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Article ; Online: Halofuginone inhibits cell proliferation and AKT/mTORC1 signaling in uterine leiomyoma cells.

Lin, Jing / Wu, Xiaochun

2022 Volume 40, Issue 5-6, Page(s) 212–220

Abstract: The present study aimed to explore the effects of antifibrotic agent halofuginone on uterine leiomyomas (ULs) cells. The survival of the uterine smooth muscle (UtSMC) cells and UL ELT3 cells were measured. Flow cytometry was used to assess the cell cycle ...

Abstract	The present study aimed to explore the effects of antifibrotic agent halofuginone on uterine leiomyomas (ULs) cells. The survival of the uterine smooth muscle (UtSMC) cells and UL ELT3 cells were measured. Flow cytometry was used to assess the cell cycle distribution and apoptosis. Effects of halofuginone on the state of AKT/mTOR pathway were evaluated. Xenograft animal model was applied to explore the effects of halofuginone
MeSH term(s)	Female ; Animals ; Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Uterine Neoplasms/drug therapy ; Uterine Neoplasms/metabolism ; Uterine Neoplasms/pathology ; Leiomyoma/drug therapy ; Leiomyoma/metabolism ; Leiomyoma/pathology ; Cell Proliferation ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/pharmacology ; TOR Serine-Threonine Kinases/therapeutic use ; Signal Transduction ; Apoptosis ; Mechanistic Target of Rapamycin Complex 1/metabolism
Chemical Substances	halofuginone (L31MM1385E) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
Language	English
Publishing date	2022-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1035755-5
ISSN	1029-2292 ; 0897-7194
ISSN (online)	1029-2292
ISSN	0897-7194
DOI	10.1080/08977194.2022.2113394
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Article ; Online: Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway.

Luo, Yan / Zhou, Feng / Wang, Xiaojing / Yang, Runwei / Li, Yi / Wu, Xiaochun / Ye, Bin

Journal of orthopaedic surgery and research

2024 Volume 19, Issue 1, Page(s) 158

Abstract: Background: Osteoarthritis (OA) is a joint disease characterized by inflammation and progressive cartilage degradation. Chondrocyte apoptosis is the most common pathological feature of OA. Interleukin-1β (IL-1β), a major inflammatory cytokine that ... ...

Abstract	Background: Osteoarthritis (OA) is a joint disease characterized by inflammation and progressive cartilage degradation. Chondrocyte apoptosis is the most common pathological feature of OA. Interleukin-1β (IL-1β), a major inflammatory cytokine that promotes cartilage degradation in OA, often stimulates primary human chondrocytes in vitro to establish an in vitro OA model. Moreover, IL-1β is involved in OA pathogenesis by stimulating the phosphoinositide-3-kinase (PI3K)/Akt and mitogen-activated protein kinases pathways. The G-protein-coupled receptor, cc chemokine receptor 10 (CCR10), plays a vital role in the occurrence and development of various malignant tumors. However, the mechanism underlying the role of CCR10 in the pathogenesis of OA remains unclear. We aimed to evaluate the protective effect of CCR10 on IL-1β-stimulated CHON-001 cells and elucidate the underlying mechanism. Methods: The CHON-001 cells were transfected with a control small interfering RNA (siRNA) or CCR10-siRNA for 24 h, and stimulated with 10 ng/mL IL-1β for 12 h to construct an OA model in vitro. The levels of CCR10, cleaved-caspase-3, MMP-3, MMP-13, Collagen II, Aggrecan, p-PI3K, PI3K, p-Akt, Akt, phosphorylated-mammalian target of rapamycin (p-mTOR), and mTOR were detected using quantitative reverse transcription polymerase chain reaction and western blotting. Viability, cytotoxicity, and apoptosis of CHON-001 cells were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, lactate dehydrogenase assay (LDH), and flow cytometry analysis, respectively. Inflammatory cytokines (TNF-α, IL-6, and IL-8) were assessed using enzyme-linked immunosorbent assay. Results: Level of CCR10 was substantially higher in the IL-1β-stimulated CHON-001 cells than that in the control group, whereas CCR10 was down-regulated in the CCR10-siRNA transfected CHON-001 cells compared to that in the control-siRNA group. Notably, CCR10 inhibition alleviated IL-1β-induced inflammatory injury in the CHON-001 cells, as verified by enhanced cell viability, inhibited LDH release, reduced apoptotic cells, and cleaved-caspase-3 expression. Meanwhile, IL-1β induced the release of tumor necrosis factor alpha, IL-6, and IL-8, increase of MMP-3 and MMP-13, and decrease of Collagen II and Aggrecan in the CHON-001 cells, which were reversed by CCR10-siRNA. However, these effects were reversed upon PI3K agonist 740Y-P treatment. Further, IL-1β-induced PI3K/Akt/mTOR signaling pathway activation was inhibited by CCR10-siRNA, which was increased by 740Y-P treatment. Conclusion: Inhibition of CCR10 alleviates IL-1β-induced chondrocytes injury via PI3K/Akt/mTOR pathway inhibition, suggesting that CCR10 might be a promising target for novel OA therapeutic strategies.
MeSH term(s)	Humans ; Aggrecans ; Caspase 3 ; Collagen ; Cytokines ; Interleukin-6 ; Interleukin-8 ; Matrix Metalloproteinase 13/genetics ; Matrix Metalloproteinase 3 ; Osteoarthritis/genetics ; Peptide Fragments ; Phosphatidylinositol 3-Kinase ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositols ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, CCR10 ; Receptors, Platelet-Derived Growth Factor ; RNA, Small Interfering ; TOR Serine-Threonine Kinases
Chemical Substances	740Y-P ; Aggrecans ; Caspase 3 (EC 3.4.22.-) ; Collagen (9007-34-5) ; Cytokines ; Interleukin-6 ; Interleukin-8 ; Matrix Metalloproteinase 13 (EC 3.4.24.-) ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; Peptide Fragments ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Phosphatidylinositols ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptors, CCR10 ; Receptors, Platelet-Derived Growth Factor (EC 2.7.10.1) ; RNA, Small Interfering ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; CCR10 protein, human ; MTOR protein, human (EC 2.7.1.1)
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-024-04642-x
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Article ; Online: MiR-361 and miR-34a suppress foot-and-mouth disease virus proliferation by activating immune response signaling in PK-15 cells.

