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Article ; Online: The SiTian Project.

Liu, Jifeng / Soria, Roberto / Wu, Xue-Feng / Wu, Hong / Shang, Zhaohui

Anais da Academia Brasileira de Ciencias

2021 Volume 93, Issue suppl 1, Page(s) e20200628

Abstract: SiTian is an ambitious ground-based all-sky optical monitoring project, developed by the Chinese Academy of Sciences. The concept is an integrated network of dozens of 1-m-class telescopes deployed partly in China and partly at various other sites around ...

Abstract	SiTian is an ambitious ground-based all-sky optical monitoring project, developed by the Chinese Academy of Sciences. The concept is an integrated network of dozens of 1-m-class telescopes deployed partly in China and partly at various other sites around the world. The main science goals are the detection, identification and monitoring of optical transients (such as gravitational wave events, fast radio bursts, supernovae) on the largely unknown timescales of less than 1 day; SiTian will also provide a treasure trove of data for studies of AGN, quasars, variable stars, planets, asteroids, and microlensing events. To achieve those goals, SiTian will scan at least 10,000 square deg of sky every 30 min, down to a detection limit of $V \approx 21$ mag. The scans will produce simultaneous light-curves in 3 optical bands. In addition, SiTian will include at least three 4-m telescopes specifically allocated for follow-up spectroscopy of the most interesting targets. We plan to complete the installation of 72 telescopes by 2030 and start full scientific operations in 2032.
MeSH term(s)	China ; Planets ; Spectrum Analysis ; Telescopes
Language	English
Publishing date	2021-04-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2046885-4
ISSN	1678-2690 ; 0001-3765
ISSN (online)	1678-2690
ISSN	0001-3765
DOI	10.1590/0001-3765202120200628
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Universal growth of perovskite thin monocrystals from high solute flux for sensitive self-driven X-ray detection.

Liu, Da / Zheng, Yichu / Sui, Xin Yuan / Wu, Xue Feng / Zou, Can / Peng, Yu / Liu, Xinyi / Lin, Miaoyu / Wei, Zhanpeng / Zhou, Hang / Yao, Ye-Feng / Dai, Sheng / Yuan, Haiyang / Yang, Hua Gui / Yang, Shuang / Hou, Yu

Nature communications

2024 Volume 15, Issue 1, Page(s) 2390

Abstract: Metal-halide perovskite thin monocrystals featuring efficient carrier collection and transport capabilities are well suited for radiation detectors, yet their growth in a generic, well-controlled manner remains challenging. Here, we reveal that mass ... ...

Abstract	Metal-halide perovskite thin monocrystals featuring efficient carrier collection and transport capabilities are well suited for radiation detectors, yet their growth in a generic, well-controlled manner remains challenging. Here, we reveal that mass transfer is one major limiting factor during solution growth of perovskite thin monocrystals. A general approach is developed to overcome synthetic limitation by using a high solute flux system, in which mass diffusion coefficient is improved from 1.7×10
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46712-y
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Article ; Online: Origin of FRB-associated X-ray burst: QED magnetic reconnection.

Xie, Yu / Geng, Jin-Jun / Zhu, Xi-Wei / Zhao, Zhong-Hai / Lei, Zhu / Yuan, Wen-Qiang / Zhao, Gang / Wu, Xue-Feng / Qiao, Bin

Science bulletin

2023 Volume 68, Issue 17, Page(s) 1857–1861

Language	English
Publishing date	2023-06-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2816140-3
ISSN	2095-9281 ; 2095-9273
ISSN (online)	2095-9281
ISSN	2095-9273
DOI	10.1016/j.scib.2023.06.005
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Article: Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway.

Lin, Tong-Tong / Jiang, Chun-Yi / Sheng, Lei / Wan, Li / Fan, Wen / Li, Jin-Can / Sun, Xiao-Di / Xu, Chen-Jie / Hu, Liang / Wu, Xue-Feng / Han, Yuan / Liu, Wen-Tao / Pan, Yin-Bing

Neural regeneration research

2023 Volume 18, Issue 9, Page(s) 2067–2074

Abstract: Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance to morphine. High mobility group box-1 (HMGB1) has been shown to participate in neuropathic or inflammatory pain, but its role in morphine ... ...

