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Article ; Online: Tanshinone IIA positively regulates the Keap1-Nrf2 system to alleviate pulmonary fibrosis via the sestrin2-sqstm1 signaling axis-mediated autophagy.

Wu, Mingyu / Li, Hongxia / Zhai, Rao / Shan, Baixi / Guo, Congying / Chen, Jun

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 129, Page(s) 155620

Abstract: Background: Activation of myofibroblasts, linked to oxidative stress, emerges as a pivotal role in the progression of pulmonary fibrosis (PF). Our prior research has underscored the therapeutic promise of tanshinone IIA (Tan-IIA) in mitigating PF by ... ...

Abstract	Background: Activation of myofibroblasts, linked to oxidative stress, emerges as a pivotal role in the progression of pulmonary fibrosis (PF). Our prior research has underscored the therapeutic promise of tanshinone IIA (Tan-IIA) in mitigating PF by enhancing nuclear factor-erythroid 2-related factor 2 (Nrf2) activity. Nevertheless, the molecular basis through which Tan-IIA influences Nrf2 activity has yet to be fully elucidated. Methods: The influence of Tan-IIA on PF was assessed in vivo and in vitro models. Inhibitors, overexpression plasmids, and small interfering RNA (siRNA) were utilized to probe its underlying mechanism of action in vitro. Results: We demonstrate that Tan-IIA effectively activates the kelch-like ECH-associated protein 1 (Keap1)-Nrf2 antioxidant pathway, which in turn inhibits myofibroblast activation and ameliorates PF. Notably, the stability and nucleo-cytoplasmic shuttling of Nrf2 is shown to be dependent on augmented autophagic flux, which is in alignment with the observation that Tan-IIA induces autophagy. Inhibition of autophagy, conversely, fosters the activation of extracellular matrix (ECM)-producing myofibroblasts. Further, Tan-IIA initiates an autophagy program through the sestrin 2 (Sesn2)-sequestosome 1 (Sqstm1) signaling axis, crucial for protecting Nrf2 from Keap1-mediated degradation. Meanwhile, these findings were corroborated in a murine model of PF. Conclusion: Collectively, we observed for the first time that the Sqstm1-Sesn2 axis-mediated autophagic degradation of Keap1 effectively prevents myofibroblast activation and reduces the synthesis of ECM. This autophagy-dependent degradation of Keap1 can be initiated by the Tan-IIA treatment, which solidifies its potential as an Nrf2-modulating agent for PF treatment.
Language	English
Publishing date	2024-04-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155620
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Article: Dependence of Interfacial Adhesion between Substances on Their Electron Work Functions

Setiawan, Raymond Christopher / Wu, Mingyu / Li, D. Y.

Langmuir. 2022 Jan. 25, v. 38, no. 5

2022

Abstract: In this article, we demonstrate the dependence of the adhesive force (FAd) between two different substances on their electron work functions (EWF or φ) without atomic diffusion involved. The adhesive forces between Si₃N₄ and a number of metals were ... ...

Abstract	In this article, we demonstrate the dependence of the adhesive force (FAd) between two different substances on their electron work functions (EWF or φ) without atomic diffusion involved. The adhesive forces between Si₃N₄ and a number of metals were measured using an atomic force microscope. It is shown that the larger the difference in φ between the two substances in contact, the larger the FAd. FAd is also influenced by the electron freedom and density (related to the charge availability). An analytical model is proposed to elucidate the underlying mechanism and quantify the adhesive interaction.
Keywords	adhesion ; atomic force microscopy ; models
Language	English
Dates of publication	2022-0125
Size	p. 1672-1679.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.1c02442
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Article ; Online: Advances in cell-penetrating poly(disulfide)s for intracellular delivery of therapeutics.

Wan, Yu / Wang, Wangxia / Lai, Qiuyue / Wu, Mingyu / Feng, Shun

Drug discovery today

2023 Volume 28, Issue 8, Page(s) 103668

Abstract: Efficient intracellular delivery is essential for most therapeutic agents; however, existing delivery vectors face a dilemma between efficiency and toxicity, and always encounter the challenge of endolysosomal trapping. The cell-penetrating poly( ... ...