Gao, Yuan / Yong, Fang / Yan, Meilin / Wei, Yanquan / Wu, Xiaochun

Veterinary microbiology

2023 Volume 280, Page(s) 109725

Abstract: Foot-and-mouth disease (FMD) severely impacts cloven-hoofed live-stock production, leading to serious economic losses and international restriction on the trade of animals and animal products worldwide. MiRNAs serve key roles in viral immunity and ... ...

Abstract	Foot-and-mouth disease (FMD) severely impacts cloven-hoofed live-stock production, leading to serious economic losses and international restriction on the trade of animals and animal products worldwide. MiRNAs serve key roles in viral immunity and regulation. However, the knowledge about miRNAs regulation in FMDV infection is still limited. In this study, we found that FMDV infection caused rapid cytopathic in PK-15 cell. To investigate the miRNAs' function in FMDV infection, we performed knockdown of endogenous Dgcr8 using its specific siRNA and found that interference of Dgcr8 inhibited cellular miRNA expression and increased FMDV production, including viral capsid proteins expression, viral genome copies and virus titer, suggesting that miRNAs play an important role in FMDV infection. To obtain a full perspective on miRNA expression profiling after FMDV infection, we performed miRNA sequencing and found that FMDV infection caused inhibition of miRNA expression in PK-15 cells. Together with the target prediction result, miR-34a and miR-361 were screened for further study. Function study showed that no matter plasmid or mimics-mediated overexpression of miR-34a and miR-361 both suppressed FMDV replication, while inhibition of endogenous miR-34a and miR-361 expression using specific inhibitors significantly increased FMDV replication. Further study showed that miR-34a and miR-361 stimulated IFN-β promoter activity and activated interferon-stimulated response element (ISRE). In addition, ELISA test found that miR-361 and miR-34a increased secretion level of IFN-β and IFN-γ, which may contribute to repression of FMDV replication. This study preliminary revealed that miR-361 and miR-34a inhibited FMDV proliferation via stimulating immune response.
MeSH term(s)	Animals ; Foot-and-Mouth Disease Virus/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA-Binding Proteins/metabolism ; Foot-and-Mouth Disease/genetics ; Immunity ; Cell Proliferation ; Virus Replication
Chemical Substances	MicroRNAs ; RNA-Binding Proteins
Language	English
Publishing date	2023-03-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2023.109725
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Article ; Online: MiR-361 and miR-34a suppress foot-and-mouth disease virus proliferation by activating immune response signaling in PK-15 cells