Abstract	Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance to morphine. High mobility group box-1 (HMGB1) has been shown to participate in neuropathic or inflammatory pain, but its role in morphine tolerance is unclear. In this study, we established rat and mouse models of morphine tolerance by intrathecal injection of morphine for 7 consecutive days. We found that morphine induced rat spinal cord neurons to release a large amount of HMGB1. HMGB1 regulated nuclear factor κB p65 phosphorylation and interleukin-1β production by increasing Toll-like receptor 4 receptor expression in microglia, thereby inducing morphine tolerance. Glycyrrhizin, an HMGB1 inhibitor, markedly attenuated chronic morphine tolerance in the mouse model. Finally, compound C (adenosine 5'-monophosphate-activated protein kinase inhibitor) and zinc protoporphyrin (heme oxygenase-1 inhibitor) alleviated the morphine-induced release of HMGB1 and reduced nuclear factor κB p65 phosphorylation and interleukin-1β production in a mouse model of morphine tolerance and an SH-SY5Y cell model of morphine tolerance, and alleviated morphine tolerance in the mouse model. These findings suggest that morphine induces HMGB1 release via the adenosine 5'-monophosphate-activated protein kinase/heme oxygenase-1 signaling pathway, and that inhibiting this signaling pathway can effectively reduce morphine tolerance.
Language	English
Publishing date	2023-03-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.366490
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Article ; Online: Natural compound fraxinellone ameliorates intestinal fibrosis in mice via direct intervention of HSP47-collagen interaction in the epithelium.

Wang, Jie / Bai, Mei / Zhang, Cui / An, Ning / Wan, Li / Wang, Xiao-Ning / Du, Rong-Hui / Shen, Yan / Yuan, Zhi-Yao / Wu, Xu-Dong / Wu, Xue-Feng / Xu, Qiang

Acta pharmacologica Sinica

2023 Volume 44, Issue 12, Page(s) 2469–2478

Abstract: Intestinal fibrosis is a common complication of inflammatory bowel disease. There is still a lack of effective drugs for the prevention or treatment of intestinal fibrosis. Heat shock protein 47 (HSP47) plays a key role in the development of intestinal ... ...

Abstract	Intestinal fibrosis is a common complication of inflammatory bowel disease. There is still a lack of effective drugs for the prevention or treatment of intestinal fibrosis. Heat shock protein 47 (HSP47) plays a key role in the development of intestinal fibrosis. In this study we investigated the therapeutic potential and underlying mechanisms of fraxinellone, a degraded limonoid isolated from the root bark of Dictamnus dasycarpus, in the treatment of intestinal fibrosis. Intestinal fibrosis was induced in mice by dextran sodium sulfate (DSS) treatment. DDS-treated mice were administered fraxinellone (7.5, 15, 30 mg·kg
MeSH term(s)	Mice ; Animals ; HSP47 Heat-Shock Proteins/metabolism ; Molecular Docking Simulation ; Collagen/metabolism ; Fibrosis ; Epithelium/metabolism ; Transforming Growth Factor beta
Chemical Substances	HSP47 Heat-Shock Proteins ; fraxinellone (28808-62-0) ; Collagen (9007-34-5) ; Transforming Growth Factor beta
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1360774-1
ISSN	1745-7254 ; 0253-9756 ; 1671-4083
ISSN (online)	1745-7254
ISSN	0253-9756 ; 1671-4083
DOI	10.1038/s41401-023-01143-1
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Article ; Online: Authentication of recycled and virgin polyethylene terephthalate based on UPLC-Q-TOF-MS using non-volatile organic compounds and chemometrics.

Hao, Tian-Ying / Lin, Qin-Bao / Wu, Xue-Feng / Wu, Si-Liang / Zhong, Huai-Ning / Dong, Ben / Chen, Zhi-Feng / Ye, Zhi-Kang / Wang, Zhi-Wei / Xu, Xiaowen

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

2023 Volume 40, Issue 8, Page(s) 1114–1130

Abstract: Plastic packaging waste, such as polyethylene terephthalate (PET) has increased significantly in recent decades, arousing a considerable and serious public concern regarding the environment, economy, and policy. Plastic recycling is a useful tool to ... ...

