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Article ; Online: New Ferrocene Formates Bearing Isoxazole Moieties: Synthesis, Characterization, X-ray Crystallography, and Preliminarily Cytotoxicity against A549, HCT116, and MCF-7 Cell Lines.

Yong, Jianping / Lu, Canzhong / Yang, Minxue / Wu, Xiaoyuan

2022 Volume 28, Issue 34, Page(s) 2835–2841

Abstract: Aims: To develop new anticancer agents based on ferrocene core.: Background: Cancer has become the major cause of human death globally. The death caused by cancer mainly focuses on lung cancer, breast cancer, liver cancer, carcinoma of the colon, and ...

Abstract	Aims: To develop new anticancer agents based on ferrocene core. Background: Cancer has become the major cause of human death globally. The death caused by cancer mainly focuses on lung cancer, breast cancer, liver cancer, carcinoma of the colon, and rectum. Some small molecular inhibitors have been authorized by FDA for the treatment of cancer and several candidates are in different phases of clinical trials. However, cancer chemotherapy is still highly inadequate. Thus, it is indispensable to develop novel anticancer agents. Objective: Based on the previous good results, twelve novel structures of ferrocene formates bearing isoxazole moiety (3a-3l) were synthesized in this work for the development of anticancer agents. Methods: The target compounds were synthesized using Ferrocenecarboxylic acid and 3-[(R)-substitutedphenyl]- isoxazole-5-methanol catalyzed by DCC and DMAP. The structures of target compounds were characterized by Results: The results showed that most compounds exhibited moderate cytotoxicity against A549, HCT116, and MCF-7 cell lines compared with the positive control gefitinib. However, (3b, 3c, 3e, 3j, and 3k) simultaneously exhibited stronger inhibitory activity against A549, HCT116, and MCF-7 cell lines, which can be regarded as promising metal-based lead compounds for the development of anticancer agents. Conclusion: In this work, twelve new structures of ferrocene derivatives containing isozaole moiety were synthesized and their cytotoxicity against 549, HCT116, and MCF-7 cell lines was evaluated. (3b, 3c, 3e, 3j, and 3k) simultaneously exhibited stronger inhibitory activity towards A549, HCT116, and MCF-7 cell lines, which can be regarded as promising metal-based lead compounds for the development of anticancer agents.
MeSH term(s)	Humans ; MCF-7 Cells ; Metallocenes/pharmacology ; Isoxazoles/pharmacology ; Isoxazoles/chemistry ; Crystallography, X-Ray ; Formates/pharmacology ; Structure-Activity Relationship ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Molecular Structure ; Cell Line, Tumor
Chemical Substances	ferrocene (U96PKG90JQ) ; Metallocenes ; Isoxazoles ; Formates ; Antineoplastic Agents
Language	English
Publishing date	2022-08-22
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612828666220822113738
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Article ; Online: Genomic architecture of leaf senescence in sorghum (Sorghum bicolor)

Wang, Lidong / Shang, Li / Wu, Xiaoyuan / Hao, Huaiqing / Jing, Hai-Chun

Theor Appl Genet. 2023 Mar., v. 136, no. 3 p.45-45

2023

Abstract: KEY MESSAGE: Leaf senescence in sorghum is primarily controlled by the progression, but not by the onset of senescence. The senescence-delaying haplotypes of 45 key genes accentuated from landraces to improved lines. Leaf senescence is a genetically ... ...

