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Article ; Online: Bioinformatics analysis identifies coagulation factor II receptor as a potential biomarker in stomach adenocarcinoma.

Wu, Xingwei / Wang, Shengnan / Wang, Chenci / Wu, Chengwei / Zhao, Zhiyong

2024 Volume 14, Issue 1, Page(s) 2468

Abstract: Coagulation factor 2 thrombin receptor (F2R), a member of the G protein-coupled receptor family, plays an important role in regulating blood clotting through protein hydrolytic cleavage mediated receptor activation. However, the underlying biological ... ...

Abstract	Coagulation factor 2 thrombin receptor (F2R), a member of the G protein-coupled receptor family, plays an important role in regulating blood clotting through protein hydrolytic cleavage mediated receptor activation. However, the underlying biological mechanisms by which F2R affects the development of gastric adenocarcinoma are not fully understood. This study aimed to systematically analyze the role of F2R in gastric adenocarcinoma. Stomach adenocarcinoma (STAD)-related gene microarray data and corresponding clinicopathological information were downloaded from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Differential expression genes (DEGs) associated with F2R were analyzed using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), gene set enrichment analysis (GSEA), and protein-protein interaction (PPI) networks. F2R mRNA expression data were utilized to estimate stromal cell and immune cell scores in gastric cancer tissue samples, including stromal score, immune score, and ESTIMATE score, derived from single-sample enrichment studies. Analysis of TCGA and GEO databases revealed significantly higher F2R expression in STAD tissues compared to normal tissues. Patients with high F2R expression had shorter survival times than those with low F2R expression. F2R expression was significantly correlated with tumor (T) stage, node (N) stage, histological grade and pathological stage. Enrichment analysis of F2R-related genes showed that GO terms were mainly related to circulation-mediated human immune response, immunoglobulin, cell recognition and phagocytosis. KEGG analysis indicated associations to extracellular matrix (ECM) receptor interactions, neuroactive ligand-receptor interactions, the phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-AKT) signaling pathway, the Wnt signaling pathway and the transforming growth factor-beta (TGF-β) signaling pathway. GSEA revealed connections to DNA replication, the Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway and oxidative phosphorylation. Drug sensitivity analysis demonstrated positive correlations between F2R and several drugs, including BEZ235, CGP-60474, Dasatinib, HG-6-64-1, Aazopanib, Rapamycin, Sunitinib and TGX221, while negative correlation with CP724714, FH535, GSK1904529A, JNK-9L, LY317615, pyrimidine, rTRAIL and Vinorelbine. Knocking down F2R in GC cell lines resulted in slowed proliferation, migration, and invasion. All statistical analyses were performed using R software (version 4.2.1) and GraphPad Prism 9.0. p < 0.05 was considered statistically significant. In conclusion, this study underscores the significance of F2R as a potential biomarker in gastric adenocarcinoma, shedding light on its molecular mechanisms in tumorigenesis. F2R holds promise for aiding in the diagnosis, prognosis, and targeted therapy of STAD.
MeSH term(s)	Humans ; Prothrombin/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Phosphatidylinositol 3-Kinases/genetics ; Gene Expression Regulation, Neoplastic ; Biomarkers ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Computational Biology/methods
Chemical Substances	Prothrombin (9001-26-7) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Biomarkers
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52397-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Systematic analysis of the role of LDHs subtype in pan-cancer demonstrates the importance of LDHD in the prognosis of hepatocellular carcinoma patients.

Wang, Shengnan / Wu, Xingwei / Wu, Xiaoming / Cheng, Jin / Chen, Qianyi / Qi, Zhilin

BMC cancer

2024 Volume 24, Issue 1, Page(s) 156

Abstract: Background: Lactate dehydrogenase (LDHs) is an enzyme involved in anaerobic glycolysis, including LDHA, LDHB, LDHC and LDHD. Given the regulatory role in the biological progression of certain tumors, we analyzed the role of LDHs in pan-cancers.: ... ...

