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  1. Article ; Online: The relay graft, a tailored supplement between the nasal hump and established tip in East Asian rhinoplasty.

    Wu, Lehao / Wang, Huan / Tian, Le / Ma, Hengyuan / Fan, Fei / You, Jianjun

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2024  Volume 91, Page(s) 94–102

    Abstract: Background: In East Asian individuals, the nasal bone already has sufficient height for an ideal dorsal profile, but the tip requires enhancement for a desired projection. Consequently, the gap between the intrinsic bony structure and the established ... ...

    Abstract Background: In East Asian individuals, the nasal bone already has sufficient height for an ideal dorsal profile, but the tip requires enhancement for a desired projection. Consequently, the gap between the intrinsic bony structure and the established nasal tip requires appropriate management. The options are either to reduce the keystone region to create a smooth bed for a conventional dorsal onlay graft or to preserve the original osseocartilaginous structures and then customize a supplementary graft. The aim of this study was to detail and validate the utilization of a relay graft, a transition graft that fills the structural gap between the upper dorsum and established tip graft. The proper application of this graft could prevent osteotomy and preserve the intrinsic dorsum.
    Methods: Relay grafts were applied during rib-based rhinoplasty in East Asian patients. Three-dimensional stereophotogrammetric evaluations of the patients were performed. Anthropometric points were analyzed in a blinded fashion. Outcome variables were tip projection improvement, radix elevation, and the angulation of kyphion and pronasale.
    Results: Fifteen female patients, ranging in age from 21 to 40 years (average 24.5 years), were included. In all cases, the relay graft was applied as one essential element for filling the structural gap. No crooked dorsal profile or visible graft was noted in all cases. Fifteen patients completed the pre- and postoperative stereophotogrammetric study. Postoperative analysis showed great improvement of tip position as well as a slight elevation of the radix, evidenced by the consistent change of kyphion/pronasale angulation and sellion elevation.
    Conclusions: The relay graft effectively mitigates the necessity of a disruptive dorsal reduction. It is entirely possible for East Asians to achieve a smooth dorsal profile when only the lower half of the dorsum is transitioned to the proposed tip position.
    Level of evidence: Level IV, case series.
    MeSH term(s) Humans ; Female ; Young Adult ; Adult ; Rhinoplasty/methods ; Nasal Septum/surgery ; East Asian People ; Retrospective Studies ; Nose/surgery ; Photogrammetry
    Language English
    Publishing date 2024-02-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2024.02.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Introducing Saddle-Shaped Radix Graft, with a Second Look into the Classic.

    Wu, Lehao / You, Jianjun / Wang, Huan / Tian, Le / Fan, Fei

    Plastic and reconstructive surgery

    2023  

    Abstract: Background: An enduringly stable tip graft is the key to achieve successful rhinoplasty cases. However, the intrinsic nature of rib graft warping renders major unpredictability for the long term outcome. The objective of this study was to detail and ... ...

    Abstract Background: An enduringly stable tip graft is the key to achieve successful rhinoplasty cases. However, the intrinsic nature of rib graft warping renders major unpredictability for the long term outcome. The objective of this study was to detail and validate the utilization of a radix graft design that is characterized by the dual curved surfaces and beveled margin, which consequently renders a shape similar to a saddle.
    Methods: Twenty-three female patients, ranging in age from 22 to 31 years completed the study. In all cases, the saddle-shaped radix graft was applied as the essential element for enhancing radix region profile. The complications that arose were collected retrospectively. Three-dimensional stereophotogrammetric evaluations of patients were performed. Anthropometric points were analyzed in a blinded fashion. Outcome variables were tip projection, nasal length, radix height and the radius of curvature.
    Results: Postoperative analysis suggested significant improvement on the aesthetics of the radix region over time, evidenced by the significant increase of radix height (4.33±1.21 vs 7.08±1.00mm), as well as the reduction of radius of curvature at nasofrontal break over long term(22.63±2.24 vs 13.94±0.98). Other postoperative evaluations including radix height, tip projection and nasal length had significant improvement.
    Conclusions: The Saddle-shaped radix graft effectively augments the radix area and creates an aesthetically pleasant nasofrontal break without causing the elevated radix deformity. It has the merits of anatomically compliance and flexibility when it comes to concomitantly improving the glabella-radix profile for those East Asians with extremely low radix.
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000010722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Utility of the Subalar Graft in Nostril Symmetry in Rhinoplasty.

    Wu, Lehao / Wang, Huan / You, Jianjun

    Plastic and reconstructive surgery

    2022  Volume 150, Issue 5, Page(s) 1108e

    MeSH term(s) Humans ; Rhinoplasty ; Nasal Cartilages/surgery ; Cleft Lip/surgery ; Nose/surgery
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000009582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A New Supplement for Postoperative Management?

