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Article: The efficacy of extracted Tanshinone compounds for infantile hemangiomas of the skin: results from a pilot study.

Huang, Yingying / Li, Chao / Wang, Rui / Wu, Yeming

2024 Volume 13, Issue 1, Page(s) 137–145

Abstract: Background: Infantile hemangiomas (IHs) on skin are conventionally treated with beta blockers, pulsed dye laser (PDL), or surgery, either invasive or limited to clinical conditions. Our preclinical studies suggested that Tanshinone, extracted from : ... ...

Abstract	Background: Infantile hemangiomas (IHs) on skin are conventionally treated with beta blockers, pulsed dye laser (PDL), or surgery, either invasive or limited to clinical conditions. Our preclinical studies suggested that Tanshinone, extracted from Methods: The single-armed pilot study included a total of 29 infants diagnosed with IHs. Thrice daily (at an interval of 6-8 hours) topical applications of Tanshinone were used for each patient. The primary response was the skin erythema index assessed by investigators using SkinColorCatch colorimeter instrument (Delfin). The Achauer score and the satisfaction of parents were also evaluated. Results: A total of 29 infants, 22 females (76%) and 7 males (24%), with a median age of 60 days (interquartile range, 45 to 99 days) were included. The position of IHs was distributed in the trunk (44.8%), head (34.5%), and limbs (20.7%). After 6 months of IHs treatment, the decrease in skin erythema index (baseline: 566.79±854.67 Conclusions: The topical use of Tanshinone compounds might be a potentially effective and noninvasive therapy in treating IHs.
Language	English
Publishing date	2024-01-10
Publishing country	China
Document type	Journal Article
ZDB-ID	2901309-4
ISSN	2224-4344 ; 2224-4344 ; 2224-4336
ISSN (online)	2224-4344
ISSN	2224-4344 ; 2224-4336
DOI	10.21037/tp-23-555
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Article ; Online: Successful thoracoscopic repair of traumatic diaphragmatic hernia in a child.

Wang, Yi / Cai, Yuanxia / Wu, Yeming

Interactive cardiovascular and thoracic surgery

2021 Volume 34, Issue 4, Page(s) 703–705

Abstract: Traumatic diaphragmatic hernia is very rare in children, and the diagnosis is often missed or delayed. Herein, we reported a 2-year-old boy who had suffered with traumatic diaphragmatic hernia due to a car crash. The child was manifested as tachypnoea ... ...

Abstract	Traumatic diaphragmatic hernia is very rare in children, and the diagnosis is often missed or delayed. Herein, we reported a 2-year-old boy who had suffered with traumatic diaphragmatic hernia due to a car crash. The child was manifested as tachypnoea without any other severe symptoms. The computed tomography scanning showed his right diaphragm was rupture. Soon, this patient was received a thoracoscopic repair surgery, and he was discharged 2 weeks later without any complication.
MeSH term(s)	Child ; Child, Preschool ; Diaphragm/surgery ; Hernia, Diaphragmatic, Traumatic/diagnostic imaging ; Hernia, Diaphragmatic, Traumatic/etiology ; Hernia, Diaphragmatic, Traumatic/surgery ; Humans ; Male ; Rupture/complications ; Thoracoscopy/methods
Language	English
Publishing date	2021-11-18
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivab314
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Zs.A 5730: Show issues

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Article ; Online: Histopathology of Ganglion Cells in the Proximal Resected Bowel Correlates With the Clinical Outcome in Hirschsprung Disease: A Pilot Study.

Zhang, Minzhong / Guan, Wenbin / Zhou, Yin / Wang, Jun / Wu, Yeming / Pan, Weihua

The Journal of surgical research

2023 Volume 290, Page(s) 116–125

Abstract: Introduction: Intraoperative leveling biopsy by identifying ganglion cells is crucial to determine surgical margin during surgery for Hirschsprung disease (HSCR). The anastomosis should be performed at least 5 cm proximal to the ganglionic segment to ... ...