Abstract	KEY MESSAGE: Leaf senescence in sorghum is primarily controlled by the progression, but not by the onset of senescence. The senescence-delaying haplotypes of 45 key genes accentuated from landraces to improved lines. Leaf senescence is a genetically programmed developmental process and plays a central role for plant survival and crop production by remobilising nutrients accumulated in senescent leaves. In theory, the ultimate outcome of leaf senescence is determined by the onset and progression of senescence, but how these two processes contribute to senescence is not fully illustrated in crops and the genetic basis for them is not well understood. Sorghum (Sorghum bicolor), which is known for the remarkable stay-green trait, is ideal for dissecting the genomic architecture underlying the regulation of senescence. In this study, a diverse panel of 333 sorghum lines was explored for the onset and progression of leaf senescence. Trait correlation analysis showed that the progression of leaf senescence, rather than the onset of leaf senescence, significantly correlated with variations of the final leaf greenness. This notion was further supported by GWAS, which identified 31 senescence-associated genomic regions containing 148 genes, of which 124 were related to the progression of leaf senescence. The senescence-delaying haplotypes of 45 key candidate genes were enriched in lines with extremely prolonged senescence duration, while senescence-promoting haplotypes in those with extremely accelerated senescence. Haplotype combinations of these genes could well explain the segregation of the senescence trait in a recombinant inbred population. We also demonstrated that senescence-delaying haplotypes of candidate genes were under strong selection during sorghum domestication and genetic improvement. Together, this research advanced our understanding of crop leaf senescence and provided a suite of candidate genes for functional genomics and molecular breeding.
Keywords	Sorghum bicolor ; crop production ; domestication ; genetic improvement ; genomics ; haplotypes ; landraces ; leaves
Language	English
Dates of publication	2023-03
Size	p. 45.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2170-2
ISSN	1432-2242 ; 0040-5752
ISSN (online)	1432-2242
ISSN	0040-5752
DOI	10.1007/s00122-023-04315-z
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Article: Hippocampal morphological atrophy and distinct patterns of structural covariance network in Alzheimer's disease and mild cognitive impairment.

Miao, Dawei / Zhou, Xiaoguang / Wu, Xiaoyuan / Chen, Chengdong / Tian, Le

Frontiers in psychology

2022 Volume 13, Page(s) 980954

Abstract: Elucidating distinct morphological atrophy patterns of Alzheimer's disease (AD) and its prodromal stage, namely, mild cognitive impairment (MCI) helps to improve early diagnosis and medical intervention of AD. On that account, we aimed to obtain distinct ...

Abstract	Elucidating distinct morphological atrophy patterns of Alzheimer's disease (AD) and its prodromal stage, namely, mild cognitive impairment (MCI) helps to improve early diagnosis and medical intervention of AD. On that account, we aimed to obtain distinct patterns of voxel-wise morphological atrophy and its further perturbation on structural covariance network in AD and MCI compared with healthy controls (HCs). T1-weighted anatomical images of matched AD, MCI, and HCs were included in this study. Gray matter volume was obtained using voxel-based morphometry and compared among three groups. In addition, structural covariance network of identified brain regions exhibiting morphological difference was constructed and compared between pairs of three groups. Thus, patients with AD have a reduced hippocampal volume and an increased rate of atrophy compared with MCI and HCs. MCI exhibited a decreased trend in bilateral hippocampal volume compared with HCs and the accelerated right hippocampal atrophy rate than HCs. In AD, the hippocampus further exhibited increased structural covariance connected to reward related brain regions, including the anterior cingulate cortex, the putamen, the caudate, and the insula compared with HCs. In addition, the patients with AD exhibited increased structural covariance of left hippocampus with the bilateral insula, the inferior frontal gyrus, the superior temporal gyrus, and the cerebellum than MCI. These results reveal distinct patterns of morphological atrophy in AD and MCI, providing new insights into pathology of AD.
Language	English
Publishing date	2022-09-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.980954
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Article ; Online: Carbon emission of China's power industry: driving factors and emission reduction path.

Wu, Xiaoyuan / Xu, Changxin / Ma, Teli / Xu, Jingru / Zhang, Chenjun

Environmental science and pollution research international

2022 Volume 29, Issue 52, Page(s) 78345–78360

Abstract: The low-carbon development of power industry is the key to low-carbon development of the whole society. In order to determine appropriate and feasible emission reduction policies, it is necessary to identify the contribution of different drivers to the ... ...

