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  1. Article ; Online: The Nobel Prize in Chemistry 2022: Fulfilling Demanding Applications with Simple Reactions.

    Wu, Peng

    ACS chemical biology

    2022  Volume 17, Issue 11, Page(s) 2959–2961

    Abstract: The Nobel Prize in Chemistry 2022 was awarded jointly to Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless "for the development of click chemistry and bioorthogonal chemistry". Such rapid, selective, and nontoxic covalent reactions that link two ...

    Abstract The Nobel Prize in Chemistry 2022 was awarded jointly to Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless "for the development of click chemistry and bioorthogonal chemistry". Such rapid, selective, and nontoxic covalent reactions that link two components together under benign conditions have led to a paradigm shift in basic research and practical applications.
    MeSH term(s) History, 20th Century ; Nobel Prize ; Click Chemistry ; Chemistry
    Language English
    Publishing date 2022-10-24
    Publishing country United States
    Document type Historical Article ; News
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.2c00788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A durable hydrophobic photothermal membrane based on a honeycomb structure MXene for stable and efficient solar desalination.

    Liu, Chunjiao / Wu, Peng

    RSC advances

    2024  Volume 14, Issue 15, Page(s) 10370–10377

    Abstract: Solar powered water evaporation is a green and environmentally friendly water treatment technology, which is a hot research topic for water purification at present. Advanced structural design and hydrophilic photothermal materials have achieved efficient ...

    Abstract Solar powered water evaporation is a green and environmentally friendly water treatment technology, which is a hot research topic for water purification at present. Advanced structural design and hydrophilic photothermal materials have achieved efficient solar evaporation of pure water, but the long-term stability of high salinity desalination has become a problem that cannot be ignored in practical applications. In order to solve this problem, a hydrophobic honeycomb structure MXene/AuNFs composite membrane was proposed in this paper, which used the three-dimensional highly porous microstructure of MXene and multibranched structure of gold nanoflowers particles to improve the light absorption and photothermal conversion efficiency of MXene/AuNFs. At the same time, the surface of the composite membrane was modified with hydrophobic fluorosilane 1
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra08157e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The impact of age, disease severity, and vaccination status on antibiotic use in hospitalized patients with COVID-19.

    Blais, Joseph E / Wu, Peng

    Expert opinion on pharmacotherapy

    2024  Volume 24, Issue 18, Page(s) 2227–2228

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; COVID-19 ; Drug Utilization ; Patient Acuity ; Vaccination
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2023.2270421
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  4. Article ; Online: A meta-analysis on the potency of foot-and-mouth disease vaccines in different animal models.

    Jiao, Jiao / Wu, Peng

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8931

    Abstract: Whether mice can be used as a foot-and-mouth disease (FMD) model has been debated for a long time. However, the major histocompatibility complex between pigs and mice is very different. In this study, the protective effects of FMD vaccines in different ... ...

    Abstract Whether mice can be used as a foot-and-mouth disease (FMD) model has been debated for a long time. However, the major histocompatibility complex between pigs and mice is very different. In this study, the protective effects of FMD vaccines in different animal models were analyzed by a meta-analysis. The databases PubMed, China Knowledge Infrastructure, EMBASE, and Baidu Academic were searched. For this purpose, we evaluated evidence from 14 studies that included 869 animals with FMD vaccines. A random effects model was used to combine effects using Review Manager 5.4 software. A forest plot showed that the protective effects in pigs were statistically non-significant from those in mice [MH = 0.56, 90% CI (0.20, 1.53), P = 0.26]. The protective effects in pigs were also statistically non-significant from those in guinea pigs [MH = 0.67, 95% CI (0.37, 1.21), P = 0.18] and suckling mice [MH = 1.70, 95% CI (0.10, 28.08), P = 0.71]. Non-inferiority test could provide a hypothesis that the models (mice, suckling mice and guinea pigs) could replace pigs as FMDV vaccine models to test the protective effect of the vaccine. Strict standard procedures should be established to promote the assumption that mice and guinea pigs should replace pigs in vaccine evaluation.
    MeSH term(s) Animals ; Guinea Pigs ; Mice ; Foot-and-Mouth Disease/prevention & control ; Foot-and-Mouth Disease Virus ; Antibodies, Viral ; Viral Vaccines ; Models, Animal
    Chemical Substances Antibodies, Viral ; Viral Vaccines
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59755-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inhibition of RNA-binding proteins with small molecules.

