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Article ; Online: Detailed mechanism study of volatile organic compound decomposition and oxidation removal based on a ReaxFF MD method.

Wang, Shuo / Wu, Xiaoqing / Chen, Xiaozhen

RSC advances

2024 Volume 14, Issue 9, Page(s) 5863–5874

Abstract: Volatile organic compounds (VOCs) are typical air pollutants as well as gaseous wastes that contain energy. Utilization and disposition of VOCs is currently an important research hotspot in the field of atmospheric environment. In this paper, the thermal ...

Abstract	Volatile organic compounds (VOCs) are typical air pollutants as well as gaseous wastes that contain energy. Utilization and disposition of VOCs is currently an important research hotspot in the field of atmospheric environment. In this paper, the thermal cracking and oxidation reaction processes of typical VOCs components were modelled and analyzed by combining molecular dynamics and detailed reaction mechanisms, focusing on the effects of temperature, oxygen and other conditions on the conversion of VOCs. The results of molecular dynamics studies show that improving temperature and reaction time benefit the decomposition of VOCs. High temperatures under an inert atmosphere can sufficiently crack the VOCs themselves, but other by-products are generated, which in turn cause secondary pollution. The activation energies derived by ReaxFF-MD calculation are 328 kJ mol
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra08122b
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Article ; Online: Clinical Value of Total Intravenous Anesthesia with Sufentanil and Propofol in Radical Mastectomy.

Qu, Lingyan / Wu, Xiaoqing

Disease markers

2022 Volume 2022, Page(s) 7294358

Abstract: Objective: To investigate the clinical value of sufentanil combined with propofol for total intravenous anesthesia (TIVA) in radical mastectomy.: Methods: The data of 120 patients undergoing radical mastectomy of breast cancer in our hospital from ... ...

Abstract	Objective: To investigate the clinical value of sufentanil combined with propofol for total intravenous anesthesia (TIVA) in radical mastectomy. Methods: The data of 120 patients undergoing radical mastectomy of breast cancer in our hospital from February 2020 to February 2021 were retrospectively analyzed, and they were randomly assigned to the experimental group (EXG) ( Results: The heart rates (HR) and mean arterial pressure (MAP) after tracheal intubation (T Conclusion: Sufentanil combined with propofol for TIVA can stabilize intraoperative hemodynamic indices of patients undergoing radical mastectomy, alleviate perioperative stress response, and reduce pain perception. Therefore, this anesthesia method is safe and merits clinical promotion.
MeSH term(s)	Anesthesia, Intravenous/adverse effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy/adverse effects ; Mastectomy, Radical ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Propofol/adverse effects ; Retrospective Studies ; Sufentanil/adverse effects
Chemical Substances	Sufentanil (AFE2YW0IIZ) ; Propofol (YI7VU623SF)
Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2022/7294358
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Article ; Online: The RNA-binding protein HuR in human cancer: A friend or foe?

Wu, Xiaoqing / Xu, Liang

Advanced drug delivery reviews

2022 Volume 184, Page(s) 114179

Abstract: The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis elements present in mRNAs whose stability and translation are subject to regulation. The RBP Hu antigen R (HuR) is overexpressed in a wide variety of human ... ...

Abstract	The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis elements present in mRNAs whose stability and translation are subject to regulation. The RBP Hu antigen R (HuR) is overexpressed in a wide variety of human cancers and serves as a prognostic factor of poor clinical outcome. HuR promotes tumorigenesis by interacting with a subset of oncogenic mRNAs implicated in different cancer hallmarks, and resistance to therapy. Reduction of HuR levels in cancer cells leads to tumor regression in mouse xenograft models. These findings prompt a working model whereby cancer cells use HuR, a master switch of multiple oncogenic mRNAs, to drive drug resistance and promote cell survival and metastasis, thus rendering the tumor cells with high cytoplasmic HuR more progressive and resistant to therapy. This review summarizes the roles of HuR in cancer and other diseases, therapeutic potential of HuR inhibition, and the current status of drug discovery on HuR.
MeSH term(s)	Animals ; Carcinogenesis ; Cell Survival ; ELAV-Like Protein 1/genetics ; ELAV-Like Protein 1/metabolism ; Humans ; Mice ; Neoplasms/drug therapy ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
Chemical Substances	ELAV-Like Protein 1 ; ELAVL1 protein, human ; RNA, Messenger ; RNA-Binding Proteins
Language	English
Publishing date	2022-03-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	639113-8
ISSN	1872-8294 ; 0169-409X
ISSN (online)	1872-8294
ISSN	0169-409X
DOI	10.1016/j.addr.2022.114179
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Article: Advanced glycation end products regulate the receptor of AGEs epigenetically.

