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Book ; Online ; E-Book: Dialysis access management

Wu, Steven

2021

Abstract: This updated volume covers the basic principles and practice of dialysis access management. To cover the latest trends and evidence from clinical trials, new chapters on the management of cephalic arch stenosis and swing zone stenosis, the role of drug ... ...

Author's details	Steven Wu [and four others], editors
Abstract	This updated volume covers the basic principles and practice of dialysis access management. To cover the latest trends and evidence from clinical trials, new chapters on the management of cephalic arch stenosis and swing zone stenosis, the role of drug eluting balloon in dialysis access interventions, the management of central vein stenosis, endovascular creation of AVF, and the management of steal syndrome have been included. Dialysis Access Management gives readers a step-by-step guide to endovascular interventions with special emphasis on the principles and rationale behind these approaches. This book is an essential text for residents, fellows, and physicians who are learning or practicing in dialysis, especially in the fields of nephrology, radiology, surgery, and vascular medicine.
Keywords	Hemodialysis ; Nephrology ; Interventional radiology
Subject code	617.461059
Language	English
Size	1 online resource (VI, 388 p. 136 illus., 93 illus. in color.)
Edition	Second edition.
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-52994-0 ; 3-030-52993-2 ; 978-3-030-52994-9 ; 978-3-030-52993-2
DOI	10.1007/978-3-030-52994-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Dialysis access management

Wu, Steven / Kalva, Sanjeeva P.

2015

Author's details	Steven Wu ; Sanjeeva P. Kalva ed
Language	English
Size	X, 274 S. : zahlr. Ill.
Publisher	Springer
Publishing place	Cham u.a.
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT018459794
ISBN	978-3-319-09092-4 ; 9783319090931 ; 3-319-09092-5 ; 3319090933
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2014 A 4339	available for loan (reading room)	Lesesaal EG

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Article ; Online: Ratiometric fluorescent semiconducting polymer dots for temperature sensing.

He, Shuyi / Wu, Steven

The Analyst

2023 Volume 148, Issue 4, Page(s) 863–868

Abstract: Semiconducting polymer dots (Pdots) have received much attention due to their unique characteristics, including high water solubility, good light stability, excellent biocompatibility, and low cost. Herein, we report a ratiometric nanoprobe based on ... ...

Abstract	Semiconducting polymer dots (Pdots) have received much attention due to their unique characteristics, including high water solubility, good light stability, excellent biocompatibility, and low cost. Herein, we report a ratiometric nanoprobe based on Pdots-Eu for temperature sensing
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d2an01717b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Semiconducting polymer dots based l-lactate sensor by enzymatic cascade reaction system.

He, Shuyi / Liu, Weichao / Wu, Steven Xu

Analytica chimica acta

2024 Volume 1303, Page(s) 342523

Abstract: Background: l-lactate detection is important for not only assessing exercise intensity, optimizing training regimens, and identifying the lactate threshold in athletes, but also for diagnosing conditions like L-lactateosis, monitoring tissue hypoxia, ... ...

Abstract	Background: l-lactate detection is important for not only assessing exercise intensity, optimizing training regimens, and identifying the lactate threshold in athletes, but also for diagnosing conditions like L-lactateosis, monitoring tissue hypoxia, and guiding critical care decisions. Moreover, l-lactate has been utilized as a biomarker to represent the state of human health. However, the sensitivity of the present l-lactate detection technique is inadequate. Results: Here, we reported a sensitive ratiometric fluorescent probe for l-lactate detection based on platinum octaethylporphyrin (PtOEP) doped semiconducting polymer dots (Pdots-Pt) with enzymatic cascade reaction. With the help of an enzyme cascade reaction, the l-lactate was continuously oxidized to pyruvic and then reduced back to l-lactate for the next cycle. During this process, oxygen and NADH were continuously consumed, which increased the red fluorescence of Pdots-Pt that responded to the changes of oxygen concentration and decreased the blue fluorescence of NADH at the same time. By comparing the fluorescence intensities at these two different wavelengths, the concentration of l-lactate was accurately measured. With the optimal conditions, the probes showed two linear detection ranges from 0.5 nM to 5.0 μM and 5.0 μM-50.0 μM for l-lactate detection. The limit of detection was calculated to be 0.18 nM by 3σ/slope method. Finally, the method shows good detection performance of l-lactate in both bovine serum and artificial serum samples, indicating its potential usage for the selective analysis of l-lactate for health monitoring and disease diagnosis. Significance: The successful application of the sensing system in the complex biological sample (bovine serum and artificial serum samples) demonstrated that this method could be used for sensitive l-lactate detection in practical clinical applications. This detection system provided an extremely low detection limit, which was several orders of magnitude lower than methods proposed in other literatures.
MeSH term(s)	Humans ; NAD ; Lactic Acid ; Athletes ; Organic Chemicals ; Oxygen ; Polymers
Chemical Substances	NAD (0U46U6E8UK) ; Lactic Acid (33X04XA5AT) ; Organic Chemicals ; Oxygen (S88TT14065) ; Polymers
Language	English
Publishing date	2024-03-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2024.342523
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ViPRA-Haplo: De Novo Reconstruction of Viral Populations Using Paired End Sequencing Data.

