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Article ; Online: Editorial commentary: Metabolic effects of cardiovascular medication: Does it matter?

Wu, Ping-Hsun

2018 Volume 29, Issue 3, Page(s) 188–189

MeSH term(s)	Cardiovascular Agents ; Cardiovascular System ; Diabetes Mellitus, Type 2 ; Humans
Chemical Substances	Cardiovascular Agents
Language	English
Publishing date	2018-09-28
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1097434-9
ISSN	1873-2615 ; 1050-1738
ISSN (online)	1873-2615
ISSN	1050-1738
DOI	10.1016/j.tcm.2018.09.015
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Zs.A 3419: Show issues

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Article ; Online: The eQTL analysis to discover unique eGFR-related SNPs for the Taiwanese population.

Wu, Ping-Hsun / Lin, Johnathan / Kuo, Mei-Chuan / Yu, Sung-Huan

Journal of nephrology

2023 Volume 37, Issue 1, Page(s) 249–252

MeSH term(s)	Humans ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Genome-Wide Association Study
Language	English
Publishing date	2023-10-19
Publishing country	Italy
Document type	Letter
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01793-8
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Zs.A 3369: Show issues

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Article ; Online: Vascular Event Risk After Herpes Zoster.

Lin, Yi-Ting / Wu, Ping-Hsun

Mayo Clinic proceedings

2019 Volume 94, Issue 8, Page(s) 1649–1650

MeSH term(s)	Herpes Zoster ; Herpesvirus 3, Human ; Humans
Language	English
Publishing date	2019-08-04
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2019.05.029
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Article: Comparison of different medical treatments for primary hyperaldosteronism: a systematic review and network meta-analysis.

Ho, Wen-Yu / Hsiao, Ching-Chung / Wu, Ping-Hsun / Chen, Jui-Yi / Tu, Yu-Kang / Wu, Vin-Cent / Chen, Jia-Jin

Therapeutic advances in chronic disease

2024 Volume 15, Page(s) 20406223241239775

Abstract: Background: The effectiveness and side effects between different medical treatments in patients with primary hyperaldosteronism have not been systematically studied.: Objective: To analyze the efficacy between different mineralocorticoid receptor ... ...

Abstract	Background: The effectiveness and side effects between different medical treatments in patients with primary hyperaldosteronism have not been systematically studied. Objective: To analyze the efficacy between different mineralocorticoid receptor antagonists (MRAs) and epithelial sodium channel (ENaC) inhibitors in a network meta-analysis (NMA) framework, while also evaluating adverse events. Design: Systematic review and NMA. Data sources and methods: The systematic review and NMA was reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, MEDLINE, the Cochrane library, and Excerpta Medica database (EMBASE) were searched for randomized controlled trials (RCTs) involving adult patients with primary hyperaldosteronism until 23 June 2023. Studies that compared the efficacy and side effects of different medical treatments of primary hyperaldosteronism were included. The primary outcomes included the effect on blood pressure, serum potassium, and major adverse cardiovascular events. The secondary outcomes were adverse events related to MRAs (hyperkalemia and gynecomastia). Frequentist NMA and pairwise meta-analysis were conducted. Results: A total of 5 RCTs comprising 392 participants were included. Eplerenone, esaxerenone, and amiloride were compared to spironolactone and demonstrated comparable effect on the reduction of systolic blood pressure. In comparison to spironolactone, eplerenone exhibited a less pronounced effect on reducing diastolic blood pressure [-4.63 mmHg; 95% confidence interval (CI): -8.87 to -0.40 mmHg] and correcting serum potassium (-0.2 mg/dL; 95% CI: -0.37 to -0.03 mg/dL). Spironolactone presented a higher risk of gynecomastia compared with eplerenone (relative risk: 4.69; 95% CI: 3.58-6.14). Conclusion: The present NMA indicated that the blood pressure reduction and potassium-correcting effects of the three MRAs may demonstrate marginal differences, with confidence levels in the evidence being very low. Therefore, further research is needed to explore the efficacy of these MRAs, especially regarding their impact on mortality and cardiovascular outcomes. Trial registration: PROSPERO (CRD: 42023446811).
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2554816-5
ISSN	2040-6231 ; 2040-6223
ISSN (online)	2040-6231
ISSN	2040-6223
DOI	10.1177/20406223241239775
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Article ; Online: Gut dysbiosis and mortality in hemodialysis patients.