    Wu, Peng

    Nature reviews. Chemistry

    2020  Volume 4, Issue 9, Page(s) 441–458

    Abstract: Protein-RNA interactions have crucial roles in various cellular activities, which, when dysregulated, can lead to a range of human diseases. The identification of small molecules that target the interaction between RNA-binding proteins (RBPs) and RNA is ... ...

    Abstract Protein-RNA interactions have crucial roles in various cellular activities, which, when dysregulated, can lead to a range of human diseases. The identification of small molecules that target the interaction between RNA-binding proteins (RBPs) and RNA is progressing rapidly and represents a novel strategy for the discovery of chemical probes that facilitate understanding of the cellular functions of RBPs and of therapeutic agents with new mechanisms of action. In this Review, I present a current overview of targeting emerging RBPs using small-molecule inhibitors and recent progress in this burgeoning field. Small-molecule inhibitors that were reported for three representative emerging classes of RBPs, the microRNA-binding protein LIN28, the single-stranded or double-stranded RNA-binding Toll-like receptors and the CRISPR-associated (Cas) proteins, are highlighted from a medicinal-chemistry and chemical-biology perspective. However, although this field is burgeoning, challenges remain in the discovery and characterization of small-molecule inhibitors of RBPs.
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-3358
    ISSN (online) 2397-3358
    DOI 10.1038/s41570-020-0201-4
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  6. Article ; Online: Targeting Ribonucleases with Small Molecules and Bifunctional Molecules.

    Borgelt, Lydia / Wu, Peng

    ACS chemical biology

    2023  Volume 18, Issue 10, Page(s) 2101–2113

    Abstract: Ribonucleases (RNases) cleave and process RNAs, thereby regulating the biogenesis, metabolism, and degradation of coding and noncoding RNAs. Thus, small molecules targeting RNases have the potential to perturb RNA biology, and RNases have been studied as ...

    Abstract Ribonucleases (RNases) cleave and process RNAs, thereby regulating the biogenesis, metabolism, and degradation of coding and noncoding RNAs. Thus, small molecules targeting RNases have the potential to perturb RNA biology, and RNases have been studied as therapeutic targets of antibiotics, antivirals, and agents for autoimmune diseases and cancers. Additionally, the recent advances in chemically induced proximity approaches have led to the discovery of bifunctional molecules that target RNases to achieve RNA degradation or inhibit RNA processing. Here, we summarize the efforts that have been made to discover small-molecule inhibitors and activators targeting bacterial, viral, and human RNases. We also highlight the emerging examples of RNase-targeting bifunctional molecules and discuss the trends in developing such molecules for both biological and therapeutic applications.
    MeSH term(s) Humans ; Ribonucleases/metabolism ; Endoribonucleases ; RNA ; Ribonuclease, Pancreatic ; Neoplasms
    Chemical Substances Ribonucleases (EC 3.1.-) ; Endoribonucleases (EC 3.1.-) ; RNA (63231-63-0) ; Ribonuclease, Pancreatic (EC 3.1.27.5)
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.3c00191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: JORA: Weakly Supervised User Identity Linkage via Jointly Learning to Represent and Align.

    Zheng, Conghui / Pan, Li / Wu, Peng

    IEEE transactions on neural networks and learning systems

    2024  Volume 35, Issue 3, Page(s) 3900–3911

    Abstract: The user identity linkage that establishes correspondence between users across networks is a fundamental issue in various social network applications. Efforts have recently been devoted to introducing network embedding techniques that map the different ... ...