Li, Weiling / Malhotra, Raunaq / Wu, Steven / Jha, Manjari / Rodrigo, Allen / Poss, Mary / Acharya, Raj

IEEE/ACM transactions on computational biology and bioinformatics

2024 Volume PP

Abstract: We present ViPRA-Haplo, a de novo strain-specific assembly workflow for reconstructing viral haplotypes in a viral population from paired-end next generation sequencing (NGS) data. The proposed Viral Path Reconstruction Algorithm (ViPRA) generates a ... ...

Abstract	We present ViPRA-Haplo, a de novo strain-specific assembly workflow for reconstructing viral haplotypes in a viral population from paired-end next generation sequencing (NGS) data. The proposed Viral Path Reconstruction Algorithm (ViPRA) generates a subset of paths from a De Bruijn graph of reads using the pairing information of reads. The paths generated by ViPRA are an over-estimation of the true contigs. We propose two refinement methods to obtain an optimal set of contigs representing viral haplotypes. The first method clusters paths reconstructed by ViPRA using VSEARCH [1] based on sequence similarity, while the second method, MLEHaplo, generates a maximum likelihood estimate of viral populations. We evaluated our pipeline on both simulated and real viral quasispecies data from HIV (and real data from SARS-COV-2). Experimental results show that ViPRA-Haplo, although still an overestimation in the number of true contigs, outperforms the existing tool, PEHaplo, providing up to 9% better genome coverage on HIV real data. In addition, ViPRA-Haplo also retains higher diversity of the viral population as demonstrated by the presence of a higher percentage of contigs less than 1000 base pairs (bps), which also contain k-mers with counts less than 100 (representing rarer sequences), which are absent in PEHaplo. For SARS-CoV-2 sequencing data, ViPRA-Haplo reconstructs contigs that cover more than 90% of the reference genome and were able to validate known SARS-CoV-2 strains in the sequencing data.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ISSN	1557-9964
ISSN (online)	1557-9964
DOI	10.1109/TCBB.2024.3374595
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Article: Free fatty acid receptor 4 in cardiac myocytes ameliorates ischemic cardiomyopathy.

Zhang, Michael J / Karachenets, Sergey / Gyberg, Dylan J / Puccini, Sara / Healy, Chastity L / Wu, Steven C / Shearer, Gregory C / O'Connell, Timothy D

bioRxiv : the preprint server for biology

2024

Abstract: Aims: Free fatty acid receptor 4 (Ffar4) is a receptor for long-chain fatty acids that attenuates heart failure driven by increased afterload. Recent findings suggest that Ffar4 prevents ischemic injury in brain, liver, and kidney, and therefore, we ... ...

