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  1. Article ; Online: Students' Foreign Language Learning Adaptability and Mental Health Supported by Artificial Intelligence.

    Wu, Lin

    Journal of autism and developmental disorders

    2023  

    Abstract: The rapid development of social reform and the economy has brought great challenges to the mental health of college students. However, there are few studies on the impact of these psychological problems on college students' English learning. As a special ...

    Abstract The rapid development of social reform and the economy has brought great challenges to the mental health of college students. However, there are few studies on the impact of these psychological problems on college students' English learning. As a special group about to enter society, studying the mental health of college students in foreign language learning is of great significance. This paper discusses the principle of Artificial Intelligence (AI) technology and the interactive mechanism to support college students' foreign language learning. Additionally, the adaptability supporting college students' foreign language learning is analyzed according to the current situation of AI supporting foreign language learning. Then, the mental health of college students in the AI environment is investigated and analyzed. This paper takes foreign and non-foreign language majors of Changchun University of Technology as the object and uses questionnaires, interviews, and classroom observation to obtain basic data. The results show that college students' adaptability to foreign language learning is higher than that of non-foreign. Students' intelligent operation and knowledge storage level impact their adaptability to foreign language learning. Psychological health problems include learning anxiety, loneliness, depression, and inferiority in college students' foreign language learning. These negative emotions, to a certain extent, affect the learning effect of college students' foreign language learning. This paper is of great significance to the adaptability of college students' foreign language learning to the intelligent environment and the analysis of their mental health problems. This paper hopes to provide data reference for the research on improving college students' foreign language learning effects.
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-023-06097-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: First-line immunotherapy for advanced non-small cell lung cancer: current progress and future prospects.

    Wang, Jingyi / Wu, Lin

    Cancer biology & medicine

    2024  Volume 21, Issue 2

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Immunotherapy
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-01-25
    Publishing country China
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2676322-9
    ISSN 2095-3941
    ISSN 2095-3941
    DOI 10.20892/j.issn.2095-3941.2023.0401
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  3. Article ; Online: Unilateral ovarian recurrence 5 years after hysterectomy for microinvasive squamous cervical cancer stage IA1: a rare case report.

    Tong, Longxia / Wu, Lin

    BMC women's health

    2023  Volume 23, Issue 1, Page(s) 350

    Abstract: Background: Ovarian metastasis or recurrence of cervical microinvasive squamous cell carcinoma (SCC) is very rare. We report a case of unilateral ovarian recurrence 5 years after hysterectomy for the SCC stage IA1 without lymph vascular space invasion ( ... ...

    Abstract Background: Ovarian metastasis or recurrence of cervical microinvasive squamous cell carcinoma (SCC) is very rare. We report a case of unilateral ovarian recurrence 5 years after hysterectomy for the SCC stage IA1 without lymph vascular space invasion (LVSI).
    Case presentation: A 49-year-old female patient suffered from a dull pain in the left lower abdomen for 3 months. And five years ago, she received a laparoscopic hysterectomy for the treatment of stage IA1 (without LVSI) SCC of the cervix. The level of squamous cell carcinoma antigen (SCC-Ag) in serum was significantly elevated (10.60 ng/mL). Pelvic magnetic resonance imaging (MRI) revealed a left ovarian solid tumor measuring 5.5 × 3.9 × 5.6 cm with heterogeneous enhancement. During laparotomy, the left ovarian tumor was measured about 5.0 × 4.5 × 3.0 cm and seemed densely adherent to the posterior peritoneal wall, including the left ureter. The tumor and pelvic lymph node were carefully removed. Postoperative anatomy revealed a solid mass with a greyish-white section. Postoperative pathology showed recurrent moderately differentiated ovarian SCC with negative pelvic lymph nodes. Immunohistochemistry showed that the tumor cells were positive for P16, P63, P40, and CK5/6 markers, and the positive rate of Ki67 was about 80%.
    Conclusions: Ovary preservation is reasonable and appropriate in young patients with microinvasive SCC. Ovarian recurrence is rare, but gynecological oncologists should not overlook its possibility. The serum SCC-Ag is an important indicator for monitoring postoperative disease progression.
    MeSH term(s) Female ; Humans ; Middle Aged ; Uterine Cervical Neoplasms/surgery ; Hysterectomy ; Ovarian Neoplasms/surgery ; Carcinoma, Squamous Cell/surgery
    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2050444-5
    ISSN 1472-6874 ; 1472-6874
    ISSN (online) 1472-6874
    ISSN 1472-6874
    DOI 10.1186/s12905-023-02496-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: MAMPs: A devil tamed becomes an angel.

