LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 3245

Search options

  1. Book ; Online: Self as Method

    Xiang, Biao / Wu, Qi

    Thinking Through China and the World

    2023  

    Author's details by Biao Xiang, Qi Wu
    Keywords Political science—Study and teaching ; China—History ; Globalization
    Subject code 370.115+Z1920
    Language English
    Size 1 Online-Ressource (VII, 268 p. 1 illus)
    Edition 1st ed. 2023
    Publisher Springer Nature Singapore ; Imprint: Palgrave Macmillan
    Publishing place Singapore
    Document type Book ; Online
    HBZ-ID HT021494664
    ISBN 978-981-19-4953-1 ; 9789811949524 ; 9789811949548 ; 9789811949555 ; 981-19-4953-0 ; 9811949522 ; 9811949549 ; 9811949557
    DOI 10.1007/978-981-19-4953-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book ; Online: Self as Method

    Xiang, Biao / Wu, Qi

    Thinking Through China and the World

    2023  

    Keywords Political science & theory ; Asian history ; Globalization ; China ; Development ; Political ; Chinese Intellectual Life ; Intellectual
    Language 0|e
    Size 1 electronic resource (268 pages)
    Publisher Springer Nature
    Publishing place Singapore
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021621212
    ISBN 9789811949531 ; 9811949530
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book: Neural regulation of metabolism

    Wu, Qi / Zheng, Ruimao

    (Advances in experimental medicine and biology ; 1090)

    2018  

    Author's details Qi Wu, Ruimao Zheng editors
    Series title Advances in experimental medicine and biology ; 1090
    Collection
    Keywords Glia cell ; Hypothalamus ; Metabolism ; Neural regulation ; Neuron ; Obesity
    Subject code 610
    Language English
    Size xi, 233 Seiten, Illustrationen, 23.5 cm x 15.5 cm
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book
    HBZ-ID HT019863268
    ISBN 978-981-13-1285-4 ; 981-13-1285-0 ; 9789811312861 ; 9811312869
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1090- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Progress in CRISPR/Cas9 for CAR-T cell therapy of tumors

    WU Qi, WANG Shaobo

    Jichu yixue yu linchuang, Vol 43, Iss 8, Pp 1313-

    2023  Volume 1316

    Abstract: CRISPR/Cas9 gene editing technology can effectively solve the problem of insufficient source of T cells in chimerical antigen receptor-T (CAR-T) therapy and enhance their anti-tumor abilities by knocking out the genes related to the suppression of T ... ...

    Abstract CRISPR/Cas9 gene editing technology can effectively solve the problem of insufficient source of T cells in chimerical antigen receptor-T (CAR-T) therapy and enhance their anti-tumor abilities by knocking out the genes related to the suppression of T cells activity. The technology can also be used to construct T cells with dual-targeting effect to stop tumor immune escape and inhibit recurrence and drug resistance development during chemotherapy. Compared with the other genetic engineering technologies that have complex processes, multiple genome editing by CRISPR/Cas9 is a technology of efficient and convenient to operate.So it is believed to be valuable and potential target molecules for CAR-T therapy.
    Keywords car-t cells|crispr/cas9|immunotherapy ; Medicine ; R
    Language Chinese
    Publishing date 2023-08-01T00:00:00Z
    Publisher Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: KRT6A Inhibits IL-1β-Mediated Pyroptosis of Keratinocytes via Blocking IL-17 Signaling.

    Li, Yuan / Wu, Qi

    Critical reviews in eukaryotic gene expression

    2024  Volume 34, Issue 4, Page(s) 1–11

    Abstract: Keratin 6A (KRT6A) is involved in the pathogenesis of various skin diseases. However, the reports on the roles of KRT6A in atopic dermatitis (AD) are limited. This study aimed to investigate the potentials of KRT6A in AD. mRNA levels were detected by RT- ... ...

