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Article ; Online: Multiplex Aptamer-Based Fluorescence Assay Using Magnetism-Encoded Nanoparticles for Simultaneous Detection of Multiple Pathogenic Bacteria.

Wu, Sixuan / Huang, Yingjie / Wen, Jin / Huang, Jiang / Ma, Guangran / Liu, Yongjun / Tan, Hongliang

2024 Volume 96, Issue 6, Page(s) 2341–2350

Abstract: Multiplex assay has emerged as a robust and versatile method for the simultaneous detection of multiple analytes in a single test. However, challenges in terms of poor accuracy and complexity remained. In this work, we developed a multiplex aptamer-based ...

Abstract	Multiplex assay has emerged as a robust and versatile method for the simultaneous detection of multiple analytes in a single test. However, challenges in terms of poor accuracy and complexity remained. In this work, we developed a multiplex aptamer-based fluorescence assay using magnetism-encoded nanoparticles for the simultaneous detection of multiple pathogenic bacteria. The encapsulation of different amounts of Fe
MeSH term(s)	Limit of Detection ; Nanoparticles ; Bacteria ; Aptamers, Nucleotide ; Metal-Organic Frameworks
Chemical Substances	ZIF-90 ; Aptamers, Nucleotide ; Metal-Organic Frameworks
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03628
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Article ; Online: A Multi-Layer Classifier Model XR-KS of Human Activity Recognition for the Problem of Similar Human Activity.

Tan, Qiancheng / Qin, Yonghui / Tang, Rui / Wu, Sixuan / Cao, Jing

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 23

Abstract: Sensor-based human activity recognition is now well developed, but there are still many challenges, such as insufficient accuracy in the identification of similar activities. To overcome this issue, we collect data during similar human activities using ... ...

Abstract	Sensor-based human activity recognition is now well developed, but there are still many challenges, such as insufficient accuracy in the identification of similar activities. To overcome this issue, we collect data during similar human activities using three-axis acceleration and gyroscope sensors. We developed a model capable of classifying similar activities of human behavior, and the effectiveness and generalization capabilities of this model are evaluated. Based on the standardization and normalization of data, we consider the inherent similarities of human activity behaviors by introducing the multi-layer classifier model. The first layer of the proposed model is a random forest model based on the XGBoost feature selection algorithm. In the second layer of this model, similar human activities are extracted by applying the kernel Fisher discriminant analysis (KFDA) with feature mapping. Then, the support vector machine (SVM) model is applied to classify similar human activities. Our model is experimentally evaluated, and it is also applied to four benchmark datasets: UCI DSA, UCI HAR, WISDM, and IM-WSHA. The experimental results demonstrate that the proposed approach achieves recognition accuracies of 97.69%, 97.92%, 98.12%, and 90.6%, indicating excellent recognition performance. Additionally, we performed K-fold cross-validation on the random forest model and utilized ROC curves for the SVM classifier to assess the model's generalization ability. The results indicate that our multi-layer classifier model exhibits robust generalization capabilities.
MeSH term(s)	Humans ; Algorithms ; Human Activities ; Support Vector Machine ; Discriminant Analysis ; Acceleration
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23239613
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Article ; Online: Study on B16 Cell Cytotoxicity by High Frequency Reversible Electroporation With Bleomycin That Induces Hallmarks of Immunogenic Death.

Lv, Yanpeng / Chen, Shuo / Wu, Sixuan / Cheng, Xian / Shi, Jinjin / Yao, Chenguo

IEEE transactions on bio-medical engineering

2023 Volume 70, Issue 4, Page(s) 1359–1367

Abstract: Hundreds of high frequency bipolar pulse bursts with ∼1 μs have been suggested to alleviate muscle contractions and pain during the irreversible electroporation (IRE) tumor treatment. This study is performed to verify whether eight bursts of high ... ...

Abstract	Hundreds of high frequency bipolar pulse bursts with ∼1 μs have been suggested to alleviate muscle contractions and pain during the irreversible electroporation (IRE) tumor treatment. This study is performed to verify whether eight bursts of high frequency reversible electroporation pulses (HFREs) with bleomycin could be used for electrochemotherapy (ECT) tumor treatment. Firstly, in vitro experiments on B16 cells are performed to determine the cytotoxicity of the HFREs with bleomycin. The result indicates that the protocol of HFREs with bleomycin has a significant killing effect compared with only bleomycin, in which the used HFRE pulses are set to induce high membrane permeabilization while maintaining high cell viability. The immunogenic cell death (ICD) that generates danger associated molecular patterns (DAMPs) could trigger an adaptive immune response against tumors. We demonstrated that HFREs with bleomycin could trigger the hallmarks of ICD with obvious up-regulation of DAMPs, including ATP, HMGB1, and CRT. The ICD process may begin at 3 h but perform at 6 h after HFREs with bleomycin stimulation. The in vivo experiment on mice tumor treatment also showed that the protocol of HFREs with bleomycin could inhibit tumor growth with more cytotoxic CD8+ T cells infiltration. The results obtained from in vitro and in vitro experiments preliminary confirmed that the HFREs with bleomycin could be used for ECT tumor treatment associated with the hallmarks of ICD and preliminary trigger the adaptive immune response.
MeSH term(s)	Humans ; Bleomycin/pharmacology ; Bleomycin/therapeutic use ; Electrochemotherapy/methods ; Neoplasms/drug therapy ; Cell Death
Chemical Substances	Bleomycin (11056-06-7)
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2022.3216869
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Article: Impact of NDUFAF6 on breast cancer prognosis: linking mitochondrial regulation to immune response and PD-L1 expression.

