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  1. Article ; Online: Linear and Nonlinear Behaviors of the Photoreceptor Coupled Network.

    Pang, Ji-Jie / Jiang, Xiaolong / Wu, Samuel M

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2024  Volume 44, Issue 16

    Abstract: Photoreceptors are electrically coupled to one another, and the spatiotemporal properties of electrical synapses in a two-dimensional retinal network are still not well studied, because of the limitation of the single electrode or pair recording ... ...

    Abstract Photoreceptors are electrically coupled to one another, and the spatiotemporal properties of electrical synapses in a two-dimensional retinal network are still not well studied, because of the limitation of the single electrode or pair recording techniques which do not allow simultaneously measuring responses of multiple photoreceptors at various locations in the retina. A multiple electrode recording system is needed. In this study, we investigate the network properties of the two-dimensional rod coupled array of the salamander retina (both sexes were used) by using the newly available multiple patch electrode system that allows simultaneous recordings from up to eight cells and to determine the electrical connectivity among multiple rods. We found direct evidence that voltage signal spread in the rod-rod coupling network in the absence of
    MeSH term(s) Animals ; Photoreceptor Cells/physiology ; Retina/physiology ; Urodela/physiology
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1433-23.2024
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  2. Book: The mouse visual system: from photoreceptors to cortex

    Wu, Samuel M.

    [meeting in Ft. Lauderdale, FL, 23 - 24 April, 2004]

    (Vision reserach ; 44,28 = Special issue)

    2004  

    Author's details guest ed.: Samuel Wu
    Series title Vision reserach ; 44,28 = Special issue
    Vision research
    Collection Vision research
    Language English
    Size S. 3233 - 3427 : Ill., graph. Darst.
    Publisher Elsevier u.a.
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT014216492
    Database Catalogue ZB MED Medicine, Health

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    Zs A 521 -44- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Light responses and amacrine cell modulation of morphologically-identified retinal ganglion cells in the mouse retina.

    Pang, Ji-Jie / Gao, Fan / Wu, Samuel M

    Vision research

    2023  Volume 205, Page(s) 108187

    Abstract: By analyzing light-evoked spike responses, cation currents ( ... ...

    Abstract By analyzing light-evoked spike responses, cation currents (ΔI
    MeSH term(s) Animals ; Mice ; Retinal Ganglion Cells/physiology ; Amacrine Cells/physiology ; Retina/physiology ; Strychnine ; Chlorides ; Cations
    Chemical Substances Strychnine (H9Y79VD43J) ; Chlorides ; Cations
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 200427-6
    ISSN 1878-5646 ; 0042-6989
    ISSN (online) 1878-5646
    ISSN 0042-6989
    DOI 10.1016/j.visres.2023.108187
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  4. Article ; Online: Ocular Pressure-Volume Relationship and Ganglion Cell Death in Glaucoma.

    Pang, Ji-Jie / Wu, Samuel M

    OBM neurobiology

    2021  Volume 5, Issue 2

    Abstract: We studied how GC death in glaucoma related to the intraocular pressure (IOP), eyeball volume ( ... ...

    Abstract We studied how GC death in glaucoma related to the intraocular pressure (IOP), eyeball volume (V
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Journal Article
    ISSN 2573-4407
    ISSN (online) 2573-4407
    DOI 10.21926/obm.neurobiol.2102098
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  5. Article ; Online: Antagonistic surround responses in different cones are mediated by feedback synapses from different horizontal cells.

    Zhang, Ai-Jun / Wu, Samuel M

    Vision research

    2021  Volume 186, Page(s) 13–22

    Abstract: Cone photoreceptors are the first neurons along the visual pathway that exhibit center-surround antagonistic receptive fields, the basic building blocks for spatial information processing in the visual system. The surround responses in cones are mediated ...

    Abstract Cone photoreceptors are the first neurons along the visual pathway that exhibit center-surround antagonistic receptive fields, the basic building blocks for spatial information processing in the visual system. The surround responses in cones are mediated by the horizontal cells (HCs) via multiple feedback synaptic mechanisms. It has been controversial on which mechanisms are responsible for the surround-elicited depolarizing responses in cones (ΔV
    MeSH term(s) Feedback ; Retina ; Retinal Cone Photoreceptor Cells ; Synapses ; Visual Pathways
    Language English
    Publishing date 2021-05-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 200427-6
    ISSN 1878-5646 ; 0042-6989
    ISSN (online) 1878-5646
    ISSN 0042-6989
    DOI 10.1016/j.visres.2021.03.013
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  6. Article: Dual-Cell Patch-Clamp Recording Revealed a Mechanism for a Ribbon Synapse to Process Both Digital and Analog Inputs and Outputs.

    Pang, Ji-Jie / Gao, Fan / Wu, Samuel M

    Frontiers in cellular neuroscience

    2021  Volume 15, Page(s) 722533

    Abstract: A chemical synapse is either an action potential (AP) synapse or a graded potential (GP) synapse but not both. This study investigated how signals passed the glutamatergic synapse between the rod photoreceptor and its postsynaptic hyperpolarizing bipolar ...

