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  1. Article ; Online: Ion Channels as a Potential Target in Pharmaceutical Designs.

    Wu, Sheng-Nan

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Voltage-gated ion channels are integral membrane proteins that respond to changes in membrane potential with rapid variations in membrane permeability to ions [ ... ]. ...

    Abstract Voltage-gated ion channels are integral membrane proteins that respond to changes in membrane potential with rapid variations in membrane permeability to ions [...].
    MeSH term(s) Ion Channels/metabolism ; Membrane Potentials ; Cell Membrane Permeability ; Ions/metabolism ; Drug Design
    Chemical Substances Ion Channels ; Ions
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Correlation between Hofstede's Cultural Dimensions and COVID-19 Data in the Early Stage of the COVID-19 Pandemic Period.

    Chang, Ling-Hsing / Wu, Sheng

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 16

    Abstract: COVID-19 (coronavirus disease 2019) has become the deadliest virus to affect the international community in recent history, with more than 760 million people infected and more than 6.87 million deaths as of March 2023; therefore, based on Hofstede's ... ...

    Abstract COVID-19 (coronavirus disease 2019) has become the deadliest virus to affect the international community in recent history, with more than 760 million people infected and more than 6.87 million deaths as of March 2023; therefore, based on Hofstede's national cultural theory, this study collected Hofstede's six national cultural dimensions on a global scale, namely, power distance (PDI), individualism/collectivism (IDV), masculinity/femininity (MAS), uncertainty avoidance (UAI), long-term/short-term orientation (LTO), and indulgence/restraint (IVR) scores, and COVID-19 data from the World Health Organization (WHO) from 22 February 2020 to 30 February 2021. Then, based on eight items of global COVID-19 data, this study analyzed the correlation between Hofstede's six dimensions and the COVID-19 data from six regions (Africa (AFRO), Europe (EURO), the Americas (AMRO), the Western Pacific (WPRO), South East Asia (SEARO), and the Eastern Mediterranean (EMRO)) divided by the WHO. This study found the following: (1) Hofstede's six cultural dimensions indeed have a significant correlation with the COVID-19 data of different WHO regions in different ways. (2) Except for IDV and UAI, PDI is a highly critical factor and has a significant correlation with the COVID-19 data from AFRO and EMRO. MAS also is an important factor and has a significant correlation with COVID-19 data from WPRO and SEARO. Meanwhile, LTO has a significant correlation with some COVID-19 data from the AMRO region, and IVR has a significant correlation with some COVID-19 data from the EURO region. Finally, the new insights from this study are worthy of further study by scholars, and they will be of great help to global governments and medical institutions in formulating policies to suppress infectious diseases in the future.
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11162258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Inhibition of Voltage-Gated Na

    Wu, Sheng-Nan / Yu, Meng-Cheng

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: KB-R7943, an isothiourea derivative, has been recognized as an inhibitor in the reverse mode of the ... ...

    Abstract KB-R7943, an isothiourea derivative, has been recognized as an inhibitor in the reverse mode of the Na
    MeSH term(s) Thiourea/pharmacology ; Sodium-Calcium Exchanger
    Chemical Substances 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate ; Thiourea (GYV9AM2QAG) ; Sodium-Calcium Exchanger
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Relationship between Discrepancies in Career Anchors of Information Technology Personnel and Career Satisfaction.

    Chang, Ling-Hsing / Wu, Sheng

    Behavioral sciences (Basel, Switzerland)

    2023  Volume 13, Issue 9

    Abstract: The career anchors of information technology personnel (ITP) are critical factors influencing their career satisfaction (CS), and these factors are also influenced by national culture. Although a number of scholars have studied the internal CS of ... ...

    Abstract The career anchors of information technology personnel (ITP) are critical factors influencing their career satisfaction (CS), and these factors are also influenced by national culture. Although a number of scholars have studied the internal CS of employees, these scholars have not explained how to increase the CS of ITP from both individual and organizational perspectives and to further improve the success rate of IS projects. Thus, this study adopts the goal-achievement gap (discrepancy) theory to explore the gap between the "internal career desires (career wants, CW)" and "external career opportunities (career have, CH)" of ITP in two different cultural societies, namely mainland China and the United Arab Emirates, and whether the gap impacts their CS. The data in this study were collected from the Internet. A survey was posted on Internet discussion forums for full-time ITP participants within organizations in China and the United Arab Emirates; thus, the results of this study are possibly only generalizable to these two countries. Finally, the results of this study provide the following contributions: (1) There are 13 career anchors (technical competence, managerial competence, autonomy, organizational stability, challenge, lifestyle, identity, creativity, variety, service, entrepreneurship, geographic security, and learning motivation) of ITP in China, which can be divided into three categories, and these are totally different from the four categories identified by ITP in the United Arab Emirates. (2) The surface analysis approach (RSA) to test the curvilinear relationship between the CW, CH, and CS of ITP indeed can explain more than the linear SEM (structural equation modeling) test between the CW and CS, CH, and CS separately, both tests are in two different cultural societies, China and the United Arab Emirates.
    Language English
    Publishing date 2023-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs13090785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Investigating the Impact of Selective Modulators on the Renin-Angiotensin-Aldosterone System: Unraveling Their Off-Target Perturbations of Transmembrane Ionic Currents.

