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  1. Article ; Online: Combination of Aroxybutynin and Atomoxetine in Obstructive Sleep Apnea: Is the Effect of One Plus One Greater than Two?

    Wu, Yanjuan / Gan, Qiming / Liu, Quanzhen / Wu, Kang

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 6, Page(s) 763–764

    MeSH term(s) Humans ; Atomoxetine Hydrochloride/therapeutic use ; Sleep Apnea, Obstructive/drug therapy ; Polysomnography
    Chemical Substances Atomoxetine Hydrochloride (57WVB6I2W0)
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202310-1799LE
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  2. Article ; Online: Numerical computation of preimage domains for spiral slit regions and simulation of flow around bodies.

    Wu, Kang / Lu, Yibin

    Mathematical biosciences and engineering : MBE

    2022  Volume 20, Issue 1, Page(s) 720–736

    Abstract: In this paper, we propose the iterative numerical methods to calculate the conformal preimage domains for the specified logarithmic spiral slit regions and develop the applications of conformal mappings in the simulations of the flow around bodies. ... ...

    Abstract In this paper, we propose the iterative numerical methods to calculate the conformal preimage domains for the specified logarithmic spiral slit regions and develop the applications of conformal mappings in the simulations of the flow around bodies. Firstly, we postulate that the boundaries of the preimage domains mapped onto logarithmic spiral slits are ellipses. The lengths of the long axes of ellipses and the coordinates of the centers are calculated using our iterative methods. Secondly, each type of the presented iterative method calculates numerical conformal mappings via solving the boundary integral equation with the generalized Neumann kernel. Finally, numerical examples show the convergence and availability of our iterative methods and display the simulations of the flow around the bodies as an application.
    MeSH term(s) Computer Simulation
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023033
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  3. Article ; Online: Bilateral effect of acupuncture on cerebrum and cerebellum in ischaemic stroke patients with hemiparesis: a randomised clinical and neuroimaging trial.

    Chen, Tianzhu / Chen, Tianyan / Zhang, Yong / Wu, Kang / Zou, Yihuai

    Stroke and vascular neurology

    2024  

    Abstract: Background: Acupuncture involving the limb region may be effective for stroke rehabilitation clinically, but the visualised and explanatory evidence is limited. Our objectives were to assess the specific effects of acupuncture for ischaemic stroke (IS) ... ...

    Abstract Background: Acupuncture involving the limb region may be effective for stroke rehabilitation clinically, but the visualised and explanatory evidence is limited. Our objectives were to assess the specific effects of acupuncture for ischaemic stroke (IS) patients with hemiparesis and investigate its therapy-driven modification in functional connectivity.
    Methods: IS patients were randomly assigned (2:1) to receive 10 sessions of hand-foot 12 needles acupuncture (HA, n=30) or non-acupoint (NA) acupuncture (n=16), enrolling gender-matched and age-matched healthy controls (HCs, n=34). The clinical outcomes were the improved Fugl-Meyer Assessment scores including upper and lower extremity (ΔFM, ΔFM-UE, ΔFM-LE). The neuroimaging outcome was voxel-mirrored homotopic connectivity (VMHC). Static and dynamic functional connectivity (sFC, DFC) analyses were used to study the neuroplasticity reorganisation.
    Results: 46 ISs (mean(SD) age, 59.37 (11.36) years) and 34 HCs (mean(SD) age, 52.88 (9.69) years) were included in the per-protocol analysis of clinical and neuroimaging. In clinical, ΔFM scores were 5.00 in HA group and 2.50 in NA group, with a dual correlation between ΔFM and ΔVMHC (angular: r=0.696, p=0.000; cerebellum: r=-0.716, p=0.000) fitting the linear regression model (R
    Conclusions: The randomised clinical and neuroimaging trial demonstrated acupuncture could promote the motor recovery and modified cerebro-cerebellar VMHC via bilateral static and dynamic reorganisations for IS patients with hemiparesis.
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ISSN 2059-8696
    ISSN (online) 2059-8696
    DOI 10.1136/svn-2023-002785
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  4. Article ; Online: Biology and Therapeutic Properties of Mesenchymal Stem Cells in Leukemia.