    Abstract A chemical synapse is either an action potential (AP) synapse or a graded potential (GP) synapse but not both. This study investigated how signals passed the glutamatergic synapse between the rod photoreceptor and its postsynaptic hyperpolarizing bipolar cells (HBCs) and light responses of retinal neurons with dual-cell and single-cell patch-clamp recording techniques. The results showed that scotopic lights evoked GPs in rods, whose depolarizing Phase 3 associated with the light offset also evoked APs of a duration of 241.8 ms and a slope of 4.5 mV/ms. The depolarization speed of Phase 3 (Speed) was 0.0001-0.0111 mV/ms and 0.103-0.469 mV/ms for rods and cones, respectively. On pairs of recorded rods and HBCs, only the depolarizing limbs of square waves applied to rods evoked clear currents in HBCs which reversed at -6.1 mV, indicating cation currents. We further used stimuli that simulated the rod light response to stimulate rods and recorded the rod-evoked excitatory current (rdEPSC) in HBCs. The normalized amplitude (R/R
    Language English
    Publishing date 2021-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2021.722533
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  7. Article ; Online: Generators of Pressure-Evoked Currents in Vertebrate Outer Retinal Neurons.

    Pang, Ji-Jie / Gao, Fan / Wu, Samuel M

    Cells

    2021  Volume 10, Issue 6

    Abstract: 1) Background: High-tension glaucoma damages the peripheral vision dominated by rods. How mechanosensitive channels (MSCs) in the outer retina mediate pressure responses is unclear. (2) Methods: Immunocytochemistry, patch clamp, and channel fluorescence ...

    Abstract (1) Background: High-tension glaucoma damages the peripheral vision dominated by rods. How mechanosensitive channels (MSCs) in the outer retina mediate pressure responses is unclear. (2) Methods: Immunocytochemistry, patch clamp, and channel fluorescence were used to study MSCs in salamander photoreceptors. (3) Results: Immunoreactivity of transient receptor potential channel vanilloid 4 (TRPV4) was revealed in the outer plexiform layer, K
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium/pharmacology ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Photoreceptor Cells/physiology ; Retina/drug effects ; Retina/physiology ; Retinal Neurons/drug effects ; Retinal Neurons/physiology ; Vertebrates/physiology ; Vision, Ocular/drug effects ; Vision, Ocular/physiology
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-05-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10061288
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  8. Article ; Online: Introducing Wolfgang Baehr, the 2014 recipient of the Proctor Award.

    Wu, Samuel M

    Investigative ophthalmology & visual science

    2014  Volume 55, Issue 12, Page(s) 8651–8652

    MeSH term(s) Awards and Prizes ; Ophthalmology ; Societies, Medical
    Language English
    Publishing date 2014-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.14-16265
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    Zs.A 45: Show issues Location:
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  9. Book: Foundations of cellular neurophysiology

    Johnston, Daniel / Wu, Samuel M.

    (A Bradford book)

    1995  

    Author's details Daniel Johnston and Samuel Miao-Sin Wu
    Series title A Bradford book
    Keywords Neurons / physiology ; Ion Channels / physiology ; Synaptic Transmission / physiology ; Neurophysiologie
    Subject Nervenphysiologie ; Nervensystem
    Language English
    Size XXXI, 676 S. : graph. Darst.
    Publisher MIT Press
    Publishing place Cambridge, Mass. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006626918
    ISBN 0-262-10053-3 ; 978-0-262-10053-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1996 A 2837 order for loan Magazin

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  10. Article ; Online: Intraocular Pressure Elevation Compromises Retinal Ganglion Cell Light Adaptation.

    Tao, Xiaofeng / Sabharwal, Jasdeep / Wu, Samuel M / Frankfort, Benjamin J

    Investigative ophthalmology & visual science

    2020  Volume 61, Issue 12, Page(s) 15

    Abstract: Purpose: Functional adaptation to ambient light is a key characteristic of retinal ganglion cells (RGCs), but little is known about how adaptation is affected by factors that are harmful to RGC health. We explored adaptation-induced changes to RGC ... ...

    Abstract Purpose: Functional adaptation to ambient light is a key characteristic of retinal ganglion cells (RGCs), but little is known about how adaptation is affected by factors that are harmful to RGC health. We explored adaptation-induced changes to RGC physiology when exposed to increased intraocular pressure (IOP), a major risk factor for glaucoma.
    Methods: Wild-type mice of both sexes were subjected to 2 weeks of IOP elevation using the bead model. Retinas were assessed using a multielectrode array to record RGC responses to checkerboard white noise stimulation under both scotopic and photopic light levels. This information was used to calculate a spike-triggered average (STA) for each RGC with which to compare between lighting levels.
    Results: Low but not high IOP elevation resulted in several distinct RGC functional changes: (1) diminished adaptation-dependent receptive field (RF) center-surround interactions; (2) increased likelihood of a scotopic STA; and (3) increased spontaneous firing rate. Center RF size change with lighting level varied among RGCs, and both the center and surround STA peak times were consistently increased under scotopic illumination, although none of these properties were impacted by IOP level.
    Conclusions: These findings provide novel evidence that RGCs exhibit reduced light-dependent adaptation and increased excitability when IOP is elevated to low but not high levels. These results may reveal functional changes that occur early in glaucoma, which can potentially be used to identify patients with glaucoma at earlier stages when intervention is most beneficial.
    MeSH term(s) Adaptation, Ocular/physiology ; Animals ; Color Vision/physiology ; Contrast Sensitivity/physiology ; Disease Models, Animal ; Electrophysiology ; Female ; Intraocular Pressure/physiology ; Light ; Male ; Mice ; Mice, Inbred C57BL ; Night Vision/physiology ; Ocular Hypertension/physiopathology ; Photic Stimulation ; Retinal Degeneration/physiopathology ; Retinal Ganglion Cells/radiation effects
    Language English
    Publishing date 2020-10-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.61.12.15
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