    Lu, Te-Ling / Wu, Sheng-Nan

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining various physiological processes in the body, including blood pressure regulation, electrolyte balance, and overall cardiovascular health. However, any compounds or drugs ... ...

    Abstract The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining various physiological processes in the body, including blood pressure regulation, electrolyte balance, and overall cardiovascular health. However, any compounds or drugs known to perturb the RAAS might have an additional impact on transmembrane ionic currents. In this retrospective review article, we aimed to present a selection of chemical compounds or medications that have long been recognized as interfering with the RAAS. It is noteworthy that these substances may also exhibit regulatory effects in different types of ionic currents. Apocynin, known to attenuate the angiotensin II-induced activation of epithelial Na
    MeSH term(s) Angiotensin II/pharmacology ; Blood Pressure ; Glucocorticoids ; Receptor, Endothelin A ; Renin-Angiotensin System ; Telmisartan ; Humans
    Chemical Substances Angiotensin II (11128-99-7) ; Glucocorticoids ; Receptor, Endothelin A ; Telmisartan (U5SYW473RQ)
    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Safinamide, an inhibitor of monoamine oxidase, modulates the magnitude, gating, and hysteresis of sodium ion current.

    Hung, Te-Yu / Wu, Sheng-Nan / Huang, Chin-Wei

    BMC pharmacology & toxicology

    2024  Volume 25, Issue 1, Page(s) 17

    Abstract: Background: Safinamide (SAF), an α-aminoamide derivative and a selective, reversible monoamine oxidase (MAO)-B inhibitor, has both dopaminergic and nondopaminergic (glutamatergic) properties. Several studies have explored the potential of SAF against ... ...

    Abstract Background: Safinamide (SAF), an α-aminoamide derivative and a selective, reversible monoamine oxidase (MAO)-B inhibitor, has both dopaminergic and nondopaminergic (glutamatergic) properties. Several studies have explored the potential of SAF against various neurological disorders; however, to what extent SAF modulates the magnitude, gating, and voltage-dependent hysteresis [Hys
    Methods: With the aid of patch-clamp technology, we investigated the effects of SAF on voltage-gated sodium ion (Na
    Results: SAF concentration-dependently stimulated the transient (peak) and late (sustained) components of voltage-gated sodium ion current (I
    Conclusion: SAF may interact directly with Na
    MeSH term(s) Monoamine Oxidase ; Molecular Docking Simulation ; Benzylamines/pharmacology ; Sodium ; Alanine/analogs & derivatives
    Chemical Substances safinamide (90ENL74SIG) ; Monoamine Oxidase (EC 1.4.3.4) ; Benzylamines ; Sodium (9NEZ333N27) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2680259-4
    ISSN 2050-6511 ; 2050-6511
    ISSN (online) 2050-6511
    ISSN 2050-6511
    DOI 10.1186/s40360-024-00739-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Effect of Zinc and Severe Plastic Deformation on Mechanical Properties of AZ61 Magnesium Alloy.

    Huang, Song-Jeng / Wu, Sheng-Yu / Subramani, Murugan

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 7

    Abstract: This study investigates the effects of zinc (4 wt.%) and severe plastic deformation on the mechanical properties of AZ61 magnesium alloy through the stir-casting process. Severe plastic deformation (Equal Channel Angular Pressing (ECAP)) has been ... ...

    Abstract This study investigates the effects of zinc (4 wt.%) and severe plastic deformation on the mechanical properties of AZ61 magnesium alloy through the stir-casting process. Severe plastic deformation (Equal Channel Angular Pressing (ECAP)) has been performed followed by T4 heat treatment. The microstructural examinations revealed that the addition of 4 wt.% Zn enhances the uniform distribution of β-phase, contributing to a more uniformly corroded surface in corrosive environments. Additionally, dynamic recrystallization (DRX) significantly reduces the grain size of as-cast alloys after undergoing ECAP. The attained mechanical properties demonstrate that after a single ECAP pass, AZ61 + 4 wt.% Zn alloy exhibits the highest yield strength (YS), ultimate compression strength (UCS), and hardness. This research highlights the promising potential of AZ61 + 4 wt.% Zn alloy for enhanced mechanical and corrosion-resistant properties, offering valuable insights for applications in diverse engineering fields.
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17071678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Semisupervised Feature Learning by Deep Entropy-Sparsity Subspace Clustering.