Abstract	Introduction: Intraoperative leveling biopsy by identifying ganglion cells is crucial to determine surgical margin during surgery for Hirschsprung disease (HSCR). The anastomosis should be performed at least 5 cm proximal to the ganglionic segment to prevent transition zone pull-through. However, the length of the transition zone could be much longer than expected and the histological evaluation of the entire circumference of the proximal margin is recommended, which is time-consuming and not applicable for leveling biopsy. We found that the histopathologic features of ganglion cells varied in the examined bowel specimens and demonstrated a pattern similar to immature and degenerated neuron cells. We assumed that the histopathologic features of ganglion cells in the proximal resected bowel were associated with the clinical outcome and might guide the leveling biopsy. In this study, we described a histopathologic grade of ganglion cells based on the degree of maturity and degeneration. We assessed the correlation between the histopathological grade of ganglion cells in the proximal surgical margin and clinical outcome. Methods: Three hundred fifty seven patients with HSCR treated between 2013 and 2020 were included. The ganglion cells were divided into six grades based on the histopathologic features in frozen sections. Medical records and detailed histopathologic results of intraoperative frozen sections were reviewed. Follow-up data were collected to evaluate clinical outcomes. The pediatric incontinence and constipation scoring system was used to predict bowel function. Results: The histopathologic results of proximal resected bowel from 357 HSCR patients were presented as follows: Grade I in 52 patients (14.6%), Grade II in 186 patients (52.1%), Grade III in 107 patients (30.0%), and Grade IV in 12 patients (3.4%). The median follow-up time was 46.8 mo (13.0-97.6 mo). The histopathologic grade of ganglion cells from the proximal resected margin was significantly related to postoperative constipation problems and the incidence of Hirschsprung-associated enterocolitis. The results from the pediatric incontinence and constipation scoring system indicated a positive correlation between better postoperative bowel function and lower histopathologic grade of ganglion cells. Conclusions: This pilot study showed an association between the histopathologic features of ganglion cells in the proximal surgical margin and the clinical outcome. It may provide additional information for intraoperative pathologic consultation in leveling biopsy to prevent insufficient resection of the affected colon. A prospective study is warranted to validate these findings before clinical application.
MeSH term(s)	Child ; Humans ; Infant ; Hirschsprung Disease/surgery ; Hirschsprung Disease/complications ; Pilot Projects ; Margins of Excision ; Prospective Studies ; Constipation/etiology ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Neurons/pathology
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2023.03.012
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Zs.A 178: Show issues

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Article ; Online: Angiomatoid fibrous histiocytoma with Castleman disease: A case report.

Gu, Yaoyao / Lv, Fan / Wu, Yeming / Wu, Zhixiang

Pediatric blood & cancer

2020 Volume 68, Issue 2, Page(s) e28590

MeSH term(s)	Castleman Disease/diagnosis ; Castleman Disease/diagnostic imaging ; Castleman Disease/therapy ; Child ; Histiocytoma, Malignant Fibrous/diagnosis ; Histiocytoma, Malignant Fibrous/diagnostic imaging ; Histiocytoma, Malignant Fibrous/therapy ; Humans ; Lymph Nodes/pathology ; Male ; Positron Emission Tomography Computed Tomography ; RNA-Binding Protein EWS/genetics
Chemical Substances	EWSR1 protein, human ; RNA-Binding Protein EWS
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Case Reports ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.28590
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Zs.A 1131: Show issues

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Article: Recent Progress in Lymphangioma.

Liu, Xiaowei / Cheng, Cheng / Chen, Kai / Wu, Yeming / Wu, Zhixiang

Frontiers in pediatrics

2021 Volume 9, Page(s) 735832

Abstract: Lymphangioma is a common type of congenital vascular disease in children with a broad spectrum of clinical manifestations. The current classification of lymphangioma by International Society for the Study of Vascular Anomalies is largely based on the ... ...

Abstract	Lymphangioma is a common type of congenital vascular disease in children with a broad spectrum of clinical manifestations. The current classification of lymphangioma by International Society for the Study of Vascular Anomalies is largely based on the clinical manifestations and complications and is not sufficient for selection of therapeutic strategies and prognosis prediction. The clinical management and outcome of lymphangioma largely depend on the clinical classification and the location of the disease, ranging from spontaneous regression with no treatment to severe sequelae even with comprehensive treatment. Recently, rapid progression has been made toward elucidating the molecular pathology of lymphangioma and the development of treatments. Several signaling pathways have been revealed to be involved in the progression and development of lymphangioma, and specific inhibitors targeting these pathways have been investigated for clinical applications and clinical trials. Some drugs already currently in clinical use for other diseases were found to be effective for lymphangioma, although the mechanisms underlying the anti-tumor effects remain unclear. Molecular classification based on molecular pathology and investigation of the molecular mechanisms of current clinical drugs is the next step toward developing more effective individualized treatment of children with lymphangioma with reduced side effects.
Language	English
Publishing date	2021-12-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.735832
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Article ; Online: Exportin-T: A Novel Prognostic Predictor and Potential Therapeutic Target for Neuroblastoma.