Abstract	Plastic packaging waste, such as polyethylene terephthalate (PET) has increased significantly in recent decades, arousing a considerable and serious public concern regarding the environment, economy, and policy. Plastic recycling is a useful tool to mitigate this issue. Here, a feasible study was performed to investigate the potential of a novel method for identifying virgin and recycled PET. Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was combined with various chemometrics, as a simple and reliable method that achieved a high discrimination rate for 105 batches of virgin PET (v-PET) and recycled PET (r-PET) based on 202 non-volatile organic compounds (NVOCs). Making use of orthogonal partial least-squares discrimination analysis (OPLS-DA) together with non-parametric tests, 26 marker compounds (i.e. 12 intentionally added substances (IAS) and 14 non-intentionally added substances (NIAS) as well as 31 marker compounds (i.e. 11 IAS and 20 NIAS) obtained from positive and combination of positive and negative ionization modes of UPLC-Q-TOF-MS, respectively, were successfully identified. Moreover, 100% accuracy was obtained using a decision tree (DT). Cross-discrimination based on misclassified samples using various chemometrics allowed the prediction accuracy to be improved and to identify a large sample set, thus greatly enhancing the application scope of this method. The possible origins of these detected compounds can be the plastic itself, as well as contamination from food, medicine, pesticides, industry-related substances, and degradation and polymerization products. As many of these compounds are toxic, especially those pesticide related, this indicates an urgent requirement for closed loop recycling. Overall, this analytical method provides a quick, accurate, and robust way to distinguish virgin from recycled PET and thus addresses the issue of potential virgin PET adulteration thereby detecting fraud in the area of PET recycling.
MeSH term(s)	Polyethylene Terephthalates/analysis ; Chemometrics ; Mass Spectrometry/methods ; Chromatography, Liquid ; Plastics/analysis ; Chromatography, High Pressure Liquid/methods
Chemical Substances	Polyethylene Terephthalates ; Plastics
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2023.2227732
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Article ; Online: Authentication of recycled and virgin polyethylene terephthalate based on UPLC-Q-TOF-MS using non-volatile organic compounds and chemometrics

Hao, Tian-Ying / Lin, Qin-Bao / Wu, Xue-Feng / Wu, Si-Liang / Zhong, Huai-Ning / Dong, Ben / Chen, Zhi-Feng / Ye, Zhi-Kang / Wang, Zhi-Wei / Xu, Xiaowen

Food Additives & Contaminants: Part A. 2023 Aug. 3, v. 40, no. 8 p.1114-1130

2023

Abstract	Plastic packaging waste, such as polyethylene terephthalate (PET) has increased significantly in recent decades, arousing a considerable and serious public concern regarding the environment, economy, and policy. Plastic recycling is a useful tool to mitigate this issue. Here, a feasible study was performed to investigate the potential of a novel method for identifying virgin and recycled PET. Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was combined with various chemometrics, as a simple and reliable method that achieved a high discrimination rate for 105 batches of virgin PET (v-PET) and recycled PET (r-PET) based on 202 non-volatile organic compounds (NVOCs). Making use of orthogonal partial least-squares discrimination analysis (OPLS-DA) together with non-parametric tests, 26 marker compounds (i.e. 12 intentionally added substances (IAS) and 14 non-intentionally added substances (NIAS) as well as 31 marker compounds (i.e. 11 IAS and 20 NIAS) obtained from positive and combination of positive and negative ionization modes of UPLC-Q-TOF-MS, respectively, were successfully identified. Moreover, 100% accuracy was obtained using a decision tree (DT). Cross-discrimination based on misclassified samples using various chemometrics allowed the prediction accuracy to be improved and to identify a large sample set, thus greatly enhancing the application scope of this method. The possible origins of these detected compounds can be the plastic itself, as well as contamination from food, medicine, pesticides, industry-related substances, and degradation and polymerization products. As many of these compounds are toxic, especially those pesticide related, this indicates an urgent requirement for closed loop recycling. Overall, this analytical method provides a quick, accurate, and robust way to distinguish virgin from recycled PET and thus addresses the issue of potential virgin PET adulteration thereby detecting fraud in the area of PET recycling.
Keywords	adulterated products ; chemometrics ; decision support systems ; fraud ; ionization ; issues and policy ; least squares ; mass spectrometry ; medicine ; pesticides ; plastics ; polyethylene terephthalates ; polymerization ; prediction ; toxicity ; wastes ; UPLC-Q-TOF-MS ; recycled polyethylene terephthalate ; non-volatile organic compounds
Language	English
Dates of publication	2023-0803
Size	p. 1114-1130.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2023.2227732
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Article ; Online: Chemical profiling and quality evaluation of Pogostemon cablin Benth by liquid chromatography tandem mass spectrometry combined with multivariate statistical analysis.