    Wu, Cheng-Hsien / Weng, Te-Fu / Li, Ju-Pi / Wu, Kang-Hsi

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: This comprehensive review delves into the multifaceted roles of mesenchymal stem cells (MSCs) in leukemia, focusing on their interactions within the bone marrow microenvironment and their impact on leukemia pathogenesis, progression, and treatment ... ...

    Abstract This comprehensive review delves into the multifaceted roles of mesenchymal stem cells (MSCs) in leukemia, focusing on their interactions within the bone marrow microenvironment and their impact on leukemia pathogenesis, progression, and treatment resistance. MSCs, characterized by their ability to differentiate into various cell types and modulate the immune system, are integral to the BM niche, influencing hematopoietic stem cell maintenance and functionality. This review extensively explores the intricate relationship between MSCs and leukemic cells in acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, and chronic lymphocytic leukemia. This review also addresses the potential clinical applications of MSCs in leukemia treatment. MSCs' role in hematopoietic stem cell transplantation, their antitumor effects, and strategies to disrupt chemo-resistance are discussed. Despite their therapeutic potential, the dual nature of MSCs in promoting and inhibiting tumor growth poses significant challenges. Further research is needed to understand MSCs' biological mechanisms in hematologic malignancies and develop targeted therapeutic strategies. This in-depth exploration of MSCs in leukemia provides crucial insights for advancing treatment modalities and improving patient outcomes in hematologic malignancies.
    MeSH term(s) Humans ; Hematopoietic Stem Cells/metabolism ; Leukemia, Myeloid, Acute/metabolism ; Mesenchymal Stem Cells/metabolism ; Hematologic Neoplasms/pathology ; Biology ; Tumor Microenvironment
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052527
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  5. Article ; Online: Ventilatory Burden in Obstructive Sleep Apnea: A Novel Indicator for Assessing Severity?

    Gan, Qiming / Zhang, Yuting / Liu, Quanzhen / Zhang, Nuofu / Wu, Kang

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 8, Page(s) 1035–1036

    MeSH term(s) Humans ; Sleep Apnea, Obstructive/diagnosis ; Respiration
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202309-1681LE
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  6. Article ; Online: Scalp nodule in a patient with adrenocortical cancer.

    Wu, Kang / Wu, Kan / Zhang, Mengni / Li, Xiang

    Asian journal of surgery

    2023  Volume 46, Issue 10, Page(s) 4582–4583

    MeSH term(s) Humans ; Scalp ; Adrenal Cortex Neoplasms/diagnostic imaging ; Adrenal Cortex Neoplasms/surgery ; Patients
    Language English
    Publishing date 2023-05-26
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.05.026
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  7. Article ; Online: Synchronous hepatic and adrenal masses in a 23-year-old woman.

    Wu, Kang / Wu, Kan / Li, Xiang

    Asian journal of surgery

    2023  Volume 47, Issue 1, Page(s) 795–796

    MeSH term(s) Female ; Humans ; Young Adult ; Adult ; Adrenal Gland Diseases ; Liver ; Adrenal Gland Neoplasms/diagnostic imaging ; Adrenal Gland Neoplasms/surgery
    Language English
    Publishing date 2023-11-13
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.10.045
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  8. Article ; Online: Change and driving forces of intercity collaborative innovation networks in the Yangtze River Delta region

    DAI Liang / DING Zijun / CAO Zhan / WU Kang / WANG Ruilin

    Ziyuan Kexue, Vol 45, Iss 5, Pp 1006-

    2023  Volume 1019

    Abstract: Objective] In the new economic development era, actively integrating into regional innovation networks has become an important way for cities to obtain external innovation resources and enhance their independent innovation capabilities. This study aimed ...

