LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1160

Search options

  1. Book ; Online: Synthesis and Applications of Copper-Based Catalysts

    Ji, Yongjun / Xing, Liwen / Wu, Ke

    2023  

    Keywords Research & information: general ; Chemistry ; Inorganic chemistry ; metal-organic frameworks ; Cu2O ; styrene oxidation ; H2O2 ; base free ; low-temperature ; CO-SCR ; Cu-Mn oxide spinels ; Cu/Cu3P nanoarrays ; Cu nano-substrates ; electrocatalyst ; HER ; ceria ; hydride ; CO2 hydrogenation ; single Cu doping ; density functional theory ; Cu-based catalysts ; CO + NO ; catalytic performances ; O2 resistance ; H2O and SO2 resistance ; adsorption ; dissociation ; density-functional theory calculations ; Cu-skin Cu3Au(111) surface ; CO catalytic oxidation ; CO preferential oxidation ; template ; CTAB ; mixed oxides ; copper oxides ; tin oxides ; BCN/graphene composite ; CVD ; anti-corrosion ; organocopper reagents ; Cu catalysts ; 1,4-conjugate addition ; sulfur heterocycles ; thiochromone ; thioflavanones ; 2-alkylthiochroman-4-ones ; copper ; catalysis ; amination ; amines ; polyamines ; aryl halides ; adamantane ; nanoparticles ; n/a
    Language English
    Size 1 electronic resource (160 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030645959
    ISBN 9783036590424 ; 3036590420
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

  2. Article ; Online: Relationship between economic growth and SO2 emissions - based on the PSTR model

    Wu Ke

    Holistica, Vol 10, Iss 2, Pp 137-

    2019  Volume 156

    Abstract: In this paper, we used the panel smooth transition model (PSTR) to study the nonlinear relationship between sulfur dioxide emissions and economic growth in the three regions of China’s eastern, middle and western regions, based on panel data from 31 ... ...

    Abstract In this paper, we used the panel smooth transition model (PSTR) to study the nonlinear relationship between sulfur dioxide emissions and economic growth in the three regions of China’s eastern, middle and western regions, based on panel data from 31 provinces and autonomous regions in China from 2005 to 2017. And calculated the elasticity of the impact of total export-import volume and urbanization rate on emissions. The empirical results indicate that economic development and sulfur dioxide emissions are positively correlated in the three regions of East, Middle and West. In the eastern region, when the economic scale is lower than the threshold value, it has a negative impact on SO2 emissions; but when it is higher than the threshold value, it has a positive impact on SO2 emissions, and the smoothing rate between the two regime is slow. The per capita GDP in the middle and western regions is weakly positively correlated with SO2 emissions. When the economic scale reaches the threshold value, its positive impact on SO2 emissions will increase, and economic development will further increase emissions.
    Keywords sulfur dioxide emissions ; economic growth ; pstr ; nonlinear ; d4 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  3. Article ; Online: Studying financial aspect of green credit and regional heterogeneity on technology innovation in China.

    Wu, Ke / Wang, Xinxiu

    Environmental science and pollution research international

    2023  Volume 30, Issue 41, Page(s) 93708–93721

    Abstract: This study examines the impact of green credit on digital technology innovation in China, focusing on the influence of financialization and regional heterogeneity. Existing research primarily explores factors like government subsidies, economic growth, ... ...