Jiang, Baohong / Wu, Sixuan / Zeng, Lijun / Tang, Yuanbin / Luo, Lunqi / Ouyang, Lianjie / Feng, Wenjie / Tan, Yeru / Li, Yuehua

Cancer cell international

2024 Volume 24, Issue 1, Page(s) 99

Abstract: Background: Breast cancer is a major global health concern, and there is a continuous search for novel biomarkers to predict its prognosis. The mitochondrial protein NDUFAF6, previously studied in liver cancer, is now being investigated for its role in ... ...

Abstract	Background: Breast cancer is a major global health concern, and there is a continuous search for novel biomarkers to predict its prognosis. The mitochondrial protein NDUFAF6, previously studied in liver cancer, is now being investigated for its role in breast cancer. This study aims to explore the expression and functional significance of NDUFAF6 in breast cancer using various databases and experimental models. Methods: We analyzed breast cancer samples from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Human Protein Atlas (HPA) databases, supplemented with immunohistochemistry (IHC) staining to assess NDUFAF6 expression. A breast cancer cell xenograft mouse model was used to evaluate tumor growth, apoptosis, and NDUFAF6 expression. Survival probabilities were estimated through Kaplan-Meier plots and Cox regression analysis. A Protein-Protein Interaction (PPI) network was constructed, and differentially expressed genes related to NDUFAF6 were analyzed using GO, KEGG, and GSEA. The relationship between NDUFAF6 expression, immune checkpoints, and immune infiltration was also evaluated. Results: NDUFAF6 was found to be overexpressed in breast cancer patients and in the xenograft mouse model. Its expression correlated with worse clinical features and prognosis. NDUFAF6 expression was an independent predictor of breast cancer outcomes in both univariate and multivariate analyses. Functionally, NDUFAF6 is implicated in several immune-related pathways. Crucially, NDUFAF6 expression correlated with various immune infiltrating cells and checkpoints, particularly promoting PD-L1 expression by inhibiting the NRF2 signaling pathway. Conclusion: The study establishes NDUFAF6 as a potential prognostic biomarker in breast cancer. Its mechanism of action, involving the inhibition of NRF2 to upregulate PD-L1, highlights its significance in the disease's progression and potential as a target for immunotherapy.
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-024-03244-1
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Article ; Online: The proliferation of beneficial bacteria influences the soil C, N, and P cycling in the soybean-maize intercropping system.

Su, Hao / Lai, Huiling / Gao, Fuyun / Zhang, Ruipeng / Wu, Sixuan / Ge, Furong / Li, Yaying / Yao, Huaiying

Environmental science and pollution research international

2024 Volume 31, Issue 17, Page(s) 25688–25705

Abstract: Soybean-maize intercropping system can improve the utilization rate of farmland and the sustainability of crop production systems. However, there is a significant gap in understanding the interaction mechanisms between soil carbon (C), nitrogen (N), and ... ...