Abstract	Background: Lactate dehydrogenase (LDHs) is an enzyme involved in anaerobic glycolysis, including LDHA, LDHB, LDHC and LDHD. Given the regulatory role in the biological progression of certain tumors, we analyzed the role of LDHs in pan-cancers. Methods: Cox regression, Kaplan-Meier curves, Receiver Operating Characteristic (ROC) curves, and correlation of clinical indicators in tumor patients were used to assess the prognostic significance of LDHs in pan-cancer. The TCGA, HPA, TIMER, UALCAN, TISIDB, and Cellminer databases were used to investigate the correlation between the expression of LDHs and immune subtypes, immune checkpoint genes, methylation levels, tumor mutational load, microsatellite instability, tumor-infiltrating immune cells and drug sensitivity. The cBioPortal database was also used to identify genomic abnormalities of LDHs in pan-cancer. A comprehensive assessment of the biological functions of LDHs was performed using GSEA. In vitro, HepG2 and Huh7 cells were transfected with LDHD siRNA and GFP-LDHD, the proliferation capacity of cells was examined using CCK-8, EdU, and colony formation assays; the migration and invasion of cells was detected by wound healing and transwell assays; western blotting was used to detect the levels of MMP-2, MMP-9, E-cadherin, N-cadherin and Akt phosphorylation. Results: LDHs were differentially expressed in a variety of human tumor tissues. LDHs subtypes can act as pro-oncogenes or anti-oncogenes in different types of cancer and have an impact on the prognosis of patients with tumors by influencing their clinicopathological characteristics. LDHs were differentially expressed in tumor immune subtypes and molecular subtypes. In addition, LDHs expression correlated with immune checkpoint genes, tumor mutational load, and microsatellite instability. LDHD was identified to play an important role in the prognosis of HCC patients, according to a comprehensive analysis of LDHs in pan-cancer. In HepG2 and Huh7 cells, knockdown of LDHD promoted cell proliferation, migration, and invasion, promoted the protein expression levels of MMP-2, MMP-9, N-cadherin, and Akt phosphorylation, but inhibited the protein expression level of E-cadherin. In addition, LDHD overexpression showed the opposite changes. Conclusion: LDHs subtypes can be used as potential prognostic markers for certain cancers. Prognostic and immunotherapeutic analysis indicated that LDHD plays an important role in the prognosis of HCC patients. In vitro experiments revealed that LDHD can affect HCC proliferation, migration, and invasion by regulating MMPs expression and EMT via Akt signaling pathway, which provides a new perspective on the anti-cancer molecular mechanism of LDHD in HCC.
MeSH term(s)	Humans ; Cadherins/genetics ; Carcinoma, Hepatocellular/genetics ; L-Lactate Dehydrogenase ; Liver Neoplasms/genetics ; Matrix Metalloproteinase 2 ; Matrix Metalloproteinase 9 ; Microsatellite Instability ; Prognosis ; Proto-Oncogene Proteins c-akt
Chemical Substances	Cadherins ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; D-lactate dehydrogenase (EC 1.1.1.28)
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-11920-8
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Article: Analysis of m

Wu, Xingwei / Wang, Shengnan / Wu, Xiaoming / Chen, Qianyi / Cheng, Jin / Qi, Zhilin

Journal of Cancer

2024 Volume 15, Issue 7, Page(s) 2045–2065

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-02-17
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.92128
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Article ; Online: Activation of LXRs Reduces Oxysterol Lipotoxicity in RPE Cells by Promoting Mitochondrial Function.

Xie, Lirong / Gu, Qing / Wu, Xingwei / Yin, Lili

Nutrients

2022 Volume 14, Issue 12

Abstract: Effective treatments for age-related macular degeneration (AMD), the most prevalent neurodegenerative form of blindness in older adults, are lacking. Genome-wide association studies have identified lipid metabolism and inflammation as AMD-associated ... ...

Abstract	Effective treatments for age-related macular degeneration (AMD), the most prevalent neurodegenerative form of blindness in older adults, are lacking. Genome-wide association studies have identified lipid metabolism and inflammation as AMD-associated pathogenic changes. Liver X receptors (LXRs) play a critical role in intracellular homeostases, such as lipid metabolism, glucose homeostasis, inflammation, and mitochondrial function. However, its specific role in AMD and its underlying molecular mechanisms remain unknown. In this study, we investigated the effects of lipotoxicity in human retinal pigmental epithelial (ARPE-19) cells and evaluated how LXRs reduce 7-ketocholesterol (7KCh) lipotoxicity in RPE cells using models, both in vivo and in vitro. A decrease in oxidative lipid accumulation was observed in mouse retinas following the activation of the LXRs; this result was also confirmed in cell experiments. At the same time, LXRs activation reduced RPE cell apoptosis induced by oxysterols. We found that oxysterols decreased the mitochondrial membrane potential in ARPE-19 cells, while LXR agonists counteracted these effects. In cultured ARPE-19 cells, activating LXRs reduced p62, mTOR, and LC3I/II levels, and the knockdown of LXRs elevated the expression of these proteins, indicating that activating LXRs could boost mitophagy. The findings of this study suggest LXR-active pharmaceuticals as a potential therapeutic target for dry AMD.
MeSH term(s)	Animals ; Genome-Wide Association Study ; Inflammation/metabolism ; Liver X Receptors/genetics ; Liver X Receptors/metabolism ; Macular Degeneration/metabolism ; Mice ; Mitochondria/metabolism ; Oxysterols/metabolism ; Oxysterols/toxicity ; Retinal Pigment Epithelium
Chemical Substances	Liver X Receptors ; Oxysterols
Language	English
Publishing date	2022-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14122473
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Article: Activation of LXRs Reduces Oxysterol Lipotoxicity in RPE Cells by Promoting Mitochondrial Function

