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  1. Article ; Online: Effects of different types and frequencies of early rehabilitation on ventilator weaning among patients in intensive care units: A systematic review and meta-analysis.

    Wu, Ruo-Yan / Yeh, Huan-Jui / Chang, Kai-Jie / Tsai, Mei-Wun

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0284923

    Abstract: Objective: This study aimed to investigate the effects of different types and frequencies of physiotherapy on ventilator weaning among patients in the intensive care unit (ICU) and to identify the optimal type and frequency of intervention.: Data ... ...

    Abstract Objective: This study aimed to investigate the effects of different types and frequencies of physiotherapy on ventilator weaning among patients in the intensive care unit (ICU) and to identify the optimal type and frequency of intervention.
    Data sources: PubMed, Cochrane Library, EMBASE, and Airiti Library.
    Study selection: Randomized controlled trials that provided information on the dosage of ICU rehabilitation and the parameters related to ventilator weaning were included.
    Data extraction and management: Treatment types were classified into conventional physical therapy, exercise-based physical therapy, neuromuscular electrical stimulation (NEMS), progressive mobility, and multi-component. The frequencies were divided into high (≥ 2 sessions/day or NEMS of > 60 minutes/day), moderate (one session/day, 3-7 days/week or NEMS of 30-60 minutes/day), and low (one session/day, < 3 days/week, or NEMS of < 30 minutes/day).
    Data synthesis: Twenty-four articles were included for systematic review and 15 out of 24 articles were analyzed in the meta-analysis. Early rehabilitation, especially the progressive mobility treatment exerted an optimal effect in reducing the ventilator duration in patients in the ICU (standardized mean difference [SMD] = 0.91; 95% confidence interval [CI] = 0.23-1.58; P < 0.01). Regarding the treatment frequency, the high-frequency intervention did not result in a favorable effect on ventilator duration compared with the moderate frequency of treatment (SMD = 0.75; 95% CI = -1.13-2.64; P = 0.43).
    Conclusion: Early rehabilitation with progressive mobility is highly recommended to decrease the ventilation duration received by patients in the ICU. Depending on clinical resources and the tolerance of patients, the frequency of interventions should reach moderate-to-high frequency, that is, at least one session per day and 3 days a week.
    Trial registration: Registration number: PROSPERO (CRD42021243331).
    MeSH term(s) Humans ; Ventilator Weaning ; Respiration, Artificial/adverse effects ; Intensive Care Units ; Ventilators, Mechanical ; Exercise Therapy
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Investigating the rate of skeletal muscle atrophy in men and women in the intensive care unit: a prospective observational study.

    Wu, Ruo-Yan / Sung, Wei-Hung / Cheng, Hui-Chen / Yeh, Huan-Jui

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 16629

    Abstract: Muscle atrophy greatly affects the prognosis of patients in the intensive care unit, but the rate of change remains unclear. In this prospective observational study, we used ultrasound to measure the change in muscle thickness of the rectus femoris (RF) ... ...

    Abstract Muscle atrophy greatly affects the prognosis of patients in the intensive care unit, but the rate of change remains unclear. In this prospective observational study, we used ultrasound to measure the change in muscle thickness of the rectus femoris (RF) and vastus intermedius (VI) in 284 patients who were admitted to the SICU of Taoyuan General Hospital between January 1 and June 30, 2020. Patients were excluded if there is a wound at the right thigh which hinders the ultrasonography probe from placing. Daily rates of muscle atrophy were calculated using linear analysis and the ratios of change were plotted against the period of hospitalization. Patient characteristics were adjusted using propensity score matching and differences between men and women were analyzed. A linear mixed model was used to calculate the influence of other factors on muscle loss. The average daily atrophy rates of the RF and VI were 0.84% and 0.98%, respectively. The rate of atrophy was the highest in the third and fourth weeks. Daily atrophy rates of the RF and VI were approximately three times higher in women than in men. Protective factors of muscle atrophy included higher BMI and lower initial thickness of the RF and VI. Our study depicts the trend of muscle atrophy in the ICU and suggests more discussion in prevention to be conducted especially for women.
    MeSH term(s) Female ; Humans ; Intensive Care Units ; Male ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/physiology ; Muscular Atrophy/diagnostic imaging ; Quadriceps Muscle/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2022-10-05
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-21052-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association between weather and utilisation of physical therapy in patients with osteoarthritis: a case-crossover study.

    Wu, Ruo-Yan / Pan, Ren-Hao / Wu, Chiung-Yi / Chan, Chien-Lung / Yeh, Huan-Jui

    BMC musculoskeletal disorders

    2022  Volume 23, Issue 1, Page(s) 269

    Abstract: Background: During varied weather conditions, patients with osteoarthritis experience different severity of symptoms and signs. However, weather may also cause barriers or incentives for patients to seek medical services. These factors may result in ... ...