    Abstract Keratin 6A (KRT6A) is involved in the pathogenesis of various skin diseases. However, the reports on the roles of KRT6A in atopic dermatitis (AD) are limited. This study aimed to investigate the potentials of KRT6A in AD. mRNA levels were detected by RT-PCR. Cytokine release was determined by ELISA. Protein expression was determined using Western blot. Cell viability was determined by CCK-8. Cytotoxicity was detected by LDH assay. Cell death was determined by TUNEL. The pyroptosis of keratinocytes was detected using flow cytometry. We found that KRT6A was overexpressed in AD patients. Moreover, KRT6A was stimulated after exposed to proinflammatory cytokines. Overexpressed KRT6A suppressed inflammatory response, while KRT6A knockdown exerted the opposite effects. Overexpressed KRT6A suppressed inflammation-induced pyroptosis of keratinocytes. Additionally, KRT6A negatively regulated interleukin-17a (IL-17a) expression, blocking IL-17 signaling. IL-17a overexpression antagonized the effects of KRT6A and promoted pyroptosis of keratinocytes. In conclusion, KRT6A exerted protective functions in AD via regulating IL-17 signaling. This KRT6A/IL-17 may be a novel target for AD.
    MeSH term(s) Humans ; Interleukin-17/genetics ; Interleukin-17/metabolism ; Interleukin-17/pharmacology ; Pyroptosis ; Keratin-6/metabolism ; Keratin-6/pharmacology ; Keratinocytes/metabolism ; Signal Transduction ; Cytokines/metabolism ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/metabolism
    Chemical Substances Interleukin-17 ; Keratin-6 ; Cytokines ; KRT6A protein, human
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1071345-1
    ISSN 1045-4403
    ISSN 1045-4403
    DOI 10.1615/CritRevEukaryotGeneExpr.2023050039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Editorial: Tumor metabolism and programmed cell death.

    Pu, Dan-Lan / Wu, Qi-Nan

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1368737

    MeSH term(s) Humans ; Neoplasms ; Apoptosis
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1368737
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: The impact of digital economy on high-quality economic development: Research based on the consumption expansion.

    Li, Xiaoxuan / Wu, Qi

    PloS one

    2023  Volume 18, Issue 12, Page(s) e0292925

    Abstract: Studies have found that the digital economy plays a positive role in promoting high-quality economic development. Meanwhile, the digital industrialization and industrial digitalization have given rise to new demands and supply modes of consumption. It is ...

    Abstract Studies have found that the digital economy plays a positive role in promoting high-quality economic development. Meanwhile, the digital industrialization and industrial digitalization have given rise to new demands and supply modes of consumption. It is necessary to analyze the role of consumption expansion in the impact of digital economy on high-quality economic development. Based on Chinese provincial panel data, we first applied the entropy weight method to construct the digital economy index and the high-quality economic development index. And on this basis, it was verified that the digital economy can positively promote the high-quality development of the inverted U-shaped structural economy. Then we separately used the mediation and the threshold effect models to analyze the role of consumption expansion in empowering high-quality development in the digital economy. Regional heterogeneity was further taken into account. The results dedicate that consumer demand and the digital economy have a partial or complete mediating effect. The promotion of high-quality development by the digital economy can be affected by the threshold of consumption expansion, which is manifested in the marginal incremental effect due to the growth of consumption supply. On the contrary, the growth of consumer demand has led to the inverted U-shape of the digital economy to promote high-quality economic development. In the heterogeneity analysis, the threshold effect also varied greatly. This research enriches the theoretical achievements and reveals the impact of consumption expansion on the digital economy affecting the high-quality development, which may provide certain reference for other countries and regions.
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0292925
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Endobronchial ultrasound-guided transbronchial needle aspiration in intrathoracic lymphadenopathy with extrathoracic malignancy.

    Li, Shi-Jie / Wu, Qi

    World journal of clinical cases

    2023  Volume 10, Issue 36, Page(s) 13227–13238

    Abstract: Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for the diagnosis of mediastinal and hilar lymph is poorly studied in patients with extrathoracic malignancies.: Aim: To evaluate the value of EBUS-TBNA for the ... ...