    Abstract This study examines the impact of green credit on digital technology innovation in China, focusing on the influence of financialization and regional heterogeneity. Existing research primarily explores factors like government subsidies, economic growth, and environmental regulations, and there is a lack of critical analysis on the influence of green credit on digital technology innovations. To examine the internal mechanisms linking green credit to digital technology innovation, this study uses panel data from 271 Chinese prefecture-level cities from 2000 to 2020. Our findings suggest that the availability of green credit and the level of financialization have a significant positive effect on technology innovation, particularly in regions with higher economic development. However, we also find that the impact of green credit and financialization on technology innovation varies across different regions of China. Study findings reveal that green credit bolsters both the quantity and quality of digital technology innovation, emerging as a significant driver for green innovations in China. This conclusion holds even after endogeneity tests. The heterogeneous analysis highlights that various aspects of green credit, such as coverage scope, usage intensity, and digitization level, can enhance digital technology innovations. Western cities demonstrate the most considerable positive effects, followed by central cities, while the weakest impact occurs in eastern cities. Green credit primarily promotes digital technology innovation indirectly by alleviating financing constraints. These empirical findings provide valuable policy insights for fostering a harmonious relationship between China's urban green credit facilities and green financial growth, thereby addressing the funding limitations green credit enterprises face.
    MeSH term(s) China ; Cities ; Economic Development ; Technology
    Language English
    Publishing date 2023-07-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-28846-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: A rapid solid form risk assessment workflow for ophthalmic drug candidates.

    Wu, Ke / Ambrus, Gyorgy

    Drug development and industrial pharmacy

    2023  Volume 49, Issue 6, Page(s) 429–437

    Abstract: Objective: This work introduces a material-sparing process that rapidly screens the solid form landscape for ophthalmic compound candidates.: Significance: Crystalline form of compound candidates generated by a Form Risk Assessment (FRA) can be used ... ...

    Abstract Objective: This work introduces a material-sparing process that rapidly screens the solid form landscape for ophthalmic compound candidates.
    Significance: Crystalline form of compound candidates generated by a Form Risk Assessment (FRA) can be used to reduce their downstream development risk.
    Methods: This workflow evaluated nine model compounds with various molecular and polymorphic profiles by using less than 350 mg of drug substances. Kinetic solubility of the model compounds in a variety of solvents was screened to support the experimental design. The FRA workflow integrated several crystallization methods such as temperature-cycled slurrying (thermocycling), cooling, and evaporation. The FRA was also applied on ten ophthalmic compound candidates for verification. X-ray powder diffractometry (XRPD) was used for form identification.
    Results: For the nine model compounds studied, multiple crystalline forms were generated. This demonstrates the potential of the FRA workflow to reveal polymorphic tendency. In addition, thermocycling process was found to be the most effective technique to capture the thermodynamically most stable form. Satisfactory results were observed with the discovery compounds intended for ophthalmic formulations.
    Conclusions: This work introduces a form risk assessment workflow by using sub-gram level of drug substances. The capability of this material-sparing workflow to discover polymorphs and capture the thermodynamically most stable forms within 2-3 weeks makes it suitable for discovery stage compounds, especially for ophthalmic candidates.
    MeSH term(s) Workflow ; Crystallization/methods ; Drug Compounding/methods ; Temperature ; Solubility ; Risk Assessment ; Calorimetry, Differential Scanning ; X-Ray Diffraction
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 751874-2
    ISSN 1520-5762 ; 0363-9045
    ISSN (online) 1520-5762
    ISSN 0363-9045
    DOI 10.1080/03639045.2023.2223288
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Intrahepatic Glisson Intrathecal Dissection via a Hepatic Parenchymal Transection-First Approach for Laparoscopic Anatomical Hemihepatectomy in Patients with Left/Right Glisson Pedicle Involvement.

    You, Nan / Wu, Ke / Li, Yongkun / Zheng, Lu

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2024  Volume 34, Issue 3, Page(s) 257–262

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Adult ; Middle Aged ; Carcinoma, Hepatocellular/surgery ; Liver Neoplasms/surgery ; Lithiasis/surgery ; Retrospective Studies ; Hepatectomy/methods ; Laparoscopy/methods
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2023.0302
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: GPR27 expression correlates with prognosis and tumor progression in gliomas.