Gao, Yuan / Yong, Fang / Yan, Meilin / Wei, Yanquan / Wu, Xiaochun

Veterinary Microbiology. 2023 May, v. 280 p.109725-

2023

Abstract	Foot-and-mouth disease (FMD) severely impacts cloven-hoofed live-stock production, leading to serious economic losses and international restriction on the trade of animals and animal products worldwide. MiRNAs serve key roles in viral immunity and regulation. However, the knowledge about miRNAs regulation in FMDV infection is still limited. In this study, we found that FMDV infection caused rapid cytopathic in PK-15 cell. To investigate the miRNAs' function in FMDV infection, we performed knockdown of endogenous Dgcr8 using its specific siRNA and found that interference of Dgcr8 inhibited cellular miRNA expression and increased FMDV production, including viral capsid proteins expression, viral genome copies and virus titer, suggesting that miRNAs play an important role in FMDV infection. To obtain a full perspective on miRNA expression profiling after FMDV infection, we performed miRNA sequencing and found that FMDV infection caused inhibition of miRNA expression in PK-15 cells. Together with the target prediction result, miR-34a and miR-361 were screened for further study. Function study showed that no matter plasmid or mimics-mediated overexpression of miR-34a and miR-361 both suppressed FMDV replication, while inhibition of endogenous miR-34a and miR-361 expression using specific inhibitors significantly increased FMDV replication. Further study showed that miR-34a and miR-361 stimulated IFN-β promoter activity and activated interferon-stimulated response element (ISRE). In addition, ELISA test found that miR-361 and miR-34a increased secretion level of IFN-β and IFN-γ, which may contribute to repression of FMDV replication. This study preliminary revealed that miR-361 and miR-34a inhibited FMDV proliferation via stimulating immune response.
Keywords	Foot-and-mouth disease virus ; animals ; capsid ; foot-and-mouth disease ; immune response ; microRNA ; microbiology ; plasmids ; prediction ; secretion ; trade ; viral genome ; viral load ; FMD ; FMDV ; miRNAs ; ORF ; SAT ; UTR ; CPE ; Hpi ; TCID50 ; GO ; KEGG ; ISRE ; IFN-β ; IFN-γ ; MiR-361 ; MiR-34a
Language	English
Dates of publication	2023-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2023.109725
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Article: Solar-driven interfacial evaporation toward clean water production: burgeoning materials, concepts and technologies

He, Fang / Wu, Xiaochun / Gao, Jie / Wang, Zhenxing

Journal of materials chemistry A. 2021 Dec. 14, v. 9, no. 48

2021

Abstract: Solar-driven interfacial evaporation, as a rising star for eco-friendly and cost-effective freshwater production with a minimized carbon footprint, has been widely studied and implemented in recent years. With the rapid development of this frontier field, ...

Abstract	Solar-driven interfacial evaporation, as a rising star for eco-friendly and cost-effective freshwater production with a minimized carbon footprint, has been widely studied and implemented in recent years. With the rapid development of this frontier field, many burgeoning materials, new concepts and innovative preparation technologies leading to the next hotspot and front have been developed very recently. It is therefore critical to update the broader scientific community on the important advances in this field. Herein, we focus on the most recently reported progress in new materials, concepts and technologies for solar-driven interfacial evaporation toward clean water production. The emerging materials are categorized into organic small molecules, bio-inspired materials and coordination compounds, which are different from most reported “traditional” materials such as plasmonic particles, semiconductors, carbonaceous materials and polymer materials. The light absorption mechanism and molecular design principle of these emerging materials are discussed in detail. Subsequently, new concepts for significantly boosting the water evaporation rate and thermal efficiency, and new designs for anti-salt-fouling toward high-salinity brine, as well as enhanced condensation, are also highlighted, followed by the introduction of newly developed technologies, such as 3D printing and antifreeze-assisted freezing techniques, for realizing new concepts and designs. Finally, the challenges and opportunities for the future development of solar-driven interfacial evaporation toward clean water production are discussed.
Keywords	absorption ; carbon footprint ; cost effectiveness ; evaporation rate ; freshwater ; polymers
Language	English
Dates of publication	2021-1214
Size	p. 27121-27139.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/d1ta08886f
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Article ; Online: An extraordinary fossil captures the struggle for existence during the Mesozoic.