Pan, Li-Jia / Chen, Jian-Lei / Wu, Zhi-Xiang / Wu, Ye-Ming

Technology in cancer research & treatment

2021 Volume 20, Page(s) 15330338211039132

Abstract: Exportins as the key mediators of nucleocytoplasmic transport have been identified as the controllers of the passage of numerous types of crucial cancer-related proteins. Targeting exportins in cancer cells might represent an emerging strategy in cancer ... ...

Abstract	Exportins as the key mediators of nucleocytoplasmic transport have been identified as the controllers of the passage of numerous types of crucial cancer-related proteins. Targeting exportins in cancer cells might represent an emerging strategy in cancer intervention with the potential to affect clinical outcomes. Here, we focused on the prognostic and therapeutic values of Exportin-T (XPOT) in neuroblastoma. The correlation between the expression and prognostic values of XPOT in patients with neuroblastoma was investigated based on both published transcriptome data and our clinical data. Then, decision curve analysis (DCA) was implemented to identify a XPOT risk prediction model. In addition, RNA inference was performed to silence the expression of XPOT to further investigate the specific roles of XPOT in the progression of neuroblastoma in vitro. Overexpression of XPOT mRNA was associated with poor clinical characteristics, such as age at diagnosis more than 18 months, amplification of MYCN, and advanced International Neuroblastoma Staging System (INSS) stage, and XPOT expression was identified as an independent poor prognosis factor for neuroblastoma using Cox proportional hazards model (
MeSH term(s)	Adolescent ; Biomarkers, Tumor ; Cell Movement ; Cell Proliferation ; Child ; Disease Management ; Disease Susceptibility ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Immunohistochemistry ; Male ; Molecular Targeted Therapy ; Neoplasm Staging ; Neuroblastoma/etiology ; Neuroblastoma/mortality ; Neuroblastoma/pathology ; Neuroblastoma/therapy ; Nucleocytoplasmic Transport Proteins/genetics ; Nucleocytoplasmic Transport Proteins/metabolism ; Prognosis ; Proportional Hazards Models ; RNA Interference ; RNA, Small Interfering/genetics ; ROC Curve ; Young Adult
Chemical Substances	Biomarkers, Tumor ; Nucleocytoplasmic Transport Proteins ; RNA, Small Interfering ; XPOT protein, human
Language	English
Publishing date	2021-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146365-7
ISSN	1533-0338 ; 1533-0346
ISSN (online)	1533-0338
ISSN	1533-0346
DOI	10.1177/15330338211039132
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Zs.A 5871: Show issues

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Article ; Online: Comparative Study of Thoracoscopic and Modified Small Incision Repair for Congenital Diaphragmatic Eventration in Children.

Cai, Yuanxia / Wu, Yeming / Wu, Zhixiang / Liu, Xiaowei / Pan, Weihua

Journal of laparoendoscopic & advanced surgical techniques. Part A

2021 Volume 31, Issue 9, Page(s) 1079–1083

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Child ; Diaphragm/surgery ; Diaphragmatic Eventration/surgery ; Humans ; Operative Time ; Recurrence ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2021.0110
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Zs.A 3246: Show issues

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Article ; Online: KHSRP modulated cell proliferation and cell cycle via regulating PPP2CA and p27 expression in Wilms tumor.

Cheng, Cheng / Cai, Yuanxia / Liu, Xiaowei / Wu, Yangkun / Cheng, Qianqian / Wu, Yeming / Wu, Zhixiang

Cellular signalling

2022 Volume 100, Page(s) 110447

Abstract: Wilms tumor (WT) is the most common renal malignancy in children, and the survival rate of high-risk WT patients was still low despite multimodality therapy. KHSRP, an RNA-binding protein, has been proved to be relative to tumor progression in different ... ...

Abstract	Wilms tumor (WT) is the most common renal malignancy in children, and the survival rate of high-risk WT patients was still low despite multimodality therapy. KHSRP, an RNA-binding protein, has been proved to be relative to tumor progression in different kinds of malignancies, but the function of KHSRP in WT remained unclear. Here, our study aimed to explore and clarify the function of KHSRP in WT cells and its molecular mechanism. Thus, our results showed that KHSRP was highly expressed in WT tumor tissues compared to normal kidney tissues and correlated with poor prognosis in WT patients. Downregulation of KHSRP using siRNAs in WT cell line SK-NEP-1 and Wit49 resulted in inhibition of cell proliferation and cell cycle arrest via stabilizing and upregulating p27 protein. Furthermore, mechanistic analyses revealed that KHSRP bound to 3'UTR of PPP2CA mRNA and modulating its mRNA stability, resulting in regulation of the phosphorylation level and protein stability of p27 in WT cell lines. In conclusion, our results demonstrated that KHSRP played an important role in WT and modulated cell proliferation and cell cycle via regulating the expression of PPP2CA and p27.
Language	English
Publishing date	2022-08-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2022.110447
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Zs.A 2579: Show issues

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Article ; Online: P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.