Abstract	Aims: Free fatty acid receptor 4 (Ffar4) is a receptor for long-chain fatty acids that attenuates heart failure driven by increased afterload. Recent findings suggest that Ffar4 prevents ischemic injury in brain, liver, and kidney, and therefore, we hypothesized that Ffar4 would also attenuate cardiac ischemic injury. Methods and results: Using a mouse model of ischemia-reperfusion (I/R), we found that mice with systemic deletion of Ffar4 (Ffar4KO) demonstrated impaired recovery of left ventricular systolic function post-I/R with no effect on initial infarct size. To identify potential mechanistic explanations for the cardioprotective effects of Ffar4, we performed bulk RNAseq to compare the transcriptomes from wild-type (WT) and Ffar4KO infarcted myocardium 3-days post-I/R. In the Ffar4KO infarcted myocardium, gene ontology (GO) analyses revealed augmentation of glycosaminoglycan synthesis, neutrophil activation, cadherin binding, extracellular matrix, rho signaling, and oxylipin synthesis, but impaired glycolytic and fatty acid metabolism, cardiac repolarization, and phosphodiesterase activity. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated impaired AMPK signaling and augmented cellular senescence in the Ffar4KO infarcted myocardium. Interestingly, phosphodiesterase 6c (PDE6c), which degrades cGMP, was the most upregulated gene in the Ffar4KO heart. Further, the soluble guanylyl cyclase stimulator, vericiguat, failed to increase cGMP in Ffar4KO cardiac myocytes, suggesting increased phosphodiesterase activity. Finally, cardiac myocyte-specific overexpression of Ffar4 prevented systolic dysfunction post-I/R, defining a cardioprotective role of Ffa4 in cardiac myocytes. Conclusions: Our results demonstrate that Ffar4 in cardiac myocytes attenuates systolic dysfunction post-I/R, potentially by attenuating oxidative stress, preserving mitochondrial function, and modulation of cGMP signaling.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.12.589280
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Article: An Analysis of Beverage Size Restrictions

Bourquard, Brian A / Wu, Steven Y

American journal of agricultural economics. 2020 Jan., v. 102, no. 1

2020

Abstract: Due to high levels of obesity, various government interventions have been proposed to curb the consumption of sugar‐sweetened beverages (SSBs). The New York City “soda ban,” which proposed to limit the size of SSBs is among the most well‐known and ... ...

Abstract	Due to high levels of obesity, various government interventions have been proposed to curb the consumption of sugar‐sweetened beverages (SSBs). The New York City “soda ban,” which proposed to limit the size of SSBs is among the most well‐known and controversial. While public debates about beverage‐size‐restrictions tend to focus on how consumers are impacted, we use a nonlinear pricing model to show that, for all but extremely tight restrictions, consumer welfare would be unaffected by an enforceable restriction. However, sellers’ profit would decline. While consumption is predicted to decline overall, the magnitude of the decline will vary by consumer segment.
Keywords	carbonated beverages ; laws and regulations ; models ; obesity ; prices ; serving size ; sugar sweetened beverages ; New York
Language	English
Dates of publication	2020-01
Size	p. 169-185.
Publishing place	Wiley Periodicals, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	218188-5
ISSN	0002-9092
ISSN	0002-9092
DOI	10.1093/ajae/aaz033
Database	NAL-Catalogue (AGRICOLA)

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Article: Softer More Frequent Stools in Infants With Difficult Stooling Fed Hydrolyzed Protein Formula With Added Prebiotics: Randomized Controlled Trial.

Fabrizio, Veronica / Harris, Cheryl L / Walsh, Kelly R / Wampler, Jennifer L / Zhuang, Weihong / Wu, Steven S

Frontiers in pediatrics

2022 Volume 10, Page(s) 894626

Abstract: Objective: To evaluate stool consistency in infants with reported hard or infrequent stools fed hydrolyzed protein formula with added prebiotics designed to promote stool softening.: Methods: In this multi-center, double-blind, controlled study, ... ...

Abstract	Objective: To evaluate stool consistency in infants with reported hard or infrequent stools fed hydrolyzed protein formula with added prebiotics designed to promote stool softening. Methods: In this multi-center, double-blind, controlled study, eligible infants (28-300 days of age at enrollment) were randomized to: partially hydrolyzed cow's milk protein formula (PHF, 75% carbohydrate as lactose; 12 mg Mg/100 kcal; Results: Baseline stool consistency (Control: 1.4 ± 0.1, PHF: 1.4 ± 0.1) and frequency were similar between groups; the majority had hard ( Conclusion: An infant formula designed to promote stool softening was well-tolerated and associated with softer, more frequent stools in infants with reported hard or infrequent stools.
Language	English
Publishing date	2022-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.894626
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Scalable single-cell profiling of chromatin modifications with sciCUT&Tag.

Janssens, Derek H / Greene, Jacob E / Wu, Steven J / Codomo, Christine A / Minot, Samuel S / Furlan, Scott N / Ahmad, Kami / Henikoff, Steven

Nature protocols

2023 Volume 19, Issue 1, Page(s) 83–112

Abstract: Cleavage under targets and tagmentation (CUT&Tag) is an antibody-directed in situ chromatin profiling strategy that is rapidly replacing immune precipitation-based methods, such as chromatin immunoprecipitation-sequencing. The efficiency of the method ... ...