Han, Gang / Mallon, Jordan C / Lussier, Aaron J / Wu, Xiao-Chun / Mitchell, Robert / Li, Ling-Ji

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11221

Abstract: Dinosaurs and mammals have coexisted for the last ~ 230 million years. Both groups arose during the Late Triassic and diversified throughout the Mesozoic and into the Cenozoic (the latter in the form of birds). Although they undoubtedly interacted in ... ...

Abstract	Dinosaurs and mammals have coexisted for the last ~ 230 million years. Both groups arose during the Late Triassic and diversified throughout the Mesozoic and into the Cenozoic (the latter in the form of birds). Although they undoubtedly interacted in many ways, direct fossil evidence for their interaction is rare. Here we report a new fossil find from the Lujiatun Member of the Lower Cretaceous Yixian Formation of China, showing a gobiconodontid mammal and psittacosaurid dinosaur locked in mortal combat. We entertain various hypothesized explanations for this association, but the balance of the evidence suggests that it represents a predation attempt on the part of the smaller mammal, suddenly interrupted by, and preserved within, a lahar-type volcanic debris flow. Mesozoic mammals are usually depicted as having lived in the shadows of their larger dinosaurian contemporaries, but this new fossil convincingly demonstrates that mammals could pose a threat even to near fully-grown dinosaurs. The Yixian Formation-and the Chinese fossil Jehol Biota more broadly-have played a particularly important role in revealing the diversity of small-bodied dinosaurs and other fauna. We anticipate that the volcanically derived obrution deposits specific to the Lujiatun Member will likewise continue to yield evidence for biotic interactions otherwise unknown from the rest of the fossil record.
MeSH term(s)	Animals ; Fossils ; Dinosaurs/anatomy & histology ; Birds ; Mammals ; Predatory Behavior ; Biological Evolution ; Phylogeny
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37545-8
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Article ; Online: miR-30b-5p inhibits osteoblast differentiation through targeting BCL6.

Luo, Yan / Zhou, Feng / Wu, Xiaochun / Li, Yi / Ye, Bin

Cell cycle (Georgetown, Tex.)

2022 Volume 21, Issue 6, Page(s) 630–640

Abstract: Human bone marrow mesenchymal stem cells (hBMSCs) are attractive candidates for new therapies to improve bone regeneration and repair. This study was to identify the function of the miR-30b-5p/BCL6 axis in osteogenic differentiation of hBMSCs. Realtime- ... ...

Abstract	Human bone marrow mesenchymal stem cells (hBMSCs) are attractive candidates for new therapies to improve bone regeneration and repair. This study was to identify the function of the miR-30b-5p/BCL6 axis in osteogenic differentiation of hBMSCs. Realtime-quantitative PCR (RT-qPCR) and Western blotting were used to measure the relative expression of ALP, OCN, RUNX2, miR-30b-5p, and BCL6 during osteogenic differentiation of hBMSCs. The relationship between miR-30b-5p and BCL6 in hBMSCs was identified using dual-luciferase reporter system and RNA pull-down assay. Alizarin red S staining (ARS) was used to detect the calcium nodules in hBMSCs. We found that the expression of miR-30b-5p was downregulated, whereas that of BCL6 was upregulated during osteogenic differentiation of hBMSCs. Downregulating miR-30b-5p enhanced the expression of OCN, RUNX2, and ALP, and promoted calcium deposition. Conversely, transfection with si-BCL6 had the opposite effect that it inhibited osteogenic differentiation. However, the inhibitory effect of si-BCL6 was abrogated by miR-30b-5p inhibitor. miR-30b-5p inhibits the osteogenic differentiation of hBMSCs by targeting BCL6.
MeSH term(s)	Calcium/metabolism ; Cell Differentiation/genetics ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Osteoblasts/metabolism ; Osteogenesis/genetics ; Proto-Oncogene Proteins c-bcl-6/genetics ; Proto-Oncogene Proteins c-bcl-6/metabolism
Chemical Substances	BCL6 protein, human ; Core Binding Factor Alpha 1 Subunit ; MIRN30a microRNA, human ; MicroRNAs ; Proto-Oncogene Proteins c-bcl-6 ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.1080/15384101.2022.2031428
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Article ; Online: A novel strategy for the multi-components division and discovering pharmacodynamic material basis of Chinese herbal compounds: A case study of Xian-Ling-Gu-Bao capsule.

Guan, Yuxin / Yang, Bing / Zeng, Jingqi / Mo, Yulin / Wu, Xiaochun / Yang, Yanjun / Feng, Liang / Jia, Xiaobin

Journal of pharmaceutical and biomedical analysis

2024 Volume 243, Page(s) 116112

Abstract: The therapeutic effects of Chinese herbal compounds are often achieved through the synergistic interactions of multiple ingredients. However, current research predominantly focuses on individual ingredients, neglecting the holistic nature of Chinese ... ...