    Wu, Lehao / Wang, Huan / You, Jianjun

    Aesthetic surgery journal

    2022  Volume 43, Issue 3, Page(s) NP229–NP230

    MeSH term(s) Humans ; Dietary Supplements ; Postoperative Period
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Letter
    ZDB-ID 2087022-X
    ISSN 1527-330X ; 1090-820X ; 1084-0761
    ISSN (online) 1527-330X
    ISSN 1090-820X ; 1084-0761
    DOI 10.1093/asj/sjac315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Hemp Seed Fermented by

    Wang, Zeyuan / Wu, Lehao / Fu, Dongmei / Zhang, Yan / Zhang, Chunzhi

    Foods (Basel, Switzerland)

    2022  Volume 11, Issue 12

    Abstract: The objective of our present work was to explore the possible enhanced anti-neuroinflammatory ability ... ...

    Abstract The objective of our present work was to explore the possible enhanced anti-neuroinflammatory ability of
    Language English
    Publishing date 2022-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods11121689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Does the Curvature of the Rim Graft Matter?

    You, Jianjun / Wu, Lehao / Wang, Huan

    Plastic and reconstructive surgery

    2021  Volume 147, Issue 4, Page(s) 704e–705e

    MeSH term(s) Humans ; Rhinoplasty
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000007738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Challenges of Skin Graft Lining in Nasal Reconstruction: Comment on "Full-Thickness Skin Grafts and Quilting Sutures for Reconstruction of Internal Nasal Lining".

    Xu, Yihao / Wu, Lehao / Fan, Fei

    Facial plastic surgery : FPS

    2021  Volume 37, Issue 3, Page(s) 411

    MeSH term(s) Humans ; Nose ; Nose Neoplasms/surgery ; Rhinoplasty ; Skin Transplantation ; Sutures
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 630090-x
    ISSN 1098-8793 ; 0736-6825
    ISSN (online) 1098-8793
    ISSN 0736-6825
    DOI 10.1055/s-0040-1717058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells.

    Wang, Zeyuan / Wu, Lehao / Wang, Huiyu / Zhang, Yan / Xiao, Hua

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 1, Page(s) 72

    Abstract: Extracellular vesicles (EVs) are important carriers for biomolecules in the microenvironment that greatly promote intercellular and extracellular communications. However, it is unclear whether bombesin receptor-subtype 3 (BRS-3), an orphan G-protein ... ...

    Abstract Extracellular vesicles (EVs) are important carriers for biomolecules in the microenvironment that greatly promote intercellular and extracellular communications. However, it is unclear whether bombesin receptor-subtype 3 (BRS-3), an orphan G-protein coupled receptor, can be packed into EVs and functionally transferred to recipient cells. In this study, we applied the synthetic agonist and antagonist to activate and inhibit the BRS-3 in HEK293-BRS-3 cells, whose EVs release was BRS-3 activation dependent. The presence of BRS-3 in harvested EVs was further confirmed by an enhanced green fluorescent protein tag. After recipient cells were co-cultured with these EVs, the presence of BRS-3 in the recipient cells was discovered, whose function was experimentally validated. Quantitative proteomics approach was utilized to decipher the proteome of the EVs derived from HEK293-BRS-3 cells after different stimulations. More than 900 proteins were identified, including 51 systematically dysregulated EVs proteins. The Ingenuity Pathway Analysis (IPA) revealed that RhoA signaling pathway was as an essential player for the secretion of EVs. Selective inhibition of RhoA signaling pathway after BRS-3 activation dramatically reversed the increased secretion of EVs. Our data, collectively, demonstrated that EVs contributed to the transfer of functional BRS-3 to the recipient cells, whose secretion was partially regulated by RhoA signaling pathway.
    MeSH term(s) Cell Membrane/metabolism ; Chromatography, Liquid ; Extracellular Vesicles/metabolism ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; Humans ; Nanoparticles/chemistry ; Proteomics/methods ; Receptors, Bombesin/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Tandem Mass Spectrometry ; rhoA GTP-Binding Protein/metabolism
    Chemical Substances Receptors, Bombesin ; Receptors, G-Protein-Coupled ; bombesin receptor subtype 3 ; RHOA protein, human (124671-05-2) ; Green Fluorescent Proteins (147336-22-9) ; rhoA GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2022-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-021-04114-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Plug-in Graft, the Essential Supplement for a Stable Cartilaginous Framework in Rhinoplasty.

    Wu, Lehao / Wang, Huan / Tian, Le / Fan, Fei / You, Jianjun

    Aesthetic surgery journal

    2022  Volume 42, Issue 8, Page(s) 862–870

    MeSH term(s) Adolescent ; Adult ; Female ; Follow-Up Studies ; Humans ; Nasal Septum/surgery ; Nose/surgery ; Retrospective Studies ; Rhinoplasty/adverse effects ; Rhinoplasty/methods ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2087022-X
    ISSN 1527-330X ; 1090-820X ; 1084-0761
    ISSN (online) 1527-330X
    ISSN 1090-820X ; 1084-0761
    DOI 10.1093/asj/sjac009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Necessity of Filling the Structural Gap: A Personal Take.

    Wu, Lehao / Wang, Huan / Tian, Le / Fan, Fei / You, Jianjun

    Aesthetic surgery journal

    2022  Volume 42, Issue 9, Page(s) NP600–NP601

    MeSH term(s) Algorithms ; Humans
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2087022-X
    ISSN 1527-330X ; 1090-820X ; 1084-0761
    ISSN (online) 1527-330X
    ISSN 1090-820X ; 1084-0761
    DOI 10.1093/asj/sjac134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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