Abstract	The low-carbon development of power industry is the key to low-carbon development of the whole society. In order to determine appropriate and feasible emission reduction policies, it is necessary to identify the contribution of different drivers to the change of carbon emissions in China's power sector and to simulate the potential evolution trend of carbon emissions. This paper constructs LMDI model to analyze the driving factors of carbon emission changes in China's power industry from 2000 to 2018 and uses Monte Carlo algorithm to simulate the evolution trend of carbon emission under different scenarios. We can find (1) economic output effect reached 3.817 billion tons from 2000 to 2018, which was the primary factor to increase the carbon emission. Population scale effect reached 251million tons, which had a weak promotion impact on carbon emission. (2) Conversion efficiency effect played a role in restraining carbon emissions, reaching 699 million tons from 2000 to 2018. (3) Emission factor effect and power intensity effect have obvious volatility. The power structure effect showed great volatility before 2013 and mainly played a role in restraining carbon emission after 2013. (4) Under the baseline scenario, the carbon emission of China's power industry shows a growth trend. Under green development scenario and enhanced carbon reduction scenario, the carbon emission shows a trend of first increasing and then decreasing.
MeSH term(s)	Carbon/analysis ; Carbon Dioxide/analysis ; Industry ; China ; Economic Development
Chemical Substances	Carbon (7440-44-0) ; Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2022-06-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-21297-5
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Article ; Online: Multi-engineered Graphene Extended-Gate Field-Effect Transistor for Peroxynitrite Sensing in Alzheimer's Disease.

Peng, Qiwen / Zeng, Qiankun / Wang, Fangbing / Wu, Xiaoyuan / Zhang, Runxi / Shi, Guoyue / Zhang, Min

ACS nano

2023 Volume 17, Issue 21, Page(s) 21984–21992

Abstract: The expression of β-amyloid peptides (Aβ), a pathological indicator of Alzheimer's disease (AD), was reported to be inapparent in the early stage of AD. While peroxynitrite ( ... ...

Abstract	The expression of β-amyloid peptides (Aβ), a pathological indicator of Alzheimer's disease (AD), was reported to be inapparent in the early stage of AD. While peroxynitrite (ONOO
MeSH term(s)	Mice ; Animals ; Alzheimer Disease/diagnosis ; Alzheimer Disease/pathology ; Peroxynitrous Acid/chemistry ; Oxides/chemistry ; Graphite/chemistry ; Manganese Compounds ; Mice, Transgenic
Chemical Substances	Peroxynitrous Acid (14691-52-2) ; Oxides ; Graphite (7782-42-5) ; Manganese Compounds
Language	English
Publishing date	2023-10-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c08499
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Article ; Online: RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68.

Nie, Qihong / Wu, Xiaoyuan / Huang, Yongming / Guo, Tao / Kuang, Jin / Du, Chuance

European journal of medical research

2023 Volume 28, Issue 1, Page(s) 552

Abstract: Purpose: There is no report about the direct relationship between m6A modification and androgen receptor (AR)-related genes in prostate cancer (PC). We aimed to study the mechanisms of m6A methylation in regulating the pathogenesis of PC from the ... ...

Abstract	Purpose: There is no report about the direct relationship between m6A modification and androgen receptor (AR)-related genes in prostate cancer (PC). We aimed to study the mechanisms of m6A methylation in regulating the pathogenesis of PC from the perspective of AR-related genes. Methods: qRT-PCR was applied to detect the expression of m6A-related genes in PC cell with or without AR inhibitor. The effects of YTHDF1 knockdown on PC cell viability, apoptosis, migration and invasion were investigated using flow cytometry, wound healing and transwell assays, respectively. The mechanism of YTHDF1 action was investigated using m6A RNA immunoprecipitation (MeRIP) sequencing. The biological functions of YTHDF1 were also explored through in vivo experiments. Results: YTHDF1 was significantly down-regulated in AR inhibitor group. YTHDF1 knockdown significantly decreased AR level, viability and m6A methylation level of PC cells. TRIM68 was identified as a direct target of YTHDF1. Both YTHDF1 and TRIM68 knockdown increased apoptosis, and decreased cell viability, migration, and invasion of PC cells, while TRIM68 overexpression reversed the effects of YTHDF1 knockdown on PC cells. In addition, knockdown of YTHDF1 or TRIM68 significantly decreased the m6A methylation level, and mRNA and protein levels of YTHDF1, TRIM68 and AR in PC cells, while TRIM68 overexpression increased the expression levels above. Furthermore, subcutaneous xenografts of nude mice also revealed that TRIM68 could reverse the effects of YTHDF1 knockdown in PC in vivo. Conclusion: This study suggested the key role of YTHDF1-mediated m6A modification in PC progression by regulating androgen function-related gene TRIM68 in PC.
MeSH term(s)	Animals ; Mice ; Male ; Humans ; Androgens ; RNA ; Mice, Nude ; Prostatic Neoplasms/genetics ; RNA-Binding Proteins/genetics ; Tripartite Motif Proteins ; Autoantigens ; Ubiquitin-Protein Ligases
Chemical Substances	Androgens ; RNA (63231-63-0) ; YTHDF1 protein, human ; RNA-Binding Proteins ; TRIM68 protein, human (EC 2.3.2.27) ; Tripartite Motif Proteins ; Autoantigens ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2023-12-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-023-01533-5
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Article ; Online: Identification of lncRNA, miRNA and mRNA expression profiles and ceRNA Networks in small cell lung cancer.