Lin, Ting-Yun / Wu, Ping-Hsun / Lin, Yi-Ting / Hung, Szu-Chun

NPJ biofilms and microbiomes

2021 Volume 7, Issue 1, Page(s) 20

Abstract: Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut ... ...

Abstract	Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut microbiota was assessed by 16S ribosomal RNA gene sequencing. During a median follow-up of 2.1 years, the adjusted risk of death among patients with higher diversity (above median) was 74% lower than that among patients with lower diversity (below median). We then compared the microbial composition between nonsurvivors and survivors in a matched case-control study. We observed significantly lower microbial diversity and higher proinflammatory cytokines among nonsurvivors than survivors. Specifically, the relative abundance of Succinivibrio and Anaerostipes, two short-chain fatty acid-producing bacteria, was markedly reduced in nonsurvivors. Thus, a unique gut microbial composition is associated with an increased risk of mortality among hemodialysis patients and may be used to identify subjects with a poor prognosis.
MeSH term(s)	Aged ; Aged, 80 and over ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Case-Control Studies ; Dysbiosis/epidemiology ; Dysbiosis/mortality ; Feces/microbiology ; Female ; Gastrointestinal Microbiome ; Humans ; Male ; Middle Aged ; Phylogeny ; Prognosis ; RNA, Ribosomal, 16S/genetics ; Renal Dialysis/mortality ; Renal Insufficiency, Chronic/microbiology ; Renal Insufficiency, Chronic/mortality ; Sequence Analysis, DNA
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2817021-0
ISSN	2055-5008 ; 2055-5008
ISSN (online)	2055-5008
ISSN	2055-5008
DOI	10.1038/s41522-021-00191-x
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Article ; Online: Epigenetic transgenerational effects of PM2.5 collected from southern Taiwan on sperm functions and DNA methylation in mouse offspring.

Lee, Chia-Wei / Chen, Kuan-Ling / Yuan, Chung-Shin / Lai, Ching-Shu / Tsai, Xiang-Yi / Wu, Ping-Hsun / Hsu, Ping-Chi

Ecotoxicology and environmental safety

2023 Volume 269, Page(s) 115802

Abstract: During respiration, particulate matter with a diameter of 2.5 µm or less ( ... ...

Abstract	During respiration, particulate matter with a diameter of 2.5 µm or less (PM
MeSH term(s)	Pregnancy ; Humans ; Female ; Mice ; Male ; Animals ; DNA Methylation ; Epigenesis, Genetic ; Prenatal Exposure Delayed Effects/metabolism ; Reactive Oxygen Species/metabolism ; Taiwan ; Semen ; Spermatozoa ; Particulate Matter/metabolism ; Water/metabolism
Chemical Substances	Reactive Oxygen Species ; Particulate Matter ; Water (059QF0KO0R)
Language	English
Publishing date	2023-12-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.115802
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Zs.A 1418: Show issues

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Article ; Online: Proximal tubule-derived exosomes contribute to mesangial cell injury in diabetic nephropathy via miR-92a-1-5p transfer.

Tsai, Yi-Chun / Kuo, Mei-Chuan / Hung, Wei-Wen / Wu, Ping-Hsun / Chang, Wei-An / Wu, Ling-Yu / Lee, Su-Chu / Hsu, Ya-Ling

Cell communication and signaling : CCS

2023 Volume 21, Issue 1, Page(s) 10

Abstract: Background: Diabetic nephropathy (DN) is an increasing threat to human health and regarded to be the leading cause of end-stage renal disease worldwide. Exosomes delivery may play a key role in cross-talk among kidney cells and the progression of DN. ... ...

