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  1. Book ; Online: Integrated Energy Systems towards Carbon Neutrality

    Liu, Pei / Liu, Ming / Wu, Xiao

    2023  

    Keywords Research & information: general ; Physics ; distributed energy system ; pipeline network layout ; reliability ; GeoSteiner algorithm ; Kruskal algorithm ; Star tree algorithm ; short-term electric load forecasting ; meteorological factors ; optimized support vector machine ; Elman neural network ; combined model ; cascade cooling system ; waste heat recovery ; LiBr-H2O absorption refrigeration ; heat load distribution ; temperature breakpoints ; electric vehicle ; intelligent control ; integrated energy system ; dual carbon target ; supercritical carbon dioxide Brayton cycle ; Simulink ; disturbance ; control strategy ; supercritical carbon dioxide brayton cycle ; dynamic model ; simulink ; performance analysis ; thermoeconomics ; exergy cost modeling ; irreversible loss ; transport decarbonisation ; systematic analysis ; modal shift ; infrastructure ; optimisation ; polygeneration ; SOFC ; optimal design ; residential ; electric vehicles ; hydrogen vehicle ; primary and recycled aluminum ; life cycle analysis ; energy consumption ; greenhouse gas emissions ; gas turbine ; conjugate heat transfer ; film cooling ; data-driven ; CFD ; energy conservation ; heat integration ; heat exchanger network synthesis ; retrofit ; mathematical programming ; superstructure ; n/a
    Language English
    Size 1 electronic resource (256 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030722322
    ISBN 9783036568041 ; 3036568042
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Assessing adverse health effects of long-term exposure to low levels of ambient air pollution: implementation of causal inference methods

    Dominici, Francesca / Zanobetti, Antonella / Schwartz, Joel / Braun, Danielle / Sabath, Ben / Wu, Xiao

    includes a commentary by the institute's low-exposure epidemiology studies review panel

    (Research report / Health Effects Institute ; 211)

    2022  

    Author's details Francesca Dominici, Antonella Zanobetti, Joel Schwartz, Danielle Braun, Ben Sabath, Xiao Wu
    Series title Research report / Health Effects Institute ; 211
    Collection
    Language English
    Size 1 Online-Ressource (xviii, 79 Seiten), Illustrationen, Karten
    Publisher Health Effects Institut
    Publishing place Boston, Mass
    Publishing country United States
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT021262166
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Scientific footprints: In memory of crocodile expert, Professor Bi-Hui Chen (1931–2022).

    Wu, Xiao-Bing

    Zoological research

    2022  Volume 43, Issue 6, Page(s) 923–926

    Language English
    Publishing date 2022-09-22
    Publishing country China
    Document type Editorial
    ISSN 2095-8137
    ISSN 2095-8137
    DOI 10.24272/j.issn.2095-8137.2022.338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pembrolizumab plus chemotherapy for advanced gastric cancer.

    Huang, Chen-Yu / Wu, Xiao-Bing

    The Lancet. Oncology

    2024  Volume 25, Issue 2, Page(s) e50

    MeSH term(s) Humans ; Stomach Neoplasms/drug therapy ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Antibodies, Monoclonal, Humanized/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
    Chemical Substances pembrolizumab (DPT0O3T46P) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Letter
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00573-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  5. Article: [Progress on treatment and prevention of complications of lumbar disc herniation].

    Wu, Xiao-Dong / Yuan, Wen

    Zhongguo gu shang = China journal of orthopaedics and traumatology

    2024  Volume 37, Issue 3, Page(s) 219–221

    MeSH term(s) Humans ; Intervertebral Disc Displacement/surgery ; Intervertebral Disc Displacement/complications ; Intervertebral Disc Degeneration/surgery ; Diskectomy ; Lumbar Vertebrae/surgery ; Treatment Outcome
    Language Chinese
    Publishing date 2024-03-22
    Publishing country China
    Document type Journal Article
    ISSN 1003-0034
    ISSN 1003-0034
    DOI 10.12200/j.issn.1003-0034.20240123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Palladium-Catalyzed Direct Carbonylation of Bromoacetonitrile to Synthesize 2-Cyano-N-acetamide and 2-Cyanoacetate Compounds.

    Bao, Zhi-Peng / Wu, Xiao-Feng

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 19, Page(s) e202301671

    Abstract: Nitrile compounds containing ester and amide groups are important functionalized chemicals in synthetic and medicinal chemistry. In this article, an efficient and convenient palladium-catalyzed carbonylative procedure toward 2-cyano-N-acetamide and 2- ... ...

