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  1. Article ; Online: Construction of self-repairing polyethersulfone membrane with high density hydrophilic microregions by two dimensional restricted channels for enhanced dyes/salts selective separation.

    Liu, Shenghui / Zhang, Jintuan / Theliander, Anette / Chen, Weibin / Wu, Junyong / Wu, Leixin

    publication RETRACTED

    Environmental research

    2024  Volume 247, Page(s) 118266

    Abstract: Based on the dye/salts separation efficiency and membrane injury caused by serious pollution of dye/salts wastewater, this study constructed a 2D tight ultrafiltration membrane that could both solve the membrane injury problem and improve the dye/salts ... ...

    Abstract Based on the dye/salts separation efficiency and membrane injury caused by serious pollution of dye/salts wastewater, this study constructed a 2D tight ultrafiltration membrane that could both solve the membrane injury problem and improve the dye/salts separation efficiency, the compatibility of good self-healing performance and penetration performance by 2D material magnesium-aluminum Layered double hydroxide (MgAl-LDH). The self-repairing of physical injury was achieved through the swelling effect of AMPS-PAN, this property was proved by permeate flux, the retention performance of salts in dye/salts solution, the comparison of scanning electron microscope (SEM), and the mechanical strength after physical injury. The healing of chemical injury occured through the reaction of CC and polyethersulfone chain breakage, which was confirmed by X-ray photoelectron spectroscopy (XPS), permeate flux, the retention performance of salts in dye/salts solution, and mechanical property. The high separation efficiency of dye/salts was achieved through 2D material MgAl-LDH, which was proved by separation selectivity ɑ. The compatibility of good self-healing performance and penetration performance was obtained by 2D material MgAl-LDH, which was proved by the penetration and self-healing performance. Morever, the membrane illustrated excellent both permeability and dye/sals separation efficiency, just like the permeate flux, the retention performance of sodium sulfate in methyl blue/sodium sulfate solution, the retention performance of Na
    MeSH term(s) Salts ; Coloring Agents/chemistry ; Sulfates ; Benzenesulfonates ; Polymers ; Sulfones
    Chemical Substances Salts ; sodium sulfate (0YPR65R21J) ; Methyl Blue (9ZI2A1BMBB) ; polyether sulfone (25667-42-9) ; Coloring Agents ; Sulfates ; Benzenesulfonates ; Polymers ; Sulfones
    Language English
    Publishing date 2024-01-20
    Publishing country Netherlands
    Document type Journal Article ; Retracted Publication
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118266
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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Retraction notice to Construction of self-repairing polyethersulfone membrane with high density hydrophilic microregions by two dimensional restricted channels for enhanced dyes/salts selective separation [Environ. Res. 247 (2027) 118266].

    Liu, Shenghui / Zhang, Jintuan / Theliander, Anette / Chen, Weibin / Wu, Junyong / Wu, Leixin

    Environmental research

    2024  Volume 252, Issue Pt 3, Page(s) 119051

    Language English
    Publishing date 2024-05-01
    Publishing country Netherlands
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.119051
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Insight into the nature of the noncovalent interactions of furan, pyridine, and pyrazine with AtX

    Zhang, Xiaojiao / Wu, Junyong / Yan, Hua / Chen, Hao / Mao, Wanxin / Dai, Guoliang

    J Mol Model. 2023 Jan., v. 29, no. 1, p. 13

    2023  , Page(s) 13

    Abstract: CONTEXT: The σ-hole, counterintuitive σ-hole, and lone pair-π interaction complexes formed between three heterocyclic compounds (C4H4O, C5H5N, and C4H4N2) and AtX (X = F, Cl, and Br) have been investigated with the MP2/aug-cc-pVTZ. The intensity of three ...