    Tang, Huayuan / Wu, Lin

    Cell host & microbe

    2023  Volume 31, Issue 9, Page(s) 1422–1425

    Abstract: Symbiotic microorganisms modulate systemic immunity with unclear mechanisms. In this issue of Cell Host & Microbe, Clarke and colleagues uncover a coherent mechanism where the systemic spread of Firmicutes cell wall glycoconjugates enhances global immune ...

    Abstract Symbiotic microorganisms modulate systemic immunity with unclear mechanisms. In this issue of Cell Host & Microbe, Clarke and colleagues uncover a coherent mechanism where the systemic spread of Firmicutes cell wall glycoconjugates enhances global immune fitness while simultaneously being delicately controlled to prevent systemic inflammation.
    MeSH term(s) Humans ; Cell Wall ; Firmicutes ; Inflammation
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2023.08.009
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  5. Article ; Online: SSNA1 Promotes Hepatocellular Carcinoma Metastasis

    Wu, Lin-Wen / Hu, Xiu

    Anticancer research

    2023  Volume 43, Issue 8, Page(s) 3479–3486

    Abstract: Background/aim: Hepatocellular carcinoma (HCC) currently represents the third most prevalent cause of cancer-related deaths globally. HCC is typically diagnosed at advanced stages with metastasis, and has a poor outcome. In order to identify useful ... ...

    Abstract Background/aim: Hepatocellular carcinoma (HCC) currently represents the third most prevalent cause of cancer-related deaths globally. HCC is typically diagnosed at advanced stages with metastasis, and has a poor outcome. In order to identify useful biomarkers for early diagnosis and develop novel therapeutic targets, it is necessary to better understand the cellular mechanisms driving HCC progression.
    Materials and methods: Public datasets were used to detect Sjögren's syndrome nuclear autoantigen-1 (SSNA1) expression in HCC. Scratch assay and transwell invasion assays were used to evaluate the migration and invasion ability of HCC cells. We explored the molecular mechanism by western blotting, viability and transfection assays.
    Results: SSNA1 was found up-regulated in human HCC tissues. SSNA1 expression increased along with HCC progression. In addition, elevated SSNA1 expression in HCC patients was closely correlated to a poor prognosis. The proliferation and apoptosis of HCC cells were unaffected by reducing SSNA1 expression. Meanwhile, STAT3/EMT axis inhibition mediated by SSNA1 depletion prevented HCC cells from migrating and invading in vitro.
    Conclusion: SSNA1 could be used as a biomarker for HCC diagnosis and prognosis, and point the direction for the future investigation of innovative approaches to target and treat HCC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Cell Movement ; Cell Line, Tumor ; Prognosis ; Epithelial-Mesenchymal Transition ; Gene Expression Regulation, Neoplastic ; Cell Proliferation/genetics ; Neoplasm Metastasis ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism
    Chemical Substances STAT3 protein, human ; STAT3 Transcription Factor
    Language English
    Publishing date 2023-07-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16524
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  6. Article ; Online: Association of intensive management on quality of nursing with the infection rate in the operating room.

    Dai, Yongqiang / Wu, Lin

    Asian journal of surgery

    2023  Volume 47, Issue 2, Page(s) 1129–1130

    MeSH term(s) Humans ; Operating Rooms ; Cross Infection/epidemiology ; Cross Infection/nursing
    Language English
    Publishing date 2023-11-30
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.10.140
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  7. Article ; Online: Surface exciton polariton enhanced Goos-Hänchen and Imbert-Fedorov shifts and their applications in refractive index sensing.

    Xu, Yi / Wu, Lin / Ang, L K

    Optics express

    2024  Volume 32, Issue 7, Page(s) 11171–11181

    Abstract: The spatial and angular Goos-Hänchen shifts (GHSs) and Imbert-Fedorov shifts (IFSs) are theoretically investigated in a modified Kretschmann-Raether configuration consisting of glass prism, J-aggregate cyanine dye, and air. With the excitation of surface ...

    Abstract The spatial and angular Goos-Hänchen shifts (GHSs) and Imbert-Fedorov shifts (IFSs) are theoretically investigated in a modified Kretschmann-Raether configuration consisting of glass prism, J-aggregate cyanine dye, and air. With the excitation of surface excitation polaritons (SEPs), the spatial and angular GHSs and IFSs for the transverse magnetic polarized light are strongly enhanced around the resonant angle of SEP. A highly sensitive gas sensor based on the SEP enhanced GHS (or IFS) is proposed, which exhibits the refractive index sensitivity on the order of 10
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.517418
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  8. Article: Temporal and Spatial Analysis of Negative Emotions in China during the COVID-19 Pandemic.