    Abstract Nitrile compounds containing ester and amide groups are important functionalized chemicals in synthetic and medicinal chemistry. In this article, an efficient and convenient palladium-catalyzed carbonylative procedure toward 2-cyano-N-acetamide and 2-cyanoacetate compounds has been developed. The reaction proceeds under mild conditions via radical intermediate which is suitable for late-stage functionalization. Gram-scale experiment was performed successfully under low catalyst loading and gave the target product in excellent yield. Additionally, this transformation can be performed under atmospheric pressure and provide alternative routes to 7 drug precursors.
    Language English
    Publishing date 2023-03-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202301671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Multiple myeloma identified within the same site of the mandible with medication-related osteonecrosis of jaw: An unusual case report.

    Wu, Xiao-Hong / Chen, Shi-Wei

    Medicine

    2023  Volume 102, Issue 29, Page(s) e34260

    Abstract: Rationale: Multiple myeloma (MM) is a malignant disease characterized by abnormal proliferation of plasma cells, which usually occurs in middle-aged and elderly male patients. Bisphosphonates (BP) are commonly used for the treatment of MM bone disease. ... ...

    Abstract Rationale: Multiple myeloma (MM) is a malignant disease characterized by abnormal proliferation of plasma cells, which usually occurs in middle-aged and elderly male patients. Bisphosphonates (BP) are commonly used for the treatment of MM bone disease. Long-time use of BP may cause medication-related osteonecrosis of the jaw (MRONJ). MRONJ occurs in jaw exclusively, and Multiple myeloma can also invade the jaw. The 2 diseases have similar clinical manifestations and imaging findings. This report present a case of MM identified in surgical specimen at the site that had been previously pathologically diagnosed as MRONJ in a patient with MM.
    Patient concerns: A 57-years-old male patient visited our clinic on October 16, 2020 because of gingival swelling and pain in the right mandible for 1 month after extraction of the lower right premolar. The patient had a long-time illness history of multiple myeloma, and received intravenous zoledronic acid treatment.
    Diagnoses: Based on the clinical characteristics, imaging, and pathological findings of sequestrum formation and high inflammatory cell infiltration, the patient was diagnosed with MRONJ. After 1 year, a mandibular osteotomy was performed and pathological analysis showed the presence of necrotic bone and a large number of abnormal plasma cell infiltration, suggesting the presence of MM in the mandible.
    Interventions: The patient was treated with a series of conservative treatments including antibiotic treatment, saline irrigation and laser irradiation, as well as superficial sequestration was. One year later, a mandibular osteotomy was performed.
    Outcomes: For the patient, the symptoms of gingival swelling, pain and discharge disappeared after surgery.
    Lessons: These findings suggested MRONJ and MM could occur simultaneously at same site, so patients with MM presenting with symptoms of MRONJ should be screened for concurrent or disease relapse of multiple myeloma to prevent misdiagnosis or inadequate management. Meanwhile, this also suggests long-term inflammatory may lead to invasion of multiple myeloma.
    MeSH term(s) Humans ; Male ; Middle Aged ; Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnosis ; Bisphosphonate-Associated Osteonecrosis of the Jaw/surgery ; Bone Density Conservation Agents/adverse effects ; Diphosphonates ; Mandible/surgery ; Multiple Myeloma/drug therapy ; Multiple Myeloma/complications ; Neoplasm Recurrence, Local/drug therapy ; Pain/drug therapy
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000034260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article: 2021—2022年度系统性红斑狼疮研究进展盘点.

    Li, Yong-Zhen / Wu, Xiao-Chuan

    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

    2023  Volume 25, Issue 8, Page(s) 785–790

    Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organ systems, presenting a complex and diverse clinical manifestation. The heterogeneous treatment response and prognosis of SLE pose significant challenges to its ... ...