Xie, Lirong / Gu, Qing / Wu, Xingwei / Yin, Lili

Nutrients. 2022 June 15, v. 14, no. 12

2022

Abstract	Effective treatments for age-related macular degeneration (AMD), the most prevalent neurodegenerative form of blindness in older adults, are lacking. Genome-wide association studies have identified lipid metabolism and inflammation as AMD-associated pathogenic changes. Liver X receptors (LXRs) play a critical role in intracellular homeostases, such as lipid metabolism, glucose homeostasis, inflammation, and mitochondrial function. However, its specific role in AMD and its underlying molecular mechanisms remain unknown. In this study, we investigated the effects of lipotoxicity in human retinal pigmental epithelial (ARPE-19) cells and evaluated how LXRs reduce 7-ketocholesterol (7KCh) lipotoxicity in RPE cells using models, both in vivo and in vitro. A decrease in oxidative lipid accumulation was observed in mouse retinas following the activation of the LXRs; this result was also confirmed in cell experiments. At the same time, LXRs activation reduced RPE cell apoptosis induced by oxysterols. We found that oxysterols decreased the mitochondrial membrane potential in ARPE-19 cells, while LXR agonists counteracted these effects. In cultured ARPE-19 cells, activating LXRs reduced p62, mTOR, and LC3I/II levels, and the knockdown of LXRs elevated the expression of these proteins, indicating that activating LXRs could boost mitophagy. The findings of this study suggest LXR-active pharmaceuticals as a potential therapeutic target for dry AMD.
Keywords	apoptosis ; blindness ; drugs ; epithelium ; glucose ; homeostasis ; humans ; inflammation ; lipid metabolism ; lipotoxicity ; liver ; macular degeneration ; membrane potential ; mice ; mitochondria ; mitochondrial membrane ; mitophagy ; oxysterols ; therapeutics
Language	English
Dates of publication	2022-0615
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14122473
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Microarray Analysis of Small Extracellular Vesicle-Derived miRNAs Involved in Oxidative Stress of RPE Cells.

Mao, Ke / Wu, Xingwei

Oxidative medicine and cellular longevity

2020 Volume 2020, Page(s) 7658921

Abstract: The aim of this study was to investigate the miRNA profiles of nanosized small extracellular vesicles (sEVs) from human retinal pigment epithelial (RPE) cells under oxidative damage. ARPE-19 cells were cultured with ox-LDL (100 mg/L) or serum-free medium ...

Abstract	The aim of this study was to investigate the miRNA profiles of nanosized small extracellular vesicles (sEVs) from human retinal pigment epithelial (RPE) cells under oxidative damage. ARPE-19 cells were cultured with ox-LDL (100 mg/L) or serum-free medium for 48 hours, sEVs were then extracted, and miRNA sequencing was conducted to identify the differentially expressed genes (DEGs) between the 2 groups. RNA sequence results were validated using quantitative real-time PCR. The Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes pathway, and ingenuity pathway analyses (IPA) were performed for the DEGs. Results revealed that oxidative stress inhibited RPE cell viability and promoted sEV secretion. A total of 877 DEGs from sEVs were identified, of which 272 were downregulated and 605 were upregulated. In total, 66 enriched GO terms showed that the 3 most significant enrichment terms were cellular processes (biological processes), cell (cellular component), and catalytic activity (molecular function). IPA were used to explore DEGs associated with oxidation damage and further construct a miRNA-target regulatory network. This study identified several DEGs from oxidation-stimulated RPE cells, which may act as potential RNA targets for prognosis and diagnosis of RPE degeneration.
MeSH term(s)	Cell Line ; Extracellular Vesicles/metabolism ; Gene Expression Profiling ; Humans ; MicroRNAs/metabolism ; Oligonucleotide Array Sequence Analysis ; Oxidative Stress ; Retinal Pigment Epithelium/metabolism
Chemical Substances	MicroRNAs
Language	English
Publishing date	2020-10-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2020/7658921
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Article ; Online: Effect of Lingqi Huangban granule plus intravitreal ranibizumab on macular edema induced by retinal vein occlusion: a randomized controlled clinical trial.