    Abstract Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for the diagnosis of mediastinal and hilar lymph is poorly studied in patients with extrathoracic malignancies.
    Aim: To evaluate the value of EBUS-TBNA for the diagnosis of enlarged intrathoracic lymph nodes in patients with extrathoracic malignancies.
    Methods: This was a retrospective study of patients with extrathoracic malignancies who were referred to Peking University Cancer Hospital from January 2013 to December 2018 for EBUS-TBNA due to intrathoracic lymphadenopathy. The specimens were defined as positive for malignancy, negative for non-malignancy (tuberculosis, sarcoidosis,
    Results: A total of 80 patients underwent EBUS-TBNA and had a final diagnosis, among which 50 (62.5%) were diagnosed with extrathoracic malignancy with intrathoracic lymph nodes metastasis, 14 (17.5%) were diagnosed with primary lung cancer with nodal involvement, and 16 (20.0%) exhibited benign behavior including tuberculosis, sarcoidosis and reactive lymphadenitis or who had benign follow-up. The diagnostic sensitivity, NPV, and accuracy of EBUS-TBNA for intrathoracic lymphadenopathy in patients with extrathoracic malignancy were 93.8% (
    Conclusion: EBUS-TBNA is a simple and accurate procedure for the diagnosis of intrathoracic lymphadenopathy with extrathoracic malignancy.
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i36.13227
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: A Microscale Analysis of Thermal Residual Stresses in Composites with Different Ply Orientations.

    Wang, Yanfeng / Wu, Qi

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 19

    Abstract: Composites, such as fiber-reinforced plastics, are produced using layering prepregs with varying ply orientations to achieve enhanced mechanical properties. However, this results in intricate residual stresses, which are influenced by the forming process ...

    Abstract Composites, such as fiber-reinforced plastics, are produced using layering prepregs with varying ply orientations to achieve enhanced mechanical properties. However, this results in intricate residual stresses, which are influenced by the forming process and ply orientation. In this study, three representative microscopic models-featuring discrete fiber and resin-represent unidirectional, cross-ply, and angle-ply laminates. These models underwent simulations under three different cooling histories using the finite element method. The findings suggest that ply orientation does not significantly influence temperature distribution. However, it significantly impacts the von Mises stress in the fiber closest to the interface between two stacked laminae. This differs from the inter-laminar stresses determined with the macroscopic lamination model. Apart from the free edge, which exhibits a complex stress distribution, the von Mises stress within a unit cell displays a recurring pattern. The magnitude of the von Mises stress decreases as the ply orientation angle increases and shifts when a temperature gradient is present throughout the composite's thickness. This study provides valuable insights into the mechanics of residual stresses at the microscopic level and highlights potential defect areas influenced by these stresses.
    Language English
    Publishing date 2023-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16196567
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Quantitation of dynamic total-body PET imaging: recent developments and future perspectives.

    Gu, Fengyun / Wu, Qi

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 12, Page(s) 3538–3557

    Abstract: Background: Positron emission tomography (PET) scanning is an important diagnostic imaging technique used in disease diagnosis, therapy planning, treatment monitoring, and medical research. The standardized uptake value (SUV) obtained at a single time ... ...

    Abstract Background: Positron emission tomography (PET) scanning is an important diagnostic imaging technique used in disease diagnosis, therapy planning, treatment monitoring, and medical research. The standardized uptake value (SUV) obtained at a single time frame has been widely employed in clinical practice. Well beyond this simple static measure, more detailed metabolic information can be recovered from dynamic PET scans, followed by the recovery of arterial input function and application of appropriate tracer kinetic models. Many efforts have been devoted to the development of quantitative techniques over the last couple of decades.
    Challenges: The advent of new-generation total-body PET scanners characterized by ultra-high sensitivity and long axial field of view, i.e., uEXPLORER (United Imaging Healthcare), PennPET Explorer (University of Pennsylvania), and Biograph Vision Quadra (Siemens Healthineers), further stimulates valuable inspiration to derive kinetics for multiple organs simultaneously. But some emerging issues also need to be addressed, e.g., the large-scale data size and organ-specific physiology. The direct implementation of classical methods for total-body PET imaging without proper validation may lead to less accurate results.
    Conclusions: In this contribution, the published dynamic total-body PET datasets are outlined, and several challenges/opportunities for quantitation of such types of studies are presented. An overview of the basic equation, calculation of input function (based on blood sampling, image, population or mathematical model), and kinetic analysis encompassing parametric (compartmental model, graphical plot and spectral analysis) and non-parametric (B-spline and piece-wise basis elements) approaches is provided. The discussion mainly focuses on the feasibilities, recent developments, and future perspectives of these methodologies for a diverse-tissue environment.
    MeSH term(s) Humans ; Kinetics ; Positron-Emission Tomography/methods ; Algorithms
    Language English
    Publishing date 2023-07-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06299-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top