Zhang, Chenxi / Zhou, Ying / Zhang, Bin / Sheng, Zhihong / Sun, Nan / Yuan, Baiyin / Wu, Xiaoyuan

BMC genomics

2023 Volume 24, Issue 1, Page(s) 217

Abstract: Background: Small cell lung cancer (SCLC) is a highly lethal malignant tumor. It accounts for approximately 15% of newly diagnosed lung cancers. Long non-coding RNAs (lncRNAs) can regulate gene expression and contribute to tumorigenesis through ... ...

Abstract	Background: Small cell lung cancer (SCLC) is a highly lethal malignant tumor. It accounts for approximately 15% of newly diagnosed lung cancers. Long non-coding RNAs (lncRNAs) can regulate gene expression and contribute to tumorigenesis through interactions with microRNAs (miRNAs). However, there are only a few studies reporting the expression profiles of lncRNAs, miRNAs, and mRNAs in SCLC. Also, the role of differentially expressed lncRNAs, miRNAs, and mRNAs in relation to competitive endogenous RNAs (ceRNA) network in SCLC remain unclear. Results: In the present study, we first performed next generation sequencing (NGS) with six pairs of SCLC tumors and adjacent non-cancerous tissues obtained from SCLC patients. Overall, 29 lncRNAs, 48 miRNAs, and 510 mRNAs were found to be differentially expressed in SCLC samples (\|log Conclusions: Our study provided the comprehensive analysis of the expression profiles of lncRNAs, miRNAs, and mRNAs of SCLC tumors and adjacent non-cancerous tissues. We constructed the ceRNA networks which may provide new evidence for the underlying regulatory mechanism of SCLC. We also found that the lncRNA TCONS_00020615 may regulate the carcinogenesis of SCLC.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Small Cell Lung Carcinoma/genetics ; Gene Regulatory Networks ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Lung Neoplasms/genetics ; Carcinogenesis/genetics ; Gene Expression Regulation, Neoplastic ; Neoplasm Proteins/genetics
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; RNA, Messenger ; TPD52 protein, human ; Neoplasm Proteins
Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-023-09306-4
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Article ; Online: Podocyte-Specific Silencing of Acid Sphingomyelinase Gene to Abrogate Hyperhomocysteinemia-Induced NLRP3 Inflammasome Activation and Glomerular Inflammation.

Huang, Dandan / Kidd, Jason M / Zou, Yao / Wu, Xiaoyuan / Li, Ningjun / Gehr, Todd W B / Li, Pin-Lan / Li, Guangbi

American journal of physiology. Renal physiology

2024

Abstract: Acid Sphingomyelinase has been reported to increase tissue ceramide and thereby mediate hHcy-induced glomerular NLRP3 inflammasome activation, inflammation, and sclerosis. In the present study, we tested whether somatic podocyte-specific silencing of ... ...

Abstract	Acid Sphingomyelinase has been reported to increase tissue ceramide and thereby mediate hHcy-induced glomerular NLRP3 inflammasome activation, inflammation, and sclerosis. In the present study, we tested whether somatic podocyte-specific silencing of Smpd1 gene attenuates hHcy-induced NLRP3 inflammasome activation and associated exosome release in podocytes and thereby suppresses glomerular inflammatory response and injury.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00195.2023
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Article ; Online: Genomic architecture of leaf senescence in sorghum (Sorghum bicolor).