Abstract	Soybean-maize intercropping system can improve the utilization rate of farmland and the sustainability of crop production systems. However, there is a significant gap in understanding the interaction mechanisms between soil carbon (C), nitrogen (N), and phosphorus (P) cycling functional genes, rhizosphere microorganisms, and nutrient availability. To reveal the key microorganisms associated with soil nutrient utilization and C, N, and P cycling function in the soybean-maize intercropping system, we investigated the changes in soil properties, microbial community structure, and abundance of functional genes for C, N, and P cycling under soybean-maize intercropping and monocropping at different fertility stages in a pot experiment. We found that there was no significant difference in the rhizosphere microbial community between soybean-maize intercropping and monocropping at the seeding stage. As the reproductive period progressed, differences in microbial community structure between intercropping and monocropping gradually became significant, manifesting the advantages of intercropping. During the intercropping process of soybean and maize, the relative abundance of beneficial bacteria in soil rhizosphere significantly increased, particularly Streptomycetaceae and Pseudomonadaceae. Moreover, the abundances of C, N, and P cycling functional genes, such as abfA, mnp, rbcL, pmoA (C cycling), nifH, nirS-3, nosZ-2, amoB (N cycling), phoD, and ppx (P cycling), also increased significantly. Redundancy analysis and correlation analysis showed that Streptomycetaceae and Pseudomonadaceae were significantly correlated with soil properties and C, N, and P cycling functional genes. In brief, soybean and maize intercropping can change the structure of microbial community and promote the proliferation of beneficial bacteria in the soil rhizosphere. The accumulation of these beneficial bacteria increased the abundance of C, N, and P cycling functional genes in soil and enhanced the ability of plants to fully utilize environmental nutrients and promoted growth.
MeSH term(s)	Soil/chemistry ; Agriculture ; Zea mays ; Glycine max ; Bacteria/genetics ; Cell Proliferation
Chemical Substances	Soil
Language	English
Publishing date	2024-03-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32851-8
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Article ; Online: Cascade amplified colorimetric immunoassay based on an integrated multifunctional composite with catalytic coordination polymers for prostate specific antigen detection.

Wu, Sixuan / Wang, Caihong / Wang, Jinhong / Tan, Hongliang

Journal of materials chemistry. B

2020 Volume 8, Issue 46, Page(s) 10662–10669

Abstract: Coordination polymers (CPs) have been extensively investigated for a variety of applications because of their tunable structures and properties. In this work, we demonstrated the potential of catalytic CPs in the fabrication of an integrated ... ...

Abstract	Coordination polymers (CPs) have been extensively investigated for a variety of applications because of their tunable structures and properties. In this work, we demonstrated the potential of catalytic CPs in the fabrication of an integrated multifunctional composite for establishing a cascade amplified immunoassay. For this purpose, an Fe(iii)-based CP (FeCP) with peroxidase-like activity was employed as a model of catalytic CPs to simultaneously integrate glucose oxidase (GOx) and the anti-prostate specific antigen (anti-PSA) antibody through a self-adaptive inclusion process. This leads to the formation of a dual-functional anti-PSA/GOx@FeCP composite with cascade catalytic activity and capture ability to target the antigen. Benefiting from the shielding effect of FeCPs as a host, a significantly improved stability against harsh environments can be achieved for the loaded GOx and anti-PSA antibody in the composite. On this basis, by utilizing anti-PSA/GOx@FeCPs as a detection antibody, a colorimetric immunoassay based on the cascade catalysis of GOx and FeCPs as a signal amplified enhancer was developed for the detection of PSA. Under optimal conditions, satisfactory detection results have been achieved in both buffered aqueous solutions and serum samples. We believe that this study will open up a new avenue for the rational design and fabrication of multifunctional composites while offering a new cascade amplification strategy for PSA detection.
MeSH term(s)	Biosensing Techniques/methods ; Catalysis ; Colorimetry/methods ; Ferric Compounds/analysis ; Glucose Oxidase/analysis ; Humans ; Immunoassay/methods ; Male ; Polymers/analysis ; Prostate-Specific Antigen/analysis ; Prostate-Specific Antigen/blood
Chemical Substances	Ferric Compounds ; Polymers ; Glucose Oxidase (EC 1.1.3.4) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2020-11-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d0tb02104k
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Article: Investigating Heritage Language Processing: Meaning Composition in Chinese Classifier-Noun Phrasal Contexts.

Li, Fei / Hong, Xiangfei / He, Zhaoying / Wu, Sixuan / Zhang, Chenyi

Frontiers in psychology

2021 Volume 12, Page(s) 782016

Abstract: The aim of the present study was to investigate how Chinese-Malay bilingual speakers with Chinese as heritage language process semantic congruency effects in Chinese and how their brain activities compare to those of monolingual Chinese speakers using ... ...

Abstract	The aim of the present study was to investigate how Chinese-Malay bilingual speakers with Chinese as heritage language process semantic congruency effects in Chinese and how their brain activities compare to those of monolingual Chinese speakers using electroencephalography (EEG) recordings. To this end, semantic congruencies were manipulated in Chinese classifier-noun phrases, resulting in four conditions: (i) a strongly constraining/high-cloze, plausible (SP) condition, (ii) a weakly constraining/low-cloze, plausible (WP) condition, (iii) a strongly constraining/implausible (SI) condition, and (iv) a weakly constraining/implausible (WI) condition. The analysis of EEG data focused on two event-related potential components, i.e., the N400, which is known for its sensitivity to semantic fit of a target word to its context, and a post-N400 late positive complex (LPC), which is linked to semantic integration after prediction violations and retrospective, evaluative processes. We found similar N400/LPC effects in response to the manipulations of semantic congruency in the mono- and bilingual groups, with a gradient N400 pattern (WI/SI > WP > SP), a larger frontal LPC in response to WP compared to SP, SI, and WI, as well as larger centro-parietal LPCs in response to WP compared to SI and WI, and a larger centro-parietal LPC for SP compared to SI. These results suggest that, in terms of event-related potential (ERP) data, Chinese-Malay early bilingual speakers predict and integrate upcoming semantic information in Chinese classifier-noun phrase to the same extent as monolingual Chinese speakers. However, the global field power (GFP) data showed significant differences between SP and WP in the N400 and LPC time windows in bilinguals, whereas no such effects were observed in monolinguals. This finding was interpreted as showing that bilinguals differ from their monolingual peers in terms of global field power intensity of the brain by processing plausible classifier-noun pairs with different congruency effects.
Language	English
Publishing date	2021-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.782016
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Article ; Online: Radiotherapy with continued EGFR-TKIs for oligoprogressive disease in EGFR-mutated non-small cell lung cancer: A real-world study.