    Cai, Changcheng / Hu, Libo / Wu, Ke / Liu, Yinggang

    PeerJ

    2024  Volume 12, Page(s) e17024

    Abstract: Backgrounds: Glioma is a highly aggressive type of brain tumor, and its prognosis is still poor despite recent progress in treatment strategies. G protein-coupled receptor 27 (GPR27) is a member of the G protein-coupled receptor family and has been ... ...

    Abstract Backgrounds: Glioma is a highly aggressive type of brain tumor, and its prognosis is still poor despite recent progress in treatment strategies. G protein-coupled receptor 27 (GPR27) is a member of the G protein-coupled receptor family and has been reported to be involved in various cellular processes, including tumor progression. Nevertheless, the clinical potential and tumor-related role of GPR27 in glioma remain unknown. Here we aimed to explore the function and role of GPR27 in gliomas.
    Methods: In the current study, we evaluated the expression and clinical significance of GPR27 in gliomas using data from The Cancer Genome Atlas (TCGA) datasets. We also conducted cellular experiments to evaluate the functional role of GPR27 in glioma cell growth.
    Results: We found that GPR27 expression level was closely associated with disease status of glioma. Of note, GPR27 was negatively correlated with WHO grade, with grade IV samples showing the lowest GPR27 levels, while grade II samples showed the highest levels. Patients with IDH mutation or 1p/19q co-deletion exhibited higher GPR27 levels. In addition, lower GPR27 levels were correlated with higher death possibilities. In cellular experiments, we confirmed that GPR27 inhibited glioma cell growth.
    Conclusions: Our results indicate that GPR27 may function as a potential prognostic biomarker and therapeutic target in gliomas. Further studies are needed to illustrate the signaling mechanism and clinical implications of GPR27 in gliomas.
    MeSH term(s) Humans ; Brain Neoplasms/genetics ; Chromosome Aberrations ; Glioma/genetics ; Mutation ; Neoplastic Processes ; Receptors, G-Protein-Coupled/genetics
    Chemical Substances Receptors, G-Protein-Coupled ; GPR27 protein, human
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.17024
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Cu-Catalyzed Regioselective Silylation of Chloro-Substituted Allenyl-Bdan.

    Ran, Qi / Wu, Ke-Fan / Xu, Yun-He

    Organic letters

    2024  

    Abstract: A copper-catalyzed efficient regioselective silylation reaction of chloro-substituted allenyl-Bdan was developed. Under mild reaction conditions, allenyl and propargyl silane compounds can be selectively obtained in moderate to high yields by adjusting ... ...

    Abstract A copper-catalyzed efficient regioselective silylation reaction of chloro-substituted allenyl-Bdan was developed. Under mild reaction conditions, allenyl and propargyl silane compounds can be selectively obtained in moderate to high yields by adjusting the bases and solvents used in the reactions. This study offers direct and efficient methods for synthesizing multifunctionalized allenyl and propargyl silane compounds from the same initial material of chloro-substituted allenyl-Bdan.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00864
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: [Identification of a novel germline BRCA2 variant in a male with breast cancer].

    Zhang, Feng / Wu, Ke

    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

    2022  Volume 39, Issue 3, Page(s) 330–333

    Abstract: Objective: To explore the genetic basis for a male with breast cancer and a sister who had deceased of the disease.: Methods: Medical and family history of the proband was collected. Next-generation sequencing was carried out to detect potential ... ...