Abstract	Efficient intracellular delivery is essential for most therapeutic agents; however, existing delivery vectors face a dilemma between efficiency and toxicity, and always encounter the challenge of endolysosomal trapping. The cell-penetrating poly(disulfide) (CPD) is an effective tool for intracellular delivery, as it is taken up through thiol-mediated cellular uptake, thus avoiding endolysosomal entrapment and ensuring efficient cytosolic availability. Upon cellular uptake, CPD undergoes reductive depolymerization by glutathione inside cells and has minimal cytotoxicity. This review summarizes CPD's chemical synthesis approaches, cellular uptake mechanism, and recent advances in the intracellular delivery of proteins, antibodies, nucleic acids, and other nanoparticles. Overall, CPD is a promising candidate carrier for efficient intracellular delivery.
MeSH term(s)	Disulfides ; Proteins/metabolism ; Nanoparticles ; Antibodies ; Biological Transport ; Cell-Penetrating Peptides/metabolism
Chemical Substances	Disulfides ; Proteins ; Antibodies ; Cell-Penetrating Peptides
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2023.103668
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Article ; Online: Dependence of Interfacial Adhesion between Substances on Their Electron Work Functions.

Setiawan, Raymond Christopher / Wu, Mingyu / Li, D Y

Langmuir : the ACS journal of surfaces and colloids

2022 Volume 38, Issue 5, Page(s) 1672–1679

Abstract: In this article, we demonstrate the dependence of the adhesive force ( ...

Abstract	In this article, we demonstrate the dependence of the adhesive force (
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.1c02442
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Article ; Online: Ability of Wearable Accelerometers-Based Measures to Assess the Stability of Working Postures.

Guo, Liangjie / Kou, Junhui / Wu, Mingyu

International journal of environmental research and public health

2022 Volume 19, Issue 8

Abstract: With the rapid development and widespread application of wearable inertial sensors in the field of human motion capture, the low-cost and non-invasive accelerometer (ACC) based measures have been widely used for working postural stability assessment. ... ...

Abstract	With the rapid development and widespread application of wearable inertial sensors in the field of human motion capture, the low-cost and non-invasive accelerometer (ACC) based measures have been widely used for working postural stability assessment. This study systematically investigated the abilities of ACC-based measures to assess the stability of working postures in terms of the ability to detect the effects of work-related factors and the ability to classify stable and unstable working postures. Thirty young males participated in this study and performed twenty-four load-holding tasks (six working postures × two standing surfaces × two holding loads), and forty-three ACC-based measures were derived from the ACC data obtained by using a 17 inertial sensors-based motion capture system. ANOVAs, t-tests and machine learning (ML) methods were adopted to study the factors’ effects detection ability and the postural stability classification ability. The results show that almost all forty-three ACC-based measures could (p < 0.05) detect the main effects of Working Posture and Load Carriage, and their interaction effects. However, most of them failed in (p ≥ 0.05) detecting Standing Surface’s main or interaction effects. Five measures could detect both main and interaction effects of all the three factors, which are recommended for working postural stability assessment. The performance in postural stability classification based on ML was also good, and the feature set exerted a greater influence on the classification accuracy than sensor configuration (i.e., sensor placement locations). The results show that the pelvis and lower legs are recommended locations overall, in which the pelvis is the first choice. The findings of this study have proved that wearable ACC-based measures could assess the stability of working postures, including the work-related factors’ effects detection ability and stable-unstable working postures classification ability. However, researchers should pay more attention to the measure selection, sensors placement, feature selection and extraction in practical applications.
MeSH term(s)	Accelerometry ; Humans ; Male ; Postural Balance ; Posture ; Standing Position ; Wearable Electronic Devices
Language	English
Publishing date	2022-04-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19084695
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Article ; Online: Fluorinated vectors for gene delivery.

Wan, Yu / Yang, Yuhan / Wu, Mingyu / Feng, Shun

Expert opinion on drug delivery

2022 Volume 19, Issue 11, Page(s) 1435–1448

Abstract: Introduction: Gene delivery vectors are a crucial determinant for gene therapeutic efficacy. Usually, it is necessary to use an excess of cationic vectors to achieve better transfection efficiency. However, it will cause severe cytotoxicity. In addition, ...