Hu, Chunhong / Wu, Sixuan / Deng, Renfang / Wu, Yuanqiang / Pan, Yue / Shu, Long / Wu, Fang

Cancer medicine

2022 Volume 12, Issue 1, Page(s) 266–273

Abstract: Background: Epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) develops resistance to tyrosine kinase inhibitors (TKIs). Here, we evaluated the efficacy of radiotherapy and continuation of TKIs in patients with advanced ... ...

Abstract	Background: Epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) develops resistance to tyrosine kinase inhibitors (TKIs). Here, we evaluated the efficacy of radiotherapy and continuation of TKIs in patients with advanced NSCLC with oligoprogression after EGFR-TKIs. Methods: From January 2011 to January 2019, 33 patients with EGFR-mutated NSCLC on TKIs were treated by radiotherapy and continuation of TKIs for oligoprogressive disease. The primary endpoints were median progression-free survival 1 (mPFS1), mPFS2, and median overall survival (mOS). PFS1 was measured from the start of EGFR-TKIs therapy to the oligoprogression of the disease. PFS2 was measured from the date of oligoprogression to the further progression of the disease, while OS was calculated from oligoprogression to death from any cause or was censored at the last follow-up date. Result: The mPFS1, mPFS2, and mOS were 11.0 (95% CI, 4.4-17.6), 6.5 (95% CI, 1.4-11.6) and 21.8 (95% CI, 14.8-28.8) months, respectively. Univariate analysis showed that EGFR mutation type (p = 0.024), radiotherapy method (p = 0.001), and performance status (p = 0.017) were significantly correlated with PFS2. Univariate analysis showed that sex (p = 0.038), smoking history (p = 0.031), EGFR mutation type (p = 0.012), and radiotherapy method (p = 0.009) were significantly correlated with OS. Multivariate analysis suggested that radiotherapy method (p = 0.001) and performance status (p = 0.048) were prognostic factors for PFS2, and radiotherapy method (p = 0.040) was a prognostic factor for OS. Conclusion: Radiotherapy with continued TKIs is effective for EGFR-mutated NSCLC with oligoprogression, and it should be conducted as soon as possible. T790M+ patients have higher sensitivity to radiotherapy, and patients with good performance status and stereotactic body radiation therapy have better PFS2 and OS.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; ErbB Receptors/genetics ; Protein Kinase Inhibitors/adverse effects ; Retrospective Studies ; Mutation
Chemical Substances	ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1)
Language	English
Publishing date	2022-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.4894
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Article: Research progress in biological control of tomato bacterial wilt.

Wu, Si-Xuan / Gao, Fu-Yun / Zhang, Rui-Peng / Su, Hao / Yao, Huai-Ying / Fan, Xue-Lian / Li, Ya-Ying

Ying yong sheng tai xue bao = The journal of applied ecology

2023 Volume 34, Issue 9, Page(s) 2585–2592

Abstract: Bacterial wilt caused by the infection ... ...

Title translation	番茄青枯病生物防治的研究进展.
Abstract	Bacterial wilt caused by the infection of
MeSH term(s)	Solanum lycopersicum ; Plant Diseases/prevention & control ; Plant Diseases/microbiology ; Bacteria ; Agriculture ; Soil
Chemical Substances	Soil
Language	English
Publishing date	2023-10-29
Publishing country	China
Document type	Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202309.028
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Article ; Online: Correction to "Nanoenabled Disruption of Multiple Barriers in Antigen Cross-Presentation of Dendritic Cells via Calcium Interference for Enhanced Chemo-Immunotherapy".

An, Jingyi / Zhang, Kaixiang / Wang, Binghua / Wu, Sixuan / Wang, Yifei / Zhang, Hongling / Zhang, Zhenzhong / Liu, Junjie / Shi, Jinjin

ACS nano

2023 Volume 17, Issue 21, Page(s) 22146

Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Published Erratum
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c10475
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