    Wu, Sheng / Zheng, Wei-Shi

    IEEE transactions on neural networks and learning systems

    2022  Volume 33, Issue 2, Page(s) 774–788

    Abstract: While feature learning by deep neural networks is currently widely used, it is still very challenging to perform this task, given the very limited quantity of labeled data. To solve this problem, we propose to unite subspace clustering with deep ... ...

    Abstract While feature learning by deep neural networks is currently widely used, it is still very challenging to perform this task, given the very limited quantity of labeled data. To solve this problem, we propose to unite subspace clustering with deep semisupervised feature learning to form a unified learning framework to pursue feature learning by subspace clustering. More specifically, we develop a deep entropy-sparsity subspace clustering (deep ESSC) model, which forces a deep neural network to learn features using subspace clustering constrained by our designed entropy-sparsity scheme. The model can inherently harmonize deep semisupervised feature learning and subspace clustering simultaneously by the proposed self-similarity preserving strategy. To optimize the deep ESSC model, we introduce two unconstrained variables to eliminate the two constraints via softmax functions. We provide a general algebraic-treatment scheme for solving the proposed deep ESSC model. Extensive experiments with comprehensive analysis substantiate that our deep ESSC model is more effective than the related methods.
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2020.3029033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Effectiveness of Teacher Support for Students' Learning of Artificial Intelligence Popular Science Activities.

    Wu, Sheng-Yi / Yang, Kuay-Keng

    Frontiers in psychology

    2022  Volume 13, Page(s) 868623

    Abstract: The burgeoning of new technologies is increasingly affecting people's lives. One new technology that is heatedly discussed is artificial intelligence (AI) in education. To allow students to understand the impact of emerging technologies on people's ... ...

    Abstract The burgeoning of new technologies is increasingly affecting people's lives. One new technology that is heatedly discussed is artificial intelligence (AI) in education. To allow students to understand the impact of emerging technologies on people's future lives from a young age, some popular science activities are being progressively introduced into elementary school curricula. Popular science activities are informal education programs and practices of universal education. However, two issues need to be discussed in the implementation of these activities. First, because these informal curricula are usually short in duration, the question of whether they only serve to generate motivation or actually enhance learning outcomes requires examination. Second, the role of teacher support in popular science activities and its impact on students' learning results need to be further investigated. To this end, this study aims to explore the effectiveness of popular AI science activities in informal curricula on students' AI achievement and the interrelationship between students' learning outcomes in popular AI science activities with and without teacher support. A 6-h-long AI popular science activity was conducted with 22 fifth- and sixth-grade students in elementary school. This study was conducted using a one-group pretest and posttest design, and the data collection tools included AI achievement pre- and posttests and an artifact scoring rubric. The results showed that with regard to learning outcomes, popular science activities were helpful for cognitive enhancement of AI concepts, but more time was needed for skills to improve. Additionally, this study found that students' learning performance was different with and without teacher support. Activities with teacher support can enhance students' learning outcomes, but students become accustomed to relying on their teachers. In contrast, activities without teacher support seem to be more effective in fostering students' independent computational thinking and problem-solving abilities.
    Language English
    Publishing date 2022-06-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.868623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Investigating the influence of XAV-939, a tankyrase inhibitor, on the density and gating of erg-mediated K

    Ng, Woei-Ming / Wu, Sheng-Nan / Huang, Bu-Miin / So, Edmund Cheung

    European journal of pharmacology

    2024  Volume 971, Page(s) 176518

    Abstract: XAV-939(XAV) is a chemical compound that inhibits the activity of tankyrase. However, the precise way in which XAV alters membrane ionic currents is not well understood. In this study,our goal was to examine the impact of XAV on the ionic currents in ... ...

    Abstract XAV-939(XAV) is a chemical compound that inhibits the activity of tankyrase. However, the precise way in which XAV alters membrane ionic currents is not well understood. In this study,our goal was to examine the impact of XAV on the ionic currents in mouse MA-10 Leydig cells, specifically focusing on the magnitude, gating properties,and voltage-dependent hysteresis of erg-mediated K
    MeSH term(s) Mice ; Male ; Animals ; Tankyrases ; Cell Line ; Neoplasms ; Heterocyclic Compounds, 3-Ring
    Chemical Substances XAV939 ; Tankyrases (EC 2.4.2.30) ; Heterocyclic Compounds, 3-Ring
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2024.176518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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