Lu, Bingwen / Wu, Xingwei

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2020 Volume 40, Issue 2, Page(s) 305–310

Abstract: Objective: To investigate the effect of Lingqi Huangban granule (LQHB) plus intravitreal ranibizumab in the treatment of macular edema (ME) induced by retinal vein occlusion (RVO).: Methods: A prospective, randomized controlled study was conducted. A ...

Abstract	Objective: To investigate the effect of Lingqi Huangban granule (LQHB) plus intravitreal ranibizumab in the treatment of macular edema (ME) induced by retinal vein occlusion (RVO). Methods: A prospective, randomized controlled study was conducted. A total of 60 subjects with RVO induced ME were randomized into control group (CG) (30 eyes) and LQHB group (LQHBG) (30 eyes). CG patients underwent intravitreal ranibizumab (IVR) injections. LQHBG patients were treated with oral LQHB combined with IVR injections. In order to reduce the financial burden of the injections, we used one injection and pro re nata (PRN) regimen for both groups. The best-corrected visual acuity (BCVA), central macular thickness (CMT), and mean number of injections were evaluated at the beginning of treatment and 3, 6, 9 and 12 months afterward. All the subjects were followed up for 1 year. Results: At the beginning of treatment, there were no statistically significant differences between the two groups in terms of the general condition of patients (P > 0.05). At 3, 6, 9 and 12 months after treatment, however, the BCVA scores improved and the CMT measurements decreased in all patients (P < 0.05), with the improvement of LQHBG significantly greater than that of CG (P < 0.05). The mean numbers of ranibizumab injections were 1.8 ± 0.3 in LQHBG and 2.3 ± 0.6 in CG, respectively (P < 0.05). No adverse events were reported in both groups. Conclusion: LQHB plus intravitreal ranibizumab could be a much more effective and economic treatment for stabilizing and improving vision with fewer intravitreal injections in the treatment of RVO induced ME. This integrative therapy appears to be a promising option for this type of patient.
MeSH term(s)	Adult ; Aged ; Drug Therapy, Combination ; Drugs, Chinese Herbal/administration & dosage ; Female ; Humans ; Intravitreal Injections ; Macular Edema/complications ; Male ; Middle Aged ; Ranibizumab/administration & dosage ; Retinal Vein Occlusion/drug therapy ; Retinal Vein Occlusion/etiology ; Retinal Vein Occlusion/physiopathology ; Vision, Ocular
Chemical Substances	Drugs, Chinese Herbal ; Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2020-04-02
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	603186-9
ISSN	2589-451X ; 0254-6272 ; 0255-2922
ISSN (online)	2589-451X ; 0254-6272
ISSN	0255-2922
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Article ; Online: Auditory Messages for Intersection Movement Assist (IMA) Systems: Effects of Speech- and Nonspeech-Based Cues.

Wu, Xingwei / Boyle, Linda Ng

Human factors

2020 Volume 63, Issue 2, Page(s) 336–347

Abstract: Objective: The objective of this study was to assess the effects of different warning messages for an Intersection Movement Assist (IMA) based on drivers' ability to avoid a potential safety hazard.: Background: An IMA system can detect hazards and ... ...

