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  1. Article ; Online: Filamentous-Actin-Mimicking Nanoplatform for Enhanced Cytosolic Protein Delivery.

    Xia, Yuqiong / Wu, Keyun / Liu, Chang / Zhao, Xuejuan / Wang, Jun / Cao, Jianxia / Chen, Zhaoxu / Fang, Minchao / Yu, Jie / Zhu, Cheng / Zhang, Xianghan / Wang, Zhongliang

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 11, Issue 10, Page(s) e2305600

    Abstract: Despite the potential of protein therapeutics, the cytosolic delivery of proteins with high efficiency and bioactivity remains a significant challenge owing to exocytosis and lysosomal degradation after endocytosis. Therefore, it is important to develop ... ...

    Abstract Despite the potential of protein therapeutics, the cytosolic delivery of proteins with high efficiency and bioactivity remains a significant challenge owing to exocytosis and lysosomal degradation after endocytosis. Therefore, it is important to develop a safe and efficient strategy to bypass endocytosis. Inspired by the extraordinary capability of filamentous-actin (F-actin) to promote cell membrane fusion, a cyanine dye assembly-containing nanoplatform mimicking the structure of natural F-actin is developed. The nanoplatform exhibits fast membrane fusion to cell membrane mimics and thus enters live cells through membrane fusion and bypasses endocytosis. Moreover, it is found to efficiently deliver protein cargos into live cells and quickly release them into the cytosol, leading to high protein cargo transfection efficiency and bioactivity. The nanoplatform also results in the superior inhibition of tumor cells when loaded with anti-tumor proteins. These results demonstrate that this fusogenic nanoplatform can be valuable for cytosolic protein delivery and tumor treatment.
    MeSH term(s) Humans ; Actins/metabolism ; Cytosol/metabolism ; Cell Membrane/metabolism ; Neoplasms/metabolism
    Chemical Substances Actins
    Language English
    Publishing date 2023-12-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202305600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An antisense Alu transposon insertion/deletion polymorphism of ALDH1A1 may functionally associate with Parkinson's disease.

    Fan, Hui-Hui / Zheng, Jing / Huang, Xiao-Ya / Wu, Ke-Yun / Cui, Lei / Dong, Hao-Jia / Wang, Zhen / Zhang, Xiong / Zhu, Jian-Hong

    BMC geriatrics

    2022  Volume 22, Issue 1, Page(s) 427

    Abstract: Background: Aldehyde dehydrogenase 1 (encoded by ALDH1A1) has been shown to protect against Parkinson's disease (PD) by reducing toxic metabolites of dopamine. We herein revealed an antisense Alu element insertion/deletion polymorphism in intron 4 of ... ...

    Abstract Background: Aldehyde dehydrogenase 1 (encoded by ALDH1A1) has been shown to protect against Parkinson's disease (PD) by reducing toxic metabolites of dopamine. We herein revealed an antisense Alu element insertion/deletion polymorphism in intron 4 of ALDH1A1, and hypothesized that it might play a role in PD.  METHODS: A Han Chinese cohort comprising 488 PD patients and 515 controls was recruited to validate the Alu insertion/deletion polymorphism following a previous study of tag-single nucleotide polymorphisms, where rs7043217 was shown to be significantly associated with PD. Functional analyses of the Alu element insertion were performed.
    Results: The Alu element of ALDH1A1 was identified to be a variant of Yb8 subfamily and termed as Yb8c4. The antisense Yb8c4 insertion/deletion polymorphism (named asYb8c4
    Conclusions: Our results consolidate an involvement of ALDH1 in PD pathogenesis. The asYb8c4 polymorphism may be a functional output of its linkage disequilibrium-linked single nucleotide polymorphisms.
    MeSH term(s) Aldehyde Dehydrogenase 1 Family ; Asians/genetics ; Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Parkinson Disease/genetics ; Polymorphism, Single Nucleotide/genetics ; RNA, Messenger ; Retinal Dehydrogenase/genetics
    Chemical Substances RNA, Messenger ; Aldehyde Dehydrogenase 1 Family (EC 1.2.1) ; ALDH1A1 protein, human (EC 1.2.1.36) ; Retinal Dehydrogenase (EC 1.2.1.36)
    Language English
    Publishing date 2022-05-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-022-03132-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Autoimmune Disease Associated

    Fan, Hui-Hui / Cui, Lei / Jiang, Xiao-Xia / Song, Ya-Dan / Liu, Shu-Shu / Wu, Ke-Yun / Dong, Hao-Jia / Mao, Miao / Ovlyakulov, Begench / Wu, Hong-Mei / Zhu, Jian-Hong / Zhang, Xiong

    Frontiers in genetics

    2022  Volume 13, Page(s) 856493

    Abstract: CLEC16A is a membrane-associated endosomal protein implicated in regulating autophagy and antigen presentation. Its genetic variants are broadly associated with multiple autoimmune diseases. Parkinson's disease (PD), which undergoes autophagy disruption ... ...

    Abstract CLEC16A is a membrane-associated endosomal protein implicated in regulating autophagy and antigen presentation. Its genetic variants are broadly associated with multiple autoimmune diseases. Parkinson's disease (PD), which undergoes autophagy disruption and neuroinflammation, has been clinically observed, for an extensive amount of time, to be associated with autoimmune diseases. In this study, we aimed to understand whether the autoimmune disease associated
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.856493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Polymorphisms of Cytochromes P450 and Glutathione S-Transferases Synergistically Modulate Risk for Parkinson's Disease.

    Fan, Hui-Hui / Li, Bao-Qing / Wu, Ke-Yun / Yan, Hai-Dan / Gu, Meng-Jie / Yao, Xing-Hao / Dong, Hao-Jia / Zhang, Xiong / Zhu, Jian-Hong

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 888942

    Abstract: Background: Environmental substances such as pesticides are well-known in link with Parkinson's disease (PD) risk. Enzymes including cytochromes P450 (CYPs), esterases and glutathione S-transferases (GSTs) are responsible for the xenobiotic metabolism ... ...

    Abstract Background: Environmental substances such as pesticides are well-known in link with Parkinson's disease (PD) risk. Enzymes including cytochromes P450 (CYPs), esterases and glutathione S-transferases (GSTs) are responsible for the xenobiotic metabolism and may functionally compensate each other for subtypes in the same class. We hypothesize that the genetic effects of each class modulate PD risk stronger in a synergistic way than individually.
    Methods: We selected 14 polymorphic loci out of 13 genes which encode enzymes in the classes of CYP, esterase, and GST, and recruited a cohort of 1,026 PD and control subjects from eastern China. The genotypes were identified using improved multiplex ligation detection reaction and analyzed using multiple models.
    Results: A total of 13 polymorphisms remained after Hardy-Weinberg equilibrium analysis. None of the polymorphisms were independently associated with PD risk after Bonferroni correction either by logistic regression or genetic models. In contrast, interaction analyses detected increased resistance to PD risk in individuals carrying the rs12441817/CC (
    Conclusion: We demonstrate a presence of synergistic but not individual impact on PD susceptibility in polymorphisms of
    Language English
    Publishing date 2022-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.888942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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