    Abstract The user identity linkage that establishes correspondence between users across networks is a fundamental issue in various social network applications. Efforts have recently been devoted to introducing network embedding techniques that map the different network users into the common representation space, thereby inferring user correspondence based on the similarities of their representations. However, existing studies that separately train the network embedding and space alignment in two stages may lead to conflict between the objectives of the two stages. Besides, the similarities between unlabeled cross-network user pairs are difficult to define and largely impact the result. Moreover, many previous methods still need plenty of labeled aligned user pairs to ensure performance, which may not be available. To address the above problems, we propose to solve the weakly-supervised user identity linkage problem via JOintly learning to Represent and Align, i.e., the JORA model. The architecture of JORA adopts the inductive graph convolutional network (GCN) that learns representations for each network. The model is jointly optimized by the representation learning component and alignment learning component. The former one aims to preserve the similarities between intranetwork users. The latter one aligns the different spaces by a projection function and aims to preserve the similarities between cross-network users. A specific attention mechanism is proposed to learn self-adaptive similarities for unlabeled user pairs during alignment learning and it reduces the error propagation caused by predefined similarities. The joint optimization helps perceive network characteristics during alignment and reduces the number of labeled users required. Experiments conducted on real social networks show that the proposed model achieves significantly better performance than the state-of-the-art methods.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2022.3201102
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  8. Article ; Online: Re: Scott et al.: SCORE2 Report 24: Nonlinear relationship of retinal thickness and visual acuity in central retinal and hemiretinal vein occlusion. (Ophthalmology. 2023;130:1066-1072).

    Wu, Peng / Gao, Rongyu / Liu, Guangsen

    Ophthalmology

    2024  

    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Letter
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2024.02.015
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    Ul II Zs.83: Show issues Location:
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  9. Article ; Online: NIR-II-Absorbing TMB Derivative for 1064 nm-Excited Photothermal Immunoassay.

    Liu, Henglin / Zhang, Xiao / Li, Xianming / Wu, Peng

    Analytical chemistry

    2024  Volume 96, Issue 14, Page(s) 5633–5639

    Abstract: Materials exhibiting strong absorption in the NIR-II region are appealing for photothermal conversion-based imaging, diagnosis, and therapy, due to better thermal effect and decreased absorption of water in such a region. 3,3',5,5'-Tetramethylbenzidine ( ... ...

    Abstract Materials exhibiting strong absorption in the NIR-II region are appealing for photothermal conversion-based imaging, diagnosis, and therapy, due to better thermal effect and decreased absorption of water in such a region. 3,3',5,5'-Tetramethylbenzidine (TMB), the typical substrate in ELISA, has been explored in photothermal immunoassay, since its oxidation product (oxTMB) is photothermally active in the NIR region. However, its absorption at 1064 nm (the most often used laser wavelength in photothermal studies) is not appreciable, thus limiting the assay sensitivity. Here, we proposed a derivative of TMB (3,3'-dimethoxy-5,5'-dimethylbenzidine, 2-OCH
    MeSH term(s) Humans ; Male ; Prostate-Specific Antigen/analysis ; Benzidines/chemistry ; Light ; Immunoassay/methods ; Nanoparticles/chemistry
    Chemical Substances 3,3',5,5'-tetramethylbenzidine (3B3T5CB8EO) ; Prostate-Specific Antigen (EC 3.4.21.77) ; Benzidines
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.4c00312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4033: Show issues Location:
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  10. Article ; Online: Integrating Recombinase Polymerase Amplification and Photosensitization Colorimetric Detection in One Tube for Fast Screening of

    Wang, Yanying / Zheng, Ting / Li, Xianming / Wu, Peng

    Analytical chemistry

    2024  Volume 96, Issue 14, Page(s) 5727–5733

    Abstract: Cronobacter ... ...

    Abstract Cronobacter sakazakii
    MeSH term(s) Infant ; Humans ; Animals ; Cronobacter sakazakii ; Powders ; Colorimetry ; Food Microbiology ; Recombinases ; Milk/microbiology ; Infant Formula ; Nucleotidyltransferases
    Chemical Substances Powders ; Recombinases ; Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.4c01130
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