    Abstract CONTEXT: The σ-hole, counterintuitive σ-hole, and lone pair-π interaction complexes formed between three heterocyclic compounds (C4H4O, C5H5N, and C4H4N2) and AtX (X = F, Cl, and Br) have been investigated with the MP2/aug-cc-pVTZ. The intensity of three noncovalent interactions formed by different heterocyclic compounds was compared, and the properties of these three noncovalent interactions were discussed. SAPT analysis shows that the electrostatic energy is dominant to the stronger interactions in the σ-hole and counterintuitive σ-hole complexes, while the dispersion energy is the main force responsible for the weaker interactions in the lone pair-π complexes. NBO analysis has also been employed. METHODS: All the structures were optimized at the MP2/aug-cc-pVTZ (aug-cc-pVTZ-pp for Br to account for relativistic effects) level using the Gaussian 03W package (Gaussian, Inc., Wallingford, CT, USA). The basis bet superposition error (BSSE) is corrected using counterpoise method proposed by Boys and Bernardi. The NBO population analysis was carried out. The molecular electrostatic surface potentials of monomers were calculated by WFA-SAS program package. The interaction energies of the three types complexes were decomposed by using the symmetric adaptive perturbation theory SAPT of the open source ab initio electronic structure software package psi 4.0.0-beta5.
    Keywords computer software ; energy ; furans ; mathematical theory ; models ; pyrazines ; pyridines
    Language English
    Dates of publication 2023-01
    Size p. 13
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-022-05411-5
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  4. Article ; Online: Investigations into the nature of halogen- and hydrogen-bonding interactions of some heteroaromatic rings with dichlorine monoxide.

    Wu, Junyong

    Journal of molecular modeling

    2014  Volume 20, Issue 9, Page(s) 2424

    Abstract: We have studied the structures, properties, and nature of halogen- and hydrogen-bonding interactions between some heteroaromatic rings (C(5)H(5)N, C(4)H(4)O, and C(4)H(4)S) with Cl(2)O at the MP2/aug-cc-pVTZ level. We also considered the solvent effect ... ...

    Abstract We have studied the structures, properties, and nature of halogen- and hydrogen-bonding interactions between some heteroaromatic rings (C(5)H(5)N, C(4)H(4)O, and C(4)H(4)S) with Cl(2)O at the MP2/aug-cc-pVTZ level. We also considered the solvent effect on the halogen bonds and hydrogen bonds in the C(5)H(5)N-Cl(2)O complexes and found that the solvent has a weakening effect on the π-type halogen bond and hydrogen bond but a prominent enhancing effect on σ-type halogen bond. The complexes have also been analyzed with symmetry adapted perturbation theory method (SAPT).
    Language English
    Publishing date 2014-08-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-014-2424-0
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  5. Article ; Online: Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1.

    He, Jun / Hou, Xuyang / Wu, Junyong / Wang, Kunpeng / Qi, Xiaoyan / Wei, Zuxing / Sun, Yin / Wang, Cong / Yao, Hongliang / Liu, Kuijie

    International journal of biological sciences

    2024  Volume 20, Issue 5, Page(s) 1707–1728

    Abstract: Acute pancreatitis (AP) is a common abdominal disease that typically resolves on its own, but the mortality rate dramatically increases when it progresses to severe acute pancreatitis (SAP). In this study, we investigated the molecular mechanism ... ...

    Abstract Acute pancreatitis (AP) is a common abdominal disease that typically resolves on its own, but the mortality rate dramatically increases when it progresses to severe acute pancreatitis (SAP). In this study, we investigated the molecular mechanism underlying the development of SAP from AP. We utilized two SAP models induced by pancreatic duct ligation and caerulein administration. Transcriptomic and proteomic analyses were subsequently performed to determine the mRNA and protein expression profiles of pancreatic samples from SAP and AP model and normal mice. To explore the role of Hspb1 in SAP, we used Hspb1 knockout (KO) mice, a genetically engineered chronic pancreatitis strain (T7D23A), Anxa2 KO mice, and acinar cell-specific Prdx1 knockout mice. Additionally, various in vivo and in vitro assays were performed to elucidate the molecular events and direct targets of Hspb1 in acinar cells. We found that Hspb1 expression was upregulated in AP samples but significantly reduced in acinar cells from SAP samples. KO or inhibition of Hspb1 worsened AP, while AAV8-Hspb1 administration mitigated the severity of SAP and reduced remote organ damage in mice. Furthermore, AAV8-Hspb1 treatment prevented the development of chronic pancreatitis. We found that KO or inhibition of Hspb1 promoted acinar cell death through apoptosis and ferroptosis but not necroptosis or autophagy by increasing reactive oxygen species (ROS) and lipid ROS levels. Mechanistically, Hspb1 directly interacted with Anxa2 to decrease its aggregation and phosphorylation, interact with the crucial antioxidant enzyme Prdx1, and maintain its antioxidative activity by decreasing Thr-90 phosphorylation. Notably, the overexpression of Hspb1 did not have a protective effect on acinar-specific Prdx1 knockout mice. In summary, our findings shed light on the role of Hspb1 in acinar cells. We showed that targeting Hspb1/Anxa2/Prdx1 could serve as a potential therapeutic strategy for SAP.
    MeSH term(s) Animals ; Mice ; Acute Disease ; Antioxidants/pharmacology ; Apoptosis/genetics ; Ferroptosis ; Mice, Knockout ; Pancreatitis, Chronic ; Peroxiredoxins/genetics ; Peroxiredoxins/pharmacology ; Proteomics ; Reactive Oxygen Species
    Chemical Substances Antioxidants ; Peroxiredoxins (EC 1.11.1.15) ; Prdx1 protein, mouse (EC 1.11.1.15) ; Reactive Oxygen Species ; ANXA2 protein, human ; HSPB1 protein, human
    Language English
    Publishing date 2024-02-25
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.84494
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  6. Article ; Online: Enhancing X-Ray Sensitization with Multifunctional Nanoparticles.

