized from plant sources, and their derivatives have been widely reported to regulate different RCD subroutines to improve potential cancer therapy. Thus, in this review, we focus on updating the intricate mechanisms of apoptosis, autophagy‐dependent cell death, and necroptosis in cancer. Moreover, we further discuss several representative plant natural compounds and their derivatives that regulate the above‐mentioned three subroutines of RCD, and their potential as candidate small‐molecule drugs for the future cancer treatment.
    Keywords apoptosis ; cancer therapy ; humans ; necroptosis ; phytotherapy ; research
    Language English
    Dates of publication 2023-04
    Size p. 1488-1525.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7738
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3092: Show issues Location:
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  2. Article ; Online: Targeting regulated cell death with plant natural compounds for cancer therapy: A revisited review of apoptosis, autophagy-dependent cell death, and necroptosis.

    Yang, Yuanyuan / Chen, Yanmei / Wu, Jun Hao / Ren, Yueting / Liu, Bo / Zhang, Yan / Yu, Haiyang

    Phytotherapy research : PTR

    2023  Volume 37, Issue 4, Page(s) 1488–1525

    Abstract: Regulated cell death (RCD) refers to programmed cell death regulated by various protein molecules, such as apoptosis, autophagy-dependent cell death, and necroptosis. Accumulating evidence has recently revealed that RCD subroutines have several links to ... ...

    Abstract Regulated cell death (RCD) refers to programmed cell death regulated by various protein molecules, such as apoptosis, autophagy-dependent cell death, and necroptosis. Accumulating evidence has recently revealed that RCD subroutines have several links to many types of human cancer; therefore, targeting RCD with pharmacological small-molecule compounds would be a promising therapeutic strategy. Moreover, plant natural compounds, small-molecule compounds synthesized from plant sources, and their derivatives have been widely reported to regulate different RCD subroutines to improve potential cancer therapy. Thus, in this review, we focus on updating the intricate mechanisms of apoptosis, autophagy-dependent cell death, and necroptosis in cancer. Moreover, we further discuss several representative plant natural compounds and their derivatives that regulate the above-mentioned three subroutines of RCD, and their potential as candidate small-molecule drugs for the future cancer treatment.
    MeSH term(s) Humans ; Autophagic Cell Death ; Necroptosis ; Apoptosis ; Regulated Cell Death ; Neoplasms/drug therapy
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Shi's Yi-Qi Bu-Shen Tong-Luo decoction combined with manipulation in the management of wrist stiffness after distal radius fracture: Study protocol clinical trial (SPIRIT Compliant).

    Wu, Hai-Yang / Wang, Yi-Ru / Gui, Jing / Wen, Guo-Wei / Tang, Zhen-Yin / Liu, Ping / Wu, Jun-Hao

    Medicine

    2020  Volume 99, Issue 9, Page(s) e19308

    Abstract: Introduction: Wrist stiffness is a common sequela of distal radial fractures. Manipulation is generally used and effective, but problems exist, such as intense pain, swelling during the process of manipulation and long treatment period. Therefore, a ... ...

    Abstract Introduction: Wrist stiffness is a common sequela of distal radial fractures. Manipulation is generally used and effective, but problems exist, such as intense pain, swelling during the process of manipulation and long treatment period. Therefore, a combinative therapeutic strategy is necessary to benefit rehabilitation after distal radius fracture. Shi's Yi-Qi Bu-Shen Tong-Luo decoction (BTD) combined with wrist manipulation has been used in the Shanghai Ninth People's Hospital Huangpu Branch in last few decades. BTD has potential therapeutic effects on rehabilitation after distal radius fracture, which should be evaluated by rigorous clinical trial.
    Methods/design: A randomized, double-blind, placebo-controlled clinical trial will be conducted to determine the efficiency of BTD in relief of wrist stiffness and pain and function rehabilitation. A total of 80 wrist stiffness patients with or without pain and edema will be enrolled, and treated with wrist manipulation plus BTD or placebo for 4 weeks. The primary outcome measure is the Cooney wrist score. The second outcome measures include pain numerical rating scale, patient rated wrist evaluation, 36-item short form health survey questionnaire, and side effects.
    Discussion: Although BTD has shown effects on rehabilitation after distal radius fracture in the Shanghai Ninth People's Hospital Huangpu Branch for decades, the universality of this efficacy needs evaluated. The results of this trial will provide a convincing evidence.
    Trial registration: ChiCTR2000029260, January 19, 2020.
    MeSH term(s) Adult ; China ; Drugs, Chinese Herbal/standards ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Physical Therapy Modalities/standards ; Physical Therapy Modalities/statistics & numerical data ; Radius Fractures/complications ; Radius Fractures/therapy ; Surveys and Questionnaires ; Treatment Outcome ; Wrist Joint/abnormalities ; Wrist Joint/physiology
    Chemical Substances Drugs, Chinese Herbal ; yi-qi-bu-shen
    Language English
    Publishing date 2020-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000019308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tai Chi on bone mineral density of postmenopausal osteoporosis: A protocol for systematic review and meta-analysis.

    Wu, Hai-Yang / Wang, Yi-Ru / Wen, Guo-Wei / Tang, Zhen-Yin / Yu, Yi-Qun / Zhang, Ji-Ren / Liu, Ping / Wu, Jun-Hao

    Medicine

    2020  Volume 99, Issue 36, Page(s) e21928

    Abstract: Background: Osteoporosis is a clinically common metabolic disease, especially in postmenopausal women. Tai Chi might be beneficial in osteoporosis patients. This study will be performed to examine the effects of Tai Chi on bone mineral density of ... ...

    Abstract Background: Osteoporosis is a clinically common metabolic disease, especially in postmenopausal women. Tai Chi might be beneficial in osteoporosis patients. This study will be performed to examine the effects of Tai Chi on bone mineral density of postmenopausal osteoporosis.
    Methods: We will search the electronical databases and hand-searching journals or reference lists. The study screening and data extraction will be carried out by 2 investigators independently. The primary outcome is bone mineral density (lumbar spine, Ward's triangle, trochanter, proximal femur, femoral neck, or total hip). Secondary outcomes are pain score, alkaline phosphatase, osteocalcin, and adverse effects. Review Manager V.5.3 software will be used to compute the data.
    Results: The results of the study will provide a reliable evidence to assess the effects of Tai Chi on bone mineral density of postmenopausal osteoporosis.
    Conclusion: The conclusion of our systematic review will answer whether Tai Chi is an effective intervention to improve bone mineral density of postmenopausal osteoporosis.
    MeSH term(s) Bone Density ; Female ; Humans ; Meta-Analysis as Topic ; Osteoporosis, Postmenopausal/therapy ; Pain Measurement ; Systematic Reviews as Topic ; Tai Ji
    Language English
    Publishing date 2020-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000021928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
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