    Ding, Yating / Wu, Lin / Peng, Zijian / Liu, Bo

    Behavioral sciences (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: This research aims to explore the spatiotemporal distribution patterns of negative emotions in mainland China during different stages of the COVID-19 pandemic and the external factors influencing this clustering. Using Baidu Index data for 91 negative ... ...

    Abstract This research aims to explore the spatiotemporal distribution patterns of negative emotions in mainland China during different stages of the COVID-19 pandemic and the external factors influencing this clustering. Using Baidu Index data for 91 negative emotion keywords, a retrospective geographic analysis was conducted across Chinese provinces from 14 October 2019 to 7 July 2022. Four spatial analysis methods (Global Moran's Index, Local Moran's Index, Bivariate Global Moran's Index, and Bivariate Local Moran's Index) are employed to identify potential clustering patterns and influencing factors of negative emotions at different stages. The results indicate that the COVID-19 pandemic significantly intensified the clustering effect of negative emotions in China, particularly with a more pronounced radiation effect in northwestern provinces. Spatial positive correlations are observed between pandemic-related Baidu indices (pandemic Baidu index, government Baidu index, nucleic acid Baidu index) and negative emotions. These findings contribute to understanding the spatiotemporal distribution characteristics of negative emotions in China post the COVID-19 outbreak and can guide the allocation of psychological resources during emergencies, thereby promoting social stability.
    Language English
    Publishing date 2024-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs14020113
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  9. Article ; Online: Targeting non-coding RNAs and N

    Wu, Lin / Zhang, Yingmei / Ren, Jun

    Biochemical pharmacology

    2024  Volume 223, Page(s) 116153

    Abstract: Hepatocellular carcinoma (HCC), the most common form of primary liver cancers, accounts for a significant portion of cancer-related death globally. However, the molecular mechanisms driving the onset and progression of HCC are still not fully understood. ...

    Abstract Hepatocellular carcinoma (HCC), the most common form of primary liver cancers, accounts for a significant portion of cancer-related death globally. However, the molecular mechanisms driving the onset and progression of HCC are still not fully understood. Emerging evidence has indicated that non-protein-coding regions of genomes could give rise to transcripts, termed non-coding RNA (ncRNA), forming novel functional driving force for aberrant cellular activity. Over the past decades, overwhelming evidence has denoted involvement of a complex array of molecular function of ncRNAs at different stages of HCC tumorigenesis and progression. In this context, several pre-clinical studies have highlighted the potentials of ncRNAs as novel therapeutic modalities in the management of human HCC. Moreover, N
    MeSH term(s) Animals ; Humans ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/drug therapy ; RNA, Untranslated/genetics ; RNA, Untranslated/therapeutic use ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; Mammals ; Adenosine/analogs & derivatives
    Chemical Substances N-methyladenosine (CLE6G00625) ; RNA, Untranslated ; MicroRNAs ; RNA, Long Noncoding ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2024.116153
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  10. Article ; Online: Long-term survival of a patient with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) and untreated multiple brain metastases treated with zorifertinib: A case report.

    Li, Kang / Chen, Bolin / Wang, Jingyi / Wu, Lin

    Thoracic cancer

    2024  

    Abstract: Brain metastases (BM) are common in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) and confer poor prognoses. Zorifertinib (AZD3759), an EGFR-tyrosine kinase inhibitor (TKI) with high blood-brain barrier ... ...

    Abstract Brain metastases (BM) are common in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) and confer poor prognoses. Zorifertinib (AZD3759), an EGFR-tyrosine kinase inhibitor (TKI) with high blood-brain barrier penetration, has previously demonstrated promising systemic and intracranial antitumor activity in phase 1-3 studies. This is the first report of a patient with EGFR-mutant (exon 21 L858R) NSCLC and symptomatic untreated multiple BM who achieved a long overall survival (OS) of more than 65 months after sequential treatment with zorifertinib and a third-generation EGFR-TKI. This new treatment paradigm offers a new treatment option and deserves further clinical exploration to prolong OS of patients with EGFR-mutant NSCLC and untreated multiple BM.
    Language English
    Publishing date 2024-04-26
    Publishing country Singapore
    Document type Case Reports
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.15317
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