Wu, Xiaoqing / Shi, Xuanren / Chen, Xiaoyong / Yin, Zhanhai

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1062229

Abstract: Advanced glycation end-products (AGEs) can boost their receptor of AGE (RAGE) expression through the downstream signaling pathway to facilitate AGE-RAGE interaction. In this regulation process, the primary signaling pathways are NF-κB and STAT3. However, ...

Abstract	Advanced glycation end-products (AGEs) can boost their receptor of AGE (RAGE) expression through the downstream signaling pathway to facilitate AGE-RAGE interaction. In this regulation process, the primary signaling pathways are NF-κB and STAT3. However, the inhibition of these transcription factors cannot completely block the upregulation of RAGE, which indicates AGEs may also impact RAGE expression
Language	English
Publishing date	2023-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1062229
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Article: Impact of hypertensive disorders of pregnancy on maternal and neonatal outcomes of twin gestation: a systematic review and meta-analysis.

Wu, Xiaoqing / Gu, Huifeng / Wang, Junlin

Frontiers in pediatrics

2023 Volume 11, Page(s) 1210569

Abstract: Background: The impact of hypertensive disorders of pregnancy (HDP) on outcomes of twin gestations is not clear. We aimed to collate data via this meta-analysis to examine how HDP alters maternal and neonatal outcomes of twin gestations.: Methods: ... ...

Abstract	Background: The impact of hypertensive disorders of pregnancy (HDP) on outcomes of twin gestations is not clear. We aimed to collate data via this meta-analysis to examine how HDP alters maternal and neonatal outcomes of twin gestations. Methods: Studies comparing pregnancy outcomes of twin gestations based on HDP and published on the databases of PubMed, CENTRAL, Scopus, Web of Science, and Embase between 1 January 2000 to 20 March 2023 were eligible for inclusion. Results: Twelve studies were included. A cumulative of 355,129 twin gestations were analyzed in the current meta-analysis. The pooled analysis found that the presence of HDP increases the risk of preterm birth (OR: 1.86 95% CI: 1.36, 2.55 Conclusion: HDP increases the risk of preterm birth, cesarean sections, low birth weight, SGA, and NICU admission in twin gestations. Contrastingly, the risk of neonatal death is reduced with HDP. Further studies are needed to corroborate the current results. Systematic review registration: PROSPERO (CRD42023407725).
Language	English
Publishing date	2023-08-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1210569
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Article: BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway.

Wu, Xiaoqing / Jing, Zheng / Huang, Tianpu / Jing, Yongsheng

Archivos espanoles de urologia

2023 Volume 76, Issue 6, Page(s) 445–453

Abstract: Background: Nucleolar prominence is a biomarker of prostate cancer (CaP), and the nucleolar protein block of proliferation 1 (BOP1) participates in the development of CaP, which has great significance for CaP therapy. Thus, this study explored the ... ...

Abstract	Background: Nucleolar prominence is a biomarker of prostate cancer (CaP), and the nucleolar protein block of proliferation 1 (BOP1) participates in the development of CaP, which has great significance for CaP therapy. Thus, this study explored the mechanism of BOP1 in CaP development. Methods: BOP1 expression levels in the tumor tissues of CaP patients and in PC3 tumor cells were determined. The viability, apoptosis rate of PC3 cells, and apoptosis-related proteins levels were determined to explore the effect of BOP1 on tumor-cell growth Results: BOP1 expression was upregulated in the tumor tissues and PC3 cells of CaP patients. BOP1 knockout reduced the activity of PC3 cells and induced apoptosis, significantly inhibiting the metastasis of PC3 cells. DUSP6 was overexpressed in tumor tissues and PC3 cells. BOP1 knockout inhibited DUSP6 expression and the MAPK pathway. DUSP6 overexpression reversed the inhibition of BOP1 siRNA (si-BOP1) on PC3 cells and the activated MAPK signaling pathway. Conclusions: This finding demonstrated that BOP1 promoted CaP progression by regulating the DUSP6/MAPK pathway.
MeSH term(s)	Male ; Humans ; Mitogen-Activated Protein Kinases ; Prostatic Neoplasms/genetics ; Signal Transduction ; Cell Proliferation ; Dual Specificity Phosphatase 6/genetics ; RNA-Binding Proteins
Chemical Substances	Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; DUSP6 protein, human (EC 3.1.3.48) ; Dual Specificity Phosphatase 6 (EC 3.1.3.48) ; BOP1 protein, human ; RNA-Binding Proteins
Language	English
Publishing date	2023-08-23
Publishing country	Spain
Document type	Journal Article
ZDB-ID	211673-x
ISSN	0004-0614
ISSN	0004-0614
DOI	10.56434/j.arch.esp.urol.20237606.54
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Article ; Online: Epigallocatechin gallate (EGCG) can epigenetically regulate the receptor of advanced glycation end products (RAGE) to ameliorate Osteoarthritis