Wang, Lidong / Shang, Li / Wu, Xiaoyuan / Hao, Huaiqing / Jing, Hai-Chun

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

2023 Volume 136, Issue 3, Page(s) 45

Abstract: Key message: Leaf senescence in sorghum is primarily controlled by the progression, but not by the onset of senescence. The senescence-delaying haplotypes of 45 key genes accentuated from landraces to improved lines. Leaf senescence is a genetically ... ...

Abstract	Key message: Leaf senescence in sorghum is primarily controlled by the progression, but not by the onset of senescence. The senescence-delaying haplotypes of 45 key genes accentuated from landraces to improved lines. Leaf senescence is a genetically programmed developmental process and plays a central role for plant survival and crop production by remobilising nutrients accumulated in senescent leaves. In theory, the ultimate outcome of leaf senescence is determined by the onset and progression of senescence, but how these two processes contribute to senescence is not fully illustrated in crops and the genetic basis for them is not well understood. Sorghum (Sorghum bicolor), which is known for the remarkable stay-green trait, is ideal for dissecting the genomic architecture underlying the regulation of senescence. In this study, a diverse panel of 333 sorghum lines was explored for the onset and progression of leaf senescence. Trait correlation analysis showed that the progression of leaf senescence, rather than the onset of leaf senescence, significantly correlated with variations of the final leaf greenness. This notion was further supported by GWAS, which identified 31 senescence-associated genomic regions containing 148 genes, of which 124 were related to the progression of leaf senescence. The senescence-delaying haplotypes of 45 key candidate genes were enriched in lines with extremely prolonged senescence duration, while senescence-promoting haplotypes in those with extremely accelerated senescence. Haplotype combinations of these genes could well explain the segregation of the senescence trait in a recombinant inbred population. We also demonstrated that senescence-delaying haplotypes of candidate genes were under strong selection during sorghum domestication and genetic improvement. Together, this research advanced our understanding of crop leaf senescence and provided a suite of candidate genes for functional genomics and molecular breeding.
MeSH term(s)	Sorghum/genetics ; Plant Senescence ; Quantitative Trait Loci ; Phenotype ; Edible Grain/genetics ; Genomics
Language	English
Publishing date	2023-03-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2170-2
ISSN	1432-2242 ; 0040-5752
ISSN (online)	1432-2242
ISSN	0040-5752
DOI	10.1007/s00122-023-04315-z
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Article ; Online: Children's Daily Living Routine Mediates the Relations Between Parent-Child Relationships and Child Adjustment Problems During School Suspension in Hong Kong.

Wu, Xiao-Yuan / Lau, Eva Yi Hung / Li, Jian-Bin / Chan, Derwin King Chung

Child psychiatry and human development

2023

Abstract: Young children's adjustment problems were found to be prevalent during the COVID-19 pandemic. Such adjustment problems may be dependent on children's relationships with their parents and children's daily living routine in the family during the pandemic- ... ...

Abstract	Young children's adjustment problems were found to be prevalent during the COVID-19 pandemic. Such adjustment problems may be dependent on children's relationships with their parents and children's daily living routine in the family during the pandemic-related school suspension period. This study examines how children's routine mediated the associations between parent-child relationships and child adjustment problems during the fifth wave of the COVID-19 pandemic in Hong Kong, when schools were suspended. The study collected data from 937 parents (87.8% mothers) of children aged 5-12 (M = 7.35 years, SD = 2.09; 50.5% girls). Parents reported on parent-child relationships, children's daily living routine, and child adjustment problems in an online survey. Our findings from structural equation modeling indicate that parent-child closeness was negatively related to child adjustment problems, whereas conflict was positively related to child adjustment problems. Children's routine mediated the associations between parent-child relationships (i.e., closeness and conflict) and child externalizing problems. However, children's routine did not mediate the associations between parent-child relationships (i.e., closeness and conflict) and child internalizing problems. The findings show that parents should be helped to establish routine, especially in difficult times when young children experience turbulence in their daily life, so as to reduce their adjustment problems, in particular of an externalizing nature.
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	223895-0
ISSN	1573-3327 ; 0009-398X
ISSN (online)	1573-3327
ISSN	0009-398X
DOI	10.1007/s10578-023-01609-7
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