    Title translation Research progress in systemic lupus erythematosus from 2021 to 2022.
    Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organ systems, presenting a complex and diverse clinical manifestation. The heterogeneous treatment response and prognosis of SLE pose significant challenges to its diagnosis, classification, and homogeneous treatment. The emergence of new technologies and fields, such as synthetic biology, genomics, and proteomics, has contributed to a deeper exploration of the pathogenesis and biomarkers of SLE, facilitating precision diagnosis and treatment. This review summarizes the latest research data and achievements in SLE for the years 2021-2022, providing an overview and summary of relevant studies conducted in the past two years.
    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/therapy ; Proteomics
    Language Chinese
    Publishing date 2023-09-06
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 1008-8830
    ISSN 1008-8830
    DOI 10.7499/j.issn.1008-8830.2302150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Copper-catalyzed synthesis of β-boryl cyclopropanes

    Geng, Hui-Qing / Wu, Xiao-Feng

    Chemical science

    2023  Volume 14, Issue 21, Page(s) 5638–5642

    Abstract: Cyclopropane represents one of the most critical rings and has been found present in various bioactive compounds, especially in clinical medicines. It can be synthesized by the reaction of olefins with diazo-derived carbenoids which are potentially ... ...

    Abstract Cyclopropane represents one of the most critical rings and has been found present in various bioactive compounds, especially in clinical medicines. It can be synthesized by the reaction of olefins with diazo-derived carbenoids which are potentially hazardous. Carbonylation is a powerful tool for synthesizing carbonylated or carbon-extended compounds. In this communication, we describe a straightforward approach for synthesizing β-boryl cyclopropane derivatives catalyzed by an inexpensive copper catalyst with CO as the C1 source. This reaction was mediated by an
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc01090b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MiR-328-3p promotes TGF-β1-induced proliferation, migration, and inflammation of airway smooth muscle cells by regulating the PTEN/Akt pathway.

    Gao, Jie / Wu, Xiao-Lei

    Allergologia et immunopathologia

    2023  Volume 51, Issue 2, Page(s) 151–159

    Abstract: Background: Recent studies have shown that the up-regulation of microRNA miR-328-3p expression increases seasonal allergy and asthma symptoms in children, but the specific mechanism remains unclear. Therefore, the aim of this study was to explore the ... ...

    Abstract Background: Recent studies have shown that the up-regulation of microRNA miR-328-3p expression increases seasonal allergy and asthma symptoms in children, but the specific mechanism remains unclear. Therefore, the aim of this study was to explore the role and mechanism of -miR-328-3p in transforming growth factor (TGF)-β1-induced airway smooth muscle cells (ASMCs).
    Methods: The effect of TGF-β1 on the expression of miR-328-3p in ASMCs was examined by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cells proliferation, migration, and inflammatory factors in TGF-β1-induced ASMCs were measured by cell counting kit-8 (CCK-8), transwell, and enzyme-linked immunosorbent assay (ELISA), respectively. Besides, TargetScan was used to predict phosphatase and tensin homolog (PTEN), the downstream target of miR-328-3p; double-luciferase reporter assay, western blot, and qRT-PCR were used to verify the targeting relationship between miR-328-3p and PTEN; western blot was also used to examine the effects of PTEN and miR-328-3p knockdown on the expression levels of PTEN, Akt, and p-Akt proteins.
    Results: The expression of miR-328-3p was up-regulated in TGF-β1-induced ASMCs. Knockdown of miR-328-3p significantly inhibited proliferation, migration, and inflammation of ASMCs induced by TGF-β1 and decreased levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1β. The dual--luciferase reporter assay results confirmed that PTEN was a target gene of miR-328-3p. Moreover, inhibition of PTEN expression reversed the inhibitory effect of low miR-328-3p expression on -TGF-β1-induced ASMC's proliferation, migration, and inflammation. In comparison to the knockdown of miR-328-3p alone, the simultaneous knockdown of miR-328-3p with PTEN decreased PTEN protein expression levels and increased p-Akt/Akt ratio in TGF-β1-induced ASMCs.
    Conclusion: Through regulating the expression of PTEN and the activity of Akt signaling pathway, miR-328-3p promotes TGF-β1-induced proliferation, migration, and inflammation of ASMCs.
    MeSH term(s) Child ; Humans ; Cell Movement ; Cell Proliferation/genetics ; Inflammation/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myocytes, Smooth Muscle ; Proto-Oncogene Proteins c-akt/metabolism ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; PTEN Phosphohydrolase/pharmacology ; Transforming Growth Factor beta1/genetics
    Chemical Substances MicroRNAs ; MIRN328 microRNA, human ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67) ; Transforming Growth Factor beta1 ; TGFB1 protein, human
    Language English
    Publishing date 2023-03-01
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    DOI 10.15586/aei.v51i2.767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1165: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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