Abstract	Background: Diabetic nephropathy (DN) is an increasing threat to human health and regarded to be the leading cause of end-stage renal disease worldwide. Exosomes delivery may play a key role in cross-talk among kidney cells and the progression of DN. However, the mechanisms underlying exosomes in DN remain unclear. Methods: The cross-disciplinary study, including in vivo, in vitro, and human studies was conducted to explore the cross-talk between proximal tubular epithelial cells (PTECs) and mesangial cells (MCs) in DN. We purified exosome from PTECs treated with high glucose and db/db mice and assessed their influences in the pathologic change of MCs and downstream signal pathway. Healthy individuals and type 2 diabetic patients were enrolled to examine the role of exosomes in clinical applications. Results: High glucose stimulated PTECs to secrete exosomal miR-92a-1-5p, which was taken-up by glomerular MCs, inducing myofibroblast transdifferentiation (MFT) in vitro and in vivo. PTEC-released exosomal 92a-1-5p decreased reticulocalbin-3 expression, leading to endoplasmic reticulum (ER) stress by downregulating genes essential for ER homeostasis including calreticulin and mesencephalic astrocyte-derived neurotrophic factor. Treatment with miR-92a-1-5p inhibitor ameliorated kidney damage in db/db mice with DN. Urinary miR-92a-1-5p could predict kidney injury in type 2 diabetic patients. Conclusions: PTEC-derived exosomal miR-92a-1-5p modulated the kidney microenvironment in vivo and in vitro models, which altered ER stress and MFT in MCs resulting in DN progression. Further blocking miR-92a-1-5p epigenetic regulatory network could be a potential therapeutic strategy to prevent the progression of DN. Video Abstract.
MeSH term(s)	Animals ; Humans ; Mice ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Nephropathies/metabolism ; Exosomes/metabolism ; Glucose/metabolism ; Mesangial Cells/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism
Chemical Substances	Glucose (IY9XDZ35W2) ; MicroRNAs ; MIRN92 microRNA, human
Language	English
Publishing date	2023-01-13
Publishing country	England
Document type	Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-022-00997-y
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Article: Does Herpes Zoster Increase the Risk of Stroke and Myocardial Infarction? A Comprehensive Review.

Wu, Ping-Hsun / Chuang, Yun-Shiuan / Lin, Yi-Ting

Journal of clinical medicine

2019 Volume 8, Issue 4

Abstract: Herpes zoster (HZ) caused by varicella zoster virus (VZV) reactivation is characterized as a vesicular rash of unilateral distribution that can also cause multiple complications; such as post-herpetic neuralgia; ophthalmic zoster; and other neurological ... ...

Abstract	Herpes zoster (HZ) caused by varicella zoster virus (VZV) reactivation is characterized as a vesicular rash of unilateral distribution that can also cause multiple complications; such as post-herpetic neuralgia; ophthalmic zoster; and other neurological issues. VZV can also increase incident hemorrhagic or ischemic complications by causing inflammatory vasculopathy. Thus; emerging epidemiological and clinical data recognizes an association between HZ and subsequent acute strokes or myocardial infarction (MI). This study reviewed published articles to elucidate the association between HZ and cerebrovascular and cardiac events. Individuals exposed to HZ or herpes zoster ophthalmicus had 1.3 to 4-fold increased risks of cerebrovascular events. Higher risks were noted among younger patients (age < 40 years) within one year after an HZ episode. The elevated risk of CV events diminished gradually according to age and length of time after an HZ episode. The putative mechanisms of VZV vasculopathy were also discussed. Several studies showed that the development of herpes zoster and herpes zoster ophthalmicus increased the risks of stroke; transient ischemic attack; and acute cardiac events. The association between VZV infection and cardiovascular events requires further studies to establish the optimal antiviral treatment and zoster vaccination to reduce zoster-associated vascular risk.
Language	English
Publishing date	2019-04-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8040547
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Article ; Online: Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis.