Wu, Xiaoqing / Shi, Xuanren / Chen, Xiaoyong / Yin, Zhanhai

Journal of Functional Foods. 2023 Aug., v. 107 p.105682-

2023

Abstract: Epigallocatechin-3-O-gallate is natural phytochemical of green tea. RAGE upregulation promotes osteoarthritis (OA) progression. Herein, we revealed that EGCG can repress RAGE expression epigenetically to ameliorate OA. Firstly we found that RAGE ... ...

Abstract	Epigallocatechin-3-O-gallate is natural phytochemical of green tea. RAGE upregulation promotes osteoarthritis (OA) progression. Herein, we revealed that EGCG can repress RAGE expression epigenetically to ameliorate OA. Firstly we found that RAGE expression was dose-dependently reduced by EGCG on chondrocyte cell C28/I2. EGCG also suppressed RAGE in human primary OA chondrocytes, and accordingly attenuated ROS production and NF-κb activity. Osteoarthritic microenvironment was also improved by EGCG, which was reflected by the enhanced chondrogenic markers and reduced inflammatory markers. EGCG-induced ameliorations were counteracted by artificial overexpression of RAGE. Additionally, EGCG modulates RAGE expression not only by its antioxidant activity, but also by facilitating RAGE promoter hypermethylation. To confirm this epigenetic modification, we employed dCAS9-Tet1 against EGCG’s epigenetic regulation. RAGE level was correspondingly rescued after EGCG-induced hypermethylation status were blocked. These findings support therapeutic roles of EGCG on OA and uncover the novel molecular mechanism of EGCG-mediated RAGE modulation.
Keywords	antioxidant activity ; chondrocytes ; epigallocatechin gallate ; epigenetics ; green tea ; humans ; osteoarthritis ; therapeutics ; EGCG ; RAGE ; DNA methylation ; Epigenetic regulation ; OA ; AGEs ; MMP ; TKA ; NAC ; Col 2a1 ; Acan
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2023.105682
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Physiochemical and biological characteristics of fouling on landfill leachate treatment systems surface

Gong, Zhourui / Yang, Shu / Zhang, Rui / Wang, Yangqing / Wu, Xiaoqing / Song, Liyan

Journal of Environmental Sciences. 2024 Jan., v. 135 p.59-71

2024

Abstract: Fouling of landfill leachate, a biofilm formation process on the surface of the collection system, migration pipeline and treatment system causes low efficiency of leachate transportation and treatment and increases cost for maintenance of those ... ...

Abstract	Fouling of landfill leachate, a biofilm formation process on the surface of the collection system, migration pipeline and treatment system causes low efficiency of leachate transportation and treatment and increases cost for maintenance of those facilities. In addition, landfill leachate fouling might accumulate pathogens and antibiotic resistance genes (ARGs), posing threats to the environment. Characterization of the landfill leachate fouling and its associated environmental behavior is essential for the management of fouling. In this study, physicochemical and biological properties of landfill leachate fouling and the possible accumulation capacity of pathogens and ARGs were investigated in nitrification (aerobic condition) and denitrification (anaerobic condition) process during landfill leachate biological treatment, respectively. Results show that microbial (bacterial, archaeal, eukaryotic, and viral) community structure and function (carbon fixation, methanogenesis, nitrification and denitrification) differed in fouling under aerobic and anaerobic conditions, driven by the supplemental leachate water quality. Aerobic fouling had a higher abundance of nitrification and denitrification functional genes, while anaerobic fouling harbored a higher abundance of carbon fixation and methanogenesis genes. Both forms of leachate fouling had a higher abundance of pathogens and ARGs than the associated leachate, suggesting the accumulation capacity of fouling on biotic pollutants. Specifically, aerobic fouling harbored three orders of magnitude higher multidrug resistance genes mexD than its associated leachate. This finding provides fundamental knowledge on the biological properties of leachate fouling and suggests that leachate fouling might harbor significant pathogens and ARGs.
Keywords	Archaea ; antibiotic resistance ; biofilm ; biological treatment ; carbon dioxide fixation ; community structure ; denitrification ; landfill leachates ; methane production ; multiple drug resistance ; nitrification ; transportation ; water quality ; Landfill leachate fouling ; Microbiome ; Carbon and nitrogen cycle ; Pathogens ; Antibiotic resistance genes
Language	English
Dates of publication	2024-01
Size	p. 59-71.
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1092300-7
ISSN	1878-7320 ; 1001-0742
ISSN (online)	1878-7320
ISSN	1001-0742
DOI	10.1016/j.jes.2022.12.006
Database	NAL-Catalogue (AGRICOLA)