Cheng, Cheng / He, Tian / Chen, Kai / Cai, Yuanxia / Gu, Yaoyao / Pan, Lijia / Duan, Peiwen / Wu, Yeming / Wu, Zhixiang

Molecular & cellular proteomics : MCP

2023 Volume 22, Issue 3, Page(s) 100504

Abstract: MYCN amplification is an independent risk factor for poor prognosis in neuroblastoma (NB), but its protein product cannot be directly targeted because of protein structure. Thus, this study aimed to explore novel ways to indirectly target N-Myc by ... ...

Abstract	MYCN amplification is an independent risk factor for poor prognosis in neuroblastoma (NB), but its protein product cannot be directly targeted because of protein structure. Thus, this study aimed to explore novel ways to indirectly target N-Myc by regulating its post-translational modifications (PTMs) and therefore protein stability. N-Myc coimmunoprecipitation combined with HPLC-MS/MS identified 16 PTM residues and 114 potential N-Myc-interacting proteins. Notably, both acetylation and ubiquitination were identified on lysine 199 of N-Myc. We then discovered that p300, which can interact with N-Myc, modulated the protein stability of N-Myc in MYCN-amplified NB cell lines and simultaneously regulated the acetylation level and ubiquitination level on lysine-199 of N-Myc protein in vitro. Furthermore, p300 correlated with poor prognosis in NB patients. Taken together, p300 can be considered as a potential therapeutic target to treat MYCN-amplified NB patients, and other identified PTMs and interacting proteins also provide potential targets for further study.
MeSH term(s)	Humans ; N-Myc Proto-Oncogene Protein/genetics ; N-Myc Proto-Oncogene Protein/metabolism ; N-Myc Proto-Oncogene Protein/therapeutic use ; Lysine/metabolism ; Tandem Mass Spectrometry ; Protein Processing, Post-Translational ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Protein Stability ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic
Chemical Substances	N-Myc Proto-Oncogene Protein ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2075924-1
ISSN	1535-9484 ; 1535-9476
ISSN (online)	1535-9484
ISSN	1535-9476
DOI	10.1016/j.mcpro.2023.100504
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Zs.A 5599: Show issues

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Article ; Online: Identification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification.

Hu, Xiaoxiao / Zhou, Yilu / Hill, Charlotte / Chen, Kai / Cheng, Cheng / Liu, Xiaowei / Duan, Peiwen / Gu, Yaoyao / Wu, Yeming / Ewing, Rob M / Li, Zhongrong / Wu, Zhixiang / Wang, Yihua

British journal of cancer

2024

Abstract: Background: Despite the extensive study of MYCN-amplified neuroblastomas, there is a significant unmet clinical need in MYCN non-amplified cases. In particular, the extent of heterogeneity within the MYCN non-amplified population is unknown.: Methods!# ...

Abstract	Background: Despite the extensive study of MYCN-amplified neuroblastomas, there is a significant unmet clinical need in MYCN non-amplified cases. In particular, the extent of heterogeneity within the MYCN non-amplified population is unknown. Methods: A total of 1566 samples from 16 datasets were identified in Gene Expression Omnibus (GEO) and ArrayExpress. Characterisation of the subtypes was analysed by ConsensusClusterPlus. Independent predictors for subgrouping were constructed from the single sample predictor based on the multiclassPairs package. Findings were verified using immunohistochemistry and CIBERSORTx analysis. Results: We demonstrate that MYCN non-amplified neuroblastomas are heterogeneous and can be classified into 3 subgroups based on their transcriptional signatures. Within these groups, subgroup_2 has the worst prognosis and this group shows a 'MYCN' signature that is potentially induced by the overexpression of Aurora Kinase A (AURKA); whilst subgroup_3 is characterised by an 'inflamed' gene signature. The clinical implications of this subtype classification are significant, as each subtype demonstrates a unique prognosis and vulnerability to investigational therapies. A total of 420 genes were identified as independent subgroup predictors with average balanced accuracy of 0.93 and 0.84 for train and test datasets, respectively. Conclusion: We propose that transcriptional subtyping may enhance precision prognosis and therapy stratification for patients with MYCN non-amplified neuroblastomas.
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-024-02666-y
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