Abstract	Cleavage under targets and tagmentation (CUT&Tag) is an antibody-directed in situ chromatin profiling strategy that is rapidly replacing immune precipitation-based methods, such as chromatin immunoprecipitation-sequencing. The efficiency of the method enables chromatin profiling in single cells but is limited by the numbers of cells that can be profiled. Here, we describe a combinatorial barcoding strategy for CUT&Tag that harnesses a nanowell dispenser for simple, high-resolution, high-throughput, single-cell chromatin profiling. In this single-cell combinatorial indexing CUT&Tag (sciCUT&Tag) protocol, lightly cross-linked nuclei are bound to magnetic beads and incubated with primary and secondary antibodies in bulk and then arrayed in a 96-well plate for a first round of cellular indexing by antibody-directed Tn5 tagmentation. The sample is then repooled, mixed and arrayed across 5,184 nanowells at a density of 12-24 nuclei per well for a second round of cellular indexing during PCR amplification of the sequencing-ready library. This protocol can be completed in 1.5 days by a research technician, and we illustrate the optimized protocol by profiling histone modifications associated with developmental gene repression (H3K27me3) as well as transcriptional activation (H3K4me1-2-3) in human peripheral blood mononuclear cells and use single-nucleotide polymorphisms to facilitate collision removal. We have also used sciCUT&Tag for simultaneous profiling of multiple chromatin epitopes in single cells. The reduced cost, improved resolution and scalability of sciCUT&Tag make it an attractive platform to profile chromatin features in single cells.
MeSH term(s)	Humans ; Histones/genetics ; Histones/metabolism ; Leukocytes, Mononuclear/metabolism ; Chromatin/genetics ; Protein Processing, Post-Translational ; Histone Code ; Single-Cell Analysis/methods
Chemical Substances	Histones ; Chromatin
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2244966-8
ISSN	1750-2799 ; 1754-2189
ISSN (online)	1750-2799
ISSN	1754-2189
DOI	10.1038/s41596-023-00905-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Streamlined synthesis of potential dual-emissive fluorescent silicon quantum dots (SiQDs) for cell imaging.

Sun, Di / Wu, Steven / Martin, Jeremy P / Tayutivutikul, Kirati / Du, Guodong / Combs, Colin / Darland, Diane C / Zhao, Julia Xiaojun

RSC advances

2023 Volume 13, Issue 38, Page(s) 26392–26405

Abstract: One of the current challenges of working with nanomaterials in bioapplications is having a tool that is biocompatible (non-toxic) and produces stable, intense fluorescence for bioimaging. To address these challenges, we have developed a streamlined and ... ...

Abstract	One of the current challenges of working with nanomaterials in bioapplications is having a tool that is biocompatible (non-toxic) and produces stable, intense fluorescence for bioimaging. To address these challenges, we have developed a streamlined and one-pot synthetic route for silicon-based quantum dots (SiQDs) using a hydrothermal method. Part of our unique approach for designing the SiQDs was to incorporate (3-aminopropyl) triethoxysilane (APTES), which is an amphipathic molecule with hydroxyl and amine functional groups available for modification. In order to reduce the toxicity of APTES, we chose glucose as a reducing agent for the reaction. The resulting SiQDs produced potent, stable, potential dual-emissive fluorescence emission peaks in the visible and near-infrared (NIR) ranges. Both peaks could be used as distinguishing fluorescence signals for bioimaging, separately or in combination. The physical and optical properties of the SiQDs were determined under a range of environmental conditions. The morphology, surface composition, and electronic structure of the SiQDs were characterized using high resolution-transmission electronic microscopy (HR-TEM), energy dispersive X-ray spectroscopy (EDS), Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The stability of the SiQDs was evaluated under a wide range of pHs. The biocompatibility and imaging potential of the SiQDs were tested in microvascular endothelial cells (MVEC), neural stem cells (NSC), and RAW 264.7 macrophage cells. The images obtained revealed different subcellular localizations, particularly during cell division, with distinct fluorescence intensities. The results demonstrated that SiQDs are a promising, non-toxic labeling tool for a variety of cell types, with the added advantage of having dual emission peaks both in visible and NIR ranges for bioimaging.
Language	English
Publishing date	2023-09-04
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra03669c
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