    Liu, Jiayi / Wu, JunYong / Chen, Taili / Yang, Bin / Liu, XiangPing / Xi, Jing / Zhang, Ziyang / Gao, Yawen / Li, ZhiHong

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2400954

    Abstract: In the progression of X-ray-based radiotherapy for the treatment of cancer, the incorporation of nanoparticles (NPs) has a transformative impact. This study investigates the potential of NPs, particularly those comprised of high atomic number elements, ... ...

    Abstract In the progression of X-ray-based radiotherapy for the treatment of cancer, the incorporation of nanoparticles (NPs) has a transformative impact. This study investigates the potential of NPs, particularly those comprised of high atomic number elements, as radiosensitizers. This aims to optimize localized radiation doses within tumors, thereby maximizing therapeutic efficacy while preserving surrounding tissues. The multifaceted applications of NPs in radiotherapy encompass collaborative interactions with chemotherapeutic, immunotherapeutic, and targeted pharmaceuticals, along with contributions to photodynamic/photothermal therapy, imaging enhancement, and the integration of artificial intelligence technology. Despite promising preclinical outcomes, the paper acknowledges challenges in the clinical translation of these findings. The conclusion maintains an optimistic stance, emphasizing ongoing trials and technological advancements that bolster personalized treatment approaches. The paper advocates for continuous research and clinical validation, envisioning the integration of NPs as a revolutionary paradigm in cancer therapy, ultimately enhancing patient outcomes.
    Language English
    Publishing date 2024-04-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202400954
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  7. Article: Recent Advance of Nanomaterial-Mediated Tumor Therapies in the Past Five Years.

    Hao, Xinyan / Wu, Junyong / Xiang, DaXiong / Yang, Yongyu

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 846715

    Abstract: Cancer has posed a major threat to human life and health with a rapidly increasing number of patients. The complexity and refractory of tumors have brought great challenges to tumor treatment. In recent years, nanomaterials and nanotechnology have ... ...

    Abstract Cancer has posed a major threat to human life and health with a rapidly increasing number of patients. The complexity and refractory of tumors have brought great challenges to tumor treatment. In recent years, nanomaterials and nanotechnology have attracted more attention and greatly improved the efficiency of tumor therapies and significantly prolonged the survival period, whether for traditional tumor treatment methods such as radiotherapy, or emerging methods, such as phototherapy and immunotherapy, sonodynamic therapy, chemodynamic therapy and RNA interference therapeutics. Various monotherapies have obtained positive results, while combination therapies are further proposed to prevent incomplete eradication and recurrence of tumors, strengthen tumor killing efficacy with minimal side effects. In view of the complementary promotion effects between different therapies, it is vital to utilize nanomaterials as the link between monotherapies to achieve synergistic performance. Further development of nanomaterials with efficient tumor-killing effect and better biosafety is more in line with the needs of clinical treatment. In a word, the development of nanomaterials provides a promising way for tumor treatment, and here we will review the emerging nanomaterials towards radiotherapy, phototherapy and immunotherapy, and summarized the developed nanocarriers applied for the tumor combination therapies in the past 5 years, besides, the advances of some other novel therapies such as sonodynamic therapy, chemodynamic therapy, and RNA interference therapeutics have also been mentioned.
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.846715
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  8. Article ; Online: Remote Sensing Analysis of Sediment Transport Dynamics under Tidal Action in the Pearl River Estuary

    Pan Hongzhou / He Yingqing / Feng Youbin / Xiong Longhai / Wu Junyong / Yang Min

    Redai dili, Vol 42, Iss 5, Pp 843-

    2022  Volume 853

    Abstract: The Pearl River Estuary is the core water area of the Greater Bay area of Guangdong, Hong Kong, and Macao. The river net of the Pearl River Delta is dense and staggered, and its sediment transport process is complex due to the influence of runoff and ... ...