Abstract	Introduction: Gene delivery vectors are a crucial determinant for gene therapeutic efficacy. Usually, it is necessary to use an excess of cationic vectors to achieve better transfection efficiency. However, it will cause severe cytotoxicity. In addition, cationic vectors are not resistant to serum, suffering from reduced transfection efficiency by forming large aggregates. Therefore, there is an urgent need to develop optimized gene delivery vectors. Recently, fluorination of vectors has been extensively applied to increase the gene delivery performance because of the unique properties of both hydrophobicity and lipophobicity, and chemical and biological inertness. Areas covered: This review will discuss the fluorophilic effects that impact gene delivery efficiency, and chemical modification approaches for fluorination. Next, recent advances and applications of fluorinated polymeric and lipidic vectors in gene therapy and gene editing are summarized. Expert opinion: Fluorinated vectors are a promising candidate for gene delivery. However, it still needs further studies to obtain pure and well-defined fluorinated polymers, guarantee the biosafety, and clarify the detailed mechanism. Apart from the improvements in gene delivery, exploiting other versatility of fluorinated vectors, such as oxygen-carrying ability, high affinity with fluorine-containing drugs, and imaging property upon introducing 19
MeSH term(s)	Gene Transfer Techniques ; Genetic Therapy/methods ; Transfection ; Cations ; Polymers ; Genetic Vectors
Chemical Substances	Cations ; Polymers
Language	English
Publishing date	2022-10-06
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2167286-6
ISSN	1744-7593 ; 1742-5247
ISSN (online)	1744-7593
ISSN	1742-5247
DOI	10.1080/17425247.2022.2131769
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Zs.A 6012: Show issues

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Article ; Online: Supporting nanoscale zero-valent iron onto shrimp shell-derived N-doped biochar to boost its reactivity and electron utilization for selenite sequestration

Wu, Mingyu / Teng, Xin / Liang, Xingtang / Zhang, Yanjun / Huang, Zuqiang / Yin, Yanzhen

Chemosphere. 2023 Apr., v. 319 p.137979-

2023

Abstract: Nanoscale zero-valent iron (nZVI) has been widely used in the reductive removal of contaminants from water, yet it still fights against the inherent passive cover and the raise of medium pH. In this study, nZVI was supported onto a nitrogen-doped biochar ...

Abstract	Nanoscale zero-valent iron (nZVI) has been widely used in the reductive removal of contaminants from water, yet it still fights against the inherent passive cover and the raise of medium pH. In this study, nZVI was supported onto a nitrogen-doped biochar (NBC) that was prepared by pyrolyzing shrimp shell for efficiently sequestrating aqueous selenite (Se(IV)). The resultant composite (NBC-nZVI) revealed a higher reactivity and electron utilization efficiency (EUE) than the bare nZVI in Se(IV) sequestration because of the positive charge, the buffering effect and the good conductivity of NBC. The kinetic rate and EUE of NBC-nZVI were increased by 143.4% and 15.3% compared to the bare nZVI, respectively, at initial pH of 3.0. The high removal capacity of 605.4 mg g⁻¹ for NBC-nZVI was obtained at Se(IV) concentration of 1000 mg L⁻¹, initial pH of 3.0, NBC-nZVI dosage of 1.0 g L⁻¹ and contact time of 12 h. Moreover, NBC-nZVI exhibited a strong tolerance to solution pHs and coexisting compounds (e.g., humic acid) and could reduce the Se(IV) concentration from 5.0 mg L⁻¹ to below the limit of drinking water (50 μg L⁻¹) in real-world samples. This work exemplified a utilization of shrimp shell-derived NBC to simultaneously enhance the reactivity and EUE of nZVI for reductively removing contaminants.
Keywords	biochar ; humic acids ; iron ; pH ; selenites ; shrimp ; shrimp shells ; N-doped biochar ; Shrimp shell ; nZVI ; Electron utilization efficiency ; Se(IV) sequestration
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.137979
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis.

Li, Hongxia / Wu, Mingyu / Guo, Congying / Zhai, Rao / Chen, Jun

The American journal of Chinese medicine

2022 Volume 50, Issue 8, Page(s) 2125–2151

Abstract: Tanshinone IIA (Tan-IIA) is a major component extracted from the traditional herbal medicine Danshen, which has shown antipulmonary fibrosis by suppress reactive oxygen species-mediated activation of myofibroblast. However, the exact mechanism of Tan-IIA ...