Xie, Bin / Wu, Xue-Feng / Luo, Hui-Tai / Huang, Xiao-Lan / Huang, Fang / Zhang, Qiu-Yan / Zhou, Xi / Wu, Hui-Qin

Journal of pharmaceutical and biomedical analysis

2021 Volume 209, Page(s) 114526

Abstract: Pogostemon cablin Benth (PCB) is a well-known traditional Chinese medicine that has been used for treatment of many ailments for several centuries. In presently, the chemical profiling and quality control study of PCB has mainly concentrated on the ... ...

Abstract	Pogostemon cablin Benth (PCB) is a well-known traditional Chinese medicine that has been used for treatment of many ailments for several centuries. In presently, the chemical profiling and quality control study of PCB has mainly concentrated on the volatile fractions. However, the non-volatile chemical profile of PCB was still unclear. In this study, 73 non-volatile constituents (i.e., 33 flavonoids, 21 organic acids, 9 phenylpropanoids, 4 sesquiterpenes, 3 alkaloids, and 3 other types of compounds) were identified and characterized in PCB using high performance liquid chromatography coupled with quadruple time-of-flight tandem mass spectrometry (HPLC-Q-TOF-MS). Meanwhile, to assess PCB samples, an established HPLC-Q-TOF-MS fingerprint was combined with multivariate statistical analysis that included similarity analysis (SA), hierarchical cluster analysis (HCA), principal component analysis (PCA), and orthogonal partial least squares-discriminant analysis (OPLS-DA). The PCB samples could be classified into two groups (herbal decoction pieces and processed medicinal materials), and acteoside, isoacteoside, 4',6-Dihydroxy-5,7-dimethoxyflavone, pachypodol and pogostone were screened as the potential chemical markers that attributed classification. In addition, nine representative components (pachypodol, vicenin-2, apigenin, rhamnocitrin, acteoside, isoacteoside, chlorogenic acid, azelaic acid and pogostone) in PCB were simultaneously determined by using an ultra-high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UPLC-QQQ-MS/MS). This study is the first to describe the chemical profile of PCB using liquid chromatography tandem mass spectrometry, which would improve our understanding of the substance basis of PCB and is helpful to the PCB further quality evaluation.
MeSH term(s)	Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/analysis ; Pogostemon/chemistry ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2021.114526
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A low-valent cobalt oxide co-catalyst to boost photocatalytic water oxidation via enhanced hole-capturing ability

Xiao, Shi Yang / Liu, Yuanwei / Wu, Xue Feng / Gan, Li Ting / Lin, Hao Yang / Zheng, Li Rong / Dai, Sheng / Liu, Peng Fei / Yang, Hua Gui

Journal of materials chemistry A. 2021 July 6, v. 9, no. 26

2021

Abstract: Co-catalysts have been widely studied to improve photocatalytic water oxidation efficiency, and the precise control of their oxidation states and minimizing particle sizes can optimize the practical performance. In this work, ultrafine cobalt oxide (CoOₓ) ...