Abstract	Objective: The objective of this study was to assess the effects of different warning messages for an Intersection Movement Assist (IMA) based on drivers' ability to avoid a potential safety hazard. Background: An IMA system can detect hazards and warn drivers when it is unsafe to enter an intersection. The effects of different warning information conveyed by these systems are still unknown. Method: A driving simulator study with 80 participants was conducted with a red light running (RLR) scenario using a 5 (warnings) x 2 (training) between-subject design. IMA warnings included the messages "Danger," "Brake now," "Vehicle on your left," a beep, and no IMA warning. Training was provided to half of the participants. Analysis of variance and logistic regression models were used to examine differences in drivers' avoidance behavior. Results: The analyses showed that all tested warning messages can significantly enhance drivers' avoidance performance. Significant differences were observed in crash occurrence, avoidance behavior (i.e., reaction time and speed change), and eye movements (i.e., fixation pattern and time to first fixation). The effects of training also differed given the warning message provided. Conclusion: The "Brake now" message performed best in reducing crash involvement and prompted better avoidance performance. The "Danger" and "Vehicle on your left" messages improved drivers' hazard detection ability. The training showed a potential to enhance the effectiveness of nonspeech warning messages. Application: The findings of this study can help designers and engineers better design IMA warning messages for RLR scenarios.
MeSH term(s)	Accidents, Traffic ; Automobile Driving ; Cues ; Humans ; Reaction Time ; Speech
Language	English
Publishing date	2020-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	212725-8
ISSN	1547-8181 ; 0018-7208
ISSN (online)	1547-8181
ISSN	0018-7208
DOI	10.1177/0018720819891977
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Article ; Online: Ectodermal‑neural cortex 1 affects the biological function of lung cancer through the MAPK pathway.

Wu, Chengwei / Wang, Xianghai / Wu, Xingwei / Chen, Xingwu

International journal of molecular medicine

2021 Volume 47, Issue 5

Abstract: Ectodermal‑neural cortex 1 (ENC1), a highly expressed protein in lung cancer tissues, was identified from the Cancer Genome Atlas (TCGA) database. The objective of the present study was to examine the effects of ENC1 on the biological functions of lung ... ...

Abstract	Ectodermal‑neural cortex 1 (ENC1), a highly expressed protein in lung cancer tissues, was identified from the Cancer Genome Atlas (TCGA) database. The objective of the present study was to examine the effects of ENC1 on the biological functions of lung cancer cells. For this purpose, the expression of ENC1 was examined by RT‑qPCR to compare mRNA expression levels between 28 lung cancer tissue samples and para‑cancerous tissue samples. The association between ENC1 expression and clinicopathological features was evaluated between the 2 tissue types. Using RT‑qPCR and western blot analysis, the expression of ENC1 was investigated in a normal lung cell line (16HBE) and 2 lung cancer cell lines (A549 and H1299). The effect of siRNA targeting ENC1 (si‑ENC1) on the proliferation of A549 and H1299 cells was detected by CCK‑8 assay at the indicated time points. Transwell assay was used to measure the migration and invasion of A549 and H1299 cells following transfection with siRNA targeting ENC1 (si‑ENC1). The expression levels of several proteins related to migration and invasion were examined by western blot analysis. A mouse model of subcutaneous tumor xenotransplantation was established in nude mice to examine the effects of ENC1 downregulation on cancer cells. The results revealed that the expression of ENC1 in lung cancer tissues and lung cancer cells was significantly higher than that in para‑cancerous tissues and non‑cancer lung cells, respectively. The knockdown of ENC1 in the A549 and H1299 cells using si‑ENC1 significantly decreased cell proliferation, migration and invasion compared with the untransfected cells. The knockdown of ENC1 significantly downregulated the levels of matrix metalloproteinase (MMP)2, MMP9, N‑cadherin, p‑c‑Jun N‑terminal kinase (JNK), p‑extracellular signal‑regulated kinase (ERK) and p‑p38. The levels of E‑cadherin were upregulated. In the mouse lung tumor model, reduced levels of ENC1 inhibited the growth of lung tumors. On the whole, the present study demonstrates that ENC1 is involved in the proliferation, migration and invasion of lung cancer cells, and may thus be an effective diagnostic target for certain cancers. The inhibition or reduction of ENC1 activity may represent a breakthrough in the treatment of lung cancer.
MeSH term(s)	A549 Cells ; Animals ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; MAP Kinase Signaling System ; Mice ; Mice, Nude ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Neoplasm Transplantation ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism
Chemical Substances	Microfilament Proteins ; Neoplasm Proteins ; Neuropeptides ; Nuclear Proteins ; ectodermal-neural cortex 1 protein
Language	English
Publishing date	2021-03-11
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2021.4912
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Article: The Antiangiogenic Effect of Sanguinarine Chloride on Experimental Choroidal Neovacularization in Mice via Inhibiting Vascular Endothelial Growth Factor.

Zhang, Junxiu / Mao, Ke / Gu, Qing / Wu, Xingwei

Frontiers in pharmacology

2021 Volume 12, Page(s) 638215

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.638215
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