    Abstract Background: During varied weather conditions, patients with osteoarthritis experience different severity of symptoms and signs. However, weather may also cause barriers or incentives for patients to seek medical services. These factors may result in changes in medical utilisation; however, no studies have investigated whether the probability of physical therapy utilisation among patients with osteoarthritis is associated with changes in meteorological factors.
    Method: By using a secondary data of NHID in Taiwan, we conducted a population-based, retrospective study with case-crossover design for patients initially diagnosed with osteoarthritis between 2000 and 2013. The meteorological factors of months with the lowest treatment rate were used as patients' own control periods and compared with the parameters of months with high treatment frequency. The risk of exposure to different meteorological factors, including mean temperature, daily highest temperature, daily minimum temperature, diurnal temperature range, relative humidity, and barometric pressure, was estimated and represented by odds ratios (ORs) and 95% confidence intervals (CIs).
    Results: A total of 8,130 patients were recruited. Regardless of univariate or multivariable analysis, increased daily highest temperature enhanced the frequency of physical therapy (OR: 1.04; 95% CI: 1.02-1.05; p < 0.01; OR: 1.07; 95% CI: 1.04-1.10; p < 0.01). When the weather was hotter (> 23 °C), higher diurnal temperature range and humidity resulted in an increase in the utilisation of physical therapy. However, when the weather was colder (< 23 °C), reverse effects were observed.
    Conclusions: An increase in temperature increases the probability of physical therapy resource use. Therefore, temperature, along with other meteorological factors, may play a key role in the utilization of physical therapy among patients with osteoarthritis.
    MeSH term(s) Cross-Over Studies ; Humans ; Osteoarthritis/epidemiology ; Osteoarthritis/therapy ; Physical Therapy Modalities ; Retrospective Studies ; Weather
    Language English
    Publishing date 2022-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-022-05233-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Investigation on the integrative course of genetics and genomics].

    Liu, Zhi-Xiang / Xu, Gang-Biao / Zeng, Chao-Zhen / Wang, Ai-Yun / Wu, Ruo-Yan

    Yi chuan = Hereditas

    2011  Volume 33, Issue 7, Page(s) 801–806

    Abstract: Genomics is an important subdiscipline of genetics, and it forms a complete research system based on novel theories and techniques. Incorporating genomics in undergraduate curriculum is a response to the need of the development of genetics. The teaching ... ...

    Abstract Genomics is an important subdiscipline of genetics, and it forms a complete research system based on novel theories and techniques. Incorporating genomics in undergraduate curriculum is a response to the need of the development of genetics. The teaching of genomics has significant advantages on developing scientific thinking, enhances bioethics accomplishment, and professional interests in undergraduate students. The integration of genomics into genetics is in accordance with the principles of subject development and education. Related textbooks for undergraduate education are currently available in China, and it is feasible to set up a genetics and genomics integrative course by modifying teaching contents of the genetics course, selecting appropriate teaching approaches, and optimal application of the computer-assisted instruction.
    MeSH term(s) China ; Computer-Assisted Instruction ; Curriculum ; Genetics/education ; Genomics/education ; Humans
    Language Chinese
    Publishing date 2011-10-29
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.3724/sp.j.1005.2011.00801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Analysis of expressed sequence tags from Ginkgo mature foliage in China

    Wang, Yi-Qiang / Shen, Ji-Kang / Berglund, Torkel / Ohlsson, Anna B / Tang, Xiao-Feng / Zhou, Zhai-Kui / Wu, Ruo-Yan / Zhou, Xiao-Hui / Chen, Jie-Nan

    Tree genetics & genomes. 2010 Apr., v. 6, no. 3

    2010  

    Abstract: Ginkgo biloba L. is a tree native to China, which has large importance within medicine and horticulture. The extracts from Ginkgo mature leaves with rich flavonoids and terpenoids are commonly used for a variety of folk remedies. We constructed a cDNA ... ...

    Abstract Ginkgo biloba L. is a tree native to China, which has large importance within medicine and horticulture. The extracts from Ginkgo mature leaves with rich flavonoids and terpenoids are commonly used for a variety of folk remedies. We constructed a cDNA library derived from mature leaves of Ginkgo, which consisted of 8.12 × 10⁵ clones with the insert length of 500-2,000 bp. We performed an analysis of expressed sequence tags (ESTs) and obtained partial sequences from 2,039 clones, which represented 1,437 unigenes consisting of 249 contigs and 1,188 singletons. The 2,039 ESTs were submitted to GenBank (dbEST) at NCBI and were assigned GenBank accession numbers from GE647881 to GE649919. The 1,235 cDNA clones out of 2,039 (60.1%) were assigned putative functions, and the remaining 804 clones were not similar to any known gene sequences in the databases. The five largest categories of Ginkgo clones were: “energy” (19.4%), “disease/defense” (16%), “metabolism” (11.3%), “unclassified proteins” (12.5%), and "secondary metabolism" (9%). The highly expressed transcripts in the cDNA library were some genes related to photosynthesis, disease/defense, and flavonoid biosynthesis, including ribulose-bisphosphate carboxylase small-chain gene, pathogenesis-related protein gene, light-harvesting chlorophyll a/b binding protein of photosystem gene, catalase gene, and phenylcoumaran benzylic ether reductase gene et al. Many genes with ESTs similar to photosynthesis, secondary metabolism, and stress-response genes were characterized. The analysis of ESTs indicates that it is a useful approach for isolating Ginkgo genes homologous to known genes. Our results provide new information about mature leaf-specific transcripts of Ginkgo.
    Keywords Ginkgo biloba ; binding proteins ; biosynthesis ; cDNA libraries ; catalase ; chlorophyll ; clones ; complementary DNA ; databases ; energy ; expressed sequence tags ; flavonoids ; leaves ; nucleotide sequences ; photosynthesis ; ribulose-bisphosphate carboxylase ; stress response ; trees ; unigenes ; China
    Language English
    Dates of publication 2010-04
    Size p. 357-365.
    Publisher Springer-Verlag
    Publishing place Berlin/Heidelberg
    Document type Article
    ZDB-ID 2180926-4
    ISSN 1614-2950 ; 1614-2942
    ISSN (online) 1614-2950
    ISSN 1614-2942
    DOI 10.1007/s11295-009-0254-5
    Database NAL-Catalogue (AGRICOLA)

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