Abstract	Tanshinone IIA (Tan-IIA) is a major component extracted from the traditional herbal medicine Danshen, which has shown antipulmonary fibrosis by suppress reactive oxygen species-mediated activation of myofibroblast. However, the exact mechanism of Tan-IIA against pulmonary fibrosis (PF) remains unclear. This work aimed to explore the underlying mechanism of the protective effects of Tan-IIA on PF. By using high-throughput RNA-Seq analysis, we have compared the genome-wide gene expression profiles and pathway enrichment of Tan-IIA-treated NIH-3T3 cells with or without transforming growth factor beta 1 (TGF-[Formula: see text]1) induction. In normal NIH-3T3 cells, Tan-IIA treatment up-regulated 181 differential expression genes (DEGs) and down-regulated 137 DEGs. In TGF-[Formula: see text]1-induced NIH-3T3 cells, Tan-IIA treatment up-regulated 709 DEGs and down-regulated 1075 DEGs, and these DEGs were enriched in extracellular matrix organization, collagen fibril organization, cell adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway and P53 signaling pathway. Moreover, there were 207 co-expressed DEGs between Tan-IIA treatment vs. the Control and TGF-[Formula: see text]1 plus Tan-IIA treatment vs. TGF-[Formula: see text]1 alone treatment, some of which were related to anti-oxidative stress. In both normal and TGF-[Formula: see text]1-induced NIH-3T3 cells, protein-protein interaction network analysis indicated that Tan-IIA can regulate the expression of several common anti-oxidant genes including Heme oxygenase 1 (Ho-1, also known as Homx1), Sestrin2 (Sesn2), GCL modifier subunit (Gclm), GCL catalytic subunit (Gclc) and Sequestosome-1 (Sqstm1). Quantitative Real-time polymerase chain reaction analysis confirmed some DEGs specifically expressing on Tan-IIA treated cells, which provided new candidates for further functional studies of Tan-IIA. In both
MeSH term(s)	Mice ; Animals ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/genetics ; Antioxidants/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Triacetoneamine-N-Oxyl/pharmacology ; Signal Transduction
Chemical Substances	Kelch-Like ECH-Associated Protein 1 ; tanshinone (03UUH3J385) ; NF-E2-Related Factor 2 ; Antioxidants ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Triacetoneamine-N-Oxyl (2896-70-0) ; Keap1 protein, mouse
Language	English
Publishing date	2022-10-29
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X22500914
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Article ; Online: Corrigendum to' The variation of flocs activity during floc breakage and aging, adsorbing phosphate, humic acid and clay particls': [Water Research 155 (2019) 131-141].

Wu, Mingyu / Yu, Wenzheng / Qu, Jiuhui / Gregory, John

Water research

2021 Volume 199, Page(s) 117192

Language	English
Publishing date	2021-05-08
Publishing country	England
Document type	Published Erratum
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2021.117192
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Article ; Online: Exosomal miR-3174 induced by hypoxia promotes angiogenesis and metastasis of hepatocellular carcinoma by inhibiting HIPK3.

Yang, Xiao / Wu, Mingyu / Kong, Xiangxu / Wang, Yun / Hu, Chunyang / Zhu, Deming / Kong, Lianbao / Qiu, Fei / Jiang, Wangjie

iScience

2024 Volume 27, Issue 2, Page(s) 108955

Abstract: Hepatocellular carcinoma (HCC) is a highly malignant tumor with rich blood supply. HCC-derived exosomes containing hereditary substances including microRNAs (miRNAs) were involved in regulating tumor angiogenesis and metastasis. Subsequently, series ... ...

Abstract	Hepatocellular carcinoma (HCC) is a highly malignant tumor with rich blood supply. HCC-derived exosomes containing hereditary substances including microRNAs (miRNAs) were involved in regulating tumor angiogenesis and metastasis. Subsequently, series experiments were performed to evaluate the effect of exosomal miR-3174 on HCC angiogenesis and metastasis. HCC-derived exosomal miR-3174 was ingested by human umbilical vein endothelial cells (HUVECs) in which HIPK3 was targeted and silenced, causing subsequent inhibition of Fas and p53 signaling pathways. Furthermore, exosomal miR-3174 induced permeability and angiogenesis of HUVECs to enhance HCC progression and metastasis. Under hypoxia, upregulated HIF-1α further promoted the transcription of miR-3174. Moreover, HNRNPA1 augmented the package of miR-3174 into exosomes. Clinical data analysis confirmed that HCC patients with high-level miR-3174 were correlated with worse prognosis. Thus, exosomal miR-3174 induced by hypoxia promotes angiogenesis and metastasis of HCC by inhibiting HIPK3/p53 and HIPK3/Fas signaling pathways. Our findings might provide potential targets for anti-tumor therapy.
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.108955
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