Abstract	Co-catalysts have been widely studied to improve photocatalytic water oxidation efficiency, and the precise control of their oxidation states and minimizing particle sizes can optimize the practical performance. In this work, ultrafine cobalt oxide (CoOₓ) co-catalysts with specific Co valence states have been successfully synthesized, which are anchored on a tantalum oxynitride (TaON) host photocatalyst via a photochemical metal–organic deposition method. Photoelectrochemical and photoluminescence analyses prove that the Co²⁺ dominant CoOₓ co-catalyst is favorable for charge separation and transportation because of its excellent hole-capturing properties, consequently enhancing the photocatalytic water oxidation performance. The resultant TaON with the Co²⁺ dominant CoOₓ co-catalyst exhibits an outstanding O₂ production rate up to 6.10 ± 0.17 mmol h⁻¹ g⁻¹ and possesses an excellent apparent quantum efficiency of 21.2% at 420 nm, which are among the best values of water-oxidation photocatalysts.
Keywords	cobalt oxide ; oxidation ; photocatalysis ; photocatalysts ; photoluminescence ; tantalum ; transportation
Language	English
Dates of publication	2021-0706
Size	p. 14786-14792.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/d1ta01858b
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Article ; Online: Neutrophil extracellular traps as a unique target in the treatment of chemotherapy-induced peripheral neuropathy.

Wang, Chao-Yu / Lin, Tong-Tong / Hu, Liang / Xu, Chen-Jie / Hu, Fan / Wan, Li / Yang, Xing / Wu, Xue-Feng / Zhang, Xiao-Tao / Li, Yan / Yin, Hao-Yuan / Jiang, Chun-Yi / Xin, Hong-Liang / Liu, Wen-Tao

EBioMedicine

2023 Volume 90, Page(s) 104499

Abstract: Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a severe dose-limiting side effect of chemotherapy and remains a huge clinical challenge. Here, we explore the role of microcirculation hypoxia induced by neutrophil extracellular traps ( ... ...

Abstract	Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a severe dose-limiting side effect of chemotherapy and remains a huge clinical challenge. Here, we explore the role of microcirculation hypoxia induced by neutrophil extracellular traps (NETs) in the development of CIPN and look for potential treatment. Methods: The expression of NETs in plasma and dorsal root ganglion (DRG) are examined by ELISA, IHC, IF and Western blotting. IVIS Spectrum imaging and Laser Doppler Flow Metry are applied to explore the microcirculation hypoxia induced by NETs in the development of CIPN. Stroke Homing peptide (SHp)-guided deoxyribonuclease 1 (DNase1) is used to degrade NETs. Findings: The level of NETs in patients received chemotherapy increases significantly. And NETs accumulate in the DRG and limbs in CIPN mice. It leads to disturbed microcirculation and ischemic status in limbs and sciatic nerves treated with oxaliplatin (L-OHP). Furthermore, targeting NETs with DNase1 significantly reduces the chemotherapy-induced mechanical hyperalgesia. The pharmacological or genetic inhibition on myeloperoxidase (MPO) or peptidyl arginine deiminase-4 (PAD4) dramatically improves microcirculation disturbance caused by L-OHP and prevents the development of CIPN in mice. Interpretation: In addition to uncovering the role of NETs as a key element in the development of CIPN, our finding provides a potential therapeutic strategy that targeted degradation of NETs by SHp-guided DNase1 could be an effective treatment for CIPN. Funding: This study was funded by the National Natural Science Foundation of China81870870, 81971047, 81773798, 82271252; Natural Science Foundation of Jiangsu ProvinceBK20191253; Major Project of "Science and Technology Innovation Fund" of Nanjing Medical University2017NJMUCX004; Key R&D Program (Social Development) Project of Jiangsu ProvinceBE2019732; Nanjing Special Fund for Health Science and Technology DevelopmentYKK19170.
MeSH term(s)	Mice ; Animals ; Extracellular Traps/metabolism ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/drug therapy ; Oxaliplatin/adverse effects ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Antineoplastic Agents/adverse effects
Chemical Substances	Oxaliplatin (04ZR38536J) ; Antineoplastic Agents
Language	English
Publishing date	2023-03-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2023.104499
Database	MEDical Literature Analysis and Retrieval System OnLINE

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