Wu, Tsai-Shan / Wu, Ping-Hsun / Lin, Hsiu-Fen / Chen, Wen-Ching / Huang, Teng-Hui / Lin, Ming-Yen / Chuang, Yun-Shiuan / Yang, Fan-Pei Gloria / Chiu, Yi-Wen / Chang, Jer-Ming / Kuo, Mei-Chuan / Lin, Yi-Ting

Annals of medicine

2024 Volume 56, Issue 1, Page(s) 2310142

Abstract: Introduction: Chronic kidney disease is related to neurodegeneration and structural changes in the brain which might lead to cognitive decline. The Fazekas scale used for assessing white matter hyperintensities (WMHs) was associated with poor cognitive ... ...

Abstract	Introduction: Chronic kidney disease is related to neurodegeneration and structural changes in the brain which might lead to cognitive decline. The Fazekas scale used for assessing white matter hyperintensities (WMHs) was associated with poor cognitive performance. Therefore, this study investigated the associations between the mini-mental status examination (MMSE), Montreal cognitive assessment (MoCA), cognitive abilities screening instrument (CASI), and Fazekas scale in patients under hemodialysis (HD). Methods: The periventricular (PV) WMHs and deep WMHs (DWMHs) in brain magnetic resonance images of 59 patients under dialysis were graded using the Fazekas scale. Three cognition function tests were also performed, then multivariable ordinal regression and logistic regression were used to identify the associations between cognitive performance and the Fazekas scale. Results: There were inverse associations between the three cognitive function tests across the Fazekas scale of PVWMHs ( Conclusion: An inverse correlation existed between the Fazekas scale, predominantly in PVWMHs, and cognition in patients undergoing HD. The PVWMHs were associated with cognitive performance assessed by MMSE, MoCA, and CASI, as well as with subdomains of CASI such as memory, language and name fluency in patients undergoing HD.
MeSH term(s)	Humans ; White Matter/diagnostic imaging ; White Matter/pathology ; Cognition ; Brain/diagnostic imaging ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/diagnosis ; Magnetic Resonance Imaging ; Renal Dialysis/adverse effects
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2024.2310142
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Zs.A 680: Show issues

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Article: Exploring the Relationship between Gut Microbiome Composition and Blood Indole-3-acetic Acid in Hemodialysis Patients.

Wu, Ping-Hsun / Tseng, Yu-Fang / Liu, Wangta / Chuang, Yun-Shiuan / Tai, Chi-Jung / Tung, Chun-Wei / Lai, Kean-Yee / Kuo, Mei-Chuan / Chiu, Yi-Wen / Hwang, Shang-Jyh / Hung, Wei-Chun / Lin, Yi-Ting

Biomedicines

2024 Volume 12, Issue 1

Abstract: Indole-3-acetic acid (IAA), a protein-bound uremic toxin resulting from gut microbiota-driven tryptophan metabolism, increases in hemodialysis (HD) patients. IAA may induce endothelial dysfunction, inflammation, and oxidative stress, elevating ... ...

Abstract	Indole-3-acetic acid (IAA), a protein-bound uremic toxin resulting from gut microbiota-driven tryptophan metabolism, increases in hemodialysis (HD) patients. IAA may induce endothelial dysfunction, inflammation, and oxidative stress, elevating cardiovascular and cognitive risk in HD patients. However, research on the microbiome-IAA association is limited. This study aimed to explore the gut microbiome's relationship with plasma IAA levels in 72 chronic HD patients aged over 18 (August 2016-January 2017). IAA levels were measured using tandem mass spectrometry, and gut microbiome analysis utilized 16s rRNA next-generation sequencing. Linear discriminative analysis effect size and random forest analysis distinguished microbial species linked to IAA levels. Patients with higher IAA levels had reduced microbial diversity. Six microbial species significantly associated with IAA levels were identified;
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12010148
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