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Book ; Thesis: Anwendungen der Satellitengestützten-Radarinterferometrie zur Bestimmung von Topographie und Geschwindigkeitsfeldern

Wu, Xiaoqing

(Deutsche Geodätische Kommission bei der Bayerischen Akademie der Wissenschaften : Reihe C, Dissertationen ; 499)

1998

Title variant	Anwendungen der satellitengestützten Radarinterferometrie zur Bestimmung von Topographie und Geschwindigkeitsfeldern
Author's details	von Xiaoqing Wu
Series title	Deutsche Geodätische Kommission bei der Bayerischen Akademie der Wissenschaften : Reihe C, Dissertationen ; 499 Deutsche Geodätische Kommission bei der Bayerischen Akademie der Wissenschaften Deutsche Geodätische Kommission bei der Bayerischen Akademie der Wissenschaften ; Reihe C, Dissertationen
Collection	Deutsche Geodätische Kommission bei der Bayerischen Akademie der Wissenschaften Deutsche Geodätische Kommission bei der Bayerischen Akademie der Wissenschaften ; Reihe C, Dissertationen
Keywords	ERS ; Radar ; Synthetische Apertur ; Interferometrie ; Topografie ; Gletscher ; Bewegungsfernmessung
Subject	Apertursynthese ; Antennensynthese ; Radartechnik ; Radio detecting and ranging ; European Remote Sensing ; European Remote Sensing Satellite ; Europäischer Fernerkundungssatellit ; ERS1 ; ERS-1 ; ERS2 ; ERS-2 ; Topographie
Language	German
Size	103 S. : zahlr. Ill., graph. Darst.
Publisher	Verl. der Bayerischen Akad. der Wiss. in Komm. bei der C. H. Beck'schen Verl.buchh
Publishing place	München
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Karlsruhe, Univ., Diss., 1998
Note	Zsfassung in engl. Sprache
HBZ-ID	HT009519539
ISBN	3-7696-9538-0 ; 978-3-7696-9538-0
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Article ; Online: Anthriscus sylvestris: An overview on Bioactive Compounds and Anticancer Mechanisms from a Traditional Medicinal Plant to Modern Investigation.

Zhang, Mengyu / Ji, Xiaoyun / Li, Yuxin / Chen, Xin / Wu, Xiaoqing / Tan, Rui / Jiang, Hezhong

Mini reviews in medicinal chemistry

2024

Abstract: Anthriscus sylvestris (L.) Hoffm. Gen. is a biennial or perennial herb commonly found in China. It has a long history of use in traditional Chinese medicine to treat various ailments such as cough, gastric disorders, spleen deficiency, and limb weakness. ...

Abstract	Anthriscus sylvestris (L.) Hoffm. Gen. is a biennial or perennial herb commonly found in China. It has a long history of use in traditional Chinese medicine to treat various ailments such as cough, gastric disorders, spleen deficiency, and limb weakness. Recently, its potential as an anticancer agent has gained considerable attention and has been the subject of extensive research focusing on extract efficacy, identification of active compounds, and proposed molecular mechanisms. Nevertheless, further high-quality research is still required to fully evaluate its potential as an anticancer drug. This review aims to comprehensively summarize the anticancer properties exhibited by the active components found in Anthriscus sylvestris. We conducted a comprehensive search, collation, and analysis of published articles on anticancer activity and active compounds of A. sylvestris using various databases that include, but are not limited to, PubMed, Web of Science, Science Direct and Google Scholar. The primary chemical composition of A. sylvestris consists of phenylpropanoids, flavonoids, steroids, fatty acids, and organic acids, showcasing an array of pharmacological activities like anticancer, antioxidant, anti-aging, and immunoregulatory properties. Thus, this review highlights the active compounds isolated from A. sylvestris extracts, which provide potential leads for the development of novel anticancer drugs and a better understanding of the plant's pharmacological effects, particularly its anticancer mechanism of action.
Language	English
Publishing date	2024-01-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2104081-3
ISSN	1875-5607 ; 1389-5575
ISSN (online)	1875-5607
ISSN	1389-5575
DOI	10.2174/0113895575271848231116095447
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