    Abstract [Objective] In the new economic development era, actively integrating into regional innovation networks has become an important way for cities to obtain external innovation resources and enhance their independent innovation capabilities. This study aimed to reveal the spatiotemporal patterns and mechanisms of change of collaborative innovation in the Yangtze River Delta region from a network perspective, and put forward policy recommendations for regional innovation space optimization and high-quality development. [Methods] Based on the co-application data of invention patents, the intercity collaborative innovation networks of 41 cities in the Yangtze River Delta region were constructed for six periods from 2010 to 2020. The characteristics of change of the regional collaborative innovation networks were further investigated through network descriptive analysis and the underlying endogenous and exogenous driving forces were explored through the temporal exponential random graph models. [Results] (1) The intercity collaborative innovation networks in the Yangtze River Delta presented the co-existence of hierarchical structures and clustering structures, as well as remote trans-local linkages and proximate local linkages. Shanghai, Hangzhou, and Nanjing were always the top three in terms of innovation collaboration, and the innovation corridor along Shanghai, Nanjing, Hangzhou, Hefei, and Ningbo became evident. Regional collaboration clusters were highly coupled with administrative divisions and gradually evolved into three communities bounded with provincial boundaries and centered on the cities with high administrative levels, i.e., Jiangsu-Shanghai community, Zhejiang local community, and Anhui local community. Except for Hefei, the development of cities in Anhui Province was more localized and marginalized. (2) The scale and strength of networks increased gradually while the overall change of the networks was stable. The overall structural similarity between the current network and its previous network ...
    Keywords |collaborative innovation|network change|patent co-application|temporal exponential random graph model|yangtze river delta region ; Environmental sciences ; GE1-350 ; Biology (General) ; QH301-705.5
    Subject code 910
    Language Chinese
    Publishing date 2023-05-01T00:00:00Z
    Publisher Science Press, PR China
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Haploidentical peripheral blood stem cell transplantation with posttransplant cyclophosphamide in a child with neuroblastoma relapse after autologous peripheral blood stem cell transplantation.

    Weng, Te-Fu / Wu, Kang-Hsi

    Pediatric blood & cancer

    2021  Volume 69, Issue 2, Page(s) e29439

    MeSH term(s) Child ; Cyclophosphamide ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation ; Humans ; Neoplasm Recurrence, Local/drug therapy ; Neuroblastoma/drug therapy ; Peripheral Blood Stem Cell Transplantation ; Transplantation Conditioning
    Chemical Substances Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2021-12-02
    Publishing country United States
    Document type Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29439
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  10. Article ; Online: Predicting Mutational Effects on Ca

    Zhang, Yue / Wu, Kang / Li, Yuqing / Wu, Song / Warshel, Arieh / Bai, Chen

    Journal of the American Chemical Society

    2024  Volume 146, Issue 7, Page(s) 4665–4679

    Abstract: The dysfunction and defects of ion channels are associated with many human diseases, especially for loss-of-function mutations in ion channels such as cystic fibrosis transmembrane conductance regulator mutations in cystic fibrosis. Understanding ion ... ...

    Abstract The dysfunction and defects of ion channels are associated with many human diseases, especially for loss-of-function mutations in ion channels such as cystic fibrosis transmembrane conductance regulator mutations in cystic fibrosis. Understanding ion channels is of great current importance for both medical and fundamental purposes. Such an understanding should include the ability to predict mutational effects and describe functional and mechanistic effects. In this work, we introduce an approach to predict mutational effects based on kinetic information (including reaction barriers and transition state locations) obtained by studying the working mechanism of target proteins. Specifically, we take the Ca
    MeSH term(s) Humans ; Chlorides/metabolism ; Anoctamin-1/genetics ; Anoctamin-1/metabolism ; Chloride Channels/genetics ; Chloride Channels/chemistry ; Chloride Channels/metabolism ; Mutation ; Signal Transduction ; Calcium/metabolism
    Chemical Substances Chlorides ; Anoctamin-1 ; Chloride Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c11940
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