    Abstract Objective: To explore the genetic basis for a male with breast cancer and a sister who had deceased of the disease.
    Methods: Medical and family history of the proband was collected. Next-generation sequencing was carried out to detect potential variant associated with breast cancer, and Sanger sequencing was used to verify the result.
    Results: The proband was found to harbor a novel heterozygous c.6018dupT variant of the BRCA2 gene which may cause premature termination of mRNA translation, resulting in a truncated protein. Combined with the family history, the variant was deduced to be a germline mutation. Based on the American College of Medical Genetics and Genomics standards and guidelines, c.6018dupT variant of BRCA2 gene was predicted to be pathogenic (PVS1+PM1/2+PP4).
    Conclusion: The germline variant of the BRCA2 gene probably underlay the breast cancer in this pedigree.
    MeSH term(s) BRCA2 Protein/genetics ; Breast Neoplasms, Male/genetics ; Genes, BRCA2 ; Germ-Line Mutation ; Humans ; Male
    Chemical Substances BRCA2 Protein ; BRCA2 protein, human
    Language Chinese
    Publishing date 2022-03-21
    Publishing country China
    Document type Case Reports ; Journal Article
    ISSN 1003-9406
    ISSN 1003-9406
    DOI 10.3760/ cma.j.cn511374-20201130-00838
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Artemisinin Alleviates Cerebral Ischemia/Reperfusion Injury via Regulation of the Forkhead Transcription Factor O1 Signaling Pathway.

    Yang, Xiaogang / Wu, Ke

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 7824436

    Abstract: The effect and mechanism of artemisinin therapy on cerebral ischemia-reperfusion injury (CIRI) was analyzed in this work. 100 healthy male C57BL/6 mice were selected and randomly divided into the sham group (no treatment), CIRI model group (IR), IR + ... ...

    Abstract The effect and mechanism of artemisinin therapy on cerebral ischemia-reperfusion injury (CIRI) was analyzed in this work. 100 healthy male C57BL/6 mice were selected and randomly divided into the sham group (no treatment), CIRI model group (IR), IR + artemisinin posttreatment group (IR + Arte), EX527 + IR group (EX527 + IR), and EX527 + IR + artemisinin posttreatment group (EX527 + IR + Arte), with 20 mice in each group. The cerebral infarct volumes of mice in different groups were measured by the 2,3,5-triphenyltetrazolium chloride (TTC) staining method. The neurological function scores and oxidative stress levels of mice in different groups were measured and compared. In addition, the expressions of silent information regulator 1 (SIRT1), forkhead transcription factor O1 (FOXO1), and p53 protein in brain tissue were detected. The results showed that the contents of reactive oxygen species (ROS) and malondialdehyde (MDA) in the EX527 + IR group and EX527 + IR + Arte group were significantly higher than those in the IR + Arte group (
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/7824436
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Individual variability in functional connectivity of human auditory cortex.

    Luo, Junhao / Qin, Peipei / Bi, Qiuhui / Wu, Ke / Gong, Gaolang

    Cerebral cortex (New York, N.Y. : 1991)

    2024  Volume 34, Issue 2

    Abstract: Individual variability in functional connectivity underlies individual differences in cognition and behaviors, yet its association with functional specialization in the auditory cortex remains elusive. Using resting-state functional magnetic resonance ... ...

    Abstract Individual variability in functional connectivity underlies individual differences in cognition and behaviors, yet its association with functional specialization in the auditory cortex remains elusive. Using resting-state functional magnetic resonance imaging data from the Human Connectome Project, this study was designed to investigate the spatial distribution of auditory cortex individual variability in its whole-brain functional network architecture. An inherent hierarchical axis of the variability was discerned, which radiates from the medial to lateral orientation, with the left auditory cortex demonstrating more pronounced variations than the right. This variability exhibited a significant correlation with the variations in structural and functional metrics in the auditory cortex. Four auditory cortex subregions, which were identified from a clustering analysis based on this variability, exhibited unique connectional fingerprints and cognitive maps, with certain subregions showing specificity to speech perception functional activation. Moreover, the lateralization of the connectional fingerprint exhibited a U-shaped trajectory across the subregions. These findings emphasize the role of individual variability in functional connectivity in understanding cortical functional organization, as well as in revealing its association with functional specialization from the activation, connectome, and cognition perspectives.
    MeSH term(s) Humans ; Auditory Cortex/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Connectome/methods ; Brain ; Cognition
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhae007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top