Abstract	The therapeutic effects of Chinese herbal compounds are often achieved through the synergistic interactions of multiple ingredients. However, current research predominantly focuses on individual ingredients, neglecting the holistic nature of Chinese herbal compounds. This study proposes a novel strategy to elucidate the pharmacodynamic material basis of Chinese herbal compounds based on their multi-components (components named 'ZuFen' in China, it refers to multiple ingredients with similar chemical structures) composition, using the Xian-Ling-Gu-Bao (XLGB) capsule as a case study. Cheminformatics-based components partitioning was conducted after sourcing ingredients from various databases, resulting in a total of 856 ingredients which were categorized into nine major components. Furthermore, the pharmacodynamic ingredients of XLGB capsule were determined by analyzing the ingredients that were absorbed into the bloodstream. Through a combination of these ingredients and screening for absorption, the Dipsacus asper saponin components, Psoralea corylifolia coumarin components, and Epimedium flavonoid polyglycosides components were isolated. The anti-osteoporosis efficacy of these components were evaluated in zebrafish, demonstrating their capability to reverse mineralization reduction caused by prednisolone. These findings further support the idea that these components serve as the material basis for the pharmacological efficacy of XLGB capsule. This study provides a novel systematic strategy for discovering the pharmacodynamic material basis of the efficacy of Chinese herbal compounds based on a 'multi-components' perspective.
MeSH term(s)	Animals ; Zebrafish ; Drugs, Chinese Herbal/chemistry ; Flavonoids ; Saponins ; Osteoporosis/drug therapy ; Chromatography, High Pressure Liquid/methods
Chemical Substances	Drugs, Chinese Herbal ; Flavonoids ; Saponins
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.116112
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Article: A Novel Nanoprobe Based on Core-Shell Au@Pt@Mesoporous SiO

Long, Lin / Cai, Rui / Liu, Jianbo / Wu, Xiaochun

Frontiers in chemistry

2020 Volume 8, Page(s) 463

Abstract: Nanoporous materials with core-shell structure have received lots of attention owing to the great versatility of the functional cores and shells and their potential application in catalysis and biological applications. In this work, a facile method has ... ...

Abstract	Nanoporous materials with core-shell structure have received lots of attention owing to the great versatility of the functional cores and shells and their potential application in catalysis and biological applications. In this work, a facile method has been developed to synthesize uniform Au@Pt@mesoporous SiO
Language	English
Publishing date	2020-06-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2020.00463
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Article ; Online: Gold-Nanoparticle-Based Chiral Plasmonic Nanostructures and Their Biomedical Applications.

Li, Hanbo / Gao, Xinshuang / Zhang, Chenqi / Ji, Yinglu / Hu, Zhijian / Wu, Xiaochun

Biosensors

2022 Volume 12, Issue 11

Abstract: As chiral antennas, plasmonic nanoparticles (NPs) can enhance chiral responses of chiral materials by forming hybrid structures and improving their own chirality preference as well. Chirality-dependent properties of plasmonic NPs broaden application ... ...

Abstract	As chiral antennas, plasmonic nanoparticles (NPs) can enhance chiral responses of chiral materials by forming hybrid structures and improving their own chirality preference as well. Chirality-dependent properties of plasmonic NPs broaden application potentials of chiral nanostructures in the biomedical field. Herein, we review the wet-chemical synthesis and self-assembly fabrication of gold-NP-based chiral nanostructures. Discrete chiral NPs are mainly obtained via the seed-mediated growth of achiral gold NPs under the guide of chiral molecules during growth. Irradiation with chiral light during growth is demonstrated to be a promising method for chirality control. Chiral assemblies are fabricated via the bottom-up assembly of achiral gold NPs using chiral linkers or guided by chiral templates, which exhibit large chiroplasmonic activities. In describing recent advances, emphasis is placed on the design and synthesis of chiral nanostructures with the tuning and amplification of plasmonic circular dichroism responses. In addition, the review discusses the most recent or even emerging trends in biomedical fields from biosensing and imaging to disease diagnosis and therapy.
MeSH term(s)	Gold/chemistry ; Nanostructures/chemistry ; Circular Dichroism ; Nanoparticles/chemistry ; Stereoisomerism
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2022-11-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios12110957
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