    Abstract The Pearl River Estuary is the core water area of the Greater Bay area of Guangdong, Hong Kong, and Macao. The river net of the Pearl River Delta is dense and staggered, and its sediment transport process is complex due to the influence of runoff and tides. While sediment transport is a key process in river evolution, it is directly related to the flood control water supply and shipping safety of the Greater Bay area. To investigate the extent of the effect of sediment transport on the Greater Bay area, we analyzed the inversion of water surface sediment under tidal action using in-situ data, high-frequency GF-4 satellite image data (including multi temporal images), water quality, and reflection spectrum data from December 28, 2019 and June 20, 2020. The Mean Absolute Percentage Error (MAPE) value for atmospheric correction was 18.85%. We built several sediment inversion models based on the near-infrared, red, and blue band ratio of the GF-4 satellite image data. The best suited models for the flood and dry seasons had MAPE errors of 30% and 23.54%, respectively. We further obtained the continuous dynamic monitoring results and the daily change of sediment transport in the Pearl River Estuary at an interval of 2 h. The high frequency remote sensing inversion results gave a clear picture of the overall sediment transport dynamics of the estuary. Compared with the in-situ sediment concentration, the inversion results were consistent with the variation of sediment concentration in the tidal cycle. Moreover, we analyzed the dynamic characteristics of sediment transport under the influence of runoff tide. We found that with the rising tide, the overall suspended sediment concentration in Lingding Bay decreased considerably, Lingding Bay is a trumpet shaped estuary located outside the Pearl River Estuary. The north area of Neilingding Island is affected by human activities, thus the riverbed is degraded owing to reduced sediment input and reduced sediment resuspension to the surface. This creates a large water area ...
    Keywords pearl river estuary ; tide action ; sediment transport ; gf-4 ; remote sensing inversion ; Geography (General) ; G1-922
    Language Chinese
    Publishing date 2022-05-01T00:00:00Z
    Publisher Editorial Committee of Tropical Geography
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: The Microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid‐β by microglia

    Huang, Si / Liao, Xiaoli / Wu, Junyong / Zhang, Xiaojie / Li, Yamin / Xiang, Daxiong / Luo, Shilin

    FEBS letters. 2022 Apr., v. 596, no. 8

    2022  

    Abstract: Considerable evidence links the microglial transmembrane receptor TREM2 to the progression of Alzheimer's disease through its involvement in Aβ phagocytosis by microglia. While previous studies have mainly focused on the phagocytic regulation of ... ...

    Abstract Considerable evidence links the microglial transmembrane receptor TREM2 to the progression of Alzheimer's disease through its involvement in Aβ phagocytosis by microglia. While previous studies have mainly focused on the phagocytic regulation of microglia itself, the antigen presentation of microglial exosomes in the process of immunity has been less investigated. Here, we identified TREM2 expressed on the membrane of microglial exosomes and found that it controlled exosome secretion without affecting exosome size. Microglial exosomes bind to Aβ in a TREM2‐dependent manner, which changes the inflammatory environment around Aβ and promotes microglia to phagocytose Aβ. These findings delineate a novel exosome‐mediated mechanism of microglial cell–Aβ crosstalk that facilitates Aβ clearance under either physiological or pathological conditions in the central nervous system.
    Keywords Alzheimer disease ; antigen presentation ; central nervous system ; exosomes ; neuroglia ; phagocytosis ; secretion
    Language English
    Dates of publication 2022-04
    Size p. 1059-1071.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14336
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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: Study on the halogen bond and π-π stacking interaction between fluoro substituted iodobenzene and pyrazine.

    Zhu, Hongyu / Wu, Junyong / Dai, Guoliang

    Journal of molecular modeling

    2020  Volume 26, Issue 12, Page(s) 333

    Abstract: The halogen bonding and π-π stacking interactions between pyrazine ( ... ...

    Abstract The halogen bonding and π-π stacking interactions between pyrazine (C
    Language English
